[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100603659":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":32,"centralContacts":37,"locations":31,"responsibleParty":44,"collaborators":31,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":50,"sex":55,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":31,"studyType":61,"phases":62,"briefSummary":64,"conditions":65,"keywords":67,"overallStatus":73,"whyStopped":31,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":31},{"fullName":5,"class":6},"Minia University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"connective tissue graft","PLACEBO_COMPARATOR","Semi-lunar flap elevation, then connective tissue graft sutured under the flap for papilla reconstruction",[13],"Biological: connective tissue graft",{"label":15,"type":16,"description":17,"interventionNames":18},"albumin-PRF","ACTIVE_COMPARATOR","Albumin- PRF for papilla reconstruction",[19],"Biological: Albumin (5% serum-protein solution containing immunoglobulins)",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BIOLOGICAL","Albumin (5% serum-protein solution containing immunoglobulins)","* Preoperative Phase:\n\n  * Oral hygiene instruction\n  * Phase I periodontal therapy\n  * Initial photography and papillary height measurements using digital calipers or customized stents\n* Surgical Technique:\n\n  * Local anesthesia\n  * Intrasulcular incision around target teeth\n  * Papilla preservation flap\n  * Harvesting CTG from the palate\n  * Injection of liquid Bio-PRF at the papillary base (test group)\n  * CTG positioned in the papilla region\n  * Suturing with microsurgical technique\n* Postoperative Protocol:\n\n  * Analgesics (e.g., ibuprofen 400 mg)\n  * Chlorhexidine 0.12% mouth rinse for 2 weeks\n  * Suture removal at 10-14 days\n  * Follow-up at 1 month, 3 months, and 6 months",[15],[27],"alb-prf",{"type":22,"name":9,"description":29,"armGroupLabels":30,"otherNames":31},"Local anesthesia. Intrasulcular incision around target teeth. Papilla preservation flap. Harvesting CTG from the palate",[9],null,[33],{"name":34,"affiliation":35,"role":36},"shaimaa Hamdy, lecturer","lecturer of periodontology Nahda University","PRINCIPAL_INVESTIGATOR",[38],{"name":39,"role":40,"phone":41,"phoneExt":42,"email":43},"shaimaa Hamdy, lecturer of Periodontology","CONTACT","+201030576405","+201555035523","shimaa.3m.sh@gmail.com",{"type":45,"investigatorFullName":46,"investigatorTitle":47,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"SPONSOR_INVESTIGATOR","shaimaa hamdy","lecturer of oral medicine, oral diagnosis and periodontology","100603659","phase-3-a-clinical-comparison-of-connective-tissue-graft-and-alb-prf-for-rebuilding-interdental-papilla-100603659",false,"NCT07139392","A Clinical Comparison of Connective Tissue Graft and Alb-PRF for Rebuilding Interdental Papilla","ALB-PRF & CTG","Inclusion Criteria:\n\n* Age 20-55 years\n* Nordland and Tarnow Class I\u002FII papillary loss\n* Good oral hygiene (FMPS \\& FMBS \\\u003C20%)\n* Systemically healthy\n\nExclusion Criteria:\n\n* Smoking\n* Periodontal pockets \\>4 mm in the target site\n* History of systemic diseases or medications affecting healing\n* Pregnant or lactating women","ALL","18 Years","55 Years",{"count":59,"type":60},30,"ESTIMATED","INTERVENTIONAL",[63],"PHASE3","The interdental papilla, a small wedge of gingival tissue positioned between adjacent teeth, plays a crucial role in both dental esthetics and oral function. Loss or deficiency of the papilla results in the formation of \"black triangles,\" which not only compromise a patient's smile but also lead to challenges such as food impaction, phonetic difficulties, and increased risk of periodontal disease. The reconstruction of the interdental papilla is recognized as one of the most challenging procedures in periodontal therapy, particularly when aiming for enhanced esthetic outcomes and patient satisfaction",[66],"Papilla Reconstruction",[68,69,70,71,72],"ALB-PRF","papilla","connective tissue","reconstruction","MINST","NOT_YET_RECRUITING","2025-08-17",{"date":76,"type":77},"2025-08-24","ACTUAL",{"date":79,"type":60},"2025-09-01",{"date":81,"type":60},"2025-09-23",{"name":46,"class":6}]