[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100327809":3},{"organization":4,"armGroups":7,"interventions":82,"overallOfficials":122,"centralContacts":126,"locations":132,"responsibleParty":1313,"collaborators":1315,"id":1318,"slug":1319,"hasResults":1320,"nctId":1321,"briefTitle":1322,"officialTitle":1323,"acronym":1324,"eligibilityCriteria":1325,"healthyVolunteers":1320,"sex":1326,"minAge":1327,"maxAge":100,"enrollmentInfo":1328,"targetDuration":100,"studyType":1331,"phases":1332,"briefSummary":1334,"conditions":1335,"keywords":100,"overallStatus":135,"whyStopped":100,"lastUpdateSubmitDate":1337,"lastUpdatePostDateStruct":1338,"startDateStruct":1341,"completionDateStruct":1343,"leadSponsor":1345,"locationsCount":1346},{"fullName":5,"class":6},"Gilead Sciences","INDUSTRY",[8,14,18,23,29,34,38,42,46,50,54,59,65,70,74,78],{"label":9,"type":10,"description":11,"interventionNames":12},"Cohort 1: Sacituzumab Govitecan-hziy (SG)","EXPERIMENTAL","Participants with urothelial cancer (UC) previously treated with platinum-based and\u002For checkpoint inhibitors (CPIs) will receive SG 10 mg\u002Fkg intravenously (IV) on Days 1 and 8 of a 21-day cycle.",[13],"Drug: Sacituzumab Govitecan-hziy",{"label":15,"type":10,"description":16,"interventionNames":17},"Cohort 2: SG","Participants with UC who are ineligible for platinum-based therapy and failed therapy with previous immune CPI therapy will receive SG 10 mg\u002Fkg intravenously on Days 1 and 8 of a 21-day cycle.",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Cohort 3: SG + Pembrolizumab","Participants who have had progression or recurrence of UC following a platinum-containing regimen in the metastatic setting, or progression or recurrence of UC within 12 months of completion of platinum-based therapy as neoadjuvant or adjuvant therapy will receive SG 10 mg\u002Fkg intravenously on Days 1 and 8 of a 21-day cycle and pembrolizumab at the standard approved dose (200 mg) only on Day 1 of a 21-day cycle. Lower doses of SG may be tested based on dose-limiting toxicities (DLTs) observed to determine the Recommended Phase 2 Dose (RP2D) of SG in combination with pembrolizumab.",[13,22],"Drug: Pembrolizumab",{"label":24,"type":10,"description":25,"interventionNames":26},"Cohort 4: SG + Cisplatin + Avelumab (Dose Escalation Phase)","Participants with UC who have never received therapy with platinum in the metastatic setting or for unresectable locally advanced disease will first receive cisplatin (either at 70 mg\u002Fm\\^2 on Day 1 of a 21-day cycle or at a split dose of 35 mg\u002Fm\\^2 on Days 1 and 8 of a 21-day cycle with a maximum body surface area of 2) and sacituzumab govitecan-hziy with maximum dose of 10 mg\u002Fkg intravenously on Days 1 and 8 of a 21-day cycle for up to 6 cycles. Based on DLTs observed, two additional lower doses may be tested to determine RP2D of sacituzumab govitecan-hziy in combination with cisplatin. If premature termination of 1 agent occurs due to toxicity, the other agent may be continued to complete up to 6 cycles of therapy. For participants who have not progressed, maintenance therapy will begin with infusions of avelumab 800 mg every 2 weeks beginning on Cycle 1, Day 1 and every 2 weeks thereafter and sacituzumab govitecan-hziy 10 mg\u002Fkg on Days 1 and 8 every 21 days.",[13,27,28],"Drug: Cisplatin","Drug: Avelumab",{"label":30,"type":10,"description":31,"interventionNames":32},"Cohort 4: SG + Cisplatin + Zimberelimab (ZIM) (Dose Expansion Phase)","Participants with UC who have never received therapy with platinum in the metastatic setting or for unresectable locally advanced disease will first receive cisplatin (either at 70 mg\u002Fm\\^2 on Day 1 of a 21-day cycle or at a split dose of 35 mg\u002Fm\\^2 on Days 1 and 8 of a 21-day cycle with a maximum body surface area of 2) and sacituzumab govitecan-hziy with maximum dose of 10 mg\u002Fkg intravenously on Days 1 and 8 of a 21-day cycle for up to 6 cycles. If premature termination of 1 agent occurs due to toxicity, the other agent may be continued to complete up to 6 cycles of therapy. For participants who have not progressed, maintenance therapy will begin with infusions of sacituzumab govitecan-hziy 10 mg\u002Fkg on Days 1 and 8 every 21 days and zimberelimab 360 mg every 3 weeks (Day 1 of a 21-day cycle).",[13,27,33],"Drug: Zimberelimab",{"label":35,"type":10,"description":36,"interventionNames":37},"Cohort 5 (Arm 1): SG + ZIM","Participants in Cohort 5 will have completed 4 to 6 cycles of gemcitabine (GEM) + cisplatin therapy without PD prior to study entry. The safety lead-in will be conducted, in 6 to 8 participants (treated with SG 10 mg\u002Fkg IV on Day 1 and Day 8 of a 21-day cycle + ZIM 360 mg IV every 3 weeks on a 21-day cycle). Upon