[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100493105":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":28,"locations":33,"responsibleParty":61,"collaborators":64,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":11,"eligibilityCriteria":75,"healthyVolunteers":71,"sex":76,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":11,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":11,"overallStatus":36,"whyStopped":11,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Teachers College, Columbia University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"In-person","ACTIVE_COMPARATOR",null,[13],"Behavioral: Expiratory Muscle Strength Training + Cough Skill Training",{"label":15,"type":16,"description":11,"interventionNames":17},"Telehealth","EXPERIMENTAL",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":11},"BEHAVIORAL","Expiratory Muscle Strength Training + Cough Skill Training","Expiratory Muscle Strength Training (EMST). EMST is a widely used and efficacious treatment approach that uses a calibrated device with a one-way, spring-loaded pressure relief valve to mechanically overload the expiratory and submental muscles.\n\nCough Skill Training (CST) involves a digital peak flow meter device which measures PEFR (peak expiratory flow rate) in liters\u002Fsecond and allows patients to receive immediate biofeedback.",[9,15],[25],{"name":26,"affiliation":5,"role":27},"Michelle Troche, PhD","PRINCIPAL_INVESTIGATOR",[29],{"name":26,"role":30,"phone":31,"phoneExt":11,"email":32},"CONTACT","212-678-3072","uadlab@tc.columbia.edu",[34,52],{"facility":35,"status":36,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Purdue University","RECRUITING","West Lafayette","Indiana","47907","United States","US",{"type":43,"coordinates":44},"Point",[45,46],-86.90807,40.42587,{"lat":46,"lon":45},[49],{"name":50,"role":30,"phone":11,"phoneExt":11,"email":51},"Georgia Malandraki, PhD","malandraki@purdue.edu",{"facility":5,"status":53,"city":54,"state":54,"zip":55,"country":40,"countryCode":41,"cosmosGeoPoint":56,"geoPoint":60,"contacts":11},"ACTIVE_NOT_RECRUITING","New York","10027",{"type":43,"coordinates":57},[58,59],-74.00597,40.71427,{"lat":59,"lon":58},{"type":27,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"Michelle Troche","Professor, Principle Investigator",[65,68],{"name":66,"class":67},"National Institute of Neurological Disorders and Stroke (NINDS)","NIH",{"name":35,"class":6},"100493105","phase-2-rehabilitation-of-airway-protection-in-parkinsons-disease-100493105",false,"NCT05700825","Rehabilitation of Airway Protection in Parkinson's Disease","Rehabilitation of Airway Protection in Parkinson's Disease: Comparing In-person and Telehealth Service Delivery Models","Inclusion criteria:\n\n* Diagnosed with PD (Hoehn and Yahr Stages II-IV)126,127 confirmed by a Movement Disorders fellowship trained neurologist having reviewed the video recorded Movement Disorders Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) assessment for each participant and using strict UK brain bank criteria\n* airway protective deficits as defined as a minimum of penetration of thin liquids (penetration-aspiration score\\>3) as determined by instrumental swallowing assessment and\u002For dystussia as determined by voluntary cough assessment (PEFR ≤4.1 L\u002Fs)\n* not actively receiving exercise-based swallowing therapy\n* between the ages of 50 and 90.\n\nExclusion criteria:\n\n* Other neurological disorders (e.g., multiple sclerosis, stroke, brain tumor, etc.)\n* history of head and neck cancer\n* history of breathing disorders or diseases (e.g., COPD)\n* history of smoking in the last five years\n* uncontrolled hypertension\n* difficulty complying due to neuropsychological dysfunction (i.e., severe depression with \\>28 on the Beck Depression Index (BDI-II), dementia with \\\u003C19 on the Montreal Cognitive Assessment (MoCA))\n* allergy to capsaicin or barium\n* further than 1.5 hours (door to door) distance from either Teachers College, Columbia University or Purdue University.","ALL","50 Years","90 Years",{"count":80,"type":81},120,"ESTIMATED","INTERVENTIONAL",[84],"PHASE2","Airway protective disorders are a prevalent and progressive consequence of Parkinson's Disease (PD), and often result in aspiration pneumonia which is the leading cause of death in PD. Despite this, a large number of patients with PD do not access specialized services to address these critical deficits. The investigators will examine the comparative effectiveness of a novel treatment paradigm delivered in-person versus via telehealth in persons with PD, as well as the role of patient burden and treatment adherence on outcomes; thus, the proposed research is relevant to public health and in line with NIH's mission to identify novel, efficacious, and accessible rehabilitation strategies for short- and long-term improvement of dysfunctional airway protection in PD.",[87,88],"Parkinson Disease","Dysphagia","2025-09-19",{"date":91,"type":92},"2025-09-24","ACTUAL",{"date":94,"type":92},"2022-08-11",{"date":96,"type":81},"2027-09-01",{"name":5,"class":6},2]