[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100615097":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":23,"centralContacts":27,"locations":34,"responsibleParty":244,"collaborators":32,"id":246,"slug":247,"hasResults":248,"nctId":249,"briefTitle":250,"officialTitle":251,"acronym":252,"eligibilityCriteria":253,"healthyVolunteers":248,"sex":254,"minAge":255,"maxAge":32,"enrollmentInfo":256,"targetDuration":32,"studyType":259,"phases":260,"briefSummary":262,"conditions":263,"keywords":32,"overallStatus":37,"whyStopped":32,"lastUpdateSubmitDate":265,"lastUpdatePostDateStruct":266,"startDateStruct":269,"completionDateStruct":271,"leadSponsor":273,"locationsCount":274},{"fullName":5,"class":6},"Genmab","INDUSTRY",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Rina-S","EXPERIMENTAL","Multiple cohorts (Cohorts A, B, C, D, and E) will receive Rina-S as monotherapy.",[13],"Drug: Rina-S",[15],{"type":16,"name":9,"description":17,"armGroupLabels":18,"otherNames":19},"DRUG","Intravenous (IV) infusion.",[9],[20,21,22],"Rinatabart Sesutecan","PRO1184","GEN1184",[24],{"name":25,"affiliation":5,"role":26},"Study Official","STUDY_DIRECTOR",[28],{"name":29,"role":30,"phone":31,"phoneExt":32,"email":33},"Genmab Trial Information","CONTACT","+4570202728",null,"clinicaltrials@genmab.com",[35,49,58,68,78,88,97,107,117,127,135,146,154,165,173,182,191,200,208,218,228,236],{"facility":36,"status":37,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":32},"Compassionate Cancer Care Center","RECRUITING","Fountain Valley","California","92708","United States","US",{"type":44,"coordinates":45},"Point",[46,47],-117.95367,33.70918,{"lat":47,"lon":46},{"facility":50,"status":37,"city":51,"state":39,"zip":52,"country":41,"countryCode":42,"cosmosGeoPoint":53,"geoPoint":57,"contacts":32},"Providence Medical Foundation (St. Joseph Heritage Healthcare)","Santa Rosa","95403",{"type":44,"coordinates":54},[55,56],-122.71443,38.44047,{"lat":56,"lon":55},{"facility":59,"status":37,"city":60,"state":61,"zip":62,"country":41,"countryCode":42,"cosmosGeoPoint":63,"geoPoint":67,"contacts":32},"Nebraska Hematology-Oncology","Lincoln","Nebraska","68506",{"type":44,"coordinates":64},[65,66],-96.66696,40.8,{"lat":66,"lon":65},{"facility":69,"status":37,"city":70,"state":71,"zip":72,"country":41,"countryCode":42,"cosmosGeoPoint":73,"geoPoint":77,"contacts":32},"Astera Cancer Care","East Brunswick","New Jersey","08816",{"type":44,"coordinates":74},[75,76],-74.41598,40.42788,{"lat":76,"lon":75},{"facility":79,"status":37,"city":80,"state":81,"zip":82,"country":41,"countryCode":42,"cosmosGeoPoint":83,"geoPoint":87,"contacts":32},"ONE Onc: New York Oncology Hematology","Albany","New York","12206",{"type":44,"coordinates":84},[85,86],-73.75623,42.65258,{"lat":86,"lon":85},{"facility":89,"status":37,"city":90,"state":81,"zip":91,"country":41,"countryCode":42,"cosmosGeoPoint":92,"geoPoint":96,"contacts":32},"Montefiore Medical Park","The Bronx","10461",{"type":44,"coordinates":93},[94,95],-73.86641,40.84985,{"lat":95,"lon":94},{"facility":98,"status":37,"city":99,"state":100,"zip":101,"country":41,"countryCode":42,"cosmosGeoPoint":102,"geoPoint":106,"contacts":32},"Tennessee Oncology - Nashville St. Thomas Midtown Clinic","Nashville","Tennessee","37203",{"type":44,"coordinates":103},[104,105],-86.78444,36.16589,{"lat":105,"lon":104},{"facility":108,"status":37,"city":109,"state":110,"zip":111,"country":41,"countryCode":42,"cosmosGeoPoint":112,"geoPoint":116,"contacts":32},"Virginia Cancer Specialists","Fairfax","Virginia","22031",{"type":44,"coordinates":113},[114,115],-77.30637,38.84622,{"lat":115,"lon":114},{"facility":118,"status":37,"city":119,"state":32,"zip":32,"country":120,"countryCode":121,"cosmosGeoPoint":122,"geoPoint":126,"contacts":32},"Icon