completion of the safety lead-in, participants will receive SG 10 mg\u002Fkg IV on Days 1 and 8 of a 21-day cycle followed by ZIM 360 mg IV, every 3 weeks (Q3W) (Day 1 of a 21-day cycle) until PD, unacceptable toxicity, or loss of clinical benefit. participants who must discontinue 1 agent may continue the other until PD, unacceptable toxicity, or loss of clinical benefit.",[13,33],{"label":39,"type":10,"description":40,"interventionNames":41},"Cohort 5 (Arm 2): Avelumab","Participants in Cohort 5 will have completed 4 to 6 cycles of gemcitabine (GEM) + cisplatin therapy without PD prior to study entry. The safety lead-in will be conducted, in 6 to 8 participants (treated with SG 10 mg\u002Fkg IV on Day 1 and Day 8 of a 21-day cycle + ZIM 360 mg IV every 3 weeks on a 21-day cycle). Upon completion of the safety lead-in, participants will be randomized to receive avelumab 800 mg IV every 2 weeks (Q2W) until PD, unacceptable toxicity, or loss of clinical benefit.",[28],{"label":43,"type":10,"description":44,"interventionNames":45},"Cohort 5 (Arm 3): ZIM","Participants in Cohort 5 will have completed 4 to 6 cycles of gemcitabine (GEM) + cisplatin therapy without PD prior to study entry. The safety lead-in will be conducted, in 6 to 8 participants (treated with SG 10 mg\u002Fkg IV on Day 1 and Day 8 of a 21-day cycle + ZIM 360 mg IV every 3 weeks on a 21-day cycle).\n\nUpon completion of the safety lead-in, participants will be randomized to receive ZIM 360 mg IV Q3W (Day\n\n1 of a 21-day cycle) until PD, unacceptable toxicity, or loss of clinical benefit.",[33],{"label":47,"type":10,"description":48,"interventionNames":49},"Cohort 6 (Arm 1): SG","Upon completion of the safety lead-in, participants in Cohort 6 will be randomized and SG will be administered in cisplatin-ineligible participants who have never received therapy in the metastatic setting or for unresectable locally advanced disease. Treatment may be discontinued at any time, but participants will continue to be followed for tumor response until progression is documented, and alternate therapy is initiated. If participants discontinue therapy before evidence of radiologic progression, imaging should continue until radiologic progression is documented, if feasible.",[13],{"label":51,"type":10,"description":52,"interventionNames":53},"Cohort 6 (Arm 2): SG + ZIM","Upon completion of the safety lead-in, participants in Cohort 6 will be randomized and SG in combination with ZIM will be administered in cisplatin-ineligible participants who have never received therapy in the metastatic setting or for unresectable locally advanced disease. The standard approved dose of SG will be used in combination with ZIM. Treatment may be discontinued at any time, but participants will continue to be followed for tumor response until progression is documented or alternate therapy is initiated. If participants discontinue therapy before evidence of radiologic progression, imaging should continue until radiologic progression is documented, if feasible.",[13,33],{"label":55,"type":10,"description":56,"interventionNames":57},"Cohort 6 (Arm 3): SG + ZIM + Domvanalimab (DOM)","Upon completion of the safety lead-in, participants in Cohort 6 will be randomized and SG in combination with ZIM and DOM will be administered in cisplatin-ineligible participants who have never received therapy in the metastatic setting or for unresectable locally advanced disease.",[13,33,58],"Drug: Domvanalimab",{"label":60,"type":10,"description":61,"interventionNames":62},"Cohort 6 (Arm 4): Carboplatin (CARBO) + Gemcitabine (GEM)","Upon completion of the safety lead-in, participants in Cohort 6 will be randomized and CARBO in combination with GEM will be administered in cisplatin-ineligible participants who have never received therapy in the metastatic setting or for unresectable locally advanced disease. Participants without disease progression as assessed by the investigator after completion of 4 to 6 cycles of therapy may continue with maintenance therapy (avelumab 800 mg every 2 weeks) until loss of clinical benefit.",[28,63,64],"Drug: Carboplatin","Drug: Gemcitabine",{"label":66,"type":10,"description":67,"interventionNames":68},"Cohort 7 (Phase 1: Safety Lad-in and Dose Expansion): SG + Enfortumab Vedotin (EV) + ZIM","In the safety lead-in phase, participants will receive a starting dose level of SG 7.5 mg\u002Fkg IV and starting dose level of EV 1.25 mg\u002Fkg IV will be administered on Days 1 and 8 of each 21-day cycle and ZIM 360 mg IV will be administered on Day 1 of each 21-day cycle.