[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100590534":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":32,"centralContacts":36,"locations":45,"responsibleParty":63,"collaborators":26,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":26,"eligibilityCriteria":71,"healthyVolunteers":67,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":26,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":86,"overallStatus":47,"whyStopped":26,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"University of Pennsylvania","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Real TMS","EXPERIMENTAL","Some of our participants will be randomized to the real treatment arm where they will receive 10 sessions of real TMS paired with language therapy.",[13,14],"Device: Transcranial Magnetic Stimulation (TMS)","Behavioral: Modified Constraint Induced Language Therapy (mCILT)",{"label":16,"type":17,"description":18,"interventionNames":19},"Fake TMS","SHAM_COMPARATOR","Some of our participants will be randomized to the sham treatment arm where they will receive 10 sessions of fake TMS paired with language therapy.",[14],[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Transcranial Magnetic Stimulation (TMS)","TMS, is a form of non-invasive brain stimulation, that uses magnetic pulses to stimulate specific areas of the brain. In this study we will utilize theta-burst stimulation which uses a higher frequency pulse of 50 Hz delivered for 40 seconds for a total of 600 pulses.",[9],null,{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":26},"BEHAVIORAL","Modified Constraint Induced Language Therapy (mCILT)","Constraint-induced language therapy (CILT) is a treatment approach for aphasia that focuses on forcing the patient to use their impaired language skills, while restricting the use of compensatory strategies like gestures or writing. All participants will receive mCILT.",[16,9],[33],{"name":34,"affiliation":5,"role":35},"H. Branch Coslett, MD","PRINCIPAL_INVESTIGATOR",[37,42],{"name":38,"role":39,"phone":40,"phoneExt":26,"email":41},"Leslie Vnenchak, MA, CCC-SLP","CONTACT","215-964-2502","leslie.vnenchak@pennmedicine.upenn.edu",{"name":43,"role":39,"phone":40,"phoneExt":26,"email":44},"Daniela Sacchetti, MS","danielas@pennmedicine.upenn.edu",[46],{"facility":5,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"RECRUITING","Philadelphia","Pennsylvania","19014","United States","US",{"type":54,"coordinates":55},"Point",[56,57],-75.16362,39.95238,{"lat":57,"lon":56},[60,61,62],{"name":38,"role":39,"phone":40,"phoneExt":26,"email":41},{"name":43,"role":39,"phone":40,"phoneExt":26,"email":44},{"name":34,"role":35,"phone":26,"phoneExt":26,"email":26},{"type":64,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100590534","phase-2-transcranial-magnetic-stimulation--language-therapy-to-treat-subacute-aphasia-100590534",false,"NCT06968663","Transcranial Magnetic Stimulation + Language Therapy to Treat Subacute Aphasia","Electrical Field Guided Transcranial Magnetic Stimulation to Treat Subacute Post-stroke Aphasia","Inclusion Criteria:\n\n* Left hemisphere stroke resulting in aphasia\n* The stroke must have occurred between 2 and 6 weeks prior to enrollment\n* Must be able to understand the nature of the study, and give informed consent\n* English proficiency\n* Right-handed\n\nExclusion Criteria:\n\n* History of serious and\u002For ongoing issues with substance abuse\n* Previous head trauma with loss of consciousness for more than 5 minutes\n* History of major psychiatric illness\n* Dementia, or other neurological conditions\n* Epilepsy, or seizure after the stroke event\n* Pacemaker\n* Diagnosis of tinnitus\n* Pregnancy","ALL","18 Years","85 Years",{"count":76,"type":77},63,"ESTIMATED","INTERVENTIONAL",[80],"PHASE2","The goal of this clinical trial is to determine if Transcranial Magnetic Stimulation (TMS) combined with modified Constraint Induced Language Therapy (mCILT) is an effective treatment for aphasia when delivered in the subacute stage after stroke.\n\nThe main questions this study aims to answer are:\n\n1. Can TMS combined with mCILT improve overall speech?\n2. Can we identify specific behavioral and biological characteristics that would benefit most from the TMS and mCILT treatment?\n\nResearchers will compare real TMS to sham (fake) TMS to see whether TMS can treat subacute aphasia.\n\nImportantly, this trial will use electric field guided TMS to identify optimal and individualized stimulation intensity and site targeting.\n\nParticipants will:\n\n* Complete a screening and medical intake to determine eligibility\n* Undergo MRI scans\n* Participate in 10 consecutive sessions (Monday-Friday) of TMS and mCILT treatment\n* Complete follow-up assessments immediately and 4 months after treatment",[83,84,85],"Stroke","Aphasia","Aphasia Following Cerebral Infarction",[87,88,89,90,91],"aphasia","stroke","Transcranial Magnetic Stimulation","Non-invasive brain stimulation","language therapy","2026-06-16",{"date":94,"type":95},"2026-06-18","ACTUAL",{"date":97,"type":95},"2024-08-01",{"date":99,"type":77},"2029-07-31",{"name":5,"class":6},1]