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M.D.",{"facility":666,"status":52,"city":667,"state":668,"zip":669,"country":670,"countryCode":671,"cosmosGeoPoint":672,"geoPoint":676,"contacts":677},"University of Alberta Hospital","Edmonton","Alberta","T6G 2G3 7802481660","Canada","CA",{"type":59,"coordinates":673},[674,675],-113.46871,53.55014,{"lat":675,"lon":674},[678,682,685],{"name":679,"role":42,"phone":680,"phoneExt":30,"email":681},"Ashfaq Shuaib","(780) 248-1927","danna.puchailo@albertahealthservices.ca",{"name":683,"role":42,"phone":684,"phoneExt":30,"email":681},"Danna Puchailo","(780) 248-1660",{"name":679,"role":35,"phone":30,"phoneExt":30,"email":30},{"facility":687,"status":52,"city":688,"state":689,"zip":690,"country":670,"countryCode":671,"cosmosGeoPoint":691,"geoPoint":695,"contacts":696},"Vancouver General Hospital","Vancouver","British Columbia","V5Z1M9",{"type":59,"coordinates":692},[693,694],-123.11934,49.24966,{"lat":694,"lon":693},[697,701],{"name":698,"role":42,"phone":699,"phoneExt":30,"email":700},"Carson 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521-2100","himed@HHSC.CA",{"name":733,"role":35,"phone":30,"phoneExt":30,"email":30},"Kelvin Ng",{"facility":735,"status":52,"city":736,"state":706,"zip":737,"country":670,"countryCode":671,"cosmosGeoPoint":30,"geoPoint":30,"contacts":738},"Sunnybrook Research Institute","North York","M4N 3M5",[739,743],{"name":740,"role":42,"phone":741,"phoneExt":30,"email":742},"Amanpreet Kaur","+14164806100","amanpreet.kaur1@sri.utoronto.ca",{"name":744,"role":35,"phone":30,"phoneExt":30,"email":30},"Richard Swartz, M.D.",{"facility":746,"status":52,"city":747,"state":748,"zip":749,"country":750,"countryCode":751,"cosmosGeoPoint":752,"geoPoint":756,"contacts":757},"CHU Pontchaillou \u002FHopital Sud Service de Neurologie","Rennes","Brittany Region","35033","France","FR",{"type":59,"coordinates":753},[754,755],-1.67431,48.11109,{"lat":755,"lon":754},[758,762],{"name":759,"role":42,"phone":760,"phoneExt":30,"email":761},"Rozenn Gouhran","+33 2 99 28 43 21","Rozenn.GOURHAN@chu-rennes.fr",{"name":763,"role":35,"phone":30,"phoneExt":30,"email":30},"Stéphane Vannier, M.D.",{"facility":765,"status":52,"city":766,"state":767,"zip":768,"country":767,"countryCode":769,"cosmosGeoPoint":770,"geoPoint":774,"contacts":775},"West Georgia Medical Center LTD","Kutaisi","Georgia","4600","GE",{"type":59,"coordinates":771},[772,773],42.69459,42.26791,{"lat":773,"lon":772},[776,780],{"name":777,"role":42,"phone":778,"phoneExt":30,"email":779},"Tamar Janelidze, M.D.","+995 598 721 985","n.gelenidze@vian.health",{"name":777,"role":35,"phone":30,"phoneExt":30,"email":30},{"facility":782,"status":52,"city":783,"state":767,"zip":784,"country":767,"countryCode":769,"cosmosGeoPoint":785,"geoPoint":789,"contacts":790},"Israel-Georgia Medical Research Clinic-Healthycore LTD","Tbilisi","0112",{"type":59,"coordinates":786},[787,788],44.83412,41.69143,{"lat":788,"lon":787},[791,795],{"name":792,"role":42,"phone":793,"phoneExt":30,"email":794},"Zurabi Akhalaia, M.D.","+ 995 599 050 169","tat99na@gmail.com",{"name":792,"role":35,"phone":30,"phoneExt":30,"email":30},{"facility":797,"status":52,"city":783,"state":767,"zip":798,"country":767,"countryCode":769,"cosmosGeoPoint":799,"geoPoint":801,"contacts":802},"New Hospitals LTD","0114",{"type":59,"coordinates":800},[787,788],{"lat":788,"lon":787},[803,807],{"name":804,"role":42,"phone":805,"phoneExt":30,"email":806},"Temur Margania, M.D","+ 995 571170194","n.pataridze@newhospitals.ge",{"name":808,"role":35,"phone":30,"phoneExt":30,"email":30},"Temur