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#0490395","Kiel","24149",{"type":59,"coordinates":650},[651,652],10.13489,54.32133,{"lat":652,"lon":651},{"facility":655,"status":52,"city":656,"state":36,"zip":657,"country":658,"countryCode":659,"cosmosGeoPoint":660,"geoPoint":664,"contacts":36},"Azienda Ospedaliera Universitaria Careggi, Merz Investigational Site #0390023","Florence","50134","Italy","IT",{"type":59,"coordinates":661},[662,663],11.24626,43.77925,{"lat":663,"lon":662},{"facility":666,"status":52,"city":667,"state":36,"zip":668,"country":658,"countryCode":659,"cosmosGeoPoint":669,"geoPoint":673,"contacts":36},"Ospedale San Raffaele, Merz Investigational Site #0390027","Milan","20132",{"type":59,"coordinates":670},[671,672],12.59836,42.78235,{"lat":672,"lon":671},{"facility":675,"status":52,"city":667,"state":36,"zip":676,"country":658,"countryCode":659,"cosmosGeoPoint":677,"geoPoint":679,"contacts":36},"Istituto Auxologico Italiano, Merz Investigational Site 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Med. Anna Szczepańska-Szerej, Merz Investigational Site #0480096","20-582",{"type":59,"coordinates":794},[781,782],{"lat":782,"lon":781},{"facility":797,"status":52,"city":798,"state":36,"zip":799,"country":702,"countryCode":703,"cosmosGeoPoint":800,"geoPoint":804,"contacts":36},"Instytut Zdrowia dr Boczarska-Jedynak, Merz Investigational Site #0480103","Oświęcim","32-600",{"type":59,"coordinates":801},[802,803],19.21037,50.03437,{"lat":803,"lon":802},{"facility":806,"status":52,"city":807,"state":36,"zip":808,"country":702,"countryCode":703,"cosmosGeoPoint":809,"geoPoint":813,"contacts":36},"Solumed Centrum Medyczne, Merz Investigational Site #0480122","Poznan","60-529",{"type":59,"coordinates":810},[811,812],16.92993,52.40692,{"lat":812,"lon":811},{"facility":815,"status":52,"city":816,"state":36,"zip":817,"country":702,"countryCode":703,"cosmosGeoPoint":818,"geoPoint":822,"contacts":36},"ETG Neuroscience, Merz Investigational Site #0480116","Warsaw","02-677",{"type":59,"coordinates":819},[820,821],21.01178,52.22977,{"lat":821,"lon":820},{"facility":824,"status":52,"city":825,"state":36,"zip":826,"country":702,"countryCode":703,"cosmosGeoPoint":827,"geoPoint":831,"contacts":36},"MIGRE Polskie Centrum Leczenia Migreny, Merz Investigational Site #0480124","Wroclaw","52-210",{"type":59,"coordinates":828},[829,830],17.03006,51.10286,{"lat":830,"lon":829},{"facility":833,"status":52,"city":825,"state":36,"zip":834,"country":702,"countryCode":703,"cosmosGeoPoint":835,"geoPoint":837,"contacts":36},"Futuremeds, Merz Investigational Site #0480123","53-673",{"type":59,"coordinates":836},[829,830],{"lat":830,"lon":829},{"facility":839,"status":52,"city":840,"state":36,"zip":841,"country":702,"countryCode":703,"cosmosGeoPoint":842,"geoPoint":846,"contacts":36},"ETG Zamosc, Merz Investigational Site #0480120","Zamość","22-400",{"type":59,"coordinates":843},[844,845],23.25196,50.72314,{"lat":845,"lon":844},{"facility":848,"status":52,"city":849,"state":36,"zip":850,"country":851,"countryCode":852,"cosmosGeoPoint":853,"geoPoint":857,"contacts":36},"MUDr. Beáta Dupejová, neurologická ambulancia, Merz Investigational Site #4210002","Banská Bystrica","974 04","Slovakia","SK",{"type":59,"coordinates":854},[855,856],19.14932,48.73947,{"lat":856,"lon":855},{"facility":859,"status":52,"city":860,"state":36,"zip":861,"country":851,"countryCode":852,"cosmosGeoPoint":862,"geoPoint":866,"contacts":36},"KONZÍLIUM, Merz Investigational Site #4210011","Dubnica nad Váhom","018 41",{"type":59,"coordinates":863},[864,865],18.16634,48.95981,{"lat":865,"lon":864},{"facility":868,"status":52,"city":869,"state":36,"zip":870,"country":851,"countryCode":852,"cosmosGeoPoint":871,"geoPoint":875,"contacts":36},"NEURES, Merz