[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100504979":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":41,"centralContacts":42,"locations":48,"responsibleParty":65,"collaborators":69,"id":75,"slug":76,"hasResults":77,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":41,"eligibilityCriteria":81,"healthyVolunteers":77,"sex":82,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":41,"studyType":88,"phases":89,"briefSummary":92,"conditions":93,"keywords":97,"overallStatus":50,"whyStopped":41,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":115},{"fullName":5,"class":6},"Medical University of South Carolina","OTHER",[8,15,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Combination Trigeminal Nerve Stimulation (TNS) and active Smell Training (ST)","ACTIVE_COMPARATOR","30 minutes of once\u002Fday TNS and twice\u002Fday ST conducted 5 days\u002Fweek for 12 weeks and a total of 60 stimulation and 120 smell training sessions",[13,14],"Device: Trigeminal Nerve Stimulation (TNS)","Other: Active Smell Training (ST)",{"label":16,"type":10,"description":17,"interventionNames":18},"Active Smell Training (ST)","5 minutes of daily ST conducted twice\u002Fday, 5 days\u002Fweek for 12 weeks and a total of 120 training session",[14],{"label":20,"type":21,"description":22,"interventionNames":23},"Placebo Smell Training (PBO)","PLACEBO_COMPARATOR","5 minutes of daily PBO conducted twice\u002Fday, 5 days\u002Fweek for 12 weeks and a total of 120 training sessions",[24],"Other: Placebo Smell Training (PBO)",[26,33,38],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"DEVICE","Trigeminal Nerve Stimulation (TNS)","Non-invasive, pain-free, low-level electrical stimulation to the forehead to modulate the trigeminal nerve and enhance smell function through activation of the highly connected olfactory-intranasal trigeminal brain circuits.",[9],[32],"Transcutaneous Electrical Nerve Stimulation",{"type":6,"name":16,"description":34,"armGroupLabels":35,"otherNames":36},"Sniffing various higher intensity odorant chemicals while performing odor-related cognitive tasks. 16 odorant chemicals will be used for training including: 2 phenyl ethanol, eugenol, lemon, eucalyptus, cinnamon, peppermint, coffee, mandarin, lavender, vanilla, lilac, ginger, chocolate, thyme, banana, and bacon.",[16,9],[37],"Olfactory Training",{"type":6,"name":20,"description":39,"armGroupLabels":40,"otherNames":41},"Sniffing the same lower intensity odorant chemicals (i.e. N-butanol and 2-phenyl ethanol) over the course of the trial and performing no odor-related cognitive tasks.",[20],null,[43],{"name":44,"role":45,"phone":46,"phoneExt":41,"email":47},"Bernadette M. Cortese, Ph.D.","CONTACT","843-792-6922","corteseb@musc.edu",[49],{"facility":5,"status":50,"city":51,"state":52,"zip":53,"country":54,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"RECRUITING","Charleston","South Carolina","29425","United States","US",{"type":57,"coordinates":58},"Point",[59,60],-79.93275,32.77632,{"lat":60,"lon":59},[63],{"name":64,"role":45,"phone":46,"phoneExt":41,"email":47},"Bernadette Cortese, PhD",{"type":66,"investigatorFullName":67,"investigatorTitle":68,"investigatorAffiliation":5,"oldNameTitle":41,"oldOrganization":41},"PRINCIPAL_INVESTIGATOR","Bernadette Cortese","Assistant Professor of Psychiatry and Behavioral Sciences",[70,73],{"name":71,"class":72},"National Institutes of Health (NIH)","NIH",{"name":74,"class":72},"National Institute on Deafness and Other Communication Disorders (NIDCD)","100504979","phase-2-study-of-chemosensory-enhancement-through-neuromodulation-training-scent-for-long-covid-100504979",false,"NCT05855369","Study of Chemosensory Enhancement Through Neuromodulation Training (SCENT for Long COVID)","A Randomized Controlled Trial of Smell Training and Trigeminal Nerve Stimulation in the Treatment of COVID-related Persistent Smell Loss","Inclusion Criteria:\n\n* treatment-seeking for COVID-related persistent SL (anosmia, hyposmia, phantosmia or parosmia)\n* at least 1-month from SARS-coV-2 PCR-positive and\u002For rapid home-positive tests\n* normal sense of smell prior to COVID\n* naïve to both smell training (ST) and trigeminal nerve stimulation (TNS)\n* able to comprehend English and provide informed consent\n\nExclusion Criteria:\n\n* history of head injury (e.g. sport, accident, combat blast)\n* sinonasal condition (e.g. upper respiratory infection, rhinosinusitis, polyps)\n* neurological disorder (e.g. epilepsy, neurodegenerative disorder, narcolepsy)\n* serious mental illness (e.g. schizophrenia, bipolar, or other psychotic disorder)\n* suicidal ideation within the last month\n* current (≤6 months) heavy cigarette smoker (heavy defined as ≥ 10 pack-years)\n* oral\u002Fnasal steroids or other intranasal medications within the last month\n* immunomodulatory medications\n* pregnant or trying to become pregnant","ALL","18 Years","65 Years",{"count":86,"type":87},145,"ESTIMATED","INTERVENTIONAL",[90,91],"PHASE2","PHASE3","Persistent smell loss that can include diminished or distorted smell function is a common symptom of long COVID syndrome. There are limited treatment options for long COVID-related smell loss. This study aims to determine the efficacy of two at-home treatments, smell training and non-invasive trigeminal nerve stimulation. This study requires participants to conduct daily at-home treatment sessions, attend three in-person study visits at the MUSC Department of Psychiatry and Behavioral Sciences, and complete electronic questionnaires over the 12-week trial, and again at the six-month timepoint. Participants in this trial may benefit directly with an improvement in sense of smell. However, participation may also help society more generally, as this study will provide new information about long COVID-related smell loss and its treatment.",[94,95,96],"Smell Dysfunction","Olfactory Disorder","Long COVID",[98,99,100,101,102,103,37,104,105],"COVID-19","Parosmia","Hyposmia","Anosmia","Phantosmia","Dysosmia","Neuromodulation","Non-invasive Brain Stimulation","2026-04-01",{"date":108,"type":109},"2026-04-02","ACTUAL",{"date":111,"type":109},"2023-10-02",{"date":113,"type":87},"2028-05-31",{"name":5,"class":6},1]