Margania, M.D.",{"facility":810,"status":52,"city":783,"state":767,"zip":798,"country":767,"countryCode":769,"cosmosGeoPoint":811,"geoPoint":813,"contacts":814},"Pineo Medical Ecosystem LTD",{"type":59,"coordinates":812},[787,788],{"lat":788,"lon":787},[815,819],{"name":816,"role":42,"phone":817,"phoneExt":30,"email":818},"Nikoloz Tsiskaridze, M.D.","+995 599 804 090","ntsiskaridze@pineo.ge",{"name":816,"role":35,"phone":30,"phoneExt":30,"email":30},{"facility":821,"status":52,"city":783,"state":767,"zip":822,"country":767,"countryCode":769,"cosmosGeoPoint":823,"geoPoint":825,"contacts":826},"JSC K. Eristavi National Center of Experimental and Clinical Surgery","0159",{"type":59,"coordinates":824},[787,788],{"lat":788,"lon":787},[827,831],{"name":828,"role":42,"phone":829,"phoneExt":30,"email":830},"Giorgi Egutidze, M.D.","+995 592 773 938","chelidze.mariam97@gmail.com",{"name":828,"role":35,"phone":30,"phoneExt":30,"email":30},{"facility":833,"status":52,"city":834,"state":835,"zip":836,"country":835,"countryCode":837,"cosmosGeoPoint":838,"geoPoint":842,"contacts":843},"Bajcsy-Zsilinszky Hospital","Budapest","Hungary","1106","HU",{"type":59,"coordinates":839},[840,841],19.04045,47.49835,{"lat":841,"lon":840},[844,848],{"name":845,"role":42,"phone":846,"phoneExt":30,"email":847},"Bernadett Bruckner","00 36 30 195 3560","bruckner.bernadett@bajcsy.hu",{"name":849,"role":35,"phone":30,"phoneExt":30,"email":30},"Ildikó Vastagh, M.D.",{"facility":851,"status":52,"city":852,"state":835,"zip":768,"country":835,"countryCode":837,"cosmosGeoPoint":853,"geoPoint":857,"contacts":858},"St. Damjan Greek Catholic Hospital","Kisvárda",{"type":59,"coordinates":854},[855,856],22.08333,48.21667,{"lat":856,"lon":855},[859,863],{"name":860,"role":42,"phone":861,"phoneExt":30,"email":862},"Edit Muskóczki","00 36 20 587 3232","muskoczkiedit@gmail.com",{"name":864,"role":35,"phone":30,"phoneExt":30,"email":30},"Marina Czurkó, M.D.",{"facility":866,"status":52,"city":867,"state":835,"zip":868,"country":835,"countryCode":837,"cosmosGeoPoint":869,"geoPoint":873,"contacts":874},"B.-A.-Z. County Central Hospital","Miskolc","3526",{"type":59,"coordinates":870},[871,872],20.77806,48.10327,{"lat":872,"lon":871},[875,879],{"name":876,"role":42,"phone":877,"phoneExt":30,"email":878},"Éva Kubiczki-Nagy","00 36 70 409 8910","kubiczkinagyeva@gmail.com",{"name":880,"role":35,"phone":30,"phoneExt":30,"email":30},"Attila Valikovics, M.D.",{"facility":882,"status":52,"city":883,"state":884,"zip":885,"country":835,"countryCode":837,"cosmosGeoPoint":886,"geoPoint":890,"contacts":891},"Petz Aladár County Teaching Hospital","Győr","Vasvári Pál U. 2-4","9024",{"type":59,"coordinates":887},[888,889],17.63512,47.68333,{"lat":889,"lon":888},[892,896],{"name":893,"role":42,"phone":894,"phoneExt":30,"email":895},"Attila Csányi, M.D.","+36303515954","csanyia77@gmail.com",{"name":893,"role":35,"phone":30,"phoneExt":30,"email":30},{"facility":898,"status":52,"city":899,"state":900,"zip":901,"country":902,"countryCode":903,"cosmosGeoPoint":904,"geoPoint":908,"contacts":909},"Fundeni Clinical Institute","Bucharest","Bucharest (Sector 2)","022328","Romania","RO",{"type":59,"coordinates":905},[906,907],26.10626,44.43225,{"lat":907,"lon":906},[910,914],{"name":911,"role":42,"phone":912,"phoneExt":30,"email":913},"Claudia Ilincuta","+40 21 275 0500","ilincutaclaudia@yahoo.com",{"name":915,"role":35,"phone":30,"phoneExt":30,"email":30},"Octaviana - Adriana Dulămea, M.D.",{"facility":917,"status":52,"city":899,"state":902,"zip":918,"country":902,"countryCode":903,"cosmosGeoPoint":919,"geoPoint":921,"contacts":922},"Elias