[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100545777":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":79,"centralContacts":83,"locations":89,"responsibleParty":188,"collaborators":78,"id":190,"slug":191,"hasResults":192,"nctId":193,"briefTitle":194,"officialTitle":195,"acronym":78,"eligibilityCriteria":196,"healthyVolunteers":192,"sex":197,"minAge":198,"maxAge":78,"enrollmentInfo":199,"targetDuration":78,"studyType":202,"phases":203,"briefSummary":205,"conditions":206,"keywords":78,"overallStatus":92,"whyStopped":78,"lastUpdateSubmitDate":212,"lastUpdatePostDateStruct":213,"startDateStruct":216,"completionDateStruct":218,"leadSponsor":220,"locationsCount":221},{"fullName":5,"class":6},"Mayo Clinic","OTHER",[8,18],{"label":9,"type":10,"description":11,"interventionNames":12},"ARM 1 (reduced dose ISRT)","EXPERIMENTAL","Patients undergo reduced dose ISRT once daily (excluding weekends): 9 Gy delivered in 3 treatment fractions or 8 Gy in 2 fractions. At physician discretion, patients may receive 10 Gy in 5 fractions. Patients also undergo CT or PET\u002FCT throughout the study. Patients may additionally undergo endoscopy during screening and during follow up.",[13,14,15,16,17],"Procedure: Computed Tomography","Procedure: Endoscopic Procedure","Radiation: Involved-site Radiation Therapy (3 Fractions)","Procedure: Positron Emission Tomography","Other: Questionnaire Administration",{"label":19,"type":20,"description":21,"interventionNames":22},"ARM 2 (SOC ISRT)","ACTIVE_COMPARATOR","Patients undergo standard of care (SOC) radiation therapy once daily (excluding weekends): 24 Gy in 12 treatment fractions. Patients also undergo CT or PET\u002FCT throughout the study. Patients may additionally undergo endoscopy during screening and during follow up.",[13,14,23,16,17],"Radiation: Involved-site Radiation Therapy (12 Fractions)",[25,41,49,56,61,74],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"PROCEDURE","Computed Tomography","Undergo CT or PET\u002FCT",[9,19],[31,32,33,34,35,36,37,38,39,40],"CAT","CAT Scan","Computed Axial Tomography","Computerized Axial Tomography","Computerized axial tomography (procedure)","Computerized Tomography","Computerized Tomography (CT) scan","CT","CT Scan","tomography",{"type":26,"name":42,"description":43,"armGroupLabels":44,"otherNames":45},"Endoscopic Procedure","Undergo endoscopy",[9,19],[46,47,48],"Endoscopic Examination","Endoscopy","ES",{"type":50,"name":51,"description":52,"armGroupLabels":53,"otherNames":54},"RADIATION","Involved-site Radiation Therapy (3 Fractions)","Undergo ISRT in 3 fractions",[9],[55],"ISRT",{"type":50,"name":57,"description":58,"armGroupLabels":59,"otherNames":60},"Involved-site Radiation Therapy (12 Fractions)","Undergo ISRT in 12 fractions",[19],[55],{"type":26,"name":62,"description":63,"armGroupLabels":64,"otherNames":65},"Positron Emission Tomography","Undergo PET\u002FCT",[9,19],[66,67,68,69,70,71,72,73],"Medical Imaging, Positron Emission Tomography","PET","PET Scan","Positron emission tomography (procedure)","Positron Emission Tomography Scan","Positron-Emission Tomography","proton magnetic resonance spectroscopic imaging","PT",{"type":6,"name":75,"description":76,"armGroupLabels":77,"otherNames":78},"Questionnaire Administration","Ancillary studies",[9,19],null,[80],{"name":81,"affiliation":5,"role":82},"Brad S. Hoppe, MD, MPH","PRINCIPAL_INVESTIGATOR",[84],{"name":85,"role":86,"phone":87,"phoneExt":78,"email":88},"Clinical Trials Referral Office","CONTACT","855-776-0015","mayocliniccancerstudies@mayo.edu",[90,108,121,135,148,161,175],{"facility":91,"status":92,"city":93,"state":94,"zip":95,"country":96,"countryCode":97,"cosmosGeoPoint":98,"geoPoint":103,"contacts":104},"Mayo Clinic in Arizona","RECRUITING","Scottsdale","Arizona","85259","United States","US",{"type":99,"coordinates":100},"Point",[101,102],-111.89903,33.50921,{"lat":102,"lon":101},[105,106],{"name":85,"role":86,"phone":87,"phoneExt":78,"email":88},{"name":107,"role":82,"phone":78,"phoneExt":78,"email":78},"William G. Rule, MD",{"facility":109,"status":92,"city":110,"state":111,"zip":112,"country":96,"countryCode":97,"cosmosGeoPoint":113,"geoPoint":117,"contacts":118},"Mayo Clinic in Florida","Jacksonville","Florida","32224-9980",{"type":99,"coordinates":114},[115,116],-81.65565,30.33218,{"lat":116,"lon":115},[119,120],{"name":85,"role":86,"phone":87,"phoneExt":78,"email":88},{"name":81,"role":82,"phone":78,"phoneExt":78,"email":78},{"facility":122,"status":92,"city":123,"state":124,"zip":125,"country":96,"countryCode":97,"cosmosGeoPoint":126,"geoPoint":130,"contacts":131},"Mayo Clinic Health System in Albert Lea","Albert Lea","Minnesota","56007",{"type":99,"coordinates":127},[128,129],-93.36827,43.64801,{"lat":129,"lon":128},[132,133],{"name":85,"role":86,"phone":87,"phoneExt":78,"email":88},{"name":134,"role":82,"phone":78,"phoneExt":78,"email":78},"John