[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100593914":3},{"organization":4,"armGroups":7,"interventions":30,"overallOfficials":29,"centralContacts":50,"locations":60,"responsibleParty":259,"collaborators":262,"id":283,"slug":284,"hasResults":285,"nctId":286,"briefTitle":287,"officialTitle":288,"acronym":289,"eligibilityCriteria":290,"healthyVolunteers":285,"sex":291,"minAge":292,"maxAge":29,"enrollmentInfo":293,"targetDuration":29,"studyType":296,"phases":297,"briefSummary":299,"conditions":300,"keywords":302,"overallStatus":94,"whyStopped":29,"lastUpdateSubmitDate":307,"lastUpdatePostDateStruct":308,"startDateStruct":311,"completionDateStruct":313,"leadSponsor":315,"locationsCount":316},{"fullName":5,"class":6},"Aarhus University Hospital","OTHER",[8,15,21,25],{"label":9,"type":10,"description":11,"interventionNames":12},"Group A: Platelet inhibitor - no Statin (\"APT alone\")","EXPERIMENTAL","All patients will initiate treatment with Aspirin or Clopidogrel. The decision on which of the two drugs to initiate is at the discretion of the treating physician\u002Fcenter.",[13,14],"Drug: acetylsalicyclic acid (ASA)","Drug: Clopidogrel",{"label":16,"type":10,"description":17,"interventionNames":18},"Group B: Statins - no Platelet inhibitor (\"Statin alone\").","Patients will be treated with high-intensity statin therapy (Atorvastatin 40 mg once daily or Rosuvastatin 20 mg once daily)",[19,20],"Drug: Rosuvastatin","Drug: Atorvastatin",{"label":22,"type":10,"description":23,"interventionNames":24},"Group C: Statins - Platelet inhibitor (\"APT AND statin\")","Both types of medication are initiated as described in group A and B",[13,14,19,20],{"label":26,"type":27,"description":28,"interventionNames":29},"Group D: No Statins - no Platelet inhibitor (current standard treatment)","NO_INTERVENTION","This group follows the current European recommendations of primary prevention which do not include statins and APT agents. If statins and\u002For platelet inhibitors are started during the study-period it should adhere to primary prevention guidelines.\n\nAll four groups receive advice on lifestyle optimization and blood pressure management.",null,[31,38,42,46],{"type":32,"name":33,"description":34,"armGroupLabels":35,"otherNames":36},"DRUG","acetylsalicyclic acid (ASA)","Daily dose 75 mg to 100 mg p.o.",[9,22],[37],"Aspirin",{"type":32,"name":39,"description":40,"armGroupLabels":41,"otherNames":29},"Clopidogrel","Daily dose 75 mg p.o.",[9,22],{"type":32,"name":43,"description":44,"armGroupLabels":45,"otherNames":29},"Rosuvastatin","Daily dose 20 mg p.o. (10 mg once daily for the first 4 weeks, then 20 mg once daily for the remainder of the study period if tolerated).\n\nIf Rosuvastatin 20 mg is not tolerated, a dose reduction to 10 mg is allowed.",[16,22],{"type":32,"name":47,"description":48,"armGroupLabels":49,"otherNames":29},"Atorvastatin","Daily dose 40 mg p.o. If Atorvastatin 40 mg is not tolerated, a dose reduction to 20 mg is allowed.",[16,22],[51,56],{"name":52,"role":53,"phone":54,"phoneExt":29,"email":55},"Rolf Blauenfeldt","CONTACT","+4529318244","rolfblau@rm.dk",{"name":57,"role":53,"phone":58,"phoneExt":29,"email":59},"Ida Thingholm Norup","+4520848978","idnoru@rm.dk",[61,79,93,100,114,125,139,153,167,181,195,211,227,243],{"facility":62,"status":63,"city":64,"state":29,"zip":65,"country":66,"countryCode":67,"cosmosGeoPoint":68,"geoPoint":73,"contacts":74},"Aalborg