Emergency University Hospital","011461",{"type":59,"coordinates":920},[906,907],{"lat":907,"lon":906},[923,927,928],{"name":924,"role":42,"phone":925,"phoneExt":30,"email":926},"Cristina Aura Panea, M.D.","+40 21 316 1600","cristina.panea@umfcd.ro",{"name":30,"role":42,"phone":30,"phoneExt":30,"email":926},{"name":929,"role":35,"phone":30,"phoneExt":30,"email":30},"Cristina Aura Panea",{"facility":931,"status":52,"city":932,"state":933,"zip":934,"country":933,"countryCode":935,"cosmosGeoPoint":936,"geoPoint":940,"contacts":941},"Instituto de Investigacion Biomedica de A Coruna (INIBIC)","A Coruña","Spain","15006","ES",{"type":59,"coordinates":937},[938,939],-8.396,43.37135,{"lat":939,"lon":938},[942,946],{"name":943,"role":42,"phone":944,"phoneExt":30,"email":945},"Maria López Fernández","+34 981 17 81 50","Maria.Lopez.Fernandez@sergas.es",{"name":947,"role":35,"phone":30,"phoneExt":30,"email":30},"Maria del Mar Castellanos Rodrigo, M.D.",{"facility":949,"status":52,"city":950,"state":933,"zip":951,"country":933,"countryCode":935,"cosmosGeoPoint":952,"geoPoint":956,"contacts":957},"Hospital Universitario Germans Trias i Pujol","Badalona","8916",{"type":59,"coordinates":953},[954,955],2.24741,41.45004,{"lat":955,"lon":954},[958,962],{"name":959,"role":42,"phone":960,"phoneExt":30,"email":961},"Clara Expósito Guanter","93 497 87 34","cexposito@igtp.cat",{"name":963,"role":35,"phone":30,"phoneExt":30,"email":30},"Marina Martínez Sánchez, M.D.",{"facility":965,"status":52,"city":966,"state":933,"zip":967,"country":933,"countryCode":935,"cosmosGeoPoint":968,"geoPoint":972,"contacts":973},"Hospital Universitari Vall d'Hebron-Institut de Recerca","Barcelona","8035",{"type":59,"coordinates":969},[970,971],2.15899,41.38879,{"lat":971,"lon":970},[974,978],{"name":975,"role":42,"phone":976,"phoneExt":30,"email":977},"Lidia Garcia","(+34) 934893000","lidiavhir@gmail.com",{"name":979,"role":35,"phone":30,"phoneExt":30,"email":30},"Carlos Molina Cateriano, M.D.",{"facility":981,"status":52,"city":982,"state":933,"zip":983,"country":933,"countryCode":935,"cosmosGeoPoint":984,"geoPoint":988,"contacts":989},"Hospital Clínico Universitario de Santiago","Santiago de Compostela","15706",{"type":59,"coordinates":985},[986,987],-8.54569,42.88052,{"lat":987,"lon":986},[990,994],{"name":991,"role":42,"phone":992,"phoneExt":30,"email":993},"Susana Arias Rivas","+34 981 95 00 00","susanaarias2001@gmail.com",{"name":995,"role":35,"phone":30,"phoneExt":30,"email":30},"Manuel Rodriguez Yanez, M.D.",{"facility":997,"status":52,"city":998,"state":999,"zip":1000,"country":1001,"countryCode":1002,"cosmosGeoPoint":1003,"geoPoint":1007,"contacts":1008},"Royal Devon and Exeter Hospital","Exeter","Devon","EX25DW","United Kingdom","UK",{"type":59,"coordinates":1004},[1005,1006],-3.52751,50.7236,{"lat":1006,"lon":1005},[1009,1013],{"name":1010,"role":42,"phone":1011,"phoneExt":30,"email":1012},"Lindsay Wilkes","(+44) 13 92 406 289","lindsaywilkes@nhs.net",{"name":1014,"role":35,"phone":30,"phoneExt":30,"email":30},"Salim Elyas, M.D.",{"facility":1016,"status":52,"city":1017,"state":1018,"zip":1019,"country":1001,"countryCode":1002,"cosmosGeoPoint":1020,"geoPoint":1024,"contacts":1025},"The Newcastle upon Tyne Hospitals NHS Foundation Trust - Royal Victoria Infirmary (RVI)","Newcastle upon Tyne","England","NE1 4LP",{"type":59,"coordinates":1021},[1022,1023],-1.61396,54.97328,{"lat":1023,"lon":1022},[1026,1030],{"name":1027,"role":42,"phone":1028,"phoneExt":30,"email":1029},"Michelle Fawcett","0044 