\n\nIn dose-expansion, participants will receive SG IV and EV IV at the RP2Ds on Days 1 and 8 of each 21-day cycle and ZIM 360 mg IV on Day 1 of each 21-day cycle.",[13,33,69],"Drug: Enfortumab Vedotin",{"label":71,"type":10,"description":72,"interventionNames":73},"Cohort 7 (Phase 2: Arm 1): SG + EV + ZIM","Upon completion of the Cohort 7 dose-expansion phase, participants will receive SG IV at the RP2D in combination with EV IV at the RP2D, and ZIM 360 mg IV until PD, unacceptable toxicity, or loss of clinical benefit.",[13,33,69],{"label":75,"type":10,"description":76,"interventionNames":77},"Cohort 7 (Phase 2: Arm 2): EV + ZIM","Upon completion of the Cohort 7 dose-expansion phase, participants will receive EV 1.25 mg\u002Fkg IV and ZIM 360 mg IV.",[33,69],{"label":79,"type":10,"description":80,"interventionNames":81},"Cohort 7 (Phase 2: Arm 3): Optional Dose Optimization SG + EV + ZIM","Upon completion of the Cohort 7 dose-expansion phase, participants will receive SG IV at 1 dose level below the RP2D in combination with EV 1.25 mg\u002Fkg IV and ZIM 360 mg IV.",[13,33,69],[83,91,97,101,106,110,113,116,119],{"type":84,"name":85,"description":86,"armGroupLabels":87,"otherNames":88},"DRUG","Sacituzumab Govitecan-hziy","Administered intravenously.",[9,15,19,24,30,35,47,51,55,66,71,79],[89,90],"IMMU-132","Trodelvy™",{"type":84,"name":92,"description":93,"armGroupLabels":94,"otherNames":95},"Pembrolizumab","Administered per package insert",[19],[96],"KEYTRUDA®",{"type":84,"name":98,"description":93,"armGroupLabels":99,"otherNames":100},"Cisplatin",[24,30],null,{"type":84,"name":102,"description":93,"armGroupLabels":103,"otherNames":104},"Avelumab",[24,39,60],[105],"BAVENCIO®",{"type":84,"name":107,"description":108,"armGroupLabels":109,"otherNames":100},"Zimberelimab","Administered intravenously",[30,35,43,51,55,66,71,75,79],{"type":84,"name":111,"description":93,"armGroupLabels":112,"otherNames":100},"Carboplatin",[60],{"type":84,"name":114,"description":93,"armGroupLabels":115,"otherNames":100},"Gemcitabine",[60],{"type":84,"name":117,"description":108,"armGroupLabels":118,"otherNames":100},"Domvanalimab",[55],{"type":84,"name":120,"description":108,"armGroupLabels":121,"otherNames":100},"Enfortumab Vedotin",[66,71,75,79],[123],{"name":124,"affiliation":5,"role":125},"Gilead Study Director","STUDY_DIRECTOR",[127],{"name":128,"role":129,"phone":130,"phoneExt":100,"email":131},"Gilead Clinical Study Information Center","CONTACT","1-833-445-3230 (GILEAD-0)","GileadClinicalTrials@gilead.com",[133,147,158,167,177,187,196,206,215,224,235,245,251,260,270,280,290,300,309,319,329,339,347,353,362,372,382,392,401,411,420,429,439,449,458,467,477,487,498,507,516,525,534,543,552,561,570,579,587,593,599,608,614,623,632,641,650,659,668,679,688,694,703,712,721,730,739,748,757,766,775,784,793,802,813,822,831,840,849,860,869,878,887,896,905,910,919,928,937,946,955,964,974,980,989,998,1007,1010,1019,1025,1031,1037,1043,1052,1062,1071,1083,1092,1098,1104,1113,1122,1131,1137,1143,1149,1155,1164,1173,1182,1191,1200,1209,1218,1228,1237,1241,1250,1256,1262,1271,1280,1291,1300,1309],{"facility":134,"status":135,"city":136,"state":137,"zip":138,"country":139,"countryCode":140,"cosmosGeoPoint":141,"geoPoint":146,"contacts":100},"The University of Arizona Cancer Center-North Campus","RECRUITING","Tucson","Arizona","85719","United States","US",{"type":142,"coordinates":143},"Point",[144,145],-110.92648,32.22174,{"lat":145,"lon":144},{"facility":148,"status":149,"city":150,"state":151,"zip":152,"country":139,"countryCode":140,"cosmosGeoPoint":153,"geoPoint":157,"contacts":100},"USC\u002FNorris Comprehensive Cancer Center","WITHDRAWN","Los Angeles","California","90033",{"type":142,"coordinates":154},[155,156],-118.24368,34.05223,{"lat":156,"lon":155},{"facility":159,"status":135,"city":160,"state":151,"zip":161,"country":139,"countryCode":140,"cosmosGeoPoint":162,"geoPoint":166,"contacts":100},"University of California San Francisco","San Francisco","94158",{"type":142,"coordinates":163},[164,165],-122.41942,37.77493,{"lat":165,"lon":164},{"facility":168,"status":135,"city":169,"state":170,"zip":171,"country":139,"countryCode":140,"cosmosGeoPoint":172,"geoPoint":176,"contacts":100},"Rocky Mountain Cancer Centers","Littleton","Colorado","80120",{"type":142,"coordinates":173},[174,175],-105.01665,39.61332,{"lat":175,"lon":174},{"facility":178,"status":135,"city":179,"state":180,"zip":181,"country":139,"countryCode":140,"cosmosGeoPoint":182,"geoPoint":186,"contacts":100},"Smilow Cancer Hospital at Yale-New Haven","New Haven","Connecticut","06510",{"type":142,"coordinates":183},[184,185],-72.92816,41.30815,{"lat":185,"lon":184},{"facility":188,"status":149,"city":189,"state":180,"zip":190,"country":139,"countryCode":140,"cosmosGeoPoint":191,"geoPoint":195,"contacts":100},"Eastern Connecticut Hematology and Oncology