[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100643786":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":30,"responsibleParty":46,"collaborators":20,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":20,"eligibilityCriteria":55,"healthyVolunteers":51,"sex":56,"minAge":57,"maxAge":20,"enrollmentInfo":58,"targetDuration":20,"studyType":61,"phases":62,"briefSummary":64,"conditions":65,"keywords":20,"overallStatus":67,"whyStopped":20,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":77},{"fullName":5,"class":6},"Huashan Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"amiloride","EXPERIMENTAL","Participants will receive oral amiloride hydrochlorothiazide 1 tablet per day (contains 2.5 mg of amiloride and 25 mg of hydrochlorothiazide per tablet) continuously for 6 months.",[13],"Drug: Amiloride hydrochlorothiazide",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DRUG","Amiloride hydrochlorothiazide","Amiloride, a potassium-sparing diuretic, also an mTORC2 inhibitor, has been widely utilized in clinical settings. It can be employed as an adjunctive agent for hypertension management and has been investigated in completed clinical trials targeting resistant hypertension.",[9],null,[22,27],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},"Liuxun Hu","CONTACT","+8615868058299","19111220090@fudan.edu.cn",{"name":28,"role":24,"phone":25,"phoneExt":20,"email":29},"Wei Zhu","drzhuwei@fudan.edu.cn",[31],{"facility":32,"status":20,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Huashan Hospital, Fudan University, Shanghai, Shanghai 200040","Shanghai","Shanghai Municipality","200040","China","CN",{"type":39,"coordinates":40},"Point",[41,42],121.45806,31.22222,{"lat":42,"lon":41},[45],{"name":28,"role":24,"phone":25,"phoneExt":20,"email":26},{"type":47,"investigatorFullName":28,"investigatorTitle":48,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"PRINCIPAL_INVESTIGATOR","Principal Investigator","100643786","phase-2-vertebrobasilar-dolichoectasia-treatment-with-amiloride-100643786",false,"NCT07634068","Vertebrobasilar Dolichoectasia Treatment With Amiloride","Vertebrobasilar Dolichoectasia Treatment With Amiloride: a Pilot Study Based On 5.0 T MRI","Inclusion Criteria:\n\n1. Age≥18 years, any gender;\n2. Patients with VBD confirmed by DSA\u002FCTA\u002FMRA;\n3. No history of VBD rupture and no surgical treatment for VBD;\n4. mRS\\\u003C4;\n5. Positive plasma SGK1;\n6. No history of posterior circulation stroke, and no symptoms or signs related to VBD;\n7. No need for subsequent use of antiplatelet or statin drugs;\n8. Capable of signing an informed consent form with the accompaniment and understanding of a guardian.\n\nExclusion Criteria:\n\n1. History of malignant tumors, systemic lupus erythematosus, or gout;\n2. Pregnancy or lactation;\n3. Amiloride or sulfonamide allergy;\n4. Hydrocephalus requiring urgent surgical intervention or respiratory failure requiring life support treatment;\n5. Abnormal hepatic and\u002For renal function (serum transaminase \\> 40 U\u002FL; serum creatinine \\> 110 μmol\u002FL); and\u002For abnormal white blood cells\u002Fplatelets (white blood cells count \\\u003C 3.5 × 10⁹\u002FL or \\> 9.5 × 10⁹\u002FL; platelets count \\\u003C 100 × 10⁹\u002FL or \\> 300 × 10⁹\u002FL); hyperkalemia, hypokalemia, hyponatremia, or hypercalcemia;\n6. Acute cerebral infarction within the last month or definite high signal on DWI indicating acute or subacute cerebral infarction;\n7. Acute stage of intracranial hemorrhage as indicated by CT;\n8. History of VBD rupture or surgery;\n9. Presence of acute active infection (such as severe bacterial, viral or fungal infection);\n10. Uncontrolled diabetes (HbA1c≥7%);\n11. Need for subsequent use of antiplatelet or statin drugs;\n12. Systolic blood pressure\\\u003C 90 mmHg or\u002Fand diastolic blood pressure\\\u003C 60 mmHg;\n13. Currently participating in other clinical studies;\n14. Presence of contraindications for MRI examination;\n15. Other situations not suitable for inclusion.","ALL","18 Years",{"count":59,"type":60},6,"ESTIMATED","INTERVENTIONAL",[63],"PHASE2","The aim of this pilot study is to assess the efficacy of amiloride in reducing wall enhancement in vertebrobasilar dolichoectasia(VBD) on high-resolution magnetic resonance vessel wall imaging(HR-VWI) via anti-inflammatory mechanisms, clarify the efficacy of amiloride in delaying the progression of VBD, evaluate the safety of amiloride in the treatment of VBD.",[66],"Vertebrobasilar Dolichoectasia","NOT_YET_RECRUITING","2026-06-03",{"date":70,"type":71},"2026-06-08","ACTUAL",{"date":73,"type":60},"2026-06",{"date":75,"type":60},"2027-12",{"name":5,"class":6},1]