[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100252125":3},{"organization":4,"armGroups":7,"interventions":45,"overallOfficials":95,"centralContacts":99,"locations":110,"responsibleParty":125,"collaborators":128,"id":131,"slug":132,"hasResults":133,"nctId":134,"briefTitle":135,"officialTitle":136,"acronym":137,"eligibilityCriteria":138,"healthyVolunteers":139,"sex":140,"minAge":141,"maxAge":142,"enrollmentInfo":143,"targetDuration":51,"studyType":146,"phases":147,"briefSummary":149,"conditions":150,"keywords":51,"overallStatus":113,"whyStopped":51,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":156,"completionDateStruct":158,"leadSponsor":160,"locationsCount":161},{"fullName":5,"class":6},"Emory University","OTHER",[8,19,23,28,34,39],{"label":9,"type":10,"description":11,"interventionNames":12},"Veterans with Post-traumatic Stress Disorder (PTSD)","EXPERIMENTAL","For examining Objective 1 of this study, participants with post-traumatic stress disorder (PTSD) will be evaluated using microneurography, static handgrip exercise, cold pressor test, combat virtual reality video clip, and baroreflex sensitivity using sodium nitroprusside and phenylephrine. For the second phase, they will be randomized to either losartan or atenolol.",[13,14,15,16,17,18],"Procedure: Microneurography","Behavioral: Combat virtual reality video clip","Procedure: Handgrip Exercise","Procedure: Cold Pressor Test (CPT)","Drug: Sodium Nitroprusside (SNP)","Drug: Phenylephrine",{"label":20,"type":10,"description":21,"interventionNames":22},"Control","For examining Objective 1 of this study, healthy controls will be evaluated using microneurography, static handgrip exercise, cold pressor test, combat virtual reality video clip, and baroreflex sensitivity using sodium nitroprusside and phenylephrine.",[13,14,15,16,17,18],{"label":24,"type":10,"description":25,"interventionNames":26},"Losartan","Participants with PTSD randomized to receive losartan for 8 to 14 weeks.",[27],"Drug: Losartan",{"label":29,"type":30,"description":31,"interventionNames":32},"Atenolol","ACTIVE_COMPARATOR","Participants with PTSD randomized to receive atenolol for 8 to 14 weeks.",[33],"Drug: Atenolol",{"label":35,"type":10,"description":36,"interventionNames":37},"Transcutaneous Vagal Nerve Stimulation (tVNS)","Participants with PTSD randomized to receive treatment with tVNS for 8 to 14 weeks.",[38],"Device: Transcutaneous Vagal Nerve Stimulation (tVNS)",{"label":40,"type":41,"description":42,"interventionNames":43},"Sham Transcutaneous Vagal Nerve Stimulation (tVNS)","SHAM_COMPARATOR","Participants with PTSD randomized to receive treatment with sham-tVNS for 8 to 14 weeks.",[44],"Device: Sham Transcutaneous Vagal Nerve Stimulation (tVNS)",[46,52,57,61,65,72,76,81,86,92],{"type":47,"name":48,"description":49,"armGroupLabels":50,"otherNames":51},"PROCEDURE","Microneurography","Skin will be stimulated with a pencil-shaped electrode to find a certain nerve. Once the nerve is found, two tiny sterile wire needles (about the size of acupuncture needles) will be put in the skin. One needle is put just under the skin at a short distance away from the nerve, and the other one into the nerve. The needles are attached to a computer recorder to record the nerve activity. It may take up to one hour to get the needles in the right place. After the tiny needle is in the right place, investigators record nerve activity at rest for about 10 minutes. Then, it will be recorded throughout the rest of the visit (up to 4 hours).",[20,9],null,{"type":53,"name":54,"description":55,"armGroupLabels":56,"otherNames":51},"BEHAVIORAL","Combat virtual reality video clip","Subjects will watch a video clip of combat on a computer screen or wearing video goggles.",[20,9],{"type":47,"name":58,"description":59,"armGroupLabels":60,"otherNames":51},"Handgrip Exercise","Subjects will squeeze a hand dynamometer intermittently.",[20,9],{"type":47,"name":62,"description":63,"armGroupLabels":64,"otherNames":51},"Cold Pressor Test (CPT)","Subjects' hand will be submerged in cold water (\\~0-1°C) up to the wrist for 1 minute.",[20,9],{"type":66,"name":67,"description":68,"armGroupLabels":69,"otherNames":70},"DRUG","Sodium Nitroprusside (SNP)","Subjects will receive sodium nitroprusside 100 µg, which is bolused through an antecubital intravenous catheter.",[20,9],[71],"Nitropress",{"type":66,"name":73,"description":74,"armGroupLabels":75,"otherNames":51},"Phenylephrine","Subjects will receive phenylephrine 150 µg, which is bolused through an antecubital intravenous catheter 60 seconds after the sodium nitroprusside