[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100612528":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":32,"locations":41,"responsibleParty":335,"collaborators":337,"id":343,"slug":344,"hasResults":345,"nctId":346,"briefTitle":347,"officialTitle":348,"acronym":349,"eligibilityCriteria":350,"healthyVolunteers":345,"sex":351,"minAge":352,"maxAge":20,"enrollmentInfo":353,"targetDuration":20,"studyType":356,"phases":357,"briefSummary":359,"conditions":360,"keywords":362,"overallStatus":44,"whyStopped":20,"lastUpdateSubmitDate":368,"lastUpdatePostDateStruct":369,"startDateStruct":372,"completionDateStruct":374,"leadSponsor":376,"locationsCount":377},{"fullName":5,"class":6},"Grupo Español de Linfomas y Transplante Autólogo de Médula Ósea","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Axicabtagene ciloleucel","EXPERIMENTAL","Treatment consists of a single dose for infusion containing a dispersion for infusion of CAR-positive viable T cells in one infusion bag. The target dose is 2 × 106 CAR-positive viable T cells per kg of body weight (within a range of 1 × 10E6 - 2 × 10E6 cells\u002Fkg), with a maximum of 2 × 10E8 CAR-positive viable T cells for patients 100 kg and above.",[13],"Drug: Axicabtagene Ciloleucel",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DRUG","Axicabtagene Ciloleucel","Treatment consists of a single dose for infusion containing a dispersion for infusion of CAR-positive viable T cells in one infusion bag. The target dose is 2 × 106 CAR-positive viable T cells per kg of body weight (within a range of 1 × 106 - 2 × 106 cells\u002Fkg), with a maximum of 2 × 108 CAR-positive viable T cells for patients 100 kg and above.",[9],null,[22,26,29],{"name":23,"affiliation":24,"role":25},"Mariana Bastos-Oreiro","Hospital General Universitario Gregorio Marañón","PRINCIPAL_INVESTIGATOR",{"name":27,"affiliation":28,"role":25},"Alejandro Martín García-Sancho","Hospital Universitario Salamanca",{"name":30,"affiliation":31,"role":25},"Armando López-Guillermo","Hospital Clinic of Barcelona",[33,38],{"name":34,"role":35,"phone":36,"phoneExt":20,"email":37},"Auxi Moreno","CONTACT","+34 683636850","amoreno@geltamo.com",{"name":39,"role":35,"phone":20,"phoneExt":20,"email":40},"Ana María Méndez","administracion@geltamo.com",[42,65,85,105,126,148,163,182,201,221,238,254,273,295,315],{"facility":43,"status":44,"city":45,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Complejo Hospitalario Universitario A Coruña","RECRUITING","A Coruña","15008","Spain","ES",{"type":50,"coordinates":51},"Point",[52,53],-8.396,43.37135,{"lat":53,"lon":52},[56,60,63],{"name":57,"role":35,"phone":58,"phoneExt":20,"email":59},"Sandra García Doval","+34 981176668","sandragarciadoval@gmail.com",{"name":61,"role":35,"phone":58,"phoneExt":20,"email":62},"Almudena Pérez Rodriguez","almudena.perez.rodriguez@sergas.es",{"name":64,"role":25,"phone":20,"phoneExt":20,"email":20},"Víctor Noriega Concepción",{"facility":66,"status":44,"city":67,"state":68,"zip":69,"country":47,"countryCode":48,"cosmosGeoPoint":70,"geoPoint":74,"contacts":75},"Hospital Universitario Son Espases","Palma de Mallorca","Balearic Islands","7120",{"type":50,"coordinates":71},[72,73],2.65024,39.56939,{"lat":73,"lon":72},[76,80,83],{"name":77,"role":35,"phone":78,"phoneExt":20,"email":79},"Mª Teresa Ros Matheu","+34 871206268","maria.ros@ssib.es",{"name":81,"role":35,"phone":78,"phoneExt":20,"email":82},"Silvia Roig