[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100582109":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":28,"centralContacts":32,"locations":25,"responsibleParty":38,"collaborators":25,"id":42,"slug":43,"hasResults":44,"nctId":45,"briefTitle":46,"officialTitle":46,"acronym":25,"eligibilityCriteria":47,"healthyVolunteers":44,"sex":48,"minAge":25,"maxAge":25,"enrollmentInfo":49,"targetDuration":25,"studyType":52,"phases":53,"briefSummary":56,"conditions":57,"keywords":59,"overallStatus":61,"whyStopped":25,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":25},{"fullName":5,"class":6},"Cairo University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"injection of dextrose 10% in retrodiscal tissues","ACTIVE_COMPARATOR","GROUP 1 will recieve 10% dextrose",[13],"Drug: injection of dextrose 10% in retrodiscal tissues",{"label":15,"type":16,"description":17,"interventionNames":18},"injection of dextrose 25% in retrodiscal tissues","EXPERIMENTAL","group 2 will recieve 25% dextrose",[19],"Drug: injection of dextrose 25% in retrodiscal tissues",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","group 1 will recieve 10% dextrose in retrodiscal tissues",[9],null,{"type":22,"name":15,"description":17,"armGroupLabels":27,"otherNames":25},[15],[29],{"name":30,"affiliation":5,"role":31},"nadia galal Professor, phd","STUDY_DIRECTOR",[33],{"name":34,"role":35,"phone":36,"phoneExt":25,"email":37},"nourhan moustafa nourhan moustafa abd el rahman hasan abo el ela, Bachelor's degree","CONTACT","01118233832","nourhan.hasan@dentistry.cu.edu.eg",{"type":39,"investigatorFullName":40,"investigatorTitle":41,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Nourhan Moustafa","dentist","100582109","phase-2-therapeutic-effect-of-proliferative-therapy-prolotherapy-on-pain-using-injectable-hypertonic-dextrose-25-versus-injectable-dextrose-10-in-retrodiscal-tissues-in-patients-with-anterior-disc-displacement-with-reduction-a-randomized-clinical-trial--100582109",false,"NCT06859034","Therapeutic Effect of Proliferative Therapy (Prolotherapy) on Pain Using Injectable Hypertonic Dextrose 25% Versus Injectable Dextrose 10% in Retrodiscal Tissues in Patients With Anterior Disc Displacement With Reduction: A Randomized Clinical Trial .","Exclusion criteria:\n\n* The clinical or radiographic signs of disc displacement without reduction .\n* A history of allergic reactions to any components of the injectable solution.\n* Blood dyscrasias and systemtic diseases .\n* Previous surgery of the affected joint.\n* Infection in pre-auricular area\n\nInclusion criteria:\n\nPatients should have one or more signs and symptoms of these\n\n* Symptoms: Patients who report typical symptoms of TMJ dysfunction, such as pain, discomfort, or clicking sounds in the joint, especially when opening or closing the mouth.\n* Mouth Opening: Limited range of motion or difficulty with full mouth opening .\n* Clicking: Audible clicking.\n* Pain: Pain or tenderness around the TMJ, often radiating to the ear, temple, or neck","ALL",{"count":50,"type":51},24,"ESTIMATED","INTERVENTIONAL",[54,55],"PHASE2","PHASE3","prolotherapy is an injection-based treatment method used to alleviate pain, particularly musculoskeletal pain associated with chronic ligament and tendon injuries. The process involves the injection of a solution, typically containing dextrose (a sugar), saline, or other irritants, into the affected tissues. Prolotherapy is believed to stimulate healing by causing a mild inflammatory response that promotes the regeneration of ligaments, tendons, and other connective tissues. This review explores the existing literature on the therapeutic effects of prolotherapy for pain management.",[58],"TMJ Disc Disorder",[60],"retrodiscal tissues","NOT_YET_RECRUITING","2025-03-02",{"date":64,"type":65},"2025-03-05","ACTUAL",{"date":67,"type":51},"2025-03-03",{"date":69,"type":51},"2025-10",{"name":5,"class":6}]