[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100609845":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":25,"locations":29,"responsibleParty":52,"collaborators":25,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":25,"eligibilityCriteria":61,"healthyVolunteers":57,"sex":62,"minAge":63,"maxAge":25,"enrollmentInfo":64,"targetDuration":25,"studyType":67,"phases":68,"briefSummary":70,"conditions":71,"keywords":25,"overallStatus":31,"whyStopped":25,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},{"fullName":5,"class":6},"University of California, Los Angeles","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Virtual Reality-Reward Training (VR-RT)","EXPERIMENTAL","13 sessions of positive VR immersion and positive memory specificity training exercises designed to savor rewarding features of immersion followed by memory specificity training exercises to savor rewarding features of autobiographical memory",[13],"Behavioral: Virtual Reality-Reward Training (VR-RT)",{"label":15,"type":16,"description":17,"interventionNames":18},"Virtual Reality-Memory Training (VR-MT)","ACTIVE_COMPARATOR","13 sessions of neutral VR immersion and neutral memory specificity training exercises, designed to train memory of objective non-emotional stimuli followed by memory exercises to neutral non-personal stories",[19],"Behavioral: Virtual Reality-Memory Training (VR-MT)",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","Participants will complete verbal recounting (present-tense, field perspective, positive details) and guided imaginal recounting of positive details for rewarding VR experiences and positive autobiographical memories.",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"Participants will complete verbal recounting (past-tense, observer perspective, objective details) and guided imaginal recounting of neutral details for neutral VR experiences and neutral non-personal stories",[15],[30],{"facility":5,"status":31,"city":32,"state":33,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"RECRUITING","Los Angeles","California","90095","United States","US",{"type":38,"coordinates":39},"Point",[40,41],-118.24368,34.05223,{"lat":41,"lon":40},[44,49],{"name":45,"role":46,"phone":47,"phoneExt":25,"email":48},"Aleeza West","CONTACT","‪(323) 508-3571‬","vrtrainingucla@proton.me",{"name":50,"role":51,"phone":25,"phoneExt":25,"email":25},"Michelle Craske, PhD","PRINCIPAL_INVESTIGATOR",{"type":51,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Michelle Craske","Principal Investigator","100609845","phase-2-training-reward-responsiveness-through-virtual-reality-100609845",false,"NCT07219875","Training Reward Responsiveness Through Virtual Reality","Virtual Reality Training Study","Inclusion Criteria:\n\n1. At least 18 years old\n2. Fluent in written and spoken English\n3. Meet all of the following dimensional score cutoffs:\n\n   1. Score on the DASS-21 depression subscale must be ≥ 8\n   2. Score on the PANAS-P of 27 or lower\n   3. Score on the WSAS of ≥ 11\n\nExclusion Criteria:\n\n1. Lifetime history of bipolar disorder, psychosis, mental retardation, or organic brain damage\n2. Substance use disorder in the past 6 months\n3. Current use of psychotropic medications\n4. Currently pregnant or planning to become pregnant\n5. Self-reported frequent motion sickness\n6. Self-reported seizures within the last year and\u002For a diagnosis of epilepsy","ALL","18 Years",{"count":65,"type":66},80,"ESTIMATED","INTERVENTIONAL",[69],"PHASE2","The purpose of this study is to compare the effects of Virtual Reality-Reward Training (VR-RT) with an active control condition, Virtual Reality-Memory Training (VR-MT), on positive affect and other clinical symptoms.\n\nVR-Reward Training is a novel intervention aimed at enhancing savoring of positive experiences among individuals with depression and low positive affect through guided imaginal recounting following immersion in positive VR experiences. The current study tests an enhanced version of this training using improved virtual reality technology.\n\nTarget enrollment is 80 participants with low positive affect, depression, and impaired functioning, who are at least 18 years old, who will be randomly assigned to 7 weeks of either Virtual Reality-Reward Training (VR-RT) or Virtual Reality-Memory Training (VR-MT). Participants will complete in-person VR sessions, laboratory assessments, self-report questionnaires as part of the study. A subset of 8 participants randomly assigned to VR-RT will complete fMRI scans and EMA surveys.\n\nThe total length of participation is around 3 months.",[72,73],"Positive Affect","Depression","2026-05-03",{"date":76,"type":77},"2026-05-07","ACTUAL",{"date":79,"type":77},"2025-07-08",{"date":81,"type":66},"2027-06",{"name":5,"class":6},1]