Juan","silvia.roig@ssib.es",{"name":84,"role":25,"phone":20,"phoneExt":20,"email":20},"Antonio Gutiérrez García",{"facility":86,"status":44,"city":87,"state":88,"zip":89,"country":47,"countryCode":48,"cosmosGeoPoint":90,"geoPoint":94,"contacts":95},"Hospital Universitario Marqués de Valdecilla","Santander","Cantabria","39008",{"type":50,"coordinates":91},[92,93],-3.80493,43.46589,{"lat":93,"lon":92},[96,100,103],{"name":97,"role":35,"phone":98,"phoneExt":20,"email":99},"Alba del Río Manzano","+34 942204078","amanzano@idival.org",{"name":101,"role":35,"phone":98,"phoneExt":20,"email":102},"Pilar González Echezarreta","mpilar.gonzaleze@scsalud.es",{"name":104,"role":25,"phone":20,"phoneExt":20,"email":20},"Sonia González de Villambrosia Pellón",{"facility":106,"status":44,"city":107,"state":108,"zip":109,"country":47,"countryCode":48,"cosmosGeoPoint":110,"geoPoint":114,"contacts":115},"Hospital Universitario de Salamanca","Salamanca","Castille and León","37007",{"type":50,"coordinates":111},[112,113],-5.66388,40.96882,{"lat":113,"lon":112},[116,121,125],{"name":117,"role":35,"phone":118,"phoneExt":119,"email":120},"Andrea Torices","+34 923291100","56078","atorices.ibsal@saludcastillayleon.es",{"name":122,"role":35,"phone":118,"phoneExt":123,"email":124},"Manuel Delgado","56022","mdelgadocri@saludcastillayleon.es",{"name":27,"role":25,"phone":20,"phoneExt":20,"email":20},{"facility":127,"status":44,"city":128,"state":129,"zip":130,"country":47,"countryCode":48,"cosmosGeoPoint":131,"geoPoint":135,"contacts":136},"Hospital Universitari Vall d'Hebron","Barcelona","Catalonia","08035",{"type":50,"coordinates":132},[133,134],2.15899,41.38879,{"lat":134,"lon":133},[137,142,146],{"name":138,"role":35,"phone":139,"phoneExt":140,"email":141},"Alicia Nogueroles Olivares","+ 34 93 274 61 00","Ext. 4976\u002F 26","alicianogueroles@vhio.net",{"name":143,"role":35,"phone":139,"phoneExt":144,"email":145},"Julia Sedó","Ext. 4976\u002F2697","jsedo@vhio.net",{"name":147,"role":25,"phone":20,"phoneExt":20,"email":20},"Gloria Iacoboni",{"facility":149,"status":44,"city":128,"state":129,"zip":150,"country":47,"countryCode":48,"cosmosGeoPoint":151,"geoPoint":153,"contacts":154},"Hospital Clinic i Provincial de Barcelona","08036",{"type":50,"coordinates":152},[133,134],{"lat":134,"lon":133},[155,159,162],{"name":156,"role":35,"phone":157,"phoneExt":20,"email":158},"Veronica Martil","+34 913303000","MARTIL@recerca.clinic.cat",{"name":160,"role":35,"phone":20,"phoneExt":20,"email":161},"Cecilia Vilas","CVILAS@recerca.clinic.cat",{"name":30,"role":25,"phone":20,"phoneExt":20,"email":20},{"facility":164,"status":44,"city":165,"state":129,"zip":166,"country":47,"countryCode":48,"cosmosGeoPoint":167,"geoPoint":171,"contacts":172},"Institut Català d'oncologia de L'Hospitalet","L'Hospitalet de Llobregat","08908",{"type":50,"coordinates":168},[169,170],2.10028,41.35967,{"lat":170,"lon":169},[173,177,180],{"name":174,"role":35,"phone":175,"phoneExt":20,"email":176},"Lydia Guillem","+34 932607750","lguillem@idibell.cat",{"name":178,"role":35,"phone":175,"phoneExt":20,"email":179},"Mariona Guillamet","mguillamet@idibell.cat",{"name":181,"role":25,"phone":20,"phoneExt":20,"email":20},"Eva González-Barca",{"facility":183,"status":44,"city":184,"state":185,"zip":20,"country":47,"countryCode":48,"cosmosGeoPoint":186,"geoPoint":190,"contacts":191},"Hospital Universitario Donostia","San