[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100538097":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":55,"collaborators":26,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":61,"acronym":26,"eligibilityCriteria":62,"healthyVolunteers":59,"sex":63,"minAge":64,"maxAge":26,"enrollmentInfo":65,"targetDuration":26,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":77,"overallStatus":39,"whyStopped":26,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"University of Pennsylvania","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Clascoterone Treatment","EXPERIMENTAL","Participants will apply 1% clasocterone cream to the affected area twice daily got a total of 12 weeks with assessment visits at weeks 0, 4, 8, and 12. At assessment visits participants will have medical photography of the diseased area, be administered a dermatology-specific quality of life questionnaire, and be assessed for any side effects.",[13],"Drug: 1% Clascoterone",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo Treatment","PLACEBO_COMPARATOR","Participants will apply a vehicle cream matched in texture, appearance, and odor to clacoterone to the affected area twice daily got a total of 12 weeks with assessment visits at weeks 0, 4, 8, and 12. At assessment visits participants will have medical photography of the diseased area, be administered a dermatology-specific quality of life questionnaire, and be assessed for any side effects.",[19],"Drug: Vehicle Cream",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","1% Clascoterone","Application of 1% clascoterone cream twice daily to affected area for 12 weeks.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Vehicle Cream","Application of a vehicle cream to the natal cleft twice daily for 12 weeks",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Lillias Maguire, MD","CONTACT","215-662-2078","lillias.maguire@pennmedicine.upenn.edu",[38],{"facility":5,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"RECRUITING","Philadelphia","Pennsylvania","19103","United States","US",{"type":46,"coordinates":47},"Point",[48,49],-75.16362,39.95238,{"lat":49,"lon":48},[52,53],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},{"name":33,"role":54,"phone":26,"phoneExt":26,"email":26},"PRINCIPAL_INVESTIGATOR",{"type":56,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100538097","phase-2-topical-anti-androgens-in-pilonidal-sinus-disease-100538097",false,"NCT06286397","Topical Anti-Androgens in Pilonidal Sinus Disease","Inclusion Criteria:\n\n* Age 18 and above\n* Diagnosis of Pilonidal Disease\n* Willingness to comply with study procedures and availability for duration of study\n* Ability to apply topical medications and willing to adhere to regimen\n\nExclusion Criteria:\n\n* Current use of any topical medication to natal cleft\n* Presence of pilonidal-associated abscess\n* Pregnancy or lactation\n* Allergic reaction to components of 1% clascoterone cream\n* Febrile illness within 7 days\n* Treatment with another investigational drug within three months","ALL","18 Years",{"count":66,"type":67},75,"ESTIMATED","INTERVENTIONAL",[70],"PHASE2","The goal of this randomized clinical trial is to test the topical drug clascoterone in patients with pilonidal disease, which is a common, benign skin condition of the gluteal cleft. The main questions it aims to answer are:\n\n* Does clascoterone improve the severity of pilonidal disease as scored by a physician?\n* Does clascoterone improve patient symptoms due to pilonidal disease?\n* Does clascoterone improve the inflammation seen under the microscope in pilonidal disease removed at surgery Participants will apply clascoterone or a placebo cream to the diseased area for 3 months. They will be assessed every 4 weeks for disease severity assessed by a physician viewing patient photos and a symptom-based survey.\n\nResearchers will compare participants who received clascoterone treatment to those who received placebo.",[73,74,75,76],"Pilonidal Disease","Pilonidal Disease of Natal Cleft","Pilonidal Sinus","Pilonidal Cyst",[76,75,78,79],"Clascoterone","Androgen","2026-02-25",{"date":82,"type":83},"2026-02-27","ACTUAL",{"date":85,"type":83},"2025-01-10",{"date":87,"type":67},"2028-01-01",{"name":5,"class":6},1]