[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100625120":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":29,"locations":35,"responsibleParty":66,"collaborators":69,"id":71,"slug":72,"hasResults":73,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":73,"sex":79,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":24,"studyType":85,"phases":86,"briefSummary":88,"conditions":89,"keywords":93,"overallStatus":96,"whyStopped":24,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"University of Texas at Austin","OTHER",[8,13],{"label":9,"type":6,"description":10,"interventionNames":11},"PTHF First","PTHF prior to CPAP",[12],"Procedure: Pressure Targeted High Flow",{"label":14,"type":6,"description":15,"interventionNames":16},"CPAP First","CPAP prior to PTHF",[17],"Procedure: CPAP",[19,25],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"PROCEDURE","Pressure Targeted High Flow","High Flow Nasal Cannula therapy with Pressure monitoring to match delivered CPAP pressure",[9],null,{"type":20,"name":26,"description":27,"armGroupLabels":28,"otherNames":24},"CPAP","Standard of care CPAP therapy",[14],[30],{"name":31,"role":32,"phone":33,"phoneExt":24,"email":34},"Alan Groves","CONTACT","512 324 1085","alan.groves@austin.utexas.edu",[36,54],{"facility":37,"status":24,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Sharp Mary Birch Hospital for Women & Newborns","San Diego","California","92123","United States","US",{"type":44,"coordinates":45},"Point",[46,47],-117.16472,32.71571,{"lat":47,"lon":46},[50],{"name":51,"role":32,"phone":52,"phoneExt":24,"email":53},"Anup Katheria","858-939-3400","anup.katheria@sharp.com",{"facility":55,"status":24,"city":56,"state":57,"zip":58,"country":41,"countryCode":42,"cosmosGeoPoint":59,"geoPoint":63,"contacts":64},"Ascension Seton Medical Center","Austin","Texas","78705",{"type":44,"coordinates":60},[61,62],-97.74306,30.26715,{"lat":62,"lon":61},[65],{"name":31,"role":32,"phone":33,"phoneExt":24,"email":34},{"type":67,"investigatorFullName":31,"investigatorTitle":68,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"PRINCIPAL_INVESTIGATOR","Professor of Pediatrics",[70],{"name":37,"class":6},"100625120","phase-2-pressure-targeting-during-high-flow-therapy-in-premature-infants-100625120",false,"NCT07418502","Pressure Targeting During High Flow Therapy in Premature Infants","A Phase 2 Crossover Trial of Pressure Targeted High Flow Therapy in Premature Infants","NeoMATCH","Inclusion Criteria:\n\n* Delivery at \\>24+0 weeks and ≤32+6 weeks of gestation\n* Postnatal age \\>7 days but \\\u003C 6 weeks old\n* Weight ≥1,000grams at the time of study\n* Receiving clinically prescribed CPAP at pressures of 5-8cm H2O\n* Requiring an FiO2 of ≤0.60\n\nExclusion Criteria:\n\n* Chromosomal disorder (aneuploidy)\n* Presence of major congenital birth defect including airway anomalies, congenital diaphragmatic hernia or cardiac defects (other than patent foramen ovale and patent ductus arteriosus)\n* Prior pneumothorax\n* Infants in whom chance of survival is uncertain","ALL","7 Days","40 Weeks",{"count":83,"type":84},78,"ESTIMATED","INTERVENTIONAL",[87],"PHASE2","The goal of this study is to see if a new approach to breathing support ('Pressure Targeted High Flow') is as effective as standard of care ('Continuous Positive Airway Pressure') in prematurely born infants. It will also learn about the effect of these types of breathing support on infant comfort and impact on staffing. The main question it aims to answer is:\n\nDoes Pressure Targeted High Flow provide enough support in premature infants?\n\nParticipants will:\n\nTake spend 24 hours supported by Pressure Targeted High Flow and 24 hours supported by CPAP. During this time their breathing rate, oxygen requirement and other markers of comfort will be monitored.",[90,91,92],"Preterm Infants","Respiratory Distress Syndrome (Neonatal)","BPD - Bronchopulmonary Dysplasia",[94,26,95],"preterm","High Flow","NOT_YET_RECRUITING","2026-02-10",{"date":99,"type":100},"2026-02-18","ACTUAL",{"date":102,"type":84},"2026-05-01",{"date":104,"type":84},"2027-09",{"name":5,"class":6},2]