[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100606972":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":41,"responsibleParty":81,"collaborators":84,"id":86,"slug":87,"hasResults":88,"nctId":89,"briefTitle":90,"officialTitle":90,"acronym":23,"eligibilityCriteria":91,"healthyVolunteers":92,"sex":93,"minAge":94,"maxAge":95,"enrollmentInfo":96,"targetDuration":23,"studyType":99,"phases":100,"briefSummary":102,"conditions":103,"keywords":105,"overallStatus":43,"whyStopped":23,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":118},{"fullName":5,"class":6},"Universiti Sains Malaysia","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Placebo","PLACEBO_COMPARATOR","Daily 6-drops of non-GMO corn starch in medium-chain triglyceride oil",[13],"Other: Placebo",{"label":15,"type":16,"description":17,"interventionNames":18},"Probiotic","EXPERIMENTAL","Daily 6-drops of Bifidobacterium longum subsp. infantis M-63, B. breve M-16V, and B. longum BB536 in non-GMO corn starch as excipient, in medium-chain triglyceride oil (1.5 × 109 CFU\u002Fday)",[19],"Other: Probiotic",[21,24],{"type":6,"name":15,"description":17,"armGroupLabels":22,"otherNames":23},[15],null,{"type":6,"name":9,"description":11,"armGroupLabels":25,"otherNames":23},[9],[27],{"name":28,"affiliation":29,"role":30},"Meiqin Cai, MD.","Shanghai Jiao Tong University School of Medicine","PRINCIPAL_INVESTIGATOR",[32,37],{"name":33,"role":34,"phone":35,"phoneExt":23,"email":36},"Min Tze Liong, Ph.D.","CONTACT","6046532114","mintze.liong@usm.my",{"name":38,"role":34,"phone":39,"phoneExt":23,"email":40},"Jie Yuan, M.Sc.","822137027899","peanut.yuan@diprobio.com",[42,62],{"facility":29,"status":43,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"RECRUITING","Huangpu","Shanghai Municipality","200001","China","CN",{"type":50,"coordinates":51},"Point",[52,53],121.4781,31.2378,{"lat":53,"lon":52},[56,59,60],{"name":28,"role":34,"phone":57,"phoneExt":23,"email":58},"86 62785846","caimeiqin@sjtu.edu.cn",{"name":23,"role":34,"phone":23,"phoneExt":23,"email":40},{"name":61,"role":30,"phone":23,"phoneExt":23,"email":23},"Meiqin Ca, MD.",{"facility":5,"status":63,"city":64,"state":65,"zip":66,"country":67,"countryCode":68,"cosmosGeoPoint":69,"geoPoint":73,"contacts":74},"NOT_YET_RECRUITING","George Town","Pulau Pinang","11800","Malaysia","MY",{"type":50,"coordinates":70},[71,72],100.33543,5.41123,{"lat":72,"lon":71},[75,76,78],{"name":33,"role":34,"phone":35,"phoneExt":23,"email":36},{"name":77,"role":34,"phone":23,"phoneExt":23,"email":40},"Yuan Jie, M.Sc.",{"name":79,"role":80,"phone":23,"phoneExt":23,"email":23},"Min Tze Liong, Ph.D","SUB_INVESTIGATOR",{"type":30,"investigatorFullName":82,"investigatorTitle":83,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"Min-Tze LIONG","Prof.",[85],{"name":29,"class":6},"100606972","phase-2-the-effect-of-bifidobacterium-probiotics-on-gut-microbiota-changes-in-healthy-adults-during-short-term-travel-along-the-silk-road-100606972",false,"NCT07182500","The Effect of Bifidobacterium Probiotics on Gut Microbiota Changes in Healthy Adults During Short-term Travel Along the Silk Road","Inclusion Criteria:\n\n* Generally healthy adults\n* Scheduled to undertake a short-term round trip (less than 7 days) to abroad\n* Able to complete study procedures\n* Willing to take intervention products\n\nExclusion Criteria:\n\n* Use of antibiotics, probiotics, hormones, immunosuppressants, biologics or JAK inhibitors within four weeks prior to study\n* Chronic or severe systemic diseases (including cardiovascular, hepatic, renal, malignant or psychiatric disorders)\n* Uncontrolled parasitic infections\n* Long-term use of corticosteroids, growth hormone, vitamin B12, lysine or inositol\n* Major surgery within one month\n* Allergy to probiotic components\n* Other conditions deemed inappropriate by investigators",true,"ALL","18 Years","65 Years",{"count":97,"type":98},75,"ESTIMATED","INTERVENTIONAL",[101],"PHASE2","Journeying along the historic Silk Road exposes travelers to dramatic dietary shifts, unfamiliar microbial environments, and the physical stresses of long-distance travel-all known to disrupt gut health and cause gastrointestinal complaints, including traveler's diarrhea and sleep disturbances. Such disruptions may also elevate the risk of acquiring antibiotic-resistant organisms.\n\nThis randomized, double-blind, placebo-controlled trial evaluated whether probiotic supplementation can help maintain gut microbial balance and support traveler well-being during trips to Silk Road regions. In addition to monitoring changes in gut microbiota composition, the study assessed gastrointestinal symptoms, sleep quality, anxiety levels, overall well-being, gut immune markers, functional profiles of the microbiome, and the presence of antibiotic resistance genes.",[104],"Healthy Adult Volunteer",[106,107,108],"probiotc","travel","Silk Road","2025-12-02",{"date":111,"type":112},"2025-12-10","ACTUAL",{"date":114,"type":112},"2025-10-16",{"date":116,"type":98},"2025-12-31",{"name":5,"class":6},2]