Cancer Centre Hobart","Hobart","Australia","AU",{"type":44,"coordinates":123},[124,125],147.32941,-42.87936,{"lat":125,"lon":124},{"facility":128,"status":37,"city":129,"state":32,"zip":32,"country":120,"countryCode":121,"cosmosGeoPoint":130,"geoPoint":134,"contacts":32},"Icon Cancer Care - Townsville","Hyde Park",{"type":44,"coordinates":131},[132,133],138.60107,-34.95467,{"lat":133,"lon":132},{"facility":136,"status":37,"city":137,"state":138,"zip":32,"country":139,"countryCode":140,"cosmosGeoPoint":141,"geoPoint":145,"contacts":32},"Shanghai East Hospital","Shanghai","Pudong","China","CN",{"type":44,"coordinates":142},[143,144],121.45806,31.22222,{"lat":144,"lon":143},{"facility":147,"status":37,"city":148,"state":32,"zip":32,"country":139,"countryCode":140,"cosmosGeoPoint":149,"geoPoint":153,"contacts":32},"Tianjin Medical University Cancer Institute and Hospital","Tianjin",{"type":44,"coordinates":150},[151,152],117.17667,39.14222,{"lat":152,"lon":151},{"facility":155,"status":37,"city":156,"state":157,"zip":32,"country":158,"countryCode":159,"cosmosGeoPoint":160,"geoPoint":164,"contacts":32},"Kitasato University Hospital","Sagamihara","Kanagawa","Japan","JP",{"type":44,"coordinates":161},[162,163],139.24167,35.56707,{"lat":163,"lon":162},{"facility":166,"status":37,"city":167,"state":157,"zip":32,"country":158,"countryCode":159,"cosmosGeoPoint":168,"geoPoint":172,"contacts":32},"Kanagawa Cardiovascular and Respiratory Center","Yokohama",{"type":44,"coordinates":169},[170,171],139.65,35.43333,{"lat":171,"lon":170},{"facility":174,"status":37,"city":175,"state":176,"zip":32,"country":158,"countryCode":159,"cosmosGeoPoint":177,"geoPoint":181,"contacts":32},"Japan Community Health Care Organization Chukyo Hospital","Nagoya","Minami Ward",{"type":44,"coordinates":178},[179,180],136.90641,35.18147,{"lat":180,"lon":179},{"facility":183,"status":37,"city":184,"state":185,"zip":32,"country":158,"countryCode":159,"cosmosGeoPoint":186,"geoPoint":190,"contacts":32},"Saitama Medical University International Medical Center","Saitama","Moroyama",{"type":44,"coordinates":187},[188,189],139.65657,35.90807,{"lat":189,"lon":188},{"facility":192,"status":37,"city":193,"state":194,"zip":32,"country":158,"countryCode":159,"cosmosGeoPoint":195,"geoPoint":199,"contacts":32},"NHO Kinki Chuo Chest Medical Center","Sakai","Osaka",{"type":44,"coordinates":196},[197,198],135.46653,34.58216,{"lat":198,"lon":197},{"facility":201,"status":37,"city":202,"state":32,"zip":32,"country":158,"countryCode":159,"cosmosGeoPoint":203,"geoPoint":207,"contacts":32},"Kyoto Prefectural University of Medicine","Kyoto",{"type":44,"coordinates":204},[205,206],135.75385,35.02107,{"lat":206,"lon":205},{"facility":209,"status":37,"city":210,"state":32,"zip":32,"country":211,"countryCode":212,"cosmosGeoPoint":213,"geoPoint":217,"contacts":32},"KOMED Roman Karaszewski I Wspolnicy Spolka Jawna","Krakow","Poland","PL",{"type":44,"coordinates":214},[215,216],19.93658,50.06143,{"lat":216,"lon":215},{"facility":219,"status":37,"city":220,"state":32,"zip":32,"country":221,"countryCode":222,"cosmosGeoPoint":223,"geoPoint":227,"contacts":32},"MD Anderson Cancer Center Madrid","Madrid","Spain","ES",{"type":44,"coordinates":224},[225,226],-3.70256,40.4165,{"lat":226,"lon":225},{"facility":229,"status":37,"city":230,"state":32,"zip":32,"country":221,"countryCode":222,"cosmosGeoPoint":231,"geoPoint":235,"contacts":32},"Clinica Universidad de Navarra - Pamplona","Pamplona",{"type":44,"coordinates":232},[233,234],-1.64323,42.81687,{"lat":234,"lon":233},{"facility":237,"status":37,"city":238,"state":32,"zip":32,"country":221,"countryCode":222,"cosmosGeoPoint":239,"geoPoint":243,"contacts":32},"Hospital Clinico Universitario de