Associates","Norwich","06360",{"type":142,"coordinates":192},[193,194],-72.07591,41.52426,{"lat":194,"lon":193},{"facility":197,"status":135,"city":198,"state":199,"zip":200,"country":139,"countryCode":140,"cosmosGeoPoint":201,"geoPoint":205,"contacts":100},"Mount Sinai Comprehensive Cancer Center","Miami Beach","Florida","33140",{"type":142,"coordinates":202},[203,204],-80.13005,25.79065,{"lat":204,"lon":203},{"facility":207,"status":135,"city":208,"state":199,"zip":209,"country":139,"countryCode":140,"cosmosGeoPoint":210,"geoPoint":214,"contacts":100},"Woodlands Medical Specialists, PA","Pensacola","32503",{"type":142,"coordinates":211},[212,213],-87.21691,30.42131,{"lat":213,"lon":212},{"facility":216,"status":135,"city":217,"state":199,"zip":218,"country":139,"countryCode":140,"cosmosGeoPoint":219,"geoPoint":223,"contacts":100},"Moffitt Cancer Center","Tampa","33612",{"type":142,"coordinates":220},[221,222],-82.45843,27.94752,{"lat":222,"lon":221},{"facility":225,"status":226,"city":227,"state":228,"zip":229,"country":139,"countryCode":140,"cosmosGeoPoint":230,"geoPoint":234,"contacts":100},"Winship Cancer Institute, Emory University","COMPLETED","Atlanta","Georgia","30322",{"type":142,"coordinates":231},[232,233],-84.38798,33.749,{"lat":233,"lon":232},{"facility":236,"status":135,"city":237,"state":238,"zip":239,"country":139,"countryCode":140,"cosmosGeoPoint":240,"geoPoint":244,"contacts":100},"University of Illinois Cancer Center","Chicago","Illinois","60612",{"type":142,"coordinates":241},[242,243],-87.65005,41.85003,{"lat":243,"lon":242},{"facility":246,"status":135,"city":237,"state":238,"zip":247,"country":139,"countryCode":140,"cosmosGeoPoint":248,"geoPoint":250,"contacts":100},"University of Chicago Medical Center","60637",{"type":142,"coordinates":249},[242,243],{"lat":243,"lon":242},{"facility":252,"status":135,"city":253,"state":238,"zip":254,"country":139,"countryCode":140,"cosmosGeoPoint":255,"geoPoint":259,"contacts":100},"Southern Illinois University School of Medicine, Simmons Cancer Institute","Springfield","62702",{"type":142,"coordinates":256},[257,258],-89.64371,39.80172,{"lat":258,"lon":257},{"facility":261,"status":149,"city":262,"state":263,"zip":264,"country":139,"countryCode":140,"cosmosGeoPoint":265,"geoPoint":269,"contacts":100},"Indiana University Melvin and Bren Simon Cancer Center","Indianapolis","Indiana","46202",{"type":142,"coordinates":266},[267,268],-86.15804,39.76838,{"lat":268,"lon":267},{"facility":271,"status":135,"city":272,"state":273,"zip":274,"country":139,"countryCode":140,"cosmosGeoPoint":275,"geoPoint":279,"contacts":100},"Norton Cancer Institute, Downtown","Louisville","Kentucky","40202",{"type":142,"coordinates":276},[277,278],-85.75941,38.25424,{"lat":278,"lon":277},{"facility":281,"status":149,"city":282,"state":283,"zip":284,"country":139,"countryCode":140,"cosmosGeoPoint":285,"geoPoint":289,"contacts":100},"Maryland Oncology Hematology, P.A.","Brandywine","Maryland","20613",{"type":142,"coordinates":286},[287,288],-76.84775,38.69678,{"lat":288,"lon":287},{"facility":291,"status":135,"city":292,"state":293,"zip":294,"country":139,"countryCode":140,"cosmosGeoPoint":295,"geoPoint":299,"contacts":100},"University of Michigan","Ann Arbor","Michigan","48109",{"type":142,"coordinates":296},[297,298],-83.74088,42.27756,{"lat":298,"lon":297},{"facility":301,"status":135,"city":302,"state":293,"zip":303,"country":139,"countryCode":140,"cosmosGeoPoint":304,"geoPoint":308,"contacts":100},"Karmanos Cancer Institute","Detroit","48201",{"type":142,"coordinates":305},[306,307],-83.04575,42.33143,{"lat":307,"lon":306},{"facility":310,"status":149,"city":311,"state":312,"zip":313,"country":139,"countryCode":140,"cosmosGeoPoint":314,"geoPoint":318,"contacts":100},"Oncology Hematology West PC dba Nebraska Cancer Specialists","Omaha","Nebraska","68130",{"type":142,"coordinates":315},[316,317],-95.94043,41.25626,{"lat":317,"lon":316},{"facility":320,"status":226,"city":321,"state":322,"zip":323,"country":139,"countryCode":140,"cosmosGeoPoint":324,"geoPoint":328,"contacts":100},"Precision Cancer Research \u002F New Mexico Oncology & Hematology Consultants","Albuquerque","New Mexico","87109",{"type":142,"coordinates":325},[326,327],-106.65114,35.08449,{"lat":327,"lon":326},{"facility":330,"status":135,"city":331,"state":332,"zip":333,"country":139,"countryCode":140,"cosmosGeoPoint":334,"geoPoint":338,"contacts":100},"Roswell Park Cancer Institute","Buffalo","New York","14263",{"type":142,"coordinates":335},[336,337],-78.87837,42.88645,{"lat":337,"lon":336},{"facility":340,"status":135,"city":332,"state":332,"zip":341,"country":139,"countryCode":140,"cosmosGeoPoint":342,"geoPoint":346,"contacts":100},"Laura & Isaac Perlmutter Cancer Center at NYU Langone