[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100563298":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":28,"centralContacts":32,"locations":11,"responsibleParty":37,"collaborators":11,"id":39,"slug":40,"hasResults":41,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":11,"eligibilityCriteria":45,"healthyVolunteers":41,"sex":46,"minAge":47,"maxAge":48,"enrollmentInfo":49,"targetDuration":11,"studyType":52,"phases":53,"briefSummary":55,"conditions":56,"keywords":59,"overallStatus":63,"whyStopped":11,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":11},{"fullName":5,"class":6},"Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Prednisolone acetate eye drop group","EXPERIMENTAL",null,[13],"Drug: Prednisolone acetate eye drop group",{"label":15,"type":16,"description":11,"interventionNames":17},"hyaluronic acid eye drop group","PLACEBO_COMPARATOR",[18],"Drug: Sodium hyaluronate eye drops",[20,24],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":11},"DRUG","Patients receive prednisolone acetate eye drops 4 times per 30min within 2 hours before cataract surgery",[9],{"type":21,"name":25,"description":26,"armGroupLabels":27,"otherNames":11},"Sodium hyaluronate eye drops","Patients receive sodium hyaluronate eye drops 4 times per 30min within 2 hours before cataract surgery",[15],[29],{"name":30,"affiliation":5,"role":31},"Huiyi Jin","PRINCIPAL_INVESTIGATOR",[33],{"name":30,"role":34,"phone":35,"phoneExt":11,"email":36},"CONTACT","021-63240090","superbaby_jin@163.com",{"type":31,"investigatorFullName":30,"investigatorTitle":38,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"Principal Investigator, Associate Chief Physician,","100563298","phase-2-prednisolone-acetate-eye-drops-for-pain-intervention-in-second-eye-cataract-surgery-100563298",false,"NCT06614348","Prednisolone Acetate Eye Drops for Pain Intervention in Second Eye Cataract Surgery","A Randomized Controlled Study of Prednisolone Acetate Eye Drops for Pain Intervention in Second Eye Cataract Surgery","Inclusion Criteria:\n\n* Age between 50-80 years old;\n* A clear diagnosis of age-related cataract, having completed the first eye cataract surgery at our hospital, and planning to have the second eye cataract surgery with the same doctor;\n* The interval between the two surgeries is ≤30 days;\n* Capable of cooperating to complete iris optical coherence tomography angiography examination;\n* Based on our team\\'s previous research, a predictive scoring formula for pain during the second eye surgery has been derived (Predicted score = 1.36 + 4.93 \\* preoperative iris vessel area density - 0.24 \\* surgical interval (weeks)), and the calculated predicted score is \\>2.\n\nExclusion Criteria:\n\n* History of ocular trauma, ocular surgery, uveitis, fundus disease, glaucoma, or recent history of episcleritis, keratitis, severe dry eye, and other ocular surface disease episodes;\n* Participation in intraocular or systemic medication clinical trials within the past 6 months;\n* Having an autoimmune disease or currently undergoing immunosuppressive therapy;\n* Having a psychiatric disorder such as anxiety or depression;\n* History of using glucocorticoid eye drops for treatment in the second eye within the past month;\n* Long-term use of drugs that can cause intraoperative floppy iris syndrome, such as alpha-blockers;\n* Severe complications occurred during or after the first eye surgery (e.g., posterior capsule rupture, zonular exercise, nuclear drop into the vitreous cavity, postoperative endophthalmitis, glaucoma, etc.).","ALL","50 Years","80 Years",{"count":50,"type":51},70,"ESTIMATED","INTERVENTIONAL",[54],"PHASE2","This study aims to evaluate the efficacy, safety, and potential mechanisms of prednisolone acetate eye drops for pain management in patients undergoing second-eye surgery for age-related cataracts.\n\nResearchers will compare prednisolone acetate eye drops to sodium hyaluronate eye drops to see if prednisolone acetate eye drops work to relieve intraoperative and postoperative pain during second-eye cataract surgery.\n\nParticipants will:\n\n1. Receive prednisolone acetate eye drops or sodium hyaluronate eye drop four drops within 2 hours before cataract surgery\n2. Finish cataract surgery and routine postoperative follow-up\n3. Pain questionnaire completed after cataract surgery",[57,58],"Age Related Cataract","Pain Management During Cataract Surgery",[60,61,62],"cataract surgery","pain","second-eye cataract surgery","NOT_YET_RECRUITING","2024-09-24",{"date":66,"type":67},"2024-09-26","ACTUAL",{"date":69,"type":51},"2024-10-08",{"date":71,"type":51},"2025-11-30",{"name":5,"class":6}]