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34",{"facility":2305,"status":73,"city":2306,"state":2307,"zip":2308,"country":2309,"countryCode":2310,"cosmosGeoPoint":2311,"geoPoint":2315,"contacts":2316},"MNE \"Clinical Center of Oncology, Hematology, Transplantology and Palliative Care of CRC\" ( Site 1706)","Cherkasy","Cherkasy Oblast","18009","Ukraine","UA",{"type":80,"coordinates":2312},[2313,2314],32.05738,49.44452,{"lat":2314,"lon":2313},[2317],{"name":87,"role":67,"phone":2318,"phoneExt":37,"email":37},"+380472319418",{"facility":2320,"status":73,"city":2321,"state":2322,"zip":2323,"country":2309,"countryCode":2310,"cosmosGeoPoint":2324,"geoPoint":2328,"contacts":2329},"RMNE \"Bukovyna Clinical Oncology Center\" ( Site 1709)","Chernivtsi","Chernivetska Oblast","58013",{"type":80,"coordinates":2325},[2326,2327],25.93241,48.29045,{"lat":2327,"lon":2326},[2330],{"name":87,"role":67,"phone":2331,"phoneExt":37,"email":37},"0443344770",{"facility":2333,"status":73,"city":2334,"state":2335,"zip":2336,"country":2309,"countryCode":2310,"cosmosGeoPoint":2337,"geoPoint":2341,"contacts":2342},"MNPE \"Prykarpattia Clinical Oncology Center of Ivano-Frankivsk Regional Council\" ( Site 1701)","Ivano-Frankivsk","Ivano-Frankivsk Oblast","76018",{"type":80,"coordinates":2338},[2339,2340],24.71248,48.92312,{"lat":2340,"lon":2339},[2343],{"name":87,"role":67,"phone":2344,"phoneExt":37,"email":37},"+380966059053",{"facility":2346,"status":73,"city":2347,"state":2348,"zip":2349,"country":2309,"countryCode":2310,"cosmosGeoPoint":2350,"geoPoint":2354,"contacts":2355},"CNE \"Regional Clinical Oncology Center of the Kirovohrad Regional Council\" ( Site 1702)","Kropyvnytskyi","Kirovohrad Oblast","25011",{"type":80,"coordinates":2351},[2352,2353],32.26618,48.50834,{"lat":2353,"lon":2352},[2356],{"name":87,"role":67,"phone":2357,"phoneExt":37,"email":37},"+380508427973",{"facility":2359,"status":73,"city":2360,"state":2361,"zip":2362,"country":2309,"countryCode":2310,"cosmosGeoPoint":2363,"geoPoint":2367,"contacts":2368},"MNPE LTMU Multidisc. Clin. Hosp. of Emerg. and Intens. Care ( Site 1708)","Lviv","Lviv Oblast","79059",{"type":80,"coordinates":2364},[2365,2366],24.02324,49.83826,{"lat":2366,"lon":2365},[2369],{"name":87,"role":67,"phone":2370,"phoneExt":37,"email":37},"+380977453295",{"facility":2372,"status":73,"city":2373,"state":2374,"zip":2375,"country":2309,"countryCode":2310,"cosmosGeoPoint":2376,"geoPoint":2380,"contacts":2381},"MNE \"Central City Hospital\" ( Site 1711)","Rivne","Rivne Oblast","33017",{"type":80,"coordinates":2377},[2378,2379],26.23695,50.62036,{"lat":2379,"lon":2378},[2382],{"name":87,"role":67,"phone":2383,"phoneExt":37,"email":37},"+380508266088",{"facility":2385,"status":73,"city":2386,"state":2387,"zip":2388,"country":2309,"countryCode":2310,"cosmosGeoPoint":2389,"geoPoint":2393,"contacts":2394},"ME \"Volyn Regional Clinical Hospital\" of the VRC ( Site 1712)","Lutsk","Volyn Oblast","+380332773100",{"type":80,"coordinates":2390},[2391,2392],25.35024,50.75784,{"lat":2392,"lon":2391},[2395],{"name":87,"role":67,"phone":2396,"phoneExt":37,"email":37},"380503782998",{"facility":2398,"status":73,"city":2399,"state":2400,"zip":2401,"country":2309,"countryCode":2310,"cosmosGeoPoint":2402,"geoPoint":2406,"contacts":2407},"Uzhgorod Central City Clinical Hospital ( Site 1700)","Uzhhorod","Zakarpattia Oblast","88000",{"type":80,"coordinates":2403},[2404,2405],22.2947,48.6242,{"lat":2405,"lon":2404},[2408],{"name":87,"role":67,"phone":2409,"phoneExt":37,"email":37},"+380953274431",{"facility":2411,"status":73,"city":2412,"state":37,"zip":2413,"country":2309,"countryCode":2310,"cosmosGeoPoint":2414,"geoPoint":2418,"contacts":2419},"Medical