bolus",[20,9],{"type":66,"name":24,"description":77,"armGroupLabels":78,"otherNames":79},"Losartan will be administered as 25 mg taken orally, once a day for to 8 to 14 weeks.",[24],[80],"Cozaar",{"type":66,"name":29,"description":82,"armGroupLabels":83,"otherNames":84},"Atenolol will be administered as 25 mg taken orally, once a day for to 8 to 14 weeks.",[29],[85],"Tenormin",{"type":87,"name":35,"description":88,"armGroupLabels":89,"otherNames":90},"DEVICE","Transcutaneous vagal nerve stimulation (tVNS) is administered using the gammaCore (ElectroCore) TENS device. The gammaCore device is a multi-use, hand-held, rechargeable portable device consisting of a rechargeable battery, signal generating and amplifying electronics, and two buttons to power on the device and for operator control of the stimulation intensity (range 0-40). A small amount of conductive gel is applied to the pair of stainless steel round discs on the device are placed vertically on the skin with the gel. The stimulation is increased until there is a strong vibration and slight muscle contraction in the lower face or neck (usual intensity 15-25). Then the dose is delivered for 2 minutes on the left side of the neck, and on the right side of the neck, for a total of 4 minutes of treatment. Participants will be instructed on the usage of the device and will self-administer up to 4 treatments twice per day.",[35],[91],"ElectroCore",{"type":87,"name":40,"description":93,"armGroupLabels":94,"otherNames":51},"A sham device that is identical to the gammaCore device will be provided to participants. Participants will be instructed on the usage of the device and will self-administer up to 4 treatments twice per day.",[40],[96],{"name":97,"affiliation":5,"role":98},"Jeanie Park, MD","PRINCIPAL_INVESTIGATOR",[100,106],{"name":101,"role":102,"phone":103,"phoneExt":104,"email":105},"Deirdre Dixon","CONTACT","404-321-6111","207040","deirdre.dixon@emory.edu",{"name":107,"role":102,"phone":108,"phoneExt":51,"email":109},"Dana DaCosta","404-727-7762","drdacos@emory.edu",[111],{"facility":112,"status":113,"city":114,"state":115,"zip":116,"country":117,"countryCode":118,"cosmosGeoPoint":119,"geoPoint":124,"contacts":51},"Atlanta VA Medical Center","RECRUITING","Decatur","Georgia","30033","United States","US",{"type":120,"coordinates":121},"Point",[122,123],-84.29631,33.77483,{"lat":123,"lon":122},{"type":98,"investigatorFullName":126,"investigatorTitle":127,"investigatorAffiliation":5,"oldNameTitle":51,"oldOrganization":51},"Jeanie Park","Associate Professor",[129],{"name":130,"class":6},"American Heart Association","100252125","phase-2-role-of-sympathetic-overactivity-and-angiotensin-ii-in-ptsd-and-cv-100252125",false,"NCT02560805","Role of Sympathetic Overactivity and Angiotensin II in PTSD and CV","Post-Traumatic Stress Disorder and Cardiovascular Disease Risk: Role of Sympathetic Overactivity and Angiotensin II","ANG-P","Inclusion Criteria:\n\n* veterans ages 18-65 years old with PTSD and without PTSD (controls) matched for age, gender, and race.\n\nExclusion Criteria:\n\n* pregnancy\n* hypertension\n* diabetes\n* heart or vascular disease\n* illicit drug use\n* excessive alcohol use (\\>2 drinks per day)\n* hyperlipidemia\n* autonomic dysfunction\n* current treatment with clonidine, beta blockers, angiotensin-converting-enzyme (ACE) inhibitors, or angiotensin II receptor blockers (ARBs)\n* treatment with monoamine oxidase (MAO) inhibitors within the last 14 days\n* any serious systemic disease\n* chronic kidney disease defined as estimated glomerular filtration rate (GFR) \\\u003C 60 cc\u002Fmin\n* hyperkalemia (serum potassium \\> 5 meq\u002FdL)\n* systolic blood pressure \\\u003C 100 mm Hg\n* diastolic blood pressure \\\u003C 60 mm Hg\n* heart rate \\\u003C 50 beats\u002Fmin\n* known hypersensitivity to ARBs or beta blockers",true,"ALL","18 Years","65 Years",{"count":144,"type":145},134,"ESTIMATED","INTERVENTIONAL",[148],"PHASE2","The purpose of this study is to find out why patients with post-traumatic stress disorder (PTSD) have an increased risk for heart disease and high blood pressure later in life. A second purpose is to find out what causes PTSD patients to have high adrenaline levels during stress. This study will also test if a medicine called losartan improves high adrenaline levels in patients with PTSD and if a certain gene that has to do with high blood pressure might be associated with high adrenaline levels.",[151],"Stress Disorders, Post-Traumatic","2026-05-14",{"date":154,"type":155},"2026-05-18","ACTUAL",{"date":157,"type":155},"2015-10",{"date":159,"type":145},"2027-03-30",{"name":5,"class":6},1]