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be lactating; male subjects must agree to use contraception during the study and for 6 months after study completion\n\nExclusion Criteria:\n\n* Stage IV metastatic breast cancer or other cases judged by the investigator as unsuitable for radical surgical resection after neoadjuvant therapy;\n* Bilateral breast cancer or inflammatory breast cancer;\n* History of invasive breast cancer or ductal carcinoma in situ;\n* Prior anti-tumor therapy for breast cancer, including chemotherapy, endocrine therapy, targeted therapy, radiotherapy, surgery, etc.;\n* Comorbidities and medical history:\n\n  * Other malignancies within 5 years or currently;\n  * Adverse reactions from prior treatment not recovered to CTCAE v5.0 grade ≤1;\n  * Major surgery, significant traumatic injury within 4 weeks before first dose, or anticipated major surgery during the study, or unhealed wounds\u002Ffractures;\n  * Conditions affecting intravenous injection or blood sampling;\n  * Congenital bleeding or coagulation disorders, or bleeding\u002Fcoagulation disorders within 28 days before study treatment, or use of aspirin \\>325 mg\u002Fday (maximum antiplatelet dose), dipyridamole, ticlopidine, clopidogrel, or cilostazol within 7 days before study treatment;\n  * Arterial\u002Fdeep venous thrombotic events within 6 months before first dose, e.g., cerebrovascular accident, deep vein thrombosis, pulmonary embolism;\n  * Poorly controlled blood pressure (systolic ≥150 mmHg or diastolic ≥100 mmHg);\n  * Significant cardiovascular disease, including；\n  * Uncontrolled ≥CTCAE grade 2 infection within 14 days before study treatment;\n  * History of interstitial lung disease\u002Fpneumonitis (non-infectious) requiring steroid treatment, current interstitial lung disease\u002Fpneumonitis, or suspected interstitial lung disease\u002Fpneumonitis on screening imaging that cannot be ruled out;\n* Tumor-related symptoms and treatment:\n\n  * Prior excisional biopsy of primary tumor and\u002For axillary lymph nodes or sentinel lymph node biopsy before study treatment;\n  * Surgery, chemotherapy, radiotherapy, or other anti-tumor therapy within 3 weeks before study treatment (washout period calculated from last treatment);\n  * Prior taxane or carboplatin therapy for any malignancy;\n  * Treatment with National Medical Products Administration-approved traditional Chinese medicine with clear anti-tumor indications within 2 weeks before study treatment.\n* Study treatment-related:\n\n  * Severe hypersensitivity to monoclonal antibodies;\n  * Uncontrolled active autoimmune disease within 2 weeks before study treatment;\n  * Allergy to any study drug or its components\u002Fexcipients;\n  * Live vaccination within 28 days before study treatment, including measles, mumps, rubella, varicella, yellow fever, seasonal flu, Influenza A virus subtype (H1N1) flu, rabies, Bacille Calmette-Guerin vaccine (BCG), and typhoid vaccines.\n* Any condition judged by the investigator to jeopardize subject safety or study completion.","ALL","18 Years","75 Years",{"count":1103,"type":1104},544,"ESTIMATED","INTERVENTIONAL",[1107],"PHASE3","This is a randomized, open, positive drug control, multi center phase III study. Through the evaluation of tpCR, bpCR, ORR, EFS, IDFS, OS , AEs and other indicators, it proves the effectiveness and safety of TQB2102 for injection versus TCbHP in the neoadjuvant treatment of HER2 positive breast cancer patients.",[1110],"HER2-positive Breast Cancer","2026-03-26",{"date":1113,"type":1114},"2026-03-27","ACTUAL",{"date":1116,"type":1114},"2025-09-15",{"date":1118,"type":1104},"2029-09",{"name":1120,"class":6},"Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd.",78]