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to the first study visit\n* Have moderate-to-severe AD at screening and baseline as defined by the following criteria:\n\n  * A vIGA score of 3 (moderate) or 4 (severe)\n  * EASI score of ≥16\n  * BSA ≥10%\n  * PP-NRS score of ≥4\n* Have had either a poor response or intolerance to topical treatments for atopic dermatitis (such as corticosteroids) within the past 6 months\n* Use a bland moisturizer at least daily\n\nExclusion Criteria:\n\n* Current or recurrent medical conditions that could affect the study drug or study assessments\n* Any illness that could impact participant safety or active infections\n* Ongoing skin condition or large tattoos that would interfere with clinical assessment\n* Clinically significant skin infection requiring treatment\n* Clinically significant abnormal laboratory assessments at screening","ALL","18 Years","75 Years",{"count":253,"type":254},60,"ESTIMATED","INTERVENTIONAL",[257],"PHASE2","The goal of this clinical trial is to learn about the safety and effectiveness of ENV-294 in adults with moderate to severe atopic dermatitis.\n\nThe main questions it will answer are:\n\n* Is there an impact on the severity and area of atopic dermatitis when participants take ENV-294\n* What medical problems do participants have when taking ENV-294\n\nParticipants will:\n\n* Take drug ENV-294 or a placebo once every day for 12 weeks\n* Visit the clinic every 2 to 4 weeks for checkups and tests\n* Keep a diary of their symptoms and when they took their study drug\n* Return to the clinic for the final study visit at approximately week 16",[260],"Atopic Dermatitis (AD)","2026-06-02",{"date":263,"type":264},"2026-06-04","ACTUAL",{"date":266,"type":264},"2025-12-22",{"date":268,"type":254},"2026-12",{"name":5,"class":6},23]