[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100544729":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":35,"centralContacts":40,"locations":46,"responsibleParty":59,"collaborators":30,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":30,"eligibilityCriteria":67,"healthyVolunteers":63,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":30,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":30,"overallStatus":80,"whyStopped":30,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Keymed Biosciences Co.Ltd","INDUSTRY",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"220 mg Group","EXPERIMENTAL","CM326 220 mg, subcutaneous (SC)",[13],"Biological: CM326",{"label":15,"type":10,"description":16,"interventionNames":17},"440 mg Group","CM326 440 mg, subcutaneous (SC)",[13],{"label":19,"type":20,"description":21,"interventionNames":22},"placebo","PLACEBO_COMPARATOR","matched placebo, subcutaneous (SC)",[23],"Drug: Placebo",[25,31],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"BIOLOGICAL","CM326","CM326 injection",[9,15],null,{"type":32,"name":33,"description":33,"armGroupLabels":34,"otherNames":30},"DRUG","Placebo",[19],[36],{"name":37,"affiliation":38,"role":39},"Luo Zhang","Beijing Tong-Ren hospital","PRINCIPAL_INVESTIGATOR",[41],{"name":42,"role":43,"phone":44,"phoneExt":30,"email":45},"Qian Jia","CONTACT","028-88610620","qianjia@keymedbio.com",[47],{"facility":48,"status":30,"city":49,"state":50,"zip":30,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":30},"Beijing Tongren Hospital, CMU","Beijing","Beijing Municipality","China","CN",{"type":54,"coordinates":55},"Point",[56,57],116.39723,39.9075,{"lat":57,"lon":56},{"type":60,"investigatorFullName":30,"investigatorTitle":30,"investigatorAffiliation":30,"oldNameTitle":30,"oldOrganization":30},"SPONSOR","100544729","phase-2-study-of-cm326-in-participants-with-chronic-rhinosinusitis-with-nasal-polyposis-100544729",false,"NCT06372678","Study of CM326 in Participants With Chronic Rhinosinusitis With Nasal Polyposis","A Randomized, Double-blind, Placebo-controlled Phase II Study to Evaluate the Efficacy and Safety of CM326 in Participants With Chronic Rhinosinusitis With Nasal Polyposis","Inclusion Criteria:\n\n* Male or female subjects, aged between 18 and 75 years old (inclusive).\n* Subjects who are capable of understanding the nature of the study and voluntarily signing the Informed consent form (ICF).\n* Prior treatment with systemic corticosteroids (SCS) within two years before screening, and\u002For contraindicate to or intolerance to systemic corticosteroids, and\u002For with prior surgery to nasal polyps 6 months before the screening.\n\nExclusion Criteria:\n\n* Allergic or intolerant to mometasone furoate spray or CM326.\n* Have received allergen-specific immunotherapy that initiated within 3 months prior to randomization or planned to be initiated during the study period.\n* Participated study of CM326.\n* Systemic immunosuppressive therapy for inflammatory or autoimmune diseases within 8 weeks or 5 half-lives prior to baseline (whichever is longer).\n* Starting leukotriene receptor antagonist therapy within 4 weeks prior to baseline.\n* With antrochoanal polyps.\n* With severe deviation of the nasal septum occludes at least one nostril.\n* With persistent rhinitis medicamentosas.\n* With acute sinusitis, nasal infection, or upper respiratory tract infection at screening.\n* Have symptoms or whose CT scan suggests allergic fungal sinusitis.\n* With malignant or benign neoplasm of nasal cavities.\n* With other uncontrolled serious diseases or recurrent chronic diseases.\n* Have severe hepatic and renal impairment.","ALL","18 Years","75 Years",{"count":72,"type":73},90,"ESTIMATED","INTERVENTIONAL",[76],"PHASE2","This is a multi-center, randomized, double blind, placebo-controlled Phase II study to evaluate the efficacy and safety of CM326, and to observe the Pharmacokinetics, Pharmacodynamics and immumogenicity of CM326 in patients with chronic rhinosinusitis with nasal polyposis (CRSwNP).",[79],"Chronic Rhinosinusitis With Nasal Polyps","NOT_YET_RECRUITING","2024-04-15",{"date":83,"type":84},"2024-04-18","ACTUAL",{"date":86,"type":73},"2024-06-30",{"date":88,"type":73},"2026-06-30",{"name":5,"class":6},1]