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service de rhumatologie","Mont-de-Marsan",{"type":53,"coordinates":139},[140,141],-0.49713,43.89022,{"lat":141,"lon":140},[144,147],{"name":145,"role":38,"phone":11,"phoneExt":11,"email":146},"Marion MIRABEL, MD","marion.mirabel@ch-mdm.fr",{"name":145,"role":31,"phone":11,"phoneExt":11,"email":11},{"facility":149,"status":48,"city":150,"state":11,"zip":11,"country":50,"countryCode":51,"cosmosGeoPoint":151,"geoPoint":155,"contacts":156},"AP-HP - Hôpital Cochin - service de médecine interne","Paris",{"type":53,"coordinates":152},[153,154],2.3488,48.85341,{"lat":154,"lon":153},[157,160],{"name":158,"role":38,"phone":11,"phoneExt":11,"email":159},"Benjamin CHAIGNE, MD","benjamin.chaigne@aphp.fr",{"name":158,"role":31,"phone":11,"phoneExt":11,"email":11},{"facility":162,"status":48,"city":163,"state":11,"zip":11,"country":50,"countryCode":51,"cosmosGeoPoint":164,"geoPoint":168,"contacts":169},"CH de Pau - service de médecine interne","Pau",{"type":53,"coordinates":165},[166,167],-0.35583,43.31117,{"lat":167,"lon":166},[170,173],{"name":171,"role":38,"phone":11,"phoneExt":11,"email":172},"Xavier DELBREL, MD","xavier.delbrel@ch-pau.fr",{"name":171,"role":31,"phone":11,"phoneExt":11,"email":11},{"facility":175,"status":66,"city":176,"state":11,"zip":11,"country":50,"countryCode":51,"cosmosGeoPoint":177,"geoPoint":181,"contacts":182},"CHU de Toulouse - service de médecine interne","Toulouse",{"type":53,"coordinates":178},[179,180],1.44367,43.60426,{"lat":180,"lon":179},[183,186],{"name":184,"role":38,"phone":11,"phoneExt":11,"email":185},"Grégory PUGNET, MD","pugnet.g@chu-toulouse.fr",{"name":184,"role":31,"phone":11,"phoneExt":11,"email":11},{"type":188,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR",[190],{"name":191,"class":192},"Ministry for Health and Solidarity, France","OTHER_GOV","100446843","phase-2-preventive-effect-of-clopidogrel-on-the-systemic-sclerosis-development-risk-100446843",false,"NCT05098704","Preventive Effect of Clopidogrel on the Systemic Sclerosis Development Risk","Phase II\u002FIII Double-blind Randomized Placebo-controlled Trial Assessing the Preventive Effect of Clopidogrel on the Systemic Sclerosis Development Risk in Subjects With Specific Dysimmunity and Raynaud Phenomenon","PSSIT","Inclusion Criteria:\n\n* Patient over 18 years old, and less than 85 years old.\n* Patient with positive AAN (AAN ≥ 1\u002F160) with the following specificity: anti-Scl70 or anti-centromere or anti-RNApolIII, or any other auto-antibodies related to systemic sclerosis\n* Patient with RP reported by the subject and confirmed by the physician.\n* Patient affiliated to a health insurance system.\n* Patient who accepts to participate to the study and signs an inform consent form.\n\nExclusion Criteria:\n\n* Patient with an SSc diagnosis according to ACR\u002FEULAR 2013 criteria.\n* Patient with skin fibrosis at screening.\n* Patient with antiplatelet treatment at screening.\n* Patient with contraindications to clopidogrel.\n* Patient treated by immunosuppressive agent at screening.\n* Patient treated by anticoagulants at screening\n* Pregnant or breastfeeding women.\n* Women of childbearing age refusing effective contraception method during the study treatment (24 months).\n* Incompetent adults (i.e. Individuals under the protection of a conservator)","ALL","18 Years","85 Years",{"count":205,"type":206},90,"ESTIMATED","INTERVENTIONAL",[209,210],"PHASE2","PHASE3","Systemic sclerosis (SSc) is a severe autoimmune disease associating dysimmunity, vasculopathy and fibrosis. No curative treatment is available. Pre-clinical abnormalities can be found such as specific autoantibodies. The association of Raynaud phenomenon and SSc-specific anti-nuclear antibodies is the hallmark of pre-scleroderma subjects, among who around 47% declare a complete disease after five years. The aim of this study is to assess in this particular population the preventive effect of an anti-platelet treatment.",[213,214],"Scleroderma","Systemic Sclerosis",[216,9,217,218,219],"systemic sclerosis","platelet","prevention","primary care","2025-07-11",{"date":222,"type":223},"2025-07-14","ACTUAL",{"date":225,"type":223},"2022-06-22",{"date":227,"type":206},"2031-06",{"name":5,"class":6},10]