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Deficiency of acid alpha-glucosidase (GAA) enzyme\n  2. GAA genotype\n* Participant has a %FVC ≥30% and ≤80% in an upright position without mechanical ventilation at screening; or Participant has ≥10% %FVC drop from upright position to supine position and %FVC ≥20% in a supine position.\n* Participant performs the 6MWT at screening, as determined by the clinical evaluator, and meets all of the following criteria:\n\n  1. Screening values of 6-minute walk distance (6MWD) are ≥75 meters\n  2. Screening values of 6MWD are ≤90% of the predicted value for healthy adults\n* Participants must be ERT-experienced, defined as currently receiving ERT and having been receiving ERT for ≥24 months, with no regimen change in the last 6 months.\n\nKey Exclusion Criteria:\n\n* Has a medical condition or any other extenuating circumstance that may pose an undue safety risk to the participant or may compromise his\u002Fher ability to comply with or adversely impact protocol requirements.\n* Has active infections at screening.\n* Malignancy within the past 5 years except for basal cell or squamous epithelial carcinomas of the skin that have been resected with no evidence of metastatic disease for 3 years.\n* Current or chronic history of liver disease.\n* Known biallelic loss of function mutations whether in glycogenin gene (GYG) or in glycogen phosphorylase muscle associated gene(PYGM) .\n* Has received any investigational therapy or pharmacological treatment for Pompe disease, within 30 days or 5 half-lives of the therapy or treatment, whichever is longer, before day 1 or is anticipated to do so during the study.\n* Has received gene therapy or small interfering ribonucleic acid (RNA) therapy for Pompe disease.\n* Participant, if female, is pregnant or breastfeeding at screening.\n* Participant, whether male or female, is planning to conceive a child during the study.\n\nNote: Other protocol-specified inclusion and exclusion criteria may apply.","ALL","18 Years",{"count":307,"type":308},45,"ESTIMATED","INTERVENTIONAL",[311],"PHASE2","The purpose of this study is to evaluate the safety, pharmacodynamics (PD), and exploratory clinical efficacy of S-606001 in adult participants with LOPD as an add-on to ERT.",[314],"Pompe Disease",[316,317,318,319,27,320,321,322,323,324,325,326,327],"Late-onset Pompe disease","Enzyme replacement therapy","LOPD","ERT","Muscle glycogen synthase","Liver glycogen synthase","Rare disease","Autosomal disease","Acid alpha-glucosidase","GAA","Glycogen storage disorder","GSD","2026-06-19",{"date":330,"type":331},"2026-06-23","ACTUAL",{"date":333,"type":331},"2025-10-30",{"date":335,"type":308},"2027-08-08",{"name":337,"class":6},"Shionogi",28]