[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100561460":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":34,"locations":44,"responsibleParty":64,"collaborators":25,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":70,"sex":76,"minAge":77,"maxAge":25,"enrollmentInfo":78,"targetDuration":25,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":88,"overallStatus":46,"whyStopped":25,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Duke University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Pyrvinium","ACTIVE_COMPARATOR","Participants will receive Pyrvinium (2 mg\u002Fkg\u002Fday) by mouth once each day for a total of 14 days.",[13],"Drug: Pyrvinium",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo","PLACEBO_COMPARATOR","Participants will receive placebo by mouth once each day for a total of 14 days.",[19],"Drug: Placebo",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Pyrvinium (2 mg\u002Fkg) per day for 14 days",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"Placebo for 14 days",[15],[30],{"name":31,"affiliation":32,"role":33},"Katherine Garman, MD","Duke Health","PRINCIPAL_INVESTIGATOR",[35,40],{"name":36,"role":37,"phone":38,"phoneExt":25,"email":39},"Nicole Pavlus","CONTACT","919-684-0311","nicole.pavlus@duke.edu",{"name":41,"role":37,"phone":42,"phoneExt":25,"email":43},"Laura Hayes, MS","919-684-8771","laura.hayes@duke.edu",[45],{"facility":32,"status":46,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"RECRUITING","Durham","North Carolina","27710","United States","US",{"type":53,"coordinates":54},"Point",[55,56],-78.89862,35.99403,{"lat":56,"lon":55},[59,63],{"name":60,"role":37,"phone":61,"phoneExt":25,"email":62},"Christy Walters, RN","919-668-5499","christy.walters@duke.edu",{"name":31,"role":33,"phone":25,"phoneExt":25,"email":25},{"type":65,"investigatorFullName":66,"investigatorTitle":67,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"SPONSOR_INVESTIGATOR","Katherine Garman","Professor of Medicine","100561460","phase-2-reverse-intestinal-metaplasia-in-the-stomach-revise-100561460",false,"NCT06590454","REVerse Intestinal Metaplasia in the Stomach (REVISE)","Therapeutic Intervention to Reverse Gastric Precancer","REVISE","Inclusion Criteria:\n\n* Adults (including men, women, and non-binary individuals) over age 18 with known GIM with at least one high-risk feature (extensive vs limited, incomplete or mixed-type GIM, family history of stomach cancer),\n* Ability to provide informed consent,\n* Evidence of prior but not active H. pylori infection\n\nExclusion Criteria:\n\n* Active gastric cancer diagnosis,\n* High-risk of bleeding complications due to anticoagulants or underlying medical condition,\n* Pregnancy (which is a contraindication to non-emergent endoscopy due to anesthesia risks)","ALL","18 Years",{"count":79,"type":80},32,"ESTIMATED","INTERVENTIONAL",[83],"PHASE2","This study is designed to test the use of Pyrvinium vs placebo as a treatment for gastric intestinal metaplasia with features associated with increased risk of cancer. Response will be determined by assessing the extent and quality of the gastric intestinal metaplasia before and after treatment.\n\nA secondary aim will be to generate gastric organoids from patient-derived samples to test the effects of pyrvinium in vitro in patient-derived samples, and also to identify new drugs that may help reverse gastric intestinal metaplasia.",[86,87],"Gastric Intestinal Metaplasia","Gastric Precancer",[86,9],"2026-02-10",{"date":91,"type":92},"2026-02-12","ACTUAL",{"date":94,"type":92},"2025-12-15",{"date":96,"type":80},"2026-10-01",{"name":66,"class":6},1]