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Clinically significant cardiovascular disease (e.g., NYHA class III\u002FIV heart failure, recent myocardial infarction, stroke, or revascularization within 3 months)\n5. History of pancreatitis or factors increasing the risk of pancreatitis\n6. Personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia type 2\n7. Clinically significant liver disease, renal impairment (eGFR \\\u003C60 mL\u002Fmin\u002F1.73 m²), or abnormal laboratory findings at screening\n8. 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