Center \"Universal Clinic \"Oberig\" of Limited Liability Company \"Kapytal\" ( Site 1704)","Kyiv","03057",{"type":80,"coordinates":2415},[2416,2417],30.5238,50.45466,{"lat":2417,"lon":2416},[2420],{"name":87,"role":67,"phone":2421,"phoneExt":37,"email":37},"+380669472333",{"facility":2423,"status":73,"city":2412,"state":37,"zip":2424,"country":2309,"countryCode":2310,"cosmosGeoPoint":2425,"geoPoint":2427,"contacts":2428},"SI \"National Institute of Surgery and Transplantology named after O. O. Shalimov\" ( Site 1713)","03126",{"type":80,"coordinates":2426},[2416,2417],{"lat":2417,"lon":2416},[2429],{"name":87,"role":67,"phone":2430,"phoneExt":37,"email":37},"+380956017249",{"facility":2432,"status":73,"city":2412,"state":37,"zip":2433,"country":2309,"countryCode":2310,"cosmosGeoPoint":2434,"geoPoint":2436,"contacts":2437},"LLC \"MEDICAL CENTER DOBROBUT-CLINIC\" ( Site 1703)","03151",{"type":80,"coordinates":2435},[2416,2417],{"lat":2417,"lon":2416},[2438],{"name":87,"role":67,"phone":2439,"phoneExt":37,"email":37},"+380671502987",{"facility":2441,"status":73,"city":2442,"state":2443,"zip":2444,"country":2445,"countryCode":2446,"cosmosGeoPoint":2447,"geoPoint":2451,"contacts":2452},"Heartlands Hospital ( Site 1759)","Birmingham","England","B9 5ss","United Kingdom","UK",{"type":80,"coordinates":2448},[2449,2450],-1.89983,52.48142,{"lat":2450,"lon":2449},[2453],{"name":87,"role":67,"phone":2454,"phoneExt":37,"email":37},"+4401214241396",{"facility":2456,"status":73,"city":2457,"state":2458,"zip":2459,"country":2445,"countryCode":2446,"cosmosGeoPoint":2460,"geoPoint":2464,"contacts":2465},"University College London Hospitals ( Site 1750)","London","London, City of","NW1 2PG",{"type":80,"coordinates":2461},[2462,2463],-0.12574,51.50853,{"lat":2463,"lon":2462},[2466],{"name":87,"role":67,"phone":2467,"phoneExt":37,"email":37},"020 3456 7890",{"facility":2469,"status":73,"city":2470,"state":2471,"zip":2472,"country":2445,"countryCode":2446,"cosmosGeoPoint":2473,"geoPoint":2477,"contacts":2478},"Churchill Hospital ( Site 1756)","Oxford","Oxfordshire","ox3 7le",{"type":80,"coordinates":2474},[2475,2476],-1.25596,51.75222,{"lat":2476,"lon":2475},[2479],{"name":87,"role":67,"phone":2480,"phoneExt":37,"email":37},"+4403003047777",{"facility":2482,"status":73,"city":2483,"state":37,"zip":2484,"country":2445,"countryCode":2446,"cosmosGeoPoint":2485,"geoPoint":2489,"contacts":2490},"The Christie NHS Foundation Trust ( Site 1755)","Manchester","M20 4BX",{"type":80,"coordinates":2486},[2487,2488],-2.23743,53.48095,{"lat":2488,"lon":2487},[2491],{"name":87,"role":67,"phone":2492,"phoneExt":37,"email":37},"+441614468370",{"type":2494,"investigatorFullName":37,"investigatorTitle":37,"investigatorAffiliation":37,"oldNameTitle":37,"oldOrganization":37},"SPONSOR","100592750","phase-3-a-clinical-study-of-calderasib-mk-1084-with-targeted-therapy-and-chemotherapy-in-people-with-colorectal-cancer-mk-1084-012kandlelit-012-100592750",false,"NCT06997497","A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012\u002FKANDLELIT-012)","A Phase 3, Randomized, Open-label, Multicenter Clinical Study to Evaluate the Safety and Efficacy of MK-1084, Cetuximab, and mFOLFOX6 Versus mFOLFOX6 With or Without Bevacizumab as First-line Treatment of Participants With KRAS G12C-mutant, Locally Advanced Unresectable or Metastatic Colorectal Cancer (KANDLELIT-012)","Inclusion Criteria:\n\nThe main inclusion criteria include but are