191 2820 317","m.fawcett@nhs.net",{"name":1031,"role":35,"phone":30,"phoneExt":30,"email":30},"Anand Dixit, M.D.",{"facility":1033,"status":52,"city":1034,"state":1001,"zip":1035,"country":1001,"countryCode":1002,"cosmosGeoPoint":1036,"geoPoint":1040,"contacts":1041},"Addenbrooke's Hospital","Cambridge","CB2 0QQ",{"type":59,"coordinates":1037},[1038,1039],0.11667,52.2,{"lat":1039,"lon":1038},[1042,1046],{"name":1043,"role":42,"phone":1044,"phoneExt":30,"email":1045},"Francis Jobbin","00 44 12 233 48532","jobbin.francis@nhs.net",{"name":1047,"role":35,"phone":30,"phoneExt":30,"email":30},"Mathilde Pauls, M.D.",{"facility":1049,"status":52,"city":1050,"state":1001,"zip":1051,"country":1001,"countryCode":1002,"cosmosGeoPoint":1052,"geoPoint":1056,"contacts":1057},"St George's Hospital","London","SW17 0QT",{"type":59,"coordinates":1053},[1054,1055],-0.12574,51.50853,{"lat":1055,"lon":1054},[1058,1062],{"name":1059,"role":42,"phone":1060,"phoneExt":30,"email":1061},"Rita Ghatala","(+44) 20 87 253 260","Ghatala.rita@stgeorges.nhs.uk",{"name":1063,"role":35,"phone":30,"phoneExt":30,"email":30},"Liqun Zhang, M.D.",{"facility":1065,"status":52,"city":1066,"state":1001,"zip":1067,"country":1001,"countryCode":1002,"cosmosGeoPoint":1068,"geoPoint":1072,"contacts":1073},"Royal Stoke University Hospital","Stoke-on-Trent","ST4 6QG",{"type":59,"coordinates":1069},[1070,1071],-2.18538,53.00415,{"lat":1071,"lon":1070},[1074,1078],{"name":1075,"role":42,"phone":1076,"phoneExt":30,"email":1077},"Joanne Hiden","+44 1782-672730","Joanne.Hiden@uhnm.nhs.uk",{"name":1079,"role":35,"phone":30,"phoneExt":30,"email":30},"Christine Roffe, M.D.",{"type":1081,"investigatorFullName":30,"investigatorTitle":30,"investigatorAffiliation":30,"oldNameTitle":30,"oldOrganization":30},"SPONSOR","100444268","phase-2-treatment-of-acute-ischemic-stroke-remedy2-trial-100444268",false,"NCT05065216","Treatment of Acute Ischemic Stroke (ReMEDy2 Trial)","Phase 2\u002F3 Adaptive Design, Randomized Double-blind Placebo-controlled Study to Evaluate the Safety and Efficacy of DM199 for the Treatment of Acute Ischemic Stroke (ReMEDy2 Trial)","ReMEDy2","Inclusion Criteria:\n\n1. Participant is between 18 and 90 years of age inclusive.\n2. Participant weight is 40 kg to 166 kg inclusive.\n3. Participant to be randomized and treatment initiated within 24 hours of last known normal\u002FAIS stroke onset.\n4. Participant has NIHSS ≥5 and ≤15 at approximately the time of randomization. This criterion also applies to participants who meet the following conditions:\n\n   * The participant initially presents with an NIHSS score below 5 but clinically worsens, including cases of progressing stroke \u002F stroke-in-evolution, resulting in a subsequent persistent NIHSS score of ≥5 and ≤15; and\n   * Participant meets all other inclusion and exclusion criteria, including repeat brain imaging to rule out hemorrhagic transformation.\n5. Participant had a pre-morbid mRS score of 0 to 1 (mRS score prior to AIS) as stated by participant or participant's representative.\n6. If participant has received fibrinolytic treatment for AIS within 4.5 hours of last know normal\u002FAIS stoke onset and at least 6 hours after completing fibrinolytic treatment, and the participant meets all of the following criteria:\n\n   * Participant's initial NIHSS score prior to fibrinolytics was ≤15; and\n   * At least six hours after fibrinolytics, the participant has NIHSS score of ≥5 and ≤15 with a persistent deficit; and\n   * The participant's NIHSS score showed less than a 4-point improvement, or worsened, after receiving fibrinolytics; and\n   * Participant meets all other inclusion and exclusion criteria including repeat brain imaging to rule out hemorrhagic transformation.