[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100477471":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":11,"locations":11,"responsibleParty":30,"collaborators":11,"id":32,"slug":33,"hasResults":34,"nctId":35,"briefTitle":36,"officialTitle":36,"acronym":11,"eligibilityCriteria":37,"healthyVolunteers":34,"sex":38,"minAge":39,"maxAge":40,"enrollmentInfo":41,"targetDuration":11,"studyType":44,"phases":45,"briefSummary":47,"conditions":48,"keywords":11,"overallStatus":50,"whyStopped":11,"lastUpdateSubmitDate":51,"lastUpdatePostDateStruct":52,"startDateStruct":55,"completionDateStruct":57,"leadSponsor":59,"locationsCount":11},{"fullName":5,"class":6},"BonusBio Group Ltd","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"treatment","EXPERIMENTAL",null,[13],"Biological: MesenCure",{"label":15,"type":16,"description":11,"interventionNames":17},"control","PLACEBO_COMPARATOR",[18],"Other: Placebo",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"BIOLOGICAL","MesenCure","Enhanced mesenchymal cell-based product",[9],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":11},"OTHER","Placebo","Saline",[15],{"type":31,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100477471","phase-3-a-controlled-study-to-evaluate-the-efficacy-of-allogeneic-mesencure-for-the-treatment-of-patients-with-ards-100477471",false,"NCT05497401","A Controlled Study to Evaluate the Efficacy of Allogeneic MesenCure for the Treatment of Patients With ARDS","Inclusion Criteria:\n\n1. Patients are able and agree to sign informed consent form before any study-specific procedure.\n2. Males or females, age range 18-80.\n3. Documented ARDS\n4. RA-O2 Saturation of ≤93% and\u002For Evidence of COVID19-related pulmonary infiltrates on chest X-ray\u002Fthoracic tomography\n5. Stable hemodynamic condition (blood pressure of systolic \\\u003C180mm Hg and diastolic \\\u003C110mm Hg)\n\nExclusion Criteria:\n\nGeneral:\n\n1. Pregnant or breast-feeding females.\n2. History of drug abuse.\n3. Heavy smokers (above 2 packages a day).\n4. Subjects incapable of giving consent.\n\nBackground medical conditions:\n\n1. Known history of any significant medical disorder, which in the investigator's judgment contraindicates the subject's participation.\n2. History of advanced congestive heart failure or active acute myocardial infarction (AMI), renal failure (estimated GFR of \\\u003C30 ml\u002Fmin\u002F1.73 m2 at screening), or hepatic disease (hepatic insufficiency classified as Child-Pugh B or C).\n3. Known autoimmune diseases.\n4. Received any investigational drug within 30 days prior to screening day (Visit 1) (Remdesivir is not considered investigational, and is not an exclusion criteria).\n5. Immunocompromised condition from any reason, at screening.\n6. Abnormal clinically significant laboratory test findings, as per the investigator's judgment.\n7. Poorly controlled diabetic subjects (HbA1c \\> 9%).\n8. Known active lung malignancy.\n\nConcomitant treatment:\n\n1. Currently treated with Immunosuppressive agents other than corticosteroids used for treating COVID19.\n2. Treatment for cancer (i.e. chemotherapy or radiotherapy treatment) within the last 12 months.\n\nHypersensitivity:\n\n1. Known history of hypersensitivity to Dextran-40.\n2. Known history of hypersensitivity to Human Serum Albumin.","ALL","18 Years","80 Years",{"count":42,"type":43},300,"ESTIMATED","INTERVENTIONAL",[46],"PHASE3","The efficacy of the allogeneic cell-therapy product MesenCure in addition to standard of care will be evaluated in comparison to placebo control in 300 moderate to severe Covid patients",[49],"ARDS","NOT_YET_RECRUITING","2025-08-06",{"date":53,"type":54},"2025-08-11","ACTUAL",{"date":56,"type":43},"2026-04",{"date":58,"type":43},"2028-10",{"name":5,"class":6}]