Sebastián","Gipuzkoa",{"type":50,"coordinates":187},[188,189],-5.9,43.56667,{"lat":189,"lon":188},[192,196,199],{"name":193,"role":35,"phone":194,"phoneExt":20,"email":195},"Nerea Castroagudín Romero","+34 943006046","NEREA.CASTROAGUDINROMERO@bio-gipuzkoa.eus",{"name":197,"role":35,"phone":194,"phoneExt":20,"email":198},"María Aurora Barbero Martínez","MARIAAURORA.BARBEROMARTINEZ@bio-gipuzkoa.eus",{"name":200,"role":25,"phone":20,"phoneExt":20,"email":20},"Izaskun Zeberio Etxetxipia",{"facility":202,"status":44,"city":203,"state":204,"zip":205,"country":47,"countryCode":48,"cosmosGeoPoint":206,"geoPoint":210,"contacts":211},"Complejo Hospitalario Universitario de Gran Canaria Dr. Negrín","Las Palmas de Gran Canaria","Las Palmas","35019",{"type":50,"coordinates":207},[208,209],-15.41573,28.10178,{"lat":209,"lon":208},[212,216,219],{"name":213,"role":35,"phone":214,"phoneExt":20,"email":215},"Elizabeth Alfonso Bermejo","+34 928450767","ealfonso@fciisc.es",{"name":217,"role":35,"phone":214,"phoneExt":20,"email":218},"Julia Wiedermann","jmwiedermann@fciisc.es",{"name":220,"role":25,"phone":20,"phoneExt":20,"email":20},"Hugo Luzardo Henríquez",{"facility":24,"status":44,"city":222,"state":222,"zip":223,"country":47,"countryCode":48,"cosmosGeoPoint":224,"geoPoint":228,"contacts":229},"Madrid","28007",{"type":50,"coordinates":225},[226,227],-3.70256,40.4165,{"lat":227,"lon":226},[230,234,237],{"name":231,"role":35,"phone":232,"phoneExt":20,"email":233},"Soraya Oviedo","+34 914269658","soraya.oviedo.hgugm@gmail.com",{"name":235,"role":35,"phone":232,"phoneExt":20,"email":236},"Ana García","ana.garcia.hgugm@gmail.com",{"name":23,"role":25,"phone":20,"phoneExt":20,"email":20},{"facility":239,"status":44,"city":222,"state":222,"zip":240,"country":47,"countryCode":48,"cosmosGeoPoint":241,"geoPoint":243,"contacts":244},"Hospital Universitario 12 de Octubre","28041",{"type":50,"coordinates":242},[226,227],{"lat":227,"lon":226},[245,249,252],{"name":246,"role":35,"phone":247,"phoneExt":20,"email":248},"Alba Gutiérrez de la Peña","+34 917792809","albagu12oct@gmail.com",{"name":250,"role":35,"phone":247,"phoneExt":20,"email":251},"Paula Garcés","paulagarcesh12oct@gmail.com",{"name":253,"role":25,"phone":20,"phoneExt":20,"email":20},"Ana Jiménez Ubieto",{"facility":255,"status":44,"city":256,"state":256,"zip":257,"country":47,"countryCode":48,"cosmosGeoPoint":258,"geoPoint":262,"contacts":263},"Hospital General Universitario Morales Meseguer","Murcia","30008",{"type":50,"coordinates":259},[260,261],-1.13004,37.98704,{"lat":261,"lon":260},[264,268,271],{"name":265,"role":35,"phone":266,"phoneExt":20,"email":267},"José Navarro Fernández","+34 968363969","josenafer79@gmail.com",{"name":269,"role":35,"phone":266,"phoneExt":20,"email":270},"Josefa Gálvez Martínez","josegalvez100@gmail.com",{"name":272,"role":25,"phone":20,"phoneExt":20,"email":20},"Oriana López Godino",{"facility":274,"status":44,"city":275,"state":276,"zip":277,"country":47,"countryCode":48,"cosmosGeoPoint":278,"geoPoint":282,"contacts":283},"Clínica Universidad de Navarra","Pamplona","Navarre","31008",{"type":50,"coordinates":279},[280,281],-1.64323,42.81687,{"lat":281,"lon":280},[284,289,293],{"name":285,"role":35,"phone":286,"phoneExt":287,"email":288},"Andoni Urrutia","+34 948 296 666","Ext. 2703","aurrutia@unav.es",{"name":290,"role":35,"phone":286,"phoneExt":291,"email":292},"Sara Morales Espinosa","Ext. 2768","smoralesesp@unav.es",{"name":294,"role":25,"phone":20,"phoneExt":20,"email":20},"Miguel