[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100593942":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":23,"centralContacts":24,"locations":30,"responsibleParty":46,"collaborators":23,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":23,"eligibilityCriteria":56,"healthyVolunteers":57,"sex":58,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":23,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":73,"overallStatus":32,"whyStopped":23,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"Nuclear Imaging Institute","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"ultralow dose imaging group","Participants will be enrolled for an ultralow dose PET scan to evaluate image quality and optimize timing and reconstruction after reducing radiation doses 10-100 fold. Participants will be injected with a very small amount of radiotracer and imaged on a PET scanner for up to 3 hours",[12],"Drug: 18F-Florbetapir or 18F-Flutemetamol",[14],{"type":15,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"DRUG","18F-Florbetapir or 18F-Flutemetamol","Participants will be injected with 18F-Florbetapir or 18F-Flutemetamol and imaged for up to 3 hours on a PET scanner",[9],[20,21,22],"CT scan","PET scan","blood collection",null,[25],{"name":26,"role":27,"phone":28,"phoneExt":23,"email":29},"Barbara Blanchfield","CONTACT","973-255-4955","bblanchfield@nii.org",[31],{"facility":5,"status":32,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"RECRUITING","Englewood","New Jersey","07631","United States","US",{"type":39,"coordinates":40},"Point",[41,42],-73.97264,40.89288,{"lat":42,"lon":41},[45],{"name":26,"role":27,"phone":28,"phoneExt":23,"email":23},{"type":47,"investigatorFullName":48,"investigatorTitle":49,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"SPONSOR_INVESTIGATOR","Akiva Mintz","Executive Director","100593942","phase-2-ultralow-dose-pet-imaging-of-18f-florbetapir-18f-flutemetamol-100593942",false,"NCT07012993","Ultralow Dose PET Imaging of 18F-Florbetapir, 18F-Flutemetamol","Evaluation of Ultralow Dose PET Imaging for Detecting Amyloid Tracer Uptake","Inclusion Criteria:\n\nAge ≥18 years; Ability to provide informed consent and comply with study procedures; For female participants: Must not be pregnant or breastfeeding; Negative pregnancy test required for women of childbearing potential.\n\nExclusion Criteria:\n\nParticipants who have exceeded NRC regulation for annual radiation exposure from prior research-related scans, including this study (50 millisievert \\[mSv\\] total); More than four prior enrollments in this study; Participants with severe claustrophobia, chronic pain, or musculoskeletal conditions that prevent completion of the PET scan; Pregnant or breastfeeding individuals (negative pregnancy test required); Inability to provide informed consent; Any condition that, in the investigator's judgment, may compromise participant safety or study integrity.",true,"ALL","18 Years","120 Years",{"count":62,"type":63},200,"ESTIMATED","INTERVENTIONAL",[66],"PHASE2","The goal of this clinical trial is to evaluate an investigational ultralow dose Positron Emission Tomography (PET) imaging technique for Alzheimer's disease, mild cognitive impairment, other forms of dementia detection and monitoring. The main question it aims to answer is:\n\nCan the investigators optimize the timing, scan duration, and image reconstruction to reduce the radiation dose 10-100 fold of the current clinical standard? Participants will be injected with a radioactive tracer called Fluorine-18 (18F)-Florbetapir or 18F-Flutemetamol and be imaged on a new type of high-sensitivity PET scanner for up to 3 hours",[69,70,71,72],"Alzheimer Disease","Mild Cognitive Impairment","Dementia","Healthy Volunteers",[74,75,76,77],"Amyloid","PET","ultralow dose","PET\u002FCT","2026-04-07",{"date":80,"type":81},"2026-04-13","ACTUAL",{"date":83,"type":81},"2025-05-20",{"date":85,"type":63},"2030-06-30",{"name":48,"class":6},1]