[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100594202":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":36,"locations":46,"responsibleParty":69,"collaborators":25,"id":73,"slug":74,"hasResults":75,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":25,"eligibilityCriteria":79,"healthyVolunteers":75,"sex":80,"minAge":81,"maxAge":25,"enrollmentInfo":82,"targetDuration":25,"studyType":85,"phases":86,"briefSummary":88,"conditions":89,"keywords":91,"overallStatus":99,"whyStopped":25,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":109},{"fullName":5,"class":6},"Laval University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Surgery A with Honey\u002F Surgery B without Honey","EXPERIMENTAL","Surgeries A and B will be performed 4 weeks apart. During both surgeries, recipient sites will be distant from donor sites (mandibular recipient site and palatal donor site). A safety distance of 2 mm from the marginal gingiva should be maintained during incisions. Glandular and fatty tissue will be removed from the graft, which may or may not be de-epithelialized depending on the procedure for which it was harvested. It will then be adapted to the recipient site and sutured in place. During post-operative healing, surgery A will include a palatal plate with Manuka honey . Surgery B will include a palatal plate without Manuka Honey.",[13,14],"Device: Palatal Plate without Manuka Honey","Device: Palatal plate with Manuka Honey",{"label":16,"type":10,"description":17,"interventionNames":18},"Surgery A without Honey\u002F Surgery B with Honey","Surgeries A and B will be performed 4 weeks apart. During both surgeries, recipient sites will be distant from donor sites (mandibular recipient site and palatal donor site). A safety distance of 2 mm from the marginal gingiva should be maintained during incisions. Glandular and fatty tissue will be removed from the graft, which may or may not be de-epithelialized depending on the procedure for which it was harvested. It will then be adapted to the recipient site and sutured in place. During post-operative healing, surgery A will include a palatal plate without Manuka honey . Surgery B will include a palatal plate with Manuka Honey.",[13,14],[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","Palatal Plate without Manuka Honey","A Palatal plate without Manuka Honey will be inserted by a blinded investigator on the donor site for post-operative procedures.",[9,16],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Palatal plate with Manuka Honey","A Palatal plate with Manuka Honey will be inserted by a blinded researcher on the donor site.",[9,16],[31,34],{"name":32,"affiliation":5,"role":33},"Nancy Mouradian, DMD, MSc, FRCD(C), Dip.ABP","STUDY_DIRECTOR",{"name":35,"affiliation":25,"role":33},"Benjamin Labelle, DMD, MSc, Cert. Perio, FRCD(C)",[37,42],{"name":38,"role":39,"phone":40,"phoneExt":25,"email":41},"Camille Côté-Laroche, DMD, MSc (candidate)","CONTACT","819-806-4806","camille.cote-laroche.1@ulaval.ca",{"name":43,"role":39,"phone":44,"phoneExt":25,"email":45},"Maya El Choueiri, Masters in Dental Sciences","4389283316","maya.choueiry.1@ulaval.ca",[47],{"facility":48,"status":25,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"Laval university- Faculty of Dentistry","Québec","Quebec","G1V 0A6","Canada","CA",{"type":55,"coordinates":56},"Point",[57,58],-71.21454,46.81228,{"lat":58,"lon":57},[61,63,65,67],{"name":62,"role":39,"phone":40,"phoneExt":25,"email":41},"Camille Côté-Laroche, DMD. MSc (candidate)",{"name":64,"role":39,"phone":44,"phoneExt":25,"email":45},"Maya El Choueiri, MSc in Dental Sciences",{"name":32,"role":66,"phone":25,"phoneExt":25,"email":25},"PRINCIPAL_INVESTIGATOR",{"name":68,"role":66,"phone":25,"phoneExt":25,"email":25},"Camille Côté-Laroche, DMD",{"type":70,"investigatorFullName":71,"investigatorTitle":72,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"SPONSOR_INVESTIGATOR","Nancy Mouradian","Clinical Professor","100594202","phase-2-role-of-manuka-honey-in-lowering-pain-and-boosting-healing-after-gum-graft-surgery-100594202",false,"NCT07016373","Role of Manuka Honey in Lowering Pain and Boosting Healing After Gum Graft Surgery.","Effect of Topical Application of Medical Grade Manuka Honey on Pain Intensity and Tissue Healing After Palatal Epithelial-connective Tissue Graft Harvesting: a Double-blinded Randomised Controlled Trial","Inclusion Criteria:\n\nParticipants must :\n\n* Be 18 years of age or older.\n* Be in good systemic health or have well-controlled systemic health.\n* Have a healthy or stable periodontium after conventional periodontal treatment.\n* Have good clinical gingival health or gingivitis on an intact or reduced periodontium, with or without a history of periodontitis\n* Maintain good oral hygiene.\n* Have a simplified plaque index and gingival bleeding index below 20%\n* Require two mucogingival surgeries involving bilateral epithelial-conjunctival graft harvesting (free gingival graft or de-epithelialised connective tissue graft).\n* The surgeries must treat single or multiple gingival recessions, or mucogingival defects around teeth or implants.\n\nExclusion Criteria:\n\n* Smokers or users of other tobacco products\n* Pregnant participants\n* Participants who are uncooperative or have a psychological condition that makes free and informed consent or compliance with instructions impossible\n* Participants with a condition that impairs healing (e.g. poorly controlled diabetes, coagulation disorder, etc.) or the objective assessment of pain at the sampling site (e.g. autoimmune diseases, orofacial pain, etc.)\n* Participants regularly taking the following medications : non-steroidal anti-inflammatory drugs, bisphosphonates, sedatives, psychotropic drugs and corticosteroids.\n* During the study, those who develop a condition that interferes with healing, become smokers, start medication that acts on the central nervous system, do not adhere strictly to instructions or do not respect follow-ups.\n* Participants who have already received a palatal surgery in the past or whose palatal tissue thickness is less than 3 mm will not be excluded, to allow comparative analyses in sub-groups.","ALL","18 Years",{"count":83,"type":84},24,"ESTIMATED","INTERVENTIONAL",[87],"PHASE2","The goal of this clinical trial is to learn if medical grade Manuka Honey works to lower pain and improve healing sites after gum grafting surgery. The main questions are:\n\n* Does medical grade Manuka honey lower pain and painkiller use after gum grafting surgery ?\n* Does medical grade Manuka honey boost healing after gum grafting surgery ?\n\nResearchers will compare, within the same patient, the results of a surgery with the application of Manuka honey in a retainer to a surgery without the application of honey in the retainer for the healing period.\n\nParticipants will:\n\n* Visit the clinic for their first surgery.\n* Fill up a daily survey to explain their level of pain and the amount of painkiller drugs used.\n* Visit the clinic once every week for 6 weeks for follow-ups.\n* Visit the clinic for their second surgery, four weeks after the first one.\n* Fill up a daily survey to explain their level of pain and the amount of painkiller drugs used after the second surgery.\n* Visit the clinic once every week for 6 weeks for follow-ups on the second surgery\n* Fill a survey to compare both surgeries .\n* Visit the clinic 2 months, 6 months and one year after the surgeries for more follow-ups.",[90],"Gingival Recession, Mucogingival Surgery",[92,93,94,95,96,97,98],"mucogingival surgery","recession","gingival graft","palatal donor site","medical grade manuka honey","healing","pain","NOT_YET_RECRUITING","2025-06-03",{"date":102,"type":103},"2025-06-11","ACTUAL",{"date":105,"type":84},"2025-06-20",{"date":107,"type":84},"2027-01-31",{"name":71,"class":6},1]