[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100563773":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":33,"locations":40,"responsibleParty":60,"collaborators":26,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":26,"eligibilityCriteria":69,"healthyVolunteers":65,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":26,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":85,"overallStatus":43,"whyStopped":26,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"George Washington University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Group A: CoQ10 1200 mg orally with Glutathione 1000 mg orally","ACTIVE_COMPARATOR","White-colored CoQ10 400 mg capsules will be dispensed AND White colored L-Glutathione 500 mg capsules will be dispensed.",[13],"Drug: CoQ10 1200 mg orally with Glutathione 1000 mg orally",{"label":15,"type":16,"description":17,"interventionNames":18},"Group B: Placebo CoQ10 orally and Placebo Glutathione orally","PLACEBO_COMPARATOR","A placebo to exactly match the CoQ10 will be made with white gelatin empty capsules containing cellulose AND a placebo to exactly match the L-Glutathione will be made with white gelatin empty capsules containing cellulose.",[19],"Drug: Group B: Placebo CoQ10 orally and Placebo Glutathione orally",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","CoQ10 1200 mg orally with Glutathione 1000 mg orally","This is the intervention to assess efficacy of CoQ10 and Glutathione in prevention of cardiac surgery associated acute kidney injury",[9],null,{"type":22,"name":15,"description":17,"armGroupLabels":28,"otherNames":26},[15],[30],{"name":31,"affiliation":5,"role":32},"Yoosif Abdalla, MD","PRINCIPAL_INVESTIGATOR",[34,39],{"name":35,"role":36,"phone":37,"phoneExt":26,"email":38},"Eduard Shaykhinurov, MS","CONTACT","2028234259","eshaykhinurov@mfa.gwu.edu",{"name":31,"role":36,"phone":26,"phoneExt":26,"email":26},[41],{"facility":42,"status":43,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"George Washington University Hospital","RECRUITING","Washington D.C.","District of Columbia","20037","United States","US",{"type":50,"coordinates":51},"Point",[52,53],-77.03637,38.89511,{"lat":53,"lon":52},[56,59],{"name":57,"role":36,"phone":58,"phoneExt":26,"email":38},"Eduard Shaykhinurov","202-823-4259",{"name":31,"role":32,"phone":26,"phoneExt":26,"email":26},{"type":32,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"yoosif abdalla","Principal Investigator","100563773","phase-2-prevent-cardiac-surgery-associated-aki-trial-100563773",false,"NCT06620523","Prevent Cardiac Surgery Associated AKI Trial","Efficacy of Mitochondrial Directed Therapy in Prevention of Cardiac Surgery Associated AKI Prevent Cardiac Surgery Associated AKI Trial (Prevent CSA-AKI Trial)","Inclusion Criteria:\n\n* Adult 18-70 years of age\n* Undergoing elective CPB (Cardiopulmonary Bypass) surgery\n* Baseline GFR (Glomerular Filtration Rate) ≥45 ml\u002Fmin\n\nExclusion Criteria:\n\n* GFR (Glomerular Filtration Rate) \\\u003C45 ml\u002Fmin\n* Solitary kidney\n* Status post-kidney transplant\n* Pregnant women\n* Allergy to CoQ10\n* Allergy to Glutathione\n* Allergy to Cellulose","ALL","18 Years","70 Years",{"count":74,"type":75},242,"ESTIMATED","INTERVENTIONAL",[78],"PHASE2","Prevent CSA-AKI (Cardiac Surgery Associated Acute Kidney Injury) trial is a double blinded randomized controlled trial, 242 patients undergoing elective cardiopulmonary bypass surgery (CPB)will either receive a placebo or daily 1200 mg of Co enzyme Q10 (CoQ10) and 1000 mg of Glutathione (GSH), the first dose will be given the day before surgery and continues while admitted up to 1 week. Blood and urine samples will be collected. Adverse events related to the study drugs will be collected.",[81,82,83,84],"Renal Failure","Coronary Artery Disease","Surgery","Surgery-Complications",[86,87,88,89,90,91,92,93],"cardiac surgery","critical care medicine","anesthesiology","nephrology","cardiopulmonary bypass","renal failure","aki","supplement","2025-10-03",{"date":96,"type":97},"2025-10-08","ACTUAL",{"date":99,"type":97},"2024-07-18",{"date":101,"type":75},"2028-06-17",{"name":5,"class":6},1]