Ángel Canales Albendea",{"facility":296,"status":44,"city":297,"state":298,"zip":299,"country":47,"countryCode":48,"cosmosGeoPoint":300,"geoPoint":304,"contacts":305},"Hospital Universitario Virgen del Rocío","Seville","Sevilla","41013",{"type":50,"coordinates":301},[302,303],-5.97317,37.38283,{"lat":303,"lon":302},[306,310,313],{"name":307,"role":35,"phone":308,"phoneExt":20,"email":309},"Rocío Jiménez","+34 955013277","rociojimenezalvarez@gmail.com",{"name":311,"role":35,"phone":308,"phoneExt":20,"email":312},"Estefanía Menéndez Pedregal","estefania.menpe@gmail.com",{"name":314,"role":25,"phone":20,"phoneExt":20,"email":20},"Javier Delgado Serrano",{"facility":316,"status":44,"city":317,"state":317,"zip":318,"country":47,"countryCode":48,"cosmosGeoPoint":319,"geoPoint":323,"contacts":324},"Hospital Clínico Universitario de Valencia","Valencia","46010",{"type":50,"coordinates":320},[321,322],-0.37966,39.47391,{"lat":322,"lon":321},[325,330,333],{"name":326,"role":35,"phone":327,"phoneExt":328,"email":329},"María Mercedes Bou Moreno","+34 96 197 3500","Ext. 436697","mbou@incliva.es",{"name":331,"role":35,"phone":327,"phoneExt":328,"email":332},"Carmen Hurtado Fontelles","carmenhurtadoincliva@gmail.com",{"name":334,"role":25,"phone":20,"phoneExt":20,"email":20},"Mª José Terol Castera",{"type":336,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR",[338,341],{"name":339,"class":340},"Kite, A Gilead Company","INDUSTRY",{"name":342,"class":6},"Evidenze CRO","100612528","phase-2-study-to-evaluate-the-efficacy-of-axicabtagene-ciloleucel-in-patients-with-late-relapse-of-diffuse-large-b-cell-lymphoma-100612528",false,"NCT07254754","Study to Evaluate the Efficacy of Axicabtagene Ciloleucel in Patients With Late Relapse of Diffuse Large B-Cell Lymphoma","LATE-R Trial. A Phase II, Single-Arm, Open-Label, Multicenter Study to Evaluate the Efficacy of Axicabtagene Ciloleucel in Patients With Late Relapse of Diffuse Large B-Cell Lymphoma","LATE-R-GEL-23","Inclusion Criteria:\n\n1. Signed written Informed Consent Form\n2. Age \\> 18 years\n3. Patient who understands and speaks one of the country official languages\n4. Histologically proven relapsed or refractory aggressive B-cell non-Hodgkin lymphoma (B-NHL) of the following histology at relapse: diffuse large B-cell lymphoma (DLBCL), high-grade B-cell lymphoma (HGBL) and follicular lymphoma Grade 3B per WHO 2016 classification. Indolent B-NHL who transformed into aggressive B-NHL and were previously treated with R-CHOP-like after transformation are eligible. Primary mediastinal B-cell lymphoma are not eligible.\n5. Positron-emission tomography (PET)-positive disease\n6. Patients must have received adequate first-line therapy including at a minimum:\n\n   * An anti-CD20 monoclonal antibody (rituximab or obinutuzumab), and\n   * CHOP or CHOP-like chemotherapy Note: CHOP-like chemotherapy corresponds to ACVBP, EPOCH, or COPADEM. Dose-reduced CHOP (i.e., miniCHOP) is excluded except for dose-reductions of vincristine due to peripheral neuropathy. Patients who have received additional drugs in combination with CHOP or CHOP-like regimen are eligible.\n7. Relapsed disease after first line chemo immunotherapy (full dose of R-CHOP or R-CHOP-like regimen), documented by PET-scan and biopsy:\n\n   • Relapsed disease defined as complete remission to first-line therapy followed by biopsy-proven disease relapse after 12 months and up to 5 years from end of first-line therapy.