[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100577576":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":27,"centralContacts":32,"locations":42,"responsibleParty":59,"collaborators":12,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":63,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":12,"studyType":74,"phases":75,"briefSummary":78,"conditions":79,"keywords":81,"overallStatus":84,"whyStopped":12,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"The University of Texas Medical Branch, Galveston","OTHER",[8,13],{"label":9,"type":10,"description":11,"interventionNames":12},"Standard of Care Treatment","NO_INTERVENTION","standard of care treatment",null,{"label":14,"type":15,"description":16,"interventionNames":17},"Standard of Care Treatment and Sildenafil","EXPERIMENTAL","Sildenafil, 50mg, daily for duration of the standard of care treatment",[18],"Drug: Sildenafil",[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Sildenafil","Sildenafil, 50mg, daily",[14],[26],"Viagra",[28],{"name":29,"affiliation":30,"role":31},"Melinda Sheffield-Moore, PhD","University of Texas","PRINCIPAL_INVESTIGATOR",[33,38],{"name":34,"role":35,"phone":36,"phoneExt":12,"email":37},"Kate Randolph, BS","CONTACT","409-223-7891","kmrandol@utmb.edu",{"name":39,"role":35,"phone":40,"phoneExt":12,"email":41},"Christopher Danesi, MA","409-772-8126","cpdanesi@utmb.edu",[43],{"facility":44,"status":12,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"The University of Texas Medical Branch","Galveston","Texas","77555","United States","US",{"type":51,"coordinates":52},"Point",[53,54],-94.7977,29.30135,{"lat":54,"lon":53},[57,58],{"name":34,"role":35,"phone":36,"phoneExt":12,"email":37},{"name":29,"role":31,"phone":12,"phoneExt":12,"email":12},{"type":60,"investigatorFullName":12,"investigatorTitle":12,"investigatorAffiliation":12,"oldNameTitle":12,"oldOrganization":12},"SPONSOR","100577576","phase-2-sildenafil-to-prevent-and-reduce-cancer-related-cognitive-impairment-100577576",false,"NCT06800092","Sildenafil to Prevent and Reduce Cancer Related Cognitive Impairment","SPARC","Inclusion Criteria:\n\n* Female\n* Ages 30 - 50 years\n* Self-reported menses occurrence within past 12 months\n* Diagnosis of ER+\u002FHER2- breast cancer\n* Willing and able to comply with study procedures\n* Willing and able to provide consent\n\nExclusion Criteria:\n\n* Untreated thyroid disorder\n* Untreated diabetes\n* BMI \\>30\n* Current treatment with metformin\n* Diagnosed neuromuscular disease\n* Diagnosed neurovascular disease\n* Prior history of cognitive impairment\n* Prior history of chemotherapy treatment\n* HIV, Hepatitis B or Hepatitis C\n* Systolic blood pressure \\\u003C90 or \\>170, diastolic blood pressure \\\u003C50 or \\>110 after repeated evaluation with proper cuff. This range is the acceptable range stated in the prescribing information for sildenafil (\\>90\u002F50 and \\\u003C170\u002F110)\n* Use of alpha blockers in the past 2 weeks\n* Use of PDE5 inhibitors in the past 2 weeks\n* Use of nitrates\n* Subjects with MRI incompatible devices\n* Subjects with severe claustrophobia\n* Any medical condition that, in the opinion of the investigator, would place the subject at increased risk for participation","FEMALE","30 Years","50 Years",{"count":72,"type":73},30,"ESTIMATED","INTERVENTIONAL",[76,77],"PHASE2","PHASE3","This study is examining the effects of standard of care cancer treatment as well as a medication called Sildenafil, on the cancer associated fatigue, cognition and the gut microbiome.",[80],"Cancer",[82,83],"Fatigue","Brain Fog","NOT_YET_RECRUITING","2026-05-08",{"date":87,"type":88},"2026-05-11","ACTUAL",{"date":90,"type":73},"2027-06-15",{"date":92,"type":73},"2030-06-01",{"name":5,"class":6},1]