Universitetshospital","NOT_YET_RECRUITING","Aalborg","9000","Denmark","DK",{"type":69,"coordinates":70},"Point",[71,72],9.9187,57.048,{"lat":72,"lon":71},[75],{"name":76,"role":53,"phone":77,"phoneExt":29,"email":78},"Boris Modrau","+4597662239","boris.modrau@rn.dk",{"facility":80,"status":63,"city":81,"state":29,"zip":82,"country":66,"countryCode":67,"cosmosGeoPoint":83,"geoPoint":87,"contacts":88},"Aarhus Universitetshospital","Aarhus","8200",{"type":69,"coordinates":84},[85,86],10.21076,56.15674,{"lat":86,"lon":85},[89],{"name":90,"role":53,"phone":91,"phoneExt":29,"email":92},"Claus Simonsen","+45 50240543","clausimo@rm.dk",{"facility":5,"status":94,"city":81,"state":29,"zip":82,"country":66,"countryCode":67,"cosmosGeoPoint":95,"geoPoint":97,"contacts":98},"RECRUITING",{"type":69,"coordinates":96},[85,86],{"lat":86,"lon":85},[99],{"name":52,"role":53,"phone":54,"phoneExt":29,"email":55},{"facility":101,"status":63,"city":102,"state":29,"zip":103,"country":66,"countryCode":67,"cosmosGeoPoint":104,"geoPoint":108,"contacts":109},"Rigshospitalet","Copenhagen","2100",{"type":69,"coordinates":105},[106,107],12.56553,55.67594,{"lat":107,"lon":106},[110],{"name":111,"role":53,"phone":112,"phoneExt":29,"email":113},"Anders Sode West","+4538630220","anders.sode.west@regionh.dk",{"facility":115,"status":63,"city":102,"state":29,"zip":116,"country":66,"countryCode":67,"cosmosGeoPoint":117,"geoPoint":119,"contacts":120},"Bispebjerg og Frederiksberg Hospital","2400",{"type":69,"coordinates":118},[106,107],{"lat":107,"lon":106},[121],{"name":122,"role":53,"phone":123,"phoneExt":29,"email":124},"Hanne Christensen","+4538635000","Hanne.Krarup.Christensen@regionh.dk",{"facility":126,"status":63,"city":127,"state":29,"zip":128,"country":66,"countryCode":67,"cosmosGeoPoint":129,"geoPoint":133,"contacts":134},"Herlev Hospital","Herlev","2730",{"type":69,"coordinates":130},[131,132],12.43998,55.72366,{"lat":132,"lon":131},[135],{"name":136,"role":53,"phone":137,"phoneExt":29,"email":138},"Anders Hougaard","+4538682790","anders.hougaard@regionh.dk",{"facility":140,"status":63,"city":141,"state":29,"zip":142,"country":66,"countryCode":67,"cosmosGeoPoint":143,"geoPoint":147,"contacts":148},"Regionshospitalet Gødstrup","Herning","7400",{"type":69,"coordinates":144},[145,146],8.97662,56.13615,{"lat":146,"lon":145},[149],{"name":150,"role":53,"phone":151,"phoneExt":29,"email":152},"Mohammed Ahmad Al-Jazi","+4578430000","moalja@rm.dk",{"facility":154,"status":63,"city":155,"state":29,"zip":156,"country":66,"countryCode":67,"cosmosGeoPoint":157,"geoPoint":161,"contacts":162},"Kolding Hospital","Kolding","6000",{"type":69,"coordinates":158},[159,160],9.47216,55.4904,{"lat":160,"lon":159},[163],{"name":164,"role":53,"phone":165,"phoneExt":29,"email":166},"Henrik Leth de Fønss","+4576302600","Henrik.Leth@rsyd.dk",{"facility":168,"status":63,"city":169,"state":29,"zip":170,"country":66,"countryCode":67,"cosmosGeoPoint":171,"geoPoint":175,"contacts":176},"Odense Universitetshospital","Odense","5000",{"type":69,"coordinates":172},[173,174],10.38831,55.39594,{"lat":174,"lon":173},[177],{"name":178,"role":53,"phone":179,"phoneExt":29,"email":180},"David