not limited to the following:\n\n* Has a histologically confirmed diagnosis of locally advanced unresectable or metastatic (unresectable Stage III or Stage IV as defined by American Joint Committee on Cancer \\[AJCC\\] eighth edition) colorectal adenocarcinoma\n* Part 2 only: Has not received systemic anticancer therapy for locally advanced unresectable or metastatic colorectal cancer; an exception is permitted for 1-2 cycles of FOLFOX or 1 cycle of CAPOX as optional chemotherapy before or during the screening period\n* Demonstrates presence of a Kirsten rat sarcoma viral oncogene homolog G12C (KRAS G12C) mutation\n* Human immunodeficiency virus (HIV)-infected participants must have well controlled HIV on antiretroviral therapy (ART)\n* Participants who are Hepatitis B surface antigen (HBsAg) positive are eligible if they have received hepatitis B virus (HBV) antiviral therapy and have undetectable HBV viral load\n* Participants with history of hepatitis C virus (HCV) infection are eligible if HCV viral load is undetectable\n\nExclusion Criteria:\n\nThe main exclusion criteria include but are not limited to the following:\n\n* Has active inflammatory bowel disease requiring immunosuppressive medication or previous clear history of inflammatory bowel disease (eg, Crohn's disease, ulcerative colitis, chronic diarrhea)\n* Has uncontrolled, significant cardiovascular disease or cerebrovascular disease\n* Has known partial or complete dihydropyrimidine dehydrogenase (DPD) deficiency\n* HIV-infected participants with a history of Kaposi's sarcoma and\u002For Multicentric Castleman's Disease\n* Has received prior systemic anticancer therapy including investigational agents within 4 weeks before randomization, with the exception of the optional chemotherapy\n* Has 1 or more conditions that, in the opinion of the investigator, make the participant ineligible for treatment with bevacizumab\n* Has known additional malignancy that is progressing or has required active treatment within the past 3 years\n* Has known active central nervous system (CNS) metastases and\u002For carcinomatous meningitis or leptomeningeal disease\n* Has active infection requiring systemic therapy\n* Has not adequately recovered from major surgery or have ongoing surgical complications\n* Has a history of (noninfectious) pneumonitis\u002Finterstitial lung disease that required steroids or has current pneumonitis\u002Finterstitial lung disease","ALL","18 Years",{"count":2505,"type":2506},477,"ESTIMATED","INTERVENTIONAL",[2509],"PHASE3","Researchers are looking for other ways to treat locally advanced or metastatic colorectal cancer (mCRC) that is unresectable and has a gene mutation called KRAS G12C.\n\nStandard (or usual) treatments for this type of colorectal cancer may include mFOLFOX6 with or without bevacizumab. Researchers want to learn if adding calderasib (the study medicine) and cetuximab to mFOLFOX6 can treat locally advanced or mCRC with the KRAS G12C mutation. Calderasib and cetuximab are targeted therapies.\n\nThe goals of this study are to learn:\n\n* About the safety of calderasib with cetuximab and mFOLFOX6 and if people tolerate the treatments\n* If people who receive calderasib with cetuximab and mFOLFOX6 live longer without mCRC growing or spreading compared to people who receive mFOLFOX6 with or without bevacizumab.",[2512,2513],"Colon Adenocarcinoma","Rectal Adenocarcinoma","2026-06-11",{"date":2516,"type":2517},"2026-06-15","ACTUAL",{"date":2519,"type":2517},"2025-07-16",{"date":2521,"type":2506},"2030-10-27",{"name":5,"class":6},200]