\n7. Participant and\u002For legally authorized representative is able to provide informed consent.\n8. Participant is willing and able to comply with the study protocol, in the Investigator's judgment.\n\nExclusion Criteria:\n\n1. At screening, or with repeat imaging (see Inclusion 4 and 6), participant has imaging confirmed hemorrhage stroke.\n2. Participant has image findings with symptomatic large vessel occlusion at one or more of the following locations: Intracranial carotid I\u002FT\u002FL or M1 segment MCA, vertebral or basilar artery (BA).\n3. Participant has large core of established infarction defined as ASPECTS 0-5.\n4. Participant has or will receive MT for their current AIS.\n5. Participant has suspected or confirmed extracranial arterial dissection.\n6. Participant has imaging findings and\u002For symptoms consistent with a brain stem or cerebellar stroke. Posterior cerebral artery strokes without any associated brain stem or cerebellar involvement are allowable.\n7. Participant has any recorded SBP \\\u003C100 mmHg or MAP \\\u003C65 mmHg; MAP = DBP + \\[1\u002F3 (SBP - DBP)\\] (measured with noninvasive BP cuff type monitor) after stroke symptom onset and prior to randomization.\n8. Participant is currently prescribed angiotensin-converting enzyme inhibitor (ACEi) and is unable or unwilling to convert to another antihypertensive pharmacological treatment through Day 29 ±1 day (8 days after last treatment).\n9. Participant is currently prescribed an ACEi, and the last dose of the ACE inhibitor medication is reported to have been taken \\\u003C 24 hours before start of IV study drug infusion as stated by participant or participant's representative.\n10. Participant has a history of clinically significant allergic reactions such as angioedema or anaphylaxis requiring hospitalization.\n11. Participant has a diagnosis or suspected diagnosis of hereditary angioedema (HAE) or is taking or prescribed medications commonly used as prophylaxis\u002Ftreatment of HAE, such as C1-esterase inhibitors (Cinryze, Berinert, Ruconest, Haegarda), Danazol, kallikrein inhibitors (Ecallantide, Berotralstat, Lanadelumab), Bradykinin B2 Receptor Antagonists (Icatibant), or other medication designed to influence the kallikrein-kinin system.\n12. Life expectancy estimated at ≤1 year prior to enrollment.\n13. Participant has clinical evidence of an active infection at the time of enrollment requiring parenteral treatment or hospitalization to monitor or manage the infection.\n\n    NOTE: Treatment of uncomplicated infections with oral antibiotics would not be an exclusion (for example, the treatment of uncomplicated urinary tract infections or sinus infections with oral antibiotics would not be exclusionary).\n14. Participant has known alpha 1-antitrypsin deficiency (α1-antitrypsin deficiency).\n15. Participant is pregnant or nursing. NOTE: Participants who agree to stop nursing may be considered for inclusion at the discretion of the Investigator.\n16. Participants of child-bearing potential must agree to use medically acceptable contraceptive measures to prevent pregnancy. All participants of childbearing potential (defined as sexually mature participants who have had menses within the preceding 24 months and have not undergone permanent sterilization methods such as hysterectomy, bilateral oophorectomy, bilateral salpingectomy, etc.) must have a negative serum pregnancy test performed locally at screening. Participants of childbearing potential must agree not to attempt to become pregnant or undergo in vitro fertilization. If participating in sexual activity that could lead to pregnancy, participants must use 2 reliable methods (1 per partner is acceptable) of contraception simultaneously while receiving protocol-specified medication and during the study follow-up period.