\n8. Patients must meet CAR-T-eligible criteria as defined by:\n\n   * Patient deemed eligible for CAR T-cells therapy by the CAR-T physician\n   * AND all the following criteria:\n\n     * ECOG performance status of 0, 1 or 2\n     * Adequate vascular access for leukapheresis procedure (either peripheral or central venous line)\n     * Absolute neutrophil count (ANC) ≥ 1 x 109\u002FL\n     * Platelets ≥ 75 x 109\u002FL\n     * Absolute lymphocyte count ≥ 0.1 x 109\u002FL\n     * Creatinine clearance (CrCl) as estimated by Cockcroft Gault or MDRD ≥ 40 mL\u002Fmin\n     * Serum alanine aminotransferase\u002Faspartate aminotransferase (ALT\u002FAST) ≤ 2.5xULN\n     * Total bilirubin \\\u003C1.5 mg\u002FdL, except in patients with Gilbert's syndrome\n     * Cardiac ejection fraction ≥ 45%\n     * Baseline oxygen saturation ≥ 92% on room air\n9. Females of childbearing potential must have a negative serum or urine pregnancy test (females who have undergone surgical sterilization or who have been postmenopausal for at least 12 months are not considered to be of childbearing potential).\n\nExclusion Criteria:\n\n1. Patients who received more than one prior line of systemic therapy\n2. Early relapsed disease defined as complete remission to first-line therapy followed by biopsy-proven disease relapse before 12 months from end of first-line therapy.\n3. Refractory disease defined as:\n\n   * Progressive disease (PD) during first-line therapy\n   * Stable disease (SD) as best response after at least 4 cycles of first-line therapy (e.g., 4 cycles of R-CHOP)\n   * Partial response (PR) as best response after at least 6 cycles, and biopsy-proven residual disease\n4. Patients who received first line of R-CHOP or obinutuzumab-CHOP for an indolent B-NHL who relapse as transformed aggressive B-NHL after a year from the end of first-line therapy are NOT eligible.\n5. Prior CD19 targeted therapy\n6. Patients with cardiac atrial or cardiac ventricular lymphoma involvement\n7. Requirement for urgent therapy due to tumor mass effects, such as bowel obstruction or blood vessel compression\n8. Patient with clinically significant pleural effusion\n9. History of another primary malignancy that has not been in remission for at least 3 years (except for nonmelanoma skin cancer or carcinoma in situ (eg, cervix, bladder, breast)). A maintenance treatment is not allowed.\n10. Patients with detectable Central Nervous System (CNS) lymphoma. Patients with a history of CNS lymphoma but no active CNS disease (after systematic MRI and lumbar puncture) at the time of enrolment will be eligible.\n11. Presence of CNS disorder such as dementia, autoimmune disease with CNS involvement, cerebral edema with confirmed structural defects by appropriate imaging, or seizure disorders requiring active anticonvulsive medication. History of stroke, transient ischemic attack, or posterior reversible encephalopathy syndrome (PRES) within 12 months prior to enrolment.\n12. Presence of any indwelling line or drain (eg, percutaneous nephrostomy tube, indwelling Foley catheter, biliary drain, or pleural\u002Fperitoneal\u002Fpericardial catheter). Ommaya reservoirs and dedicated central venous access catheters, such as a Port-a-Cath or Hickman catheter, are permitted.