Health","10016",{"type":142,"coordinates":343},[344,345],-74.00597,40.71427,{"lat":345,"lon":344},{"facility":348,"status":135,"city":332,"state":332,"zip":349,"country":139,"countryCode":140,"cosmosGeoPoint":350,"geoPoint":352,"contacts":100},"Drug Shipping Address: New York-Presbyterian Hospital","10065",{"type":142,"coordinates":351},[344,345],{"lat":345,"lon":344},{"facility":354,"status":226,"city":355,"state":332,"zip":356,"country":139,"countryCode":140,"cosmosGeoPoint":357,"geoPoint":361,"contacts":100},"Stony Brook Cancer Center","Stony Brook","11794",{"type":142,"coordinates":358},[359,360],-73.14094,40.92565,{"lat":360,"lon":359},{"facility":363,"status":135,"city":364,"state":365,"zip":366,"country":139,"countryCode":140,"cosmosGeoPoint":367,"geoPoint":371,"contacts":100},"St. Luke's Hosptial - Bethlehem Campus","Easton","Pennsylvania","18045",{"type":142,"coordinates":368},[369,370],-75.22073,40.68843,{"lat":370,"lon":369},{"facility":373,"status":135,"city":374,"state":375,"zip":376,"country":139,"countryCode":140,"cosmosGeoPoint":377,"geoPoint":381,"contacts":100},"Medical University of Southern Carolina","Charleston","South Carolina","29425",{"type":142,"coordinates":378},[379,380],-79.93275,32.77632,{"lat":380,"lon":379},{"facility":383,"status":135,"city":384,"state":385,"zip":386,"country":139,"countryCode":140,"cosmosGeoPoint":387,"geoPoint":391,"contacts":100},"Thompson Oncology Group - Knoxville West","Knoxville","Tennessee","37932",{"type":142,"coordinates":388},[389,390],-83.92074,35.96064,{"lat":390,"lon":389},{"facility":393,"status":135,"city":394,"state":385,"zip":395,"country":139,"countryCode":140,"cosmosGeoPoint":396,"geoPoint":400,"contacts":100},"Henry-Joyce Cancer Clinic","Nashville","37232",{"type":142,"coordinates":397},[398,399],-86.78444,36.16589,{"lat":399,"lon":398},{"facility":402,"status":135,"city":403,"state":404,"zip":405,"country":139,"countryCode":140,"cosmosGeoPoint":406,"geoPoint":410,"contacts":100},"Houston Methodist Hospital, Houston Methodist Cancer Center","Houston","Texas","77030",{"type":142,"coordinates":407},[408,409],-95.36327,29.76328,{"lat":409,"lon":408},{"facility":412,"status":135,"city":413,"state":404,"zip":414,"country":139,"countryCode":140,"cosmosGeoPoint":415,"geoPoint":419,"contacts":100},"Mays Cancer Center","San Antonio","78229",{"type":142,"coordinates":416},[417,418],-98.49363,29.42412,{"lat":418,"lon":417},{"facility":421,"status":149,"city":422,"state":404,"zip":423,"country":139,"countryCode":140,"cosmosGeoPoint":424,"geoPoint":428,"contacts":100},"Renovatio Clinical","The Woodlands","77380",{"type":142,"coordinates":425},[426,427],-95.48938,30.15799,{"lat":427,"lon":426},{"facility":430,"status":135,"city":431,"state":432,"zip":433,"country":139,"countryCode":140,"cosmosGeoPoint":434,"geoPoint":438,"contacts":100},"University of Utah - Huntsman Cancer Hospital (IP Shipping Address)","Salt Lake City","Utah","84112",{"type":142,"coordinates":435},[436,437],-111.89105,40.76078,{"lat":437,"lon":436},{"facility":440,"status":149,"city":441,"state":442,"zip":443,"country":139,"countryCode":140,"cosmosGeoPoint":444,"geoPoint":448,"contacts":100},"University of Virginia Cancer Center","Charlottesville","Virginia","22903",{"type":142,"coordinates":445},[446,447],-78.47668,38.02931,{"lat":447,"lon":446},{"facility":450,"status":135,"city":451,"state":442,"zip":452,"country":139,"countryCode":140,"cosmosGeoPoint":453,"geoPoint":457,"contacts":100},"Virginia Oncology Associates","Hampton","23666",{"type":142,"coordinates":454},[455,456],-76.34522,37.02987,{"lat":456,"lon":455},{"facility":459,"status":135,"city":460,"state":442,"zip":461,"country":139,"countryCode":140,"cosmosGeoPoint":462,"geoPoint":466,"contacts":100},"Oncology Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care","Roanoke","24014",{"type":142,"coordinates":463},[464,465],-79.94143,37.27097,{"lat":465,"lon":464},{"facility":468,"status":135,"city":469,"state":470,"zip":471,"country":139,"countryCode":140,"cosmosGeoPoint":472,"geoPoint":476,"contacts":100},"Seattle Cancer Care Alliance","Seattle","Washington","98109",{"type":142,"coordinates":473},[474,475],-122.33207,47.60621,{"lat":475,"lon":474},{"facility":478,"status":135,"city":479,"state":480,"zip":481,"country":139,"countryCode":140,"cosmosGeoPoint":482,"geoPoint":486,"contacts":100},"University of Wisconsin Clinical Science 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Centre","Madrid","28033",{"type":142,"coordinates":1127},[1128,1129],-3.70256,40.4165,{"lat":1129,"lon":1128},{"facility":1132,"status":135,"city":1124,"state":100,"zip":1133,"country":1076,"countryCode":1077,"cosmosGeoPoint":1134,"geoPoint":1136,"contacts":100},"Hospital Universitario Ramon Y