\n\n    Participants participating in sexual activity must agree to use, or for their partner to use highly effective birth control methods (those with a failure rate of less than 1% per year when used consistently and correctly) until they have completed the study (after the Day 90 visit). Such methods include:\n    * Combined (estrogen and progesterone containing) hormonal oral, intravaginal, or transdermal contraception associated with the inhibition of ovulation\n    * Progesterone-only oral, injectable, or implantable hormonal contraception associated with the inhibition of ovulation\n    * Intrauterine device (IUD)\n    * Intrauterine hormone-releasing system (IUS)\n    * Bilateral tubal occlusion\n    * Vasectomized partner\n    * Sexual abstinence Participants who are not of reproductive potential (who have been postmenopausal for more than 24 consecutive months or have undergone hysterectomy, bilateral oophorectomy, bilateral salpingectomy, etc.) are not required to use contraception.\n\n    Participants are prohibited from sperm donation. NOTE: A negative serum pregnancy test will be documented during screening if a participant is of child-bearing potential.\n17. Participant is currently participating in or has participated in a study using an investigational device or drug or received an investigational drug or investigational use of a licensed drug within 30 days prior to screening.\n18. Participant does not have sufficient venous access for infusion of study treatment or blood sampling.\n19. Participant is unable or unwilling to comply with protocol requirements, including assessments, tests, and follow-up visits.\n20. Participant has any other medical condition which in the opinion of the Investigator will make participation medically unsafe or interfere with the study results.","ALL","18 Years","90 Years",{"count":1094,"type":1095},728,"ESTIMATED","INTERVENTIONAL",[1098,1099],"PHASE2","PHASE3","This is a Phase 2\u002F3 study evaluating the safety and efficacy of DM199 (rinvecalinase alfa) in treating participants with moderate stroke severity, who present within 24 hours of Acute Ischemic Stroke (AIS) onset due to small and medium vessel occlusions. This study focuses on participants with limited treatment options. Participants who have or will receive mechanical thrombectomy (MT) are not eligible for participation. Additionally, participants who have received fibrinolytics are excluded unless they experience a persistent neurological deficit of moderate severity six or more hours after fibrinolytic treatment. Participants considered for this trial should not be denied the use of standard of care (SoC) AIS therapies, such as fibrinolytics or MT, when appropriate. The double-blinded study will be randomized and placebo-controlled at up to approximately 100 sites.",[1102,1103,1104],"Acute Stroke","Ischemic Stroke","Stroke",[1106,1107,1108,1109,1110,1111,1112,1113,1114],"acute","ischemic","stroke","AIS","tPA","LVO","MT","KLK1","Kallikreins","2026-04-23",{"date":1117,"type":1118},"2026-04-28","ACTUAL",{"date":1120,"type":1118},"2021-11-07",{"date":1122,"type":1095},"2026-12",{"name":5,"class":6},66]