\n13. History of acute or chronic active hepatitis B or C infection (seropositivity). If there is a positive history of treated hepatitis B or hepatitis C (negative HBsAg and positive Anti-HBc\u002F positive anti-HCV), the viral load HBV DNA\u002F HCV RNA) must be undetectable per quantitative polymerase chain reaction (PCR) and\u002For nucleic acid testing\n14. Positive for human immunodeficiency virus (HIV) unless taking appropriate anti-HIV medications, with an undetectable viral load by PCR and with a CD4 count \\> 200 cells\u002FuL.\n15. Uncontrolled systemic fungal, bacterial, viral or other infection despite appropriate antimicrobials or other treatment at the time of leukapheresis or axicabtagene ciloleucel administration\n16. History of any one of the following cardiovascular conditions within the past 12 months: Class III or IV heart failure as defined by the New York Heart Association, cardiac angioplasty or stenting, myocardial infarction, unstable angina, or other clinically significant cardiac disease\n17. Presence of primary immunodeficiency\n18. History of any medical condition including but not limited to autoimmune disease (e.g., Crohn's disease, rheumatoid arthritis, systemic lupus) requiring systemic immunosuppression and\u002For systemic disease modifying agents within the last year. Endocrine conditions that require maintenance with physiologic dose steroids are allowed.\n19. History of idiopathic pulmonary fibrosis, organizing pneumonia (e.g., bronchiolitis obliterans), drug-induced pneumonitis, idiopathic pneumonitis, or evidence of active pneumonitis per chest computed tomography (CT) scan at screening. History of radiation pneumonitis in the radiation field (fibrosis) is allowed.\n20. History of severe immediate hypersensitivity reaction to tocilizumab or any of the agents used in this study\n21. History of severe, immediate hypersensitivity reaction attributed to aminoglycosides, cyclophosphamide or fludarabine\n22. Treatment with a live, attenuated vaccine within 6 weeks prior to initiation of study treatment or anticipation of need for such a vaccine during the study\n23. Women of childbearing potential who are pregnant or breastfeeding because of the potentially dangerous effects of lymphodepletion chemotherapy on the fetus or infant.\n24. Patients of either sex who are not willing to practice birth control from the time of consent during treatment and for at least 12 months after conditioning chemotherapy dosing or axicabtagene ciloleucel dosing, whichever is later\n25. In the investigator's judgment, the patient is unlikely to complete all protocol-required study visits or procedures, including follow-up visits, or comply with the study requirements for participation\n26. Adult person unable to provide informed consent because of intellectual impairment, any serious medical condition, laboratory abnormality or psychiatric illness.","ALL","18 Years",{"count":354,"type":355},45,"ESTIMATED","INTERVENTIONAL",[358],"PHASE2","Single-arm, open-label, multicenter, phase II trial aiming to include approximately 45 patients over 24 months. Patients will receive axicabtagene ciloleucel infusion and will be followed up to 5 years.\n\nThe total duration of the study is therefore of 7 years.",[361],"DIFFUSE LARGE B-CELL LYMPHOMA",[363,364,365,361,366,367],"lymphoma","axicabtagene","geltamo","DLBCL","RELAPSE","2025-11-20",{"date":370,"type":371},"2025-11-28","ACTUAL",{"date":373,"type":371},"2024-11-20",{"date":375,"type":355},"2031-12-31",{"name":5,"class":6},15]