Cajal","28034",{"type":142,"coordinates":1135},[1128,1129],{"lat":1129,"lon":1128},{"facility":1138,"status":135,"city":1124,"state":100,"zip":1139,"country":1076,"countryCode":1077,"cosmosGeoPoint":1140,"geoPoint":1142,"contacts":100},"Hospital Universitario Clinico San Carlos","28040",{"type":142,"coordinates":1141},[1128,1129],{"lat":1129,"lon":1128},{"facility":1144,"status":135,"city":1124,"state":100,"zip":1145,"country":1076,"countryCode":1077,"cosmosGeoPoint":1146,"geoPoint":1148,"contacts":100},"Hospital Universitario 12 de Octubre","28041",{"type":142,"coordinates":1147},[1128,1129],{"lat":1129,"lon":1128},{"facility":1150,"status":135,"city":1124,"state":100,"zip":1151,"country":1076,"countryCode":1077,"cosmosGeoPoint":1152,"geoPoint":1154,"contacts":100},"Hospital Universitario La Paz","28046",{"type":142,"coordinates":1153},[1128,1129],{"lat":1129,"lon":1128},{"facility":1156,"status":135,"city":1157,"state":100,"zip":1158,"country":1076,"countryCode":1077,"cosmosGeoPoint":1159,"geoPoint":1163,"contacts":100},"Hospital Universitario Puera de Hierro Majadahonda","Majadahonda","28222",{"type":142,"coordinates":1160},[1161,1162],-3.87182,40.47353,{"lat":1162,"lon":1161},{"facility":1165,"status":135,"city":1166,"state":100,"zip":1167,"country":1076,"countryCode":1077,"cosmosGeoPoint":1168,"geoPoint":1172,"contacts":100},"Hospital Sant Joan de Deu","Manresa","08243",{"type":142,"coordinates":1169},[1170,1171],1.82399,41.72815,{"lat":1171,"lon":1170},{"facility":1174,"status":135,"city":1175,"state":100,"zip":1176,"country":1076,"countryCode":1077,"cosmosGeoPoint":1177,"geoPoint":1181,"contacts":100},"Complejo Hospitalario de Ourense","Ourense","32005",{"type":142,"coordinates":1178},[1179,1180],-7.86407,42.33669,{"lat":1180,"lon":1179},{"facility":1183,"status":135,"city":1184,"state":100,"zip":1185,"country":1076,"countryCode":1077,"cosmosGeoPoint":1186,"geoPoint":1190,"contacts":100},"Hospital Universitario Marques de Valdecilla","Santander","39008",{"type":142,"coordinates":1187},[1188,1189],-3.80493,43.46589,{"lat":1189,"lon":1188},{"facility":1192,"status":135,"city":1193,"state":100,"zip":1194,"country":1076,"countryCode":1077,"cosmosGeoPoint":1195,"geoPoint":1199,"contacts":100},"Complejo Hospitalario Universitario de Santiago","Santiago de Compostela","15706",{"type":142,"coordinates":1196},[1197,1198],-8.54569,42.88052,{"lat":1198,"lon":1197},{"facility":1201,"status":135,"city":1202,"state":100,"zip":1203,"country":1076,"countryCode":1077,"cosmosGeoPoint":1204,"geoPoint":1208,"contacts":100},"Hospital Clinico Universitario de Valencia","Valencia","46010",{"type":142,"coordinates":1205},[1206,1207],-0.37966,39.47391,{"lat":1207,"lon":1206},{"facility":1210,"status":135,"city":1211,"state":100,"zip":1212,"country":1076,"countryCode":1077,"cosmosGeoPoint":1213,"geoPoint":1217,"contacts":100},"Hospital Universitario Miguel Servet","Zaragoza","50009",{"type":142,"coordinates":1214},[1215,1216],-0.87734,41.65606,{"lat":1216,"lon":1215},{"facility":1219,"status":135,"city":1220,"state":100,"zip":1221,"country":1222,"countryCode":100,"cosmosGeoPoint":1223,"geoPoint":1227,"contacts":100},"Ankara Sehir Hastanesi","Ankara","06550","Turkey (Türkiye)",{"type":142,"coordinates":1224},[1225,1226],32.85427,39.91987,{"lat":1226,"lon":1225},{"facility":1229,"status":135,"city":1230,"state":100,"zip":1231,"country":1222,"countryCode":100,"cosmosGeoPoint":1232,"geoPoint":1236,"contacts":100},"Dicle Universitesi Tip Fakultesi Hastanesi","Diyarbakır","21280",{"type":142,"coordinates":1233},[1234,1235],40.21721,37.91363,{"lat":1235,"lon":1234},{"facility":1238,"status":135,"city":1239,"state":100,"zip":1240,"country":1222,"countryCode":100,"cosmosGeoPoint":100,"geoPoint":100,"contacts":100},"Trakya Universitesi Saglik Arastirma ve Uygulama Merkezi","Edrine","22030",{"facility":1242,"status":135,"city":1243,"state":100,"zip":1244,"country":1222,"countryCode":100,"cosmosGeoPoint":1245,"geoPoint":1249,"contacts":100},"Istanbul Universitesi Cerrahpasa Tip Fakultesi Hastanesi","Istanbul","34098",{"type":142,"coordinates":1246},[1247,1248],28.94966,41.01384,{"lat":1248,"lon":1247},{"facility":1251,"status":135,"city":1243,"state":100,"zip":1252,"country":1222,"countryCode":100,"cosmosGeoPoint":1253,"geoPoint":1255,"contacts":100},"Medipol Mega Universite Hastanesi","34214",{"type":142,"coordinates":1254},[1247,1248],{"lat":1248,"lon":1247},{"facility":1257,"status":135,"city":1243,"state":100,"zip":1258,"country":1222,"countryCode":100,"cosmosGeoPoint":1259,"geoPoint":1261,"contacts":100},"T.C. Saglik Bakanligi Goztepe Prof Dr. Suleyman Yalcin Sehir Hastanesi","34722",{"type":142,"coordinates":1260},[1247,1248],{"lat":1248,"lon":1247},{"facility":1263,"status":135,"city":1264,"state":100,"zip":1265,"country":1222,"countryCode":100,"cosmosGeoPoint":1266,"geoPoint":1270,"contacts":100},"Izmir