Gaist","+4565504185","dgaist@health.sdu.dk",{"facility":182,"status":63,"city":183,"state":29,"zip":184,"country":66,"countryCode":67,"cosmosGeoPoint":185,"geoPoint":189,"contacts":190},"Roskilde Hospital","Roskilde","4000",{"type":69,"coordinates":186},[187,188],12.08035,55.64152,{"lat":188,"lon":187},[191],{"name":192,"role":53,"phone":193,"phoneExt":29,"email":194},"Troels Wienecke","+4547322808","trw@regionsjaelland.dk",{"facility":196,"status":63,"city":197,"state":29,"zip":198,"country":199,"countryCode":200,"cosmosGeoPoint":201,"geoPoint":205,"contacts":206},"University Medical Center Hamburg-Eppendorf","Hamburg","20246","Germany","DE",{"type":69,"coordinates":202},[203,204],9.99302,53.55073,{"lat":204,"lon":203},[207],{"name":208,"role":53,"phone":209,"phoneExt":29,"email":210},"Götz Thomalla","+4940741050137","thomalla@uke.de",{"facility":212,"status":63,"city":213,"state":29,"zip":214,"country":215,"countryCode":216,"cosmosGeoPoint":217,"geoPoint":221,"contacts":222},"Oslo University Hospital","Oslo","0450","Norway","NO",{"type":69,"coordinates":218},[219,220],10.74609,59.91273,{"lat":220,"lon":219},[223],{"name":224,"role":53,"phone":225,"phoneExt":29,"email":226},"Anne Hege Aamodt","+4795867270","a.h.aamodt@medisin.uio.no",{"facility":228,"status":63,"city":229,"state":29,"zip":230,"country":231,"countryCode":232,"cosmosGeoPoint":233,"geoPoint":237,"contacts":238},"Skånes Universitetssjukhus","Lund","22242","Sweden","SE",{"type":69,"coordinates":234},[235,236],13.19321,55.70584,{"lat":236,"lon":235},[239],{"name":240,"role":53,"phone":241,"phoneExt":29,"email":242},"Jesper Petersson","0046406733000","Jesper.Petersson@skane.se",{"facility":244,"status":63,"city":245,"state":29,"zip":246,"country":247,"countryCode":248,"cosmosGeoPoint":249,"geoPoint":253,"contacts":254},"Universitätsspital - Inselspital - University of Bern","Bern","3010","Switzerland","CH",{"type":69,"coordinates":250},[251,252],7.44744,46.94809,{"lat":252,"lon":251},[255],{"name":256,"role":53,"phone":257,"phoneExt":29,"email":258},"Thomas Meinel","+41 76 4928 545","thomas.meinel@insel.ch",{"type":260,"investigatorFullName":52,"investigatorTitle":261,"investigatorAffiliation":5,"oldNameTitle":29,"oldOrganization":29},"PRINCIPAL_INVESTIGATOR","MD, PhD, Associate professor of Neurology.",[263,265,267,268,270,272,274,276,277,279,281],{"name":264,"class":6},"Rigshospitalet, Denmark",{"name":266,"class":6},"Bispebjerg Hospital",{"name":126,"class":6},{"name":269,"class":6},"Zealand University Hospital",{"name":271,"class":6},"Odense University Hospital",{"name":273,"class":6},"Aalborg University Hospital",{"name":275,"class":6},"Gødstrup Hospital",{"name":212,"class":6},{"name":278,"class":6},"Universitätsklinikum Hamburg-Eppendorf",{"name":280,"class":6},"Insel Gruppe AG, University Hospital Bern",{"name":282,"class":6},"Lund University Hospital","100593914","phase-3-a-european-randomized-study-on-blood-thinners-and-cholesterol-lowering-treatments-to-prevent-future-vascular-events-in-people-with-covert-brain-infarcts-cbi-100593914",false,"NCT07012629","A EUROpean Randomized Study on Blood-thinners and Cholesterol-lowering Treatments to Prevent Future Vascular Events in People With Covert Brain Infarcts (CBI)","A EUROpean Pragmatic Multicenter Randomized Trial on Platelet Inhibition and\u002For Lipid Lowering Treatment in Covert Brain Infarction (CBI)","EURO-CBI","Inclusion Criteria:\n\n* MRI demonstrating a