[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100565554":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":40,"responsibleParty":85,"collaborators":87,"id":92,"slug":93,"hasResults":94,"nctId":95,"briefTitle":96,"officialTitle":97,"acronym":98,"eligibilityCriteria":99,"healthyVolunteers":94,"sex":100,"minAge":101,"maxAge":26,"enrollmentInfo":102,"targetDuration":26,"studyType":105,"phases":106,"briefSummary":108,"conditions":109,"keywords":112,"overallStatus":116,"whyStopped":26,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":126},{"fullName":5,"class":6},"Second Affiliated Hospital, School of Medicine, Zhejiang University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Tranilast Treatment Group","EXPERIMENTAL","Participants in this group will receive Tranilast for the prevention of stricture after cESD of superficial esophageal tumors.",[13],"Drug: Tranilast",{"label":15,"type":16,"description":17,"interventionNames":18},"Steroid Treatment Group","ACTIVE_COMPARATOR","Participants in this group will receive steroids for the prevention of stricture after cESD of superficial esophageal tumors.",[19],"Drug: Dexamethasone",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Tranilast","Tranilast is an anti-allergic agent that is hypothesized to prevent stricture formation in patients undergoing cESD for superficial esophageal tumors. Participants in this group will receive 100 mg orally three times a day for 8 weeks.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Dexamethasone","Prednisone is a corticosteroid used to reduce inflammation and prevent stricture in patients undergoing cESD for superficial esophageal tumors. Participants in this group will receive an oral dose of 30 mg once daily for 8 weeks, with a gradual tapering of the dosage as follows: Weeks 1-2: 30 mg daily; Weeks 3-4: 25 mg daily; Weeks 5-6: 20 mg daily; Weeks 7-8: 15 mg daily; and then tapering to 10 mg daily in Week 7 and 5 mg daily in Week 8.",[15],[32],{"name":33,"affiliation":5,"role":34},"Yue Yu, Dr.","PRINCIPAL_INVESTIGATOR",[36],{"name":33,"role":37,"phone":38,"phoneExt":26,"email":39},"CONTACT","+86 18258868659","2320065@zju.edu.cn",[41,60,70],{"facility":42,"status":26,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Hangzhou Third People's Hospital","Hangzhou","Zhejiang","310009","China","CN",{"type":49,"coordinates":50},"Point",[51,52],120.16142,30.29365,{"lat":52,"lon":51},[55,59],{"name":56,"role":37,"phone":57,"phoneExt":26,"email":58},"Yufang Wang, Master of Medicine","+86 571 87062660","hzyy@hzhospital.com",{"name":56,"role":37,"phone":26,"phoneExt":26,"email":26},{"facility":61,"status":26,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":62,"geoPoint":64,"contacts":65},"The Second Affiliated Hospital, Zhejiang University School of Medicine",{"type":49,"coordinates":63},[51,52],{"lat":52,"lon":51},[66,67,68],{"name":33,"role":37,"phone":38,"phoneExt":26,"email":39},{"name":33,"role":37,"phone":26,"phoneExt":26,"email":26},{"name":69,"role":37,"phone":26,"phoneExt":26,"email":26},"Litao Jia, Dr.",{"facility":71,"status":26,"city":72,"state":44,"zip":73,"country":46,"countryCode":47,"cosmosGeoPoint":74,"geoPoint":78,"contacts":79},"Shaoxing Central Hospital","Shaoxing","312000",{"type":49,"coordinates":75},[76,77],120.57864,30.00237,{"lat":77,"lon":76},[80,84],{"name":81,"role":37,"phone":82,"phoneExt":26,"email":83},"Yingchao Sun, Master of Medicine","+86 575 8519 0114","szxyy@163.com",{"name":81,"role":37,"phone":26,"phoneExt":26,"email":26},{"type":86,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR",[88,90],{"name":89,"class":6},"The Third People's Hospital of Hangzhou",{"name":91,"class":6},"Xiangya Hospital of Central South University","100565554","phase-2-tranilast-vs-steroids-to-prevent-esophageal-stricture-tapes-after-endoscopic-resection-for-superficial-neoplasms-100565554",false,"NCT06643689","Tranilast Vs. Steroids to Prevent Esophageal Stricture (TAPES) After Endoscopic Resection for Superficial Neoplasms","Tranilast Vs. Steroids to Prevent Esophageal Stricture (TAPES) Following Circumferential Endoscopic Submucosal Dissection (cESD) for Superficial Neoplasms","TAPES","Inclusion Criteria:\n\n1. age\\>18 and proficient in Mandarin.\n2. underwent cESD treatment for superficial esophageal neoplasms.\n3. agree to sign an informed consent form.\n\nExclusion Criteria:\n\n1. allergic to tranilast.\n2. with severe comorbid conditions.\n3. pregnant or breastfeeding.","ALL","18 Years",{"count":103,"type":104},394,"ESTIMATED","INTERVENTIONAL",[107],"PHASE2","The goal of this clinical trial is to learn if tranilast works to prevent esophageal stricture after circumferential endoscopic submucosal dissection (cESD) in adults. It will also help us learn more about the safety of tranilast. The main questions it aims to answer are: 1. Does tranilast reduce the occurence of esophageal stricture in participants after cESD? 2. What medical problems do participants have when taking tranilast.\n\nResearchers will compare tranilast to prednisone (a steroid used in clinical practice with potential defects) to see if tranilast works well to prevent esophageal stricture.\n\nParticipants will: 1. Take tranilast or prednisone every day for 8 weeks. 2. Attend visit (at clinic or phone) once every 2 weeks for checkups and tests until 16 weeks. 3. Keep a diary of their symptoms and let researchers know during the 16 weeks follow up.",[110,111],"Esophageal Stricture","Esophageal Neoplasms",[23,111,113,114,115],"Steroids","Esophageal stricture","Circumferential Endoscopic Submucosal Dissection","NOT_YET_RECRUITING","2024-11-12",{"date":119,"type":120},"2024-11-14","ACTUAL",{"date":122,"type":104},"2025-01-01",{"date":124,"type":104},"2028-12-31",{"name":5,"class":6},3]