[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100602086":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":34,"locations":39,"responsibleParty":57,"collaborators":25,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":25,"eligibilityCriteria":65,"healthyVolunteers":61,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":25,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":80,"overallStatus":41,"whyStopped":25,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"Affiliated Hospital of Nantong University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Sivelestat Sodium","EXPERIMENTAL","Sivelestat Sodium injection or a placebo 2 h after OPCABG for 72 h",[13],"Drug: Sivelestat Sodium injection 2 h after OPCABG for 72 h",{"label":15,"type":16,"description":17,"interventionNames":18},"Routine therapy","PLACEBO_COMPARATOR","Saline instead of Sivelestat",[19],"Drug: Saline (0.9% NaCl)",[21,26],{"type":22,"name":23,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Sivelestat Sodium injection 2 h after OPCABG for 72 h",[9],null,{"type":22,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Saline (0.9% NaCl)","Saline (0.9% NaCl) instead of Sivelestat",[15],[31],{"name":32,"affiliation":5,"role":33},"Weizhang Xiao, Dr.","STUDY_CHAIR",[35],{"name":32,"role":36,"phone":37,"phoneExt":25,"email":38},"CONTACT","8615996546951","xwz191201@163.com",[40],{"facility":5,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"RECRUITING","Nantong","Jiangsu","226001","China","CN",{"type":48,"coordinates":49},"Point",[50,51],120.87472,32.03028,{"lat":51,"lon":50},[54],{"name":5,"role":36,"phone":55,"phoneExt":25,"email":56},"86051385052447","yaowushiyanjigou@163.com",{"type":58,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100602086","phase-2-study-of-sivelestat-sodium-in-opcabg-100602086",false,"NCT07118930","Study of Sivelestat Sodium in OPCABG","Prospective Double-Blind Controlled Study of Sivelestat Sodium in the Perioperative Management of Off-Pump Coronary Artery Bypass Grafting","Inclusion Criteria:\n\n* Undergoing elective OPCABG (≥2 bridged vessels). LVEF≥35%, no severe liver or kidney function abnormalities (ALT\u002FAST≤3 times the upper limit, eGFR≥60 mL\u002Fmin). Sign the informed consent form.\n\nExclusion Criteria:\n\n* Emergency operation, combined valve surgery or aortic surgery. Usage of immunosuppressants or potent anti-inflammatory drugs within 30 days before the operation.\n* Active infections, autoimmune diseases, and allergy history.\n* Preoperative liver and kidney dysfunction\n* Severe cardiopulmonary insufficiency before the operation.","ALL","18 Years","75 Years",{"count":70,"type":71},62,"ESTIMATED","INTERVENTIONAL",[74],"PHASE2","The goal of this clinical trial is to learn if drug Sivelestat Sodium works to improve the prognosis of off-pump coronary artery bypass grafting (OPCABG) in adults. It will also learn about the safety of drug Sivelestat Sodium. The main questions it aims to answer are:\n\n* Does drug Sivelestat Sodium have a protective effect on myocardial injury after OPCABG?\n* Does Sivelestat Sodium exert a protective effect on myocardial inflammatory stress after OPCABG? Researchers will compare drug Sivelestat Sodium to a placebo (a look-alike substance that contains no drug) to see if drug Sivelestat Sodium works to protect myocardium following OPCABG.\n\nParticipants will:\n\n* Accept drug Sivelestat Sodium injection or a placebo 2 h after OPCABG for 72 h.\n* Undergo a series of blood tests and echocardiography examinations after the OPCABG.",[77,78,79],"Coronary Heart Disease","Coronary Artery Disease","Coronary Arterial Disease (CAD)",[81,82,9,83,84],"coronary heart disease","coronary artery bypass grafting","prognosis","myocardial injury","2025-08-11",{"date":87,"type":88},"2025-08-12","ACTUAL",{"date":90,"type":88},"2025-08-01",{"date":92,"type":71},"2027-07-31",{"name":5,"class":6},1]