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Replacement therapy (eg, thyroxine, insulin, or physiologic corticosteroid) is allowed\n* Active infection requiring systemic therapy\n* HIV-infected participants with a history of Kaposi's sarcoma and\u002For Multicentric Castleman's Disease\n* Active inflammatory bowel disease requiring immunosuppressive medication or previous clear history of inflammatory bowel disease (eg, Crohn's disease, ulcerative colitis, or chronic diarrhea)\n* Known history of, or active, neurologic paraneoplastic syndrome\n* History of allogeneic tissue\u002Fsolid organ transplant\n* Has not adequately recovered from major surgery or have ongoing surgical complications","ALL","18 Years",{"count":596,"type":597},144,"ESTIMATED","INTERVENTIONAL",[600],"PHASE2","Researchers are looking for other ways to treat metastatic squamous non-small cell lung cancer (NSCLC). Squamous NSCLC is cancer that starts in squamous cells, which are flat cells that line the inside of the airways in the lungs. Metastatic means the cancer has spread to other parts of the body.\n\nStandard treatment (usual treatment) for metastatic squamous NSCLC is immunotherapy with or without chemotherapy. Immunotherapy is a treatment that helps the immune system fight cancer. Chemotherapy is medicine that destroys cancer cells or stops them from growing. However, standard treatment may not work or may stop working to treat metastatic squamous NSCLC.\n\nResearchers want to learn if study treatments that are antibody drug conjugates (ADCs) can treat metastatic squamous NSCLC that did not respond (get smaller or go away) to standard treatment. An ADC attaches to a protein on cancer cells and delivers treatment to destroy those cells.\n\nThe main goals of this study are to learn about:\n\n* The cancer response to the study treatments compared to chemotherapy\n* The safety of the study treatments and if people tolerate them\n\nThis study is one of the substudies being conducted under one pembrolizumab umbrella master protocol (MK-3475-U01\u002FKEYMAKER-U01).",[603],"Lung Neoplasm","2026-05-21",{"date":606,"type":607},"2026-05-26","ACTUAL",{"date":609,"type":607},"2025-05-28",{"date":611,"type":597},"2032-03-02",{"name":5,"class":6},40]