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(i.e., no change in dosage in the past 30 days)\n* If on supplements, must be on stable dose with no plan to change; not on or planning any acupuncture or other specific supportive modalities for fatigue or AI arthralgias\n* Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0, 1 or 2\n* White blood cell count (WBC) ≥ 3,000\u002Fmm\\^3 (obtained ≤ 30 days prior to randomization)\n* Hemoglobin ≥ 10 g\u002FdL (obtained ≤ 30 days prior to randomization)\n* Platelet count ≥ 100,000\u002Fmm\\^3 (obtained ≤ 30 days prior to randomization)\n* Total bilirubin ≤ 1.5 x upper limit of normal (ULN) (obtained ≤ 30 days prior to randomization)\n* Alanine aminotransferase (ALT) or aspartate transaminase (AST) ≤ 1.2 x ULN (obtained ≤ 30 days prior to randomization)\n* Prothrombin time (PT)\u002Factivated partial thromboplastin time (aPTT) ≤ 1.5 x ULN (obtained ≤ 30 days prior to randomization)\n* Negative pregnancy test done ≤ 7 days prior to registration, for persons on concurrent ovarian suppression only\n* Provide informed consent\n* Ability to complete questionnaires\n* Willing to return to enrolling institution during the active monitoring phase of the study\n* Patients who have had a recent surgery or procedure should be healed and cleared by their clinician and\u002For surgeon per local standards, prior to registration\n\nExclusion Criteria:\n\n* Other known uncontrolled medical conditions causing fatigue such as untreated thyroid disease, depression, fibromyalgia, chronic fatigue syndrome, infection, autoimmune disease, or active\u002Funtreated hepatitis\n* Allergy to mushrooms\n* On anticoagulation medication or aspirin or having a known bleeding disorder\n* On any specific medication for fatigue (e.g., methylphenidate)\n* Metastatic cancer diagnosis (history of nodal metastases is allowed)\n* Chronic steroid use, unless on physiologic replacement doses\n* Current use of any medical mushrooms\n* On medications for diabetes\n* History of symptomatic hypotension\n* Taking CYP3A4, CYP2D6 sensitive substrates which can be located at the following link:\n\nhttps:\u002F\u002Fwww.fda.gov\u002Fdrugs\u002Fdrug-interactions-labeling\u002Fhealthcare-professionals-fdas-examples-drugs-interact-cyp-enzymes-and-transporter-systems\n\n* Drugs which exhibit either \\>20% inhibition or \\>20% induction of CYP2E1 in vivo, such as: Acetaminophen, Dapsone, Enflurane, Halothane, Isoflurane, \\& Theophylline\n* Taking olaparib\n* Any of the following because this study involves an agent that has unknown genotoxic, mutagenic and teratogenic effects:\n\n  * Pregnant persons\n  * Nursing persons\n  * Persons on concurrent ovarian suppression who are unwilling to employ adequate contraception (e.g., hormonal methods, barrier methods, intrauterine device, abstinence)\n* Planned surgery or procedure during time on study and ≤ 14 days after last dose, due to bleeding risks","FEMALE","18 Years",{"count":358,"type":359},80,"ESTIMATED","INTERVENTIONAL",[362],"PHASE2","This phase II trial tests how well Reishi mushroom extract works in treating fatigue and\u002For joint\u002Fmuscle pain (arthralgias\u002Fmyalgias) in patients with breast cancer on aromatase inhibitors. Fatigue and arthralgias\u002Fmyalgias are common symptoms in breast cancer patients taking aromatase inhibitors (AI). Given the long duration of AI treatment for some women (up to 10 years), these symptoms can significantly impact quality of life and premature discontinuation of AIs, a beneficial medication. Reishi mushrooms are among several medicinal mushrooms that have been used for hundreds of years, mainly in Asian countries, to help enhance the immune system, reduce stress, improve sleep, and lessen fatigue. Reishi mushroom extracts have not been studied explicitly for treatment-induced arthralgias\u002Fmyalgias, but have been shown to improve quality of life, muscular strength, pain, and flexibility. Information from this study may help researchers determine the effect of Reishi mushroom extract on fatigue and arthralgias\u002Fmyalgias in breast cancer patients receiving an AI.",[365],"Estrogen Receptor-Positive Breast Carcinoma","2026-06-15",{"date":368,"type":369},"2026-06-16","ACTUAL",{"date":371,"type":369},"2023-10-18",{"date":373,"type":359},"2027-09-15",{"name":5,"class":6},23]