[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100639981":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":11,"locations":11,"responsibleParty":28,"collaborators":11,"id":32,"slug":33,"hasResults":34,"nctId":35,"briefTitle":36,"officialTitle":37,"acronym":11,"eligibilityCriteria":38,"healthyVolunteers":34,"sex":39,"minAge":11,"maxAge":11,"enrollmentInfo":40,"targetDuration":11,"studyType":43,"phases":44,"briefSummary":47,"conditions":48,"keywords":11,"overallStatus":50,"whyStopped":11,"lastUpdateSubmitDate":51,"lastUpdatePostDateStruct":52,"startDateStruct":55,"completionDateStruct":57,"leadSponsor":59,"locationsCount":11},{"fullName":5,"class":6},"Cairo University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Phenytoin","ACTIVE_COMPARATOR",null,[13],"Drug: phenytoin cream",{"label":15,"type":16,"description":11,"interventionNames":17},"Placebo","PLACEBO_COMPARATOR",[18],"Other: Placebo",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"DRUG","phenytoin cream","Phenytoin 1% paste",[9],{"type":6,"name":15,"description":26,"armGroupLabels":27,"otherNames":11},"placebo paste",[15],{"type":29,"investigatorFullName":30,"investigatorTitle":31,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Ayat Gamal-AbdelNaser","PI","100639981","phase-2-topical-phenytoin-for-management-of-gingival-recession-100639981",false,"NCT07590375","Topical Phenytoin for Management of Gingival Recession","Topical Phenytoin for Management of Gingival Recession: a Randomized Placebo-controlled Trial","Inclusion Criteria:\n\n* Patients having gingival recession types RT1 and RT2\n* Patients refusing surgical treatment options of their gingival recession.\n\nExclusion Criteria:\n\n* Patients who underwent periodontal surgery in the affected teeth.\n* Patients with sensitivity to the medication used in the study.\n* Patients with systemic problems or administering drugs which could affect their periodontium or healing.\n* Pregnant or lactating women.\n* Smoking patients.","ALL",{"count":41,"type":42},30,"ESTIMATED","INTERVENTIONAL",[45,46],"PHASE2","PHASE3","Gingival recession (GR) is a term that describes the displacement of the gingival margin apical to the cemento-enamel junction (CEJ) of a tooth. The gold standard of GR treatment is surgical coverage through coronally advanced flap with subepithelial connective tissue graft (CAF+SCTG) (3). But, the need for a non-invasive technique for managing GR has not been frequently addressed.\n\nPhenytoin (PHT), used as an anti-seizure medication, has an established side effect of causing drug-influenced gingival enlargement. Its stimulatory effects on soft tissue metabolism suggested PHT to be tested topically for its effectiveness in wound healing. However, none of the previous studies that investigated topical phenytoin has assessed gingival recession; except for a case series.",[49],"Gingival Recession","NOT_YET_RECRUITING","2026-05-14",{"date":53,"type":54},"2026-05-15","ACTUAL",{"date":56,"type":42},"2026-06-01",{"date":58,"type":42},"2027-10",{"name":5,"class":6}]