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Prior history of malignancies other than AML, unless disease-free for 5 years or more or prior basal cell carcinoma of the skin, non-metastatic squamous cell carcinoma of the skin, carcinoma in situ of cervix, breast or bladder, and incidental histological finding of prostate cancer (TMN stage T1a or T1b)\n* Impairment of gastrointestinal function or gastrointestinal disease that may significantly alter the absorption of RVU120 and\u002For venetoclax\n* Taking any medications, herbal supplements, or other substances (including smoking( that are known to be strong inhibitors or moderate\u002Fstrong inducers or sensitive substrates of CYP1A2\n* Taking any medications, over-the-counter medications, foods or herbal supplements that are known to be strong or moderate inhibitors of CYP3A4 or P-gp (P-glycoprotein)\n* Known allergy or hypersensitivity to any component of RVU120 or venetoclax formulations","ALL","18 Years",{"count":526,"type":527},98,"ESTIMATED","INTERVENTIONAL",[530],"PHASE2","The goal of this study is to assess the safety, tolerability, efficacy, pharmacokinetics (PK), and pharmacodynamics (PD) of RVU120 when administered in combination with venetoclax to adult patients with acute myeloid leukemia (AML) who are relapsed or refractory to prior therapy with venetoclax and a hypomethylating agent. 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