Investigational Site #4210006","Krompachy","053 42",{"type":59,"coordinates":872},[873,874],20.87514,48.91447,{"lat":874,"lon":873},{"facility":877,"status":52,"city":878,"state":36,"zip":879,"country":851,"countryCode":852,"cosmosGeoPoint":880,"geoPoint":884,"contacts":36},"Liptovská nemocnica s poliklinikou, Merz Investigational Site #4210013","Liptovský Mikuláš","031 23",{"type":59,"coordinates":881},[882,883],19.62218,49.08061,{"lat":883,"lon":882},{"facility":886,"status":52,"city":887,"state":36,"zip":888,"country":889,"countryCode":890,"cosmosGeoPoint":891,"geoPoint":895,"contacts":36},"Hospital Clinic de Barcelona-Hospital Plato, Merz Investigational Site #0340047","Barcelona","08006","Spain","ES",{"type":59,"coordinates":892},[893,894],2.15899,41.38879,{"lat":894,"lon":893},{"facility":897,"status":52,"city":887,"state":36,"zip":898,"country":889,"countryCode":890,"cosmosGeoPoint":899,"geoPoint":901,"contacts":36},"Hospital Universitari Vall d'Hebron, Merz Investigational Site 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#0340057","28055",{"type":59,"coordinates":921},[908,909],{"lat":909,"lon":908},{"facility":924,"status":52,"city":925,"state":36,"zip":926,"country":889,"countryCode":890,"cosmosGeoPoint":927,"geoPoint":931,"contacts":36},"Hospital Regional Universitario de Malaga, Merz Investigational Site #0340050","Málaga","29010",{"type":59,"coordinates":928},[929,930],-4.42034,36.72016,{"lat":930,"lon":929},{"facility":933,"status":52,"city":925,"state":36,"zip":926,"country":889,"countryCode":890,"cosmosGeoPoint":934,"geoPoint":936,"contacts":36},"Hospital Universitario Virgen de la Victoria, Merz Investigational Site #0340056",{"type":59,"coordinates":935},[929,930],{"lat":930,"lon":929},{"facility":938,"status":52,"city":925,"state":36,"zip":939,"country":889,"countryCode":890,"cosmosGeoPoint":940,"geoPoint":942,"contacts":36},"Hospital Vithas Malaga, Merz Investigational Site #0340054","29016",{"type":59,"coordinates":941},[929,930],{"lat":930,"lon":929},{"facility":944,"status":52,"city":945,"state":36,"zip":946,"country":889,"countryCode":890,"cosmosGeoPoint":947,"geoPoint":951,"contacts":36},"Hospital Universitario Virgen del Rocio, Merz Investigational Site #0340046","Seville","41013",{"type":59,"coordinates":948},[949,950],-5.97317,37.38283,{"lat":950,"lon":949},{"facility":953,"status":52,"city":954,"state":36,"zip":955,"country":889,"countryCode":890,"cosmosGeoPoint":956,"geoPoint":960,"contacts":36},"Consorci Sanitari de Terrassa, Merz Investigational Site #0340051","Terrassa","08227",{"type":59,"coordinates":957},[958,959],2.01667,41.56667,{"lat":959,"lon":958},{"facility":962,"status":52,"city":963,"state":36,"zip":964,"country":889,"countryCode":890,"cosmosGeoPoint":965,"geoPoint":969,"contacts":36},"Hospital Universitari i Politecnic La Fe de Valencia, Merz Investigational Site #0340049","Valencia","46026",{"type":59,"coordinates":966},[967,968],-0.37966,39.47391,{"lat":968,"lon":967},{"facility":971,"status":52,"city":972,"state":36,"zip":973,"country":889,"countryCode":890,"cosmosGeoPoint":974,"geoPoint":978,"contacts":36},"Complejo Hospitalario Universitario de Vigo, Merz Investigational Site #0340052","Vigo","36312",{"type":59,"coordinates":975},[976,977],-8.72264,42.23282,{"lat":977,"lon":976},{"facility":980,"status":52,"city":981,"state":36,"zip":982,"country":889,"countryCode":890,"cosmosGeoPoint":983,"geoPoint":987,"contacts":36},"Hospital Viamed Montecanal, Merz Investigational Site #0340053","Zaragoza","50012",{"type":59,"coordinates":984},[985,986],-0.87734,41.65606,{"lat":986,"lon":985},{"facility":989,"status":52,"city":990,"state":36,"zip":991,"country":992,"countryCode":993,"cosmosGeoPoint":994,"geoPoint":998,"contacts":36},"Inselspital Bern, Merz Investigational Site #0410003","Bern","3010","Switzerland","CH",{"type":59,"coordinates":995},[996,997],7.44744,46.94809,{"lat":997,"lon":996},{"facility":1000,"status":52,"city":1001,"state":36,"zip":1002,"country":992,"countryCode":993,"cosmosGeoPoint":1003,"geoPoint":1007,"contacts":36},"Kopfwehzentrum Hirslanden, Merz Investigational Site #0410017","Zollikon","8702",{"type":59,"coordinates":1004},[1005,1006],8.57407,47.34019,{"lat":1006,"lon":1005},{"facility":1009,"status":52,"city":1010,"state":36,"zip":1011,"country":1012,"countryCode":1013,"cosmosGeoPoint":1014,"geoPoint":1018,"contacts":36},"Royal Stoke University Hospital, Merz Investigational Site #0440048","Stoke-on-Trent","ST4 6QG","United Kingdom","UK",{"type":59,"coordinates":1015},[1016,1017],-2.18538,53.00415,{"lat":1017,"lon":1016},{"type":1020,"investigatorFullName":36,"investigatorTitle":36,"investigatorAffiliation":36,"oldNameTitle":36,"oldOrganization":36},"SPONSOR","100594381","phase-3-a-clinical-trial-to-evaluate-efficacy-and-safety-of-xeomin-injections-for-preventing-episodic-migraine-100594381",false,"NCT07018700","A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Episodic Migraine","A Phase 3, Randomized, Double-blind, Placebo-controlled, Multicenter, Clinical Trial With Extension Period to Evaluate the Efficacy and Safety of Xeomin® Injections for the Prevention of Episodic Migraine","MINT-E","Inclusion Criteria:\n\n* Participant has a diagnosis of EM with or without aura according to current International Classification of Headache Disorders (Edition 3 and Edition 4 alpha) criteria for ≥ 12 months and is able to distinguish migraine headaches from all other types of headaches;\n* Participant age \\\u003C 50 years at the time of migraine onset;\n* Participant meeting the following headache and migraine day criteria in each of the 3 months prior to screening: history of ≤ 14 headache days per month and history of 6 to 14 migraine days per month; and\n* During the last 28 days of the screening period, participant experiencing: ≤ 14 headache days and 6 to 14 migraine days that qualify as such per the headache diary.\n\nExclusion Criteria:\n\n* Diagnosis of chronic migraine;\n* Diagnosis of other primary headache types, except tension-type headache, which is permitted;\n* Diagnosis of aura without headache, migraine with brainstem aura, hemicrania continua, hypnic headache, hemiplegic migraine, retinal migraine, persistent aura without infarction, migraine aura-triggered seizure, or previous migrainous infarction;\n* Diagnosis of secondary headache types, except medication overuse headache, which is permitted;\n* Currently taking \\> 1 prescribed drug for the preventive treatment of migraine;\n* Discontinuation of anti-calcitonin gene-related peptide (CGRP) \u002F anti-CGRP receptor monoclonal antibody treatment less than 5 months prior to screening.","ALL","18 Years",{"count":1032,"type":1033},990,"ESTIMATED","INTERVENTIONAL",[1036],"PHASE3","In this clinical trial, participants with episodic migraine will receive injections with Xeomin or Placebo into muscles of the head and neck. The purpose is to measure the change in monthly migraine days with Xeomin injections compared to Placebo injections.\n\nTrial details include:\n\n* Trial duration: 52 to 55 weeks;\n\n  * Screening period: 4 to 5 weeks;\n  * Treatment duration: 4 treatments, each about 12 weeks apart; and\n* Visit frequency: about every 4 weeks, 14 visits in total. The first and last visit and the 4 treatment visits are on-site, the other 8 visits are remote by phone \u002F video call.",[1039],"Episodic Migraine","2026-06-22",{"date":1042,"type":1043},"2026-06-25","ACTUAL",{"date":1045,"type":1043},"2025-08-21",{"date":1047,"type":1033},"2027-10",{"name":1049,"class":6},"Merz Therapeutics GmbH",108]