[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100483549":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":42,"centralContacts":47,"locations":52,"responsibleParty":72,"collaborators":75,"id":79,"slug":80,"hasResults":81,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":81,"sex":87,"minAge":88,"maxAge":89,"enrollmentInfo":90,"targetDuration":23,"studyType":93,"phases":94,"briefSummary":96,"conditions":97,"keywords":100,"overallStatus":55,"whyStopped":23,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":114},{"fullName":5,"class":6},"Ruijin Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"SCRT sequential Penpulimab in combination with CAPEOX","EXPERIMENTAL","* Short-course radiotherapy (SCRT) + one dose of immunotherapy in week 1：Radiotherapy once daily at 5Gy, D1-D5 (5×5Gy); Penpulimab, 200mg, intravenous for 60±5min, D6 or D7.\n* Rest at week 2, 4 cycles of chemotherapy (CAPEOX) + immunotherapy from week 3 in cycles of 3 weeks: Capecitabine, 1000 mg\u002Fm2 orally, administered twice daily, D1-D14 per cycle; Oxaliplatin, 135 mg\u002Fm2, intravenous \\>2h, administered every cycle D1; Penpulimab, 200 mg, administered intravenously for 60 ± 5 min every cycle D1.\n* Clinical re-staging assessment at the end of neoadjuvant therapy allows for a watch-and-wait strategy if cCR is achieved. If any residual lesions remained, radical rectal cancer surgery would be performed at least 2 weeks after the last dose of capecitabine. Whether post-operative adjuvant treatment is performed and the option of post-operative adjuvant treatment is decided by the investigator.",[13,14,15,16],"Radiation: Short-course radiotherapy","Drug: Penpulimab","Drug: CAPEOX","Procedure: TME surgery",[18,24,31,37],{"type":19,"name":20,"description":21,"armGroupLabels":22,"otherNames":23},"RADIATION","Short-course radiotherapy","5×5Gy in Week 1",[9],null,{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":29},"DRUG","Penpulimab","Apply once in the first week, then every 3 weeks from the third week for four cycles",[9],[30],"PD-1 monoclonal antibody",{"type":25,"name":32,"description":33,"armGroupLabels":34,"otherNames":35},"CAPEOX","Apply every 3 weeks from week 3 for 4 cycles",[9],[36],"Capecitabine and oxaliplatin",{"type":38,"name":39,"description":40,"armGroupLabels":41,"otherNames":23},"PROCEDURE","TME surgery","Patient will receive radical rectal cancer surgery",[9],[43],{"name":44,"affiliation":45,"role":46},"Ren Zhao, MD, PHD","Ruijin Hospitlal , Shanghai Jiaotong University School of Medicine","PRINCIPAL_INVESTIGATOR",[48],{"name":44,"role":49,"phone":50,"phoneExt":23,"email":51},"CONTACT","+8618917762018","zhaorensurgeon@aliyun.com",[53],{"facility":54,"status":55,"city":56,"state":57,"zip":58,"country":59,"countryCode":60,"cosmosGeoPoint":61,"geoPoint":66,"contacts":67},"Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine","RECRUITING","Shanghai","None Selected","200025","China","CN",{"type":62,"coordinates":63},"Point",[64,65],121.45806,31.22222,{"lat":65,"lon":64},[68],{"name":69,"role":49,"phone":70,"phoneExt":23,"email":71},"Ren Zhao, M.D., Ph.D.","86-021-64370045","rjzhaoren@139.com",{"type":46,"investigatorFullName":73,"investigatorTitle":74,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"Zhao Ren","Chief Physicion",[76],{"name":77,"class":78},"Chia Tai Tianqing Pharmaceutical Group Co., Ltd.","INDUSTRY","100483549","phase-2-scrt-sequential-penpulimab-in-combination-with-capeox-in-the-neoadjuvant-treatment-of-mss-locally-advanced-rectal-cancer-100483549",false,"NCT05576480","SCRT Sequential Penpulimab in Combination With CAPEOX in the Neoadjuvant Treatment of MSS Locally Advanced Rectal Cancer","Efficacy and Safety of Short-course Radiotherapy Sequential Penpulimab in Combination With CAPEOX in the Neoadjuvant Treatment of Microsatellite Stable Locally Advanced Rectal Cancer: a Single-centre, Single-arm, Phase 2 Study","SPARC","Inclusion Criteria:\n\n* Informed consent\n* 18 years \\\u003C age ≤ 75 years\n* ECOG score is 0-1\n* Patients with pathologically confirmed rectal adenocarcinoma, assessed by MRI as mid-low rectal cancer (the lower border of the tumor is less than 10cm from the anal verge), clinical stage II-III (cT1-2N1-2M0 or T3-4N0-2M0) according to the 8th Edition of AJCC Cancer Staging Manual\n* Without emergency operation due to complication (bleeding, perforation or obstruction) caused by rectal cancer\n* Microsatellite Instability detection using PCR capillary electrophoresis results in MSS\n* Without any anti-tumor treatment\n* No distant metastasis\n* Have an imaging measurable or clinically assessable lesion\n* Adequate organ and bone marrow function\n* Female participants of childbearing age or male participants whose sexual partners are women of childbearing age are required to use effective contraception for the entire treatment period and for 6 months after the end of the treatment period\n\nExclusion Criteria:\n\n* Recurrent rectal cancer\n* Previous treatment with pelvic radiotherapy, rectal cancer surgery, chemotherapy, targeted therapy, immune checkpoint inhibitors (including but not limited to PD-1, PD-L1, CTLA-4)\n* Proven inability to receive radiotherapy or allergy to the components of Penpulimab, capecitabine, oxaliplatin or their excipients\n* Intestinal obstruction due to tumor (except in patients who have received a stoma)\n* History of other primary malignancies, except for: malignancies in complete remission for at least 2 years prior to enrolment and not requiring other treatment during the study period; adequately treated non-melanoma skin cancer or lentigo maligna with no evidence of disease recurrence; adequately treated carcinoma in situ with no evidence of disease recurrence\n* Active, known or suspected autoimmune disease or history of this disease within the previous 2 years (patients with vitiligo, psoriasis, alopecia or Graves' disease not requiring systemic treatment within the last 2 years, hypothyroidism requiring only thyroid hormone replacement therapy and type I diabetes requiring only insulin replacement therapy may be enrolled)\n* Any of the following within 6 months prior to the start of treatment: myocardial infarction, severe\u002Funstable angina pectoris, coronary\u002Fperipheral artery bypass graft, symptomatic congestive heart failure (New York Heart Association classification II-IV), cerebrovascular event, transient ischaemic attack, severe arrhythmia requiring drug treatment or symptomatic pulmonary embolism\n* History of allogeneic organ transplantation and allogeneic haematopoietic stem cell transplantation\n* Uncontrolled comorbidities including but not limited to: HIV infected; Serious infections that are active or poorly controlled clinically\n* Pregnant woman or lactating woman\n* Patients who have participated in another drug clinical trial within 4 weeks\n* Suffering from acute or chronic active hepatitis B (HBsAg-positive and HBV DNA ≥ 200 IU\u002FmL or ≥ 103 copies\u002FmL) or acute or chronic active hepatitis C (HCV-positive and HCV RNA-positive)\n* Received live attenuated vaccine within 4 weeks prior to enrolment or planned during the study period\n* Major surgical procedure within 4 weeks prior to enrolment\n* History of interstitial pneumonia\n* Other acute or chronic diseases, mental disorders, or laboratory test abnormalities that may result in: increasing the risk associated with research participation or drug administration, or interfering with the interpretation of the results of the study, and the patient was classified as not eligible to participate in this study according to the judgment of the researchers","ALL","18 Years","75 Years",{"count":91,"type":92},55,"ESTIMATED","INTERVENTIONAL",[95],"PHASE2","The goal of this phase 2 study is to learn about the efficacy and safety of short-course radiotherapy (SCRT) sequential Penpulimab in combination with CAPEOX in the neoadjuvant treatment of microsatellite stable (MSS) locally advanced rectal cancer. The main question it aims to answer is the role of immune checkpoint inhibitors in the neoadjuvant treatment of MSS rectal cancer. Participants will receive neoadjuvant treatment of SCRT sequential Penpulimab in combination with CAPEOX. Participants will undergo a clinical re-staging assessment at the end of neoadjuvant therapy to determine whether to adopt a watch-and-wait strategy or undergo radical surgery.",[98,99],"Rectal Cancer","Locally Advanced",[101,102,103,104],"Immunotherapy","Neoadjuvant Treatment","Locally Advanced Rectal Cancer","Microsatellite stable","2025-08-21",{"date":107,"type":108},"2025-08-28","ACTUAL",{"date":110,"type":108},"2023-02-06",{"date":112,"type":92},"2026-12",{"name":5,"class":6},1]