lacunar infarct (acute\u002Fsubacute\u002Fchronic) without prior stroke\u002FTIA symptoms. (A round or ovoid, subcortical, fluid-filled cavity (signal similar to cerebrospinal fluid (CSF)) between 3 and 15 mm in diameter and demonstrating a peripheral T2\u002FFLAIR hyperintense rim of marginal gliosis. For infratentorial lesions the hyperintense rim may be less marked and a complete ring is not required) OR\n* MRI demonstrating a cortical infarct (acute\u002Fsubacute\u002Fchronic) without prior stroke\u002FTIA symptoms (A cortical infarct is defined as a fluid-filled cavity (signal similar to CSF) in the cortex, juxtacortical region or cerebellar cortex and with a ring of T2\u002FFLAIR hyperintense lesions or as cortical T2\u002FFLAIR lesions without a fluid-filled cavity with presumed vascular origin. Both supra- and infratentorial lesion will be included) AND Life expectancy \\> 12 months AND Predominantly independent in actives of daily living (mRS score ≤ 3) AND Age ≥ 50 years\n\nExclusion Criteria:\n\n* History of stroke\u002FTIA\n* High risk of bleeding (e.g., recent or recurrent gastrointestinal or genitourinary bleeding associated with a decrease in hemoglobin levels of at least 1 mmol\u002FL, active peptic ulcer disease, MRI with cortical siderosis and\u002For prior lobar hemorrhage)\n* Indication for long-term use of anticoagulants (e.g. deep vein thrombosis, pulmonary embolism, atrial fibrillation, and rarer indications; such as mechanical heart valve, antiphospholipid antibody syndrome etc.)\n* Concurrent indication for lipid-lowering treatment and\u002For platelet-inhibitors for secondary cardiovascular prevention (ischemic heart disease, recent stenting, ischemic stroke, revascularization surgeries, lower-extremity atherosclerotic arterial disease etc.)\n* Co-existing progressive neurodegenerative disease including dementia or Parkinson's disease.\n* Neoplastic condition that is uncontrolled or associated with an increased risk of bleeding\n* Patient already on antiplatelet or anticoagulation agent, regardless of indication\n* Women with a history of menopause below 12 months are only included after negative pregnancy test","ALL","50 Years",{"count":294,"type":295},1652,"ESTIMATED","INTERVENTIONAL",[298],"PHASE3","Magnetic resonance imaging (MRI) is commonly used in healthcare, and sometimes it shows small areas of brain damage called Covert Brain Infarcts (CBIs). These are usually found by chance when people have scans for things like headaches or dizziness. Although CBIs don't cause symptoms at the time, they are linked to a higher risk of future stroke and death.\n\nThere is currently no standard treatment for CBIs, and doctors have different approaches-some give stroke-preventing medication (like antiplatelets or statins), while others don't treat at all. This is mostly because there isn't enough research yet.\n\nThis study will test whether stroke-preventing treatments help people with CBIs. It will also look at whether having a CBI increases the risk of dementia, and whether treatment might lower that risk.",[301],"Covert Brain Infarction",[303,304,305,306],"CBI","Prevention","Asymptomatic brain infarction","Dementia","2025-11-27",{"date":309,"type":310},"2025-12-04","ACTUAL",{"date":312,"type":310},"2025-11-26",{"date":314,"type":295},"2040-01-01",{"name":5,"class":6},14]