Medical Point Hastanesi, Medikal Onkoloji Departmant","Izmir","35575",{"type":142,"coordinates":1267},[1268,1269],27.13838,38.41273,{"lat":1269,"lon":1268},{"facility":1272,"status":135,"city":1273,"state":100,"zip":1274,"country":1222,"countryCode":100,"cosmosGeoPoint":1275,"geoPoint":1279,"contacts":100},"Baskent Universitesi Adana Dr.Turgut Noyan Uygulama ve Arastima Merkezi","Seyhan","01250",{"type":142,"coordinates":1276},[1277,1278],35.30592,36.98747,{"lat":1278,"lon":1277},{"facility":1281,"status":135,"city":1282,"state":100,"zip":1283,"country":1284,"countryCode":1285,"cosmosGeoPoint":1286,"geoPoint":1290,"contacts":100},"University Hospitals Birmingham NHS Foundation Trust","Birmingham","B9 5SS","United Kingdom","UK",{"type":142,"coordinates":1287},[1288,1289],-1.89983,52.48142,{"lat":1289,"lon":1288},{"facility":1292,"status":135,"city":1293,"state":100,"zip":1294,"country":1284,"countryCode":1285,"cosmosGeoPoint":1295,"geoPoint":1299,"contacts":100},"Barts Health NHS Trust","London","E1 1BB",{"type":142,"coordinates":1296},[1297,1298],-0.12574,51.50853,{"lat":1298,"lon":1297},{"facility":1301,"status":135,"city":1302,"state":100,"zip":1303,"country":1284,"countryCode":1285,"cosmosGeoPoint":1304,"geoPoint":1308,"contacts":100},"East and North Hertfordshire NHS Trust","Northwood","HA6 2JW",{"type":142,"coordinates":1305},[1306,1307],-0.42454,51.61162,{"lat":1307,"lon":1306},{"facility":1310,"status":135,"city":1311,"state":100,"zip":1312,"country":1284,"countryCode":1285,"cosmosGeoPoint":100,"geoPoint":100,"contacts":100},"The Royal Marsden NHS Foundation Trust","Surrey","SM2 5PT",{"type":1314,"investigatorFullName":100,"investigatorTitle":100,"investigatorAffiliation":100,"oldNameTitle":100,"oldOrganization":100},"SPONSOR",[1316],{"name":1317,"class":6},"Merck KGaA, Darmstadt, Germany","100327809","phase-2-study-of-sacituzumab-govitecan-in-participants-with-urothelial-cancer-that-cannot-be-removed-or-has-spread-100327809",false,"NCT03547973","Study of Sacituzumab Govitecan in Participants With Urothelial Cancer That Cannot Be Removed or Has Spread","A Phase II Open-Label Study of Sacituzumab Govitecan in Unresectable Locally Advanced\u002FMetastatic Urothelial Cancer","TROPHY U-01","Key Inclusion Criteria:\n\nInclusion Criteria for All Cohorts:\n\n* Female or male individuals, ≥ 18 years of age (19 Years old for South Korea).\n* Eastern Cooperative Oncology Group (ECOG) Performance status score of 0 or 1.\n* Adequate renal and hepatic function.\n* Adequate hematologic parameters without transfusional support.\n* Individuals must have a 3-month life expectancy.\n\nAdditional Inclusion Criteria for Cohorts 1 to 6:\n\n* Cohort 1: Have had progression or recurrence of urothelial cancer following receipt of platinum-containing regimen (cisplatin or carboplatin):\n\n  1. Received a first-line platinum-containing regimen in the metastatic setting or for inoperable locally advanced disease;\n  2. Or received neo\u002Fadjuvant platinum-containing therapy for localized muscle-invasive urothelial cancer, with recurrence\u002Fprogression ≤12 months following completion of therapy.\n* Cohort 1: In addition to above criterion, have had progression or recurrence of urothelial cancer following receipt of an Anti-programmed Cell Death Protein 1 (anti-PD-1)\u002F Anti-programmed Death Ligand 1 (PD-L1) therapy.\n* Cohort 2: Were ineligible for platinum-based therapy for first line metastatic disease and have had progression or recurrence of urothelial cancer after a first-line therapy for metastatic disease with anti-PD-1\u002FPD-L1 therapy. Individual may not have received any platinum for treatment of recurrent, metastatic or advanced disease.\n* Cohort 3: Progression or recurrence of UC following a platinum containing regimen in the metastatic setting, or progression or recurrence of UC within 12 months of completion of platinum-based therapy as neoadjuvant or adjuvant therapy.\n* Cohort 4: Individual has not received any platinum-based chemotherapy in the metastatic or unresectable locally advanced setting. Creatinine clearance of at least 50 mL\u002Fmin calculated by Cockcroft-Gault formula or another validated tool. For individuals receiving cisplatin at 70 mg\u002Fm\\^2 on Day 1 of every 21-day cycle, a creatinine clearance of least 60 mL\u002Fmin calculated by Cockcroft -Gault formula or another validated tool is required. Individuals with creatinine clearance between 50 to 59 mL\u002Fmin are to receive a split dose of cisplatin (35 mg\u002Fm\\^2 Day 1 and Day 8 of every 21-day cycle).\n* Cohorts 4, 5, 6: Archival tumor tissue comprising muscle-invasive or metastatic urothelial carcinoma, or a biopsy of metastatic urothelial carcinoma.