Valencia","Valencia",{"type":44,"coordinates":240},[241,242],-0.37966,39.47391,{"lat":242,"lon":241},{"type":245,"investigatorFullName":32,"investigatorTitle":32,"investigatorAffiliation":32,"oldNameTitle":32,"oldOrganization":32},"SPONSOR","100615097","phase-2-study-to-assess-the-efficacy-and-safety-of-rina-s-in-participants-with-non-small-cell-lung-cancer-100615097",false,"NCT07288177","Study to Assess the Efficacy and Safety of Rina-S in Participants With Non-small Cell Lung Cancer","A Phase 2, Open-label, Multicohort Study of Rinatabart Sesutecan (Rina-S) in Participants With Non-Small Cell Lung Cancer","RAINFOL-05","Key Inclusion Criteria:\n\n* Participant has histologically or cytologically confirmed metastatic or locally advanced NSCLC of adenocarcinoma histology, not amenable to curative surgery or radiotherapy.\n* Participant must have radiological disease progression while on or after receiving the most recent regimen.\n* Participants either may have actionable genetic alterations (AGAs) or no AGAs.\n* Participant has measurable disease according to RECIST v1.1.\n* Participant has an Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) score of 0 or 1 within 7 days of Cycle 1 Day 1.\n\nKey Exclusion Criteria (all study cohorts):\n\n* Participant has NSCLC with histology other than adenocarcinoma\n* Participant has a past or current malignancy other than the inclusion diagnosis before the planned first dose of trial treatment, or any evidence of residual disease from a previously diagnosed malignancy. Exceptions are malignancies with a negligible risk of metastasis or death (eg, 5-year OS ≥ 90%), including, but not limited to, adequately treated cervical carcinoma of stage 1B or less, in situ basal cell or squamous cell skin carcinoma, in situ bladder cancer, ductal carcinoma in situ, or any past malignancy considered cured for ≥ 3 years.\n* Participants with newly identified or known unstable (eg, progressing brain metastases) or symptomatic central nervous system (CNS) metastases or history of carcinomatous meningitis (also known as leptomeningeal disease). Participants with history of spinal cord compression (from disease). Participants with previous CNS-directed therapy (eg, radiotherapy and\u002For surgery) for brain metastases may participate provided lesion(s) are radiologically stable (ie, without evidence of progression) for at least 28 days by repeat imaging.\n\nNote: Other protocol-defined Inclusion and Exclusion criteria may apply.","ALL","18 Years",{"count":257,"type":258},240,"ESTIMATED","INTERVENTIONAL",[261],"PHASE2","This Phase 2 study will be conducted in different countries around the world with up to about 240 participants.\n\nThe purpose of this study is to evaluate how well Rina-S works against lung cancer.\n\nThe treatment in this study is Rina-S monotherapy (by itself). All participants will receive active drug; no one will be given placebo.\n\nThe treatment duration will be different for every participant, but an average of 12 months is expected. Participants will be asked to attend 1 to 5 visits at the study clinic for each cycle (duration of cycle is 3 weeks). If a participant's cancer stays the same or gets better, and there are not any serious problems, participants can keep getting study treatment for as long as the study is open.\n\nParticipation in the study will require visits to the study site(s). During site visits, there will be various tests (such as blood draws) and procedures (such as recording of heart activity, imaging\u002FX-rays) to monitor whether the study treatment is safe and effective.",[264],"Non-small Cell Lung Cancer (NSCLC)","2026-06-01",{"date":267,"type":268},"2026-06-02","ACTUAL",{"date":270,"type":268},"2026-01-30",{"date":272,"type":258},"2028-11-22",{"name":5,"class":6},22]