[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100632297":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":24,"centralContacts":27,"locations":36,"responsibleParty":53,"collaborators":57,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":24,"eligibilityCriteria":65,"healthyVolunteers":66,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":24,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":79,"overallStatus":85,"whyStopped":24,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Universiti Sains Malaysia","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Placebo","PLACEBO_COMPARATOR","Daily one sachet containing maltodextrin",[13],"Dietary Supplement: Placebo",{"label":15,"type":16,"description":17,"interventionNames":18},"Probiotic","ACTIVE_COMPARATOR","Daily one sachet containing Bifidobacterium longum subsp. longum dipro-O and Bifidobacterium longum subsp. longum dipro-X, with a combined total dose of 5 × 10⁹colony-forming units (CFU) and maltodextrin as carrier",[19],"Dietary Supplement: Probiotic",[21,25],{"type":22,"name":9,"description":11,"armGroupLabels":23,"otherNames":24},"DIETARY_SUPPLEMENT",[9],null,{"type":22,"name":15,"description":17,"armGroupLabels":26,"otherNames":24},[15],[28,33],{"name":29,"role":30,"phone":31,"phoneExt":24,"email":32},"Daisy Zhao, Ph.D.","CONTACT","3400 8680","daisydy.zhao@polyu.edu.hk",{"name":34,"role":30,"phone":24,"phoneExt":24,"email":35},"Jie Yuan, M.Sc.","peanut.yuan@diprobio.com",[37],{"facility":38,"status":24,"city":39,"state":39,"zip":24,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"The Hong Kong Polytechnic University","Kowloon","Hong Kong","HK",{"type":43,"coordinates":44},"Point",[45,46],114.18333,22.31667,{"lat":46,"lon":45},[49,50,51],{"name":29,"role":30,"phone":31,"phoneExt":24,"email":32},{"name":34,"role":30,"phone":24,"phoneExt":24,"email":35},{"name":29,"role":52,"phone":24,"phoneExt":24,"email":24},"PRINCIPAL_INVESTIGATOR",{"type":54,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"SPONSOR_INVESTIGATOR","Min-Tze LIONG","Prof.",[58],{"name":38,"class":6},"100632297","phase-2-stress-buffering-and-sleep-disturbance-resilient-effects-of-a-dual-bifidobacterium-longum-combination-under-short-term-travel-100632297",false,"NCT07511855","Stress-buffering and Sleep Disturbance-resilient Effects of a Dual Bifidobacterium Longum Combination Under Short-term Travel","Stress-buffering and Sleep Disturbance-resilient Effects of a Dual Bifidobacterium Longum Combination Under Short-term Travel: A Randomized, Double-blind, Placebo-controlled Study","Inclusion Criteria:\n\n* Willing to participate in this study and able to provide written informed consent before any study procedures are initiated.\n* Able and willing to comply with all study procedures as required by the protocol, including continuous wearable device use, saliva and stool sample collection, and completion of questionnaire assessments.\n* Willing to accept randomization and group allocation as determined by the study protocol.\n\nExclusion Criteria:\n\n* Known use of antibiotics or systemic corticosteroids within 4 weeks prior to enrollment.\n* Use of probiotic supplements within 4 weeks prior to enrollment.\n* Planned use of any probiotic supplements during the study period.\n* Known history or current presence of major endocrine disorders, active inflammatory bowel disease or other severe gastrointestinal diseases, or severe sleep disorders requiring treatment adjustment.\n* Pregnant or intend to get pregnant, or lactating women.\n* Known allergy to any probiotic products.\n* Participation in any other clinical interventional study involving drugs, dietary supplements, probiotics, or prebiotics within the past three months.\n* Or those who, according to the researcher's judgment, may have inadequate adherence or are unable to complete the study protocol.",true,"ALL","25 Years","50 Years",{"count":71,"type":72},60,"ESTIMATED","INTERVENTIONAL",[75],"PHASE2","This study aims to evaluate the effects of a dual Bifidobacterium longum probiotic formulation (dipro-O and dipro-X) on sleep quality, stress responses, and gut microbiota stability in healthy adults during short-term travel. Using a randomized, double-blind, placebo-controlled design, the study investigates whether probiotic supplementation can enhance sleep resilience, buffer stress, and modulate microbiome and physiological responses under travel-related environmental changes.",[78],"Healthy",[80,81,82,83,84],"probiotic","Bifidobacterium","short term travel","sleep","gut microbiota","NOT_YET_RECRUITING","2026-06-29",{"date":88,"type":89},"2026-07-02","ACTUAL",{"date":91,"type":72},"2026-07-01",{"date":93,"type":72},"2027-05-31",{"name":55,"class":6},1]