\n* Cohort 5: Individuals received at least 4 cycles and no more than 6 cycles of GEM + cisplatin. No other chemotherapy regimens are allowed in this cohort, with the exception of prior adjuvant or neoadjuvant systemic therapy with curative intent after \\> 12 months from completion of therapy.\n* No evidence of progressive disease following completion of first-line chemotherapy (ie, CR, PR, or SD per RECIST v1.1 guidelines as per investigator).\n* Treatment-free interval of 4 to 10 weeks since the last dose of chemotherapy.\n* Cohort 6: Cis-ineligible and no prior therapy for metastatic disease or for unresectable locally advanced disease. Checkpoint inhibitor therapy naïve or \\>12 months from completion of adjuvant therapy are permitted.\n* Cohorts 4 and 6: Have measurable disease by CT or MRI as per RECIST 1.1 criteria. Tumor lesions situated in a previously irradiated area are considered measurable if progression has been demonstrated in such lesions.\n* Cohorts 1, 2, 3 and 5: Creatinine clearance ≥ 30 mL\u002Fmin as calculated by the Cockcroft-Gault formula unless otherwise specified\n\nAdditional Inclusion Criteria for Cohort 7:\n\n* No prior systemic therapy for locally advanced or metastatic UC. Therapy in the curative setting is allowed provided recurrence is \\> 12 months since the last dose of systemic therapy.\n* Archival tumor tissue comprising muscle-invasive or metastatic urothelial carcinoma, or a biopsy of metastatic urothelial carcinoma.\n* Have measurable disease by CT or MRI as per RECIST 1.1 criteria. Tumor lesions situated in a previously irradiated area are considered measurable if progression has been demonstrated in such lesions.\n\nKey Exclusion Criteria:\n\nExclusion Criteria for All cohorts:\n\n* Females who are pregnant or lactating.\n* Has had a prior anti-cancer monoclonal antibody (mAb) within 4 weeks prior to study Day 1 or who has not recovered (i.e., ≤ Grade 1 or at baseline) from adverse events due to agents administered more than 4 weeks earlier.\n* Has an active second malignancy.\n* Has known active Hepatitis B or Hepatitis C.\n* Has other concurrent medical or psychiatric conditions.\n* Has known active central nervous system (CNS) metastases and\u002For carcinomatous meningitis.\n* Has an active second malignancy.\n\nAdditional Exclusion Criteria for Cohorts 1 to 6:\n\n* For Cohort 5: Alopecia, sensory neuropathy Grade ≤2 is acceptable, or other Grade \\\u003C\\\u003C 2 adverse events not constituting a safety risk based on the investigator's judgment are acceptable.\n* Cohort 3: Has received anti-PD-1\u002FPD-L1 therapy previously.\n* Cohorts 3 to 6: Has an active autoimmune disease that required systemic treatment in past 2 years (ie, with use of disease-modifying agents, corticosteroids, or immunosuppressive drugs). Replacement therapy (eg, thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency) is not considered a form of systemic treatment.\n* Cohorts 3 to 6: Has received a live vaccine within 30 days prior to the first dose of study drug(s), has history or evidence of interstitial lung disease (ILD) or non-infectious pneumonitis.\n* Cohort 4: Refractory to platinum (i.e., relapsed ≤ 12 months after completion of chemotherapy) in the neoadjuvant\u002Fadjuvant setting.\n* Cohorts 4, 5, and 6: For individuals who received prior CPI, a treatment-free interval \\>12 months between the last treatment administration and the date of recurrence is required.\n\nAdditional Exclusion Criteria for Cohort 7:\n\n* Have had a prior anticancer therapy within 12 months prior to C1D1 or prior radiation therapy within 2 weeks prior to C1D1. Individuals participating in observational studies are eligible. Use of other investigational drugs (drugs not marketed for any indication) within 28 days or 5 half-lives (whichever is longer) of first dose of investigational product.\n* Have a history of idiopathic pulmonary fibrosis, organizing pneumonia, drug-induced pneumonitis, idiopathic pneumonitis, or evidence of active pneumonitis on screening chest CT scan.\n* Have a Child-Pugh score of B or C.\n* Individuals with uncontrolled diabetes.\n* Have active keratitis or corneal ulcerations.\n* Participants with ongoing sensory or motor neuropathy Grade ≥ 2.\n\nNote: Other protocol defined Inclusion\u002FExclusion criteria may apply.","ALL","18 Years",{"count":1329,"type":1330},827,"ESTIMATED","INTERVENTIONAL",[1333],"PHASE2","The objective of this study is to evaluate the efficacy and safety of sacituzumab govitecan-hziy monotherapy and with novel combinations in participants with metastatic urothelial cancer (mUC).",[1336],"Metastatic Urothelial Cancer","2026-03-12",{"date":1339,"type":1340},"2026-03-16","ACTUAL",{"date":1342,"type":1340},"2018-08-13",{"date":1344,"type":1330},"2030-04",{"name":5,"class":6},135]