Yeakel, MD",{"facility":136,"status":92,"city":137,"state":124,"zip":138,"country":96,"countryCode":97,"cosmosGeoPoint":139,"geoPoint":143,"contacts":144},"Mayo Clinic Health System - Mankato","Mankato","56001",{"type":99,"coordinates":140},[141,142],-94.00915,44.15906,{"lat":142,"lon":141},[145,146],{"name":85,"role":86,"phone":87,"phoneExt":78,"email":88},{"name":147,"role":82,"phone":78,"phoneExt":78,"email":78},"Jason T. Hayes, MD",{"facility":149,"status":92,"city":150,"state":124,"zip":151,"country":96,"countryCode":97,"cosmosGeoPoint":152,"geoPoint":156,"contacts":157},"Mayo Clinic in Rochester","Rochester","55905",{"type":99,"coordinates":153},[154,155],-92.4699,44.02163,{"lat":155,"lon":154},[158,159],{"name":85,"role":86,"phone":87,"phoneExt":78,"email":88},{"name":160,"role":82,"phone":78,"phoneExt":78,"email":78},"Scott C. Lester, MD",{"facility":162,"status":92,"city":163,"state":164,"zip":165,"country":96,"countryCode":97,"cosmosGeoPoint":166,"geoPoint":170,"contacts":171},"Mayo Clinic Health System-Eau Claire Clinic","Eau Claire","Wisconsin","54701",{"type":99,"coordinates":167},[168,169],-91.49849,44.81135,{"lat":169,"lon":168},[172,173],{"name":85,"role":86,"phone":87,"phoneExt":78,"email":88},{"name":174,"role":82,"phone":78,"phoneExt":78,"email":78},"Now Bahar Alam, MD",{"facility":176,"status":92,"city":177,"state":164,"zip":178,"country":96,"countryCode":97,"cosmosGeoPoint":179,"geoPoint":183,"contacts":184},"Mayo Clinic Health System-Franciscan Healthcare","La Crosse","54601",{"type":99,"coordinates":180},[181,182],-91.23958,43.80136,{"lat":182,"lon":181},[185,186],{"name":85,"role":86,"phone":87,"phoneExt":78,"email":88},{"name":187,"role":82,"phone":78,"phoneExt":78,"email":78},"Abigail L. Stockham, MD",{"type":189,"investigatorFullName":78,"investigatorTitle":78,"investigatorAffiliation":78,"oldNameTitle":78,"oldOrganization":78},"SPONSOR","100545777","phase-2-reduced-dose-radiotherapy-for-the-treatment-of-indolent-non-hodgkin-lymphoma-100545777",false,"NCT06386315","Reduced Dose Radiotherapy for the Treatment of Indolent Non-Hodgkin Lymphoma","MC230808 Reduced Dose Hypofractionated Radiotherapy (3Gy x 3 Fractions) for Indolent Non-Hodgkin Lymphoma (POSEIDON): A Multisite Phase 2 Randomized Trial","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Histological confirmation of indolent B-cell lymphoma that can include any of the following:\n\n  * Follicular lymphoma (grade 1 or 2 or 3A)\n  * Marginal zone lymphoma (nodal or extranodal)\n  * Follicle center lymphoma\n* Any stage disease\n* Initial, refractory, or relapsed disease. If relapse involves the site to be treated there must be evidence of disease progression\n* Eastern Cooperative Oncology Group (ECOG) performance status (PS) ≤ 3\n* Negative pregnancy test done ≤ 7 days prior to registration, for persons of childbearing potential only\n* Provide written informed consent\n* Ability to complete questionnaire(s) by themselves or with assistance\n* Willing to return to enrolling institution for follow-up visits (during the active monitoring phase of the study). Virtual visits can also be considered as an option for applicable items\n* Confirmation from radiation oncologist of suitability to participate in study\n\nExclusion Criteria:\n\n* Any of the following:\n\n  * Pregnant women\n  * Nursing women\n  * Women of childbearing potential who are unwilling to employ adequate contraception\n* T-cell lymphoma\n* Receiving treatment for small and chronic lymphocytic lymphoma\n* Grade 3B follicular lymphoma","ALL","18 Years",{"count":200,"type":201},112,"ESTIMATED","INTERVENTIONAL",[204],"PHASE2","This phase II trial compares the safety, side effects and effectiveness of reduced dose radiation therapy to standard of care dose radiation in treating patients with indolent non-Hodgkin lymphoma. Radiation therapy uses high energy x-rays, particles, or radioactive seeds to kill cancer cells and shrink tumors. Standard of care radiation treatment for indolent non-Hodgkin lymphoma is usually delivered in 12 treatments. Studies have shown indolent lymphoma to be sensitive to radiation treatment, however, larger doses have higher rates of toxicities. A reduced radiation dose may be safe, tolerable and\u002For effective compared to standard of care radiation dose in treating patients with indolent non-Hodgkin lymphoma.",[207,208,209,210,211],"Indolent B-Cell Non-Hodgkin Lymphoma","Recurrent Indolent B-Cell Non-Hodgkin Lymphoma","Refractory Indolent B-Cell Non-Hodgkin Lymphoma","Recurrent Indolent Non-Hodgkin Lymphoma","Refractory Indolent Non-Hodgkin Lymphoma","2026-04-17",{"date":214,"type":215},"2026-04-22","ACTUAL",{"date":217,"type":215},"2024-05-15",{"date":219,"type":201},"2027-05-30",{"name":5,"class":6},7]