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Cardiac arrhythmias including paroxysmal atrial fibrillation.\n* Transient ischemic attack or stroke \\\u003C6 months from Screening Visit; hospitalization for any cardiovascular or cerebrovascular event \\\u003C6 months from Screening Visit.\n* Known or suspected history of immunosuppression.\n* History of known immunodeficiency disorder or hepatitis B or C.\n* History of alcohol abuse and\u002For drug abuse.\n* Recent history of cancer except basal cell carcinoma or in situ carcinoma of the cervix treated with apparent success.\n* Chronic treatment with long-term oxygen therapy (LTOT) or nocturnal oxygen therapy required for \\>15 hours a day.\n* Participants on long-term macrolide.\n* Current acute COPD exacerbation for which SoC was started \\>48 hours prior to Screening.\n* A recent chest X-ray or computed tomography (CT) scan at Screening reveals evidence of clinically significant abnormalities not believed to be due to the presence of COPD, or a clinically significant pulmonary infection identified by chest X-ray (CT scan).\n* Female participant who is pregnant, lactating or breast-feeding, or has a positive urinary β-hCG test prior to randomization.\n* Receipt of any marketed nonbiologic drug that modulates type 2 cytokines 30 days or 5 half-lives prior to randomization, whichever is longer.\n* Receipt of any marketed or any investigational biologic for COPD or other diseases within 16 weeks or 5 half-lives prior to randomization, whichever is longer.\n* Live, attenuated vaccinations within 4 weeks prior to randomization or planned live, attenuated vaccinations during the trial.\n* Treatment with systemic corticosteroids (ie, oral or by injection) and\u002For hospitalization for an exacerbation of COPD completed less than 4 weeks prior to randomization.\n\nThe above inclusion and exclusion criteria are not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.","ALL","40 Years","80 Years",{"count":635,"type":636},160,"ESTIMATED","INTERVENTIONAL",[639],"PHASE2","This is a Phase 2, multicenter study in adult participants with an acute COPD exacerbation and type 2 inflammation",[642],"COPD Acute Exacerbation",[644,645,646,647,26,648,649],"COPD","chronic obstructive pulmonary disease","rademikibart","Connect Biopharma","COPD exacerbation","type 2 inflammation","2026-06-10",{"date":652,"type":653},"2026-06-12","ACTUAL",{"date":655,"type":653},"2025-08-12",{"date":657,"type":636},"2026-07",{"name":5,"class":6},53]