[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100387762":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":36,"responsibleParty":51,"collaborators":24,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":56,"sex":62,"minAge":63,"maxAge":24,"enrollmentInfo":64,"targetDuration":24,"studyType":67,"phases":68,"briefSummary":70,"conditions":71,"keywords":73,"overallStatus":38,"whyStopped":24,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"National Cancer Center, Japan","OTHER_GOV",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Chemoradiation therapy with elective nodal irradiation","EXPERIMENTAL","Chemoradiotherapy consists of 5-FU (1,000 mg \u002F m2, day1-4, day29-32), CDDP (75 mg \u002Fm2, day1, 29) and radiotherapy (50.4 Gy\u002F28Fr)",[13],"Radiation: Chemoradiotherapy",{"label":15,"type":16,"description":17,"interventionNames":18},"Chemoradiation therapy with involved field irradiation","ACTIVE_COMPARATOR","Chemoradiotherapy consists of 5-FU (700 mg \u002Fm2, day1-4, day29-32), CDDP (70 mg \u002Fm2, day1,29) and radiotherapy (60 Gy\u002F30Fr)",[13],[20],{"type":21,"name":22,"description":22,"armGroupLabels":23,"otherNames":24},"RADIATION","Chemoradiotherapy",[9,15],null,[26],{"name":27,"affiliation":28,"role":29},"Ken Kato, MD\u002FPhD","National Cancer Center Hospital","STUDY_CHAIR",[31],{"name":32,"role":33,"phone":34,"phoneExt":24,"email":35},"Motoo Nomura, MD\u002FPhD","CONTACT","81335422511","mnomura@kuhp.kyoto-u.ac.jp",[37],{"facility":28,"status":38,"city":39,"state":24,"zip":24,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"RECRUITING","Tokyo","Japan","JP",{"type":43,"coordinates":44},"Point",[45,46],139.69171,35.6895,{"lat":46,"lon":45},[49],{"name":50,"role":33,"phone":24,"phoneExt":24,"email":24},"Ken Kato, M.D.\u002FPh.D",{"type":52,"investigatorFullName":53,"investigatorTitle":28,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"PRINCIPAL_INVESTIGATOR","Ken Kato","100387762","phase-3-a-randomized-controlled-trial-evaluating-of-prophylactic-irradiation-in-crt-for-ct1bn0m0-escc-100387762",false,"NCT04328948","A Randomized Controlled Trial Evaluating of Prophylactic Irradiation in CRT for cT1bN0M0 ESCC","A Randomized Controlled Phase III Trial of Comparing Local Field With Additional Prophylactic Irradiation in Chemoradiotherapy for Clinical-T1bN0M0 Esophageal Cancer","ARMADILLO","Inclusion criteria:\n\n1. Histologically proven squamous cell carcinoma, adenosquamous carcinoma, or basaloid cell carcinoma.\n2. All lesions located in the thoracic esophagus. Secondary lesions with an absolute indication for endoscopic resection (EMR\u002FESD) may not be confined to the thoracic esophagus.\n3. Clinical N0M0 with cervical to abdominal contrast-enhanced CT.\n4. The deepest lesion is diagnosed as cT1b (SM1 \u002F SM2 \u002F SM3) with upper gastrointestinal endoscopy. If it is difficult to differentiate cT1a-MM and cT1b-SM1 clinically, the wall depth is diagnosed as cT1b-SM1.\n5. Aged 20 years and older.\n6. ECOG Performance status 0 or 1.\n7. No previous therapy against esophageal cancer except for complete resection by EMR\u002FESD with either pT1a-LPM (pM2) \u002F pT1a-MM (M3) disease or pT1a-MM (M3) disease without vascular infiltration.\n8. No history of radiotherapy for the neck, chest, and upper abdomen for any cancers. No chemotherapy or hormone therapy with less than 3 years of disease-free interval for any cancers.\n9. Major organ function is preserved. 1) WBC\\\u003C=12,000\u002Fmm3 2) ANC\\>=1,500\u002Fmm3 3) Hb\\>=10.0 g \u002FdL 4) PLT\\>=10,000\u002Fmm3 5) T-bil\\\u003C=1.5 mg \u002FdL 6) AST\\\u003C=100 IU\u002FL 7) ALT\\\u003C=100 IU\u002FL 8) SpO2\\>=95% 9) Ccr\\>=60 mL\u002Fmin\n10. Patients do not have a preference to receive a surgical resection as an initial therapy after receiving explanations.\n11. Written informed consent is obtained.\n\nExclusion criteria:\n\n1. Simultaneous or metachronous (within 5 years) double cancers, except for intramucosal tumor curable with local therapy.\n2. Active infection requiring systemic therapy.\n3. Fever over 38 degrees Celsius\n4. Female during pregnancy, within 28 days of post parturition, or during lactation. Male who wants a partner's pregnancy.\n5. Psychological disorder, which is difficult to participate in this clinical study.\n6. Receiving continuous systemic corticosteroid or immunosuppressant treatment.\n7. Positive for HBs antigen or HIV antigen.\n8. Diabetes mellitus, which is uncontrollable with continuous use of insulin or hypoglycemic agents.\n9. Uncontrolled arterial hypertension.\n10. History of unstable angina pectoris within three weeks or myocardial infarction within six months before registration.\n11. Uncontrolled valvular disease, dilated cardiomyopathy, and hypertrophic cardiomyopathy.\n12. Severe emphysema, interstitial pneumonia or pulmonary fibrosis based on chest CT.\n13. With a history of cerebrovascular disorder within 6 months.\n14. Drug allergy for iodic drugs.","ALL","20 Years",{"count":65,"type":66},280,"ESTIMATED","INTERVENTIONAL",[69],"PHASE3","This study is conducted to investigate whether modified chemoradiotherapy with elective nodal irradiation reduces the locoregional recurrence that cannot be completely resected by salvage endoscopic resection and preserve esophagus without compromising overall survival.",[72],"Esophageal Squamous Cell Carcinoma",[74,75,76],"Esophageal squamous cell carcinoma","chemoradiotherapy","Radiation Field","2025-05-19",{"date":79,"type":80},"2025-05-22","ACTUAL",{"date":82,"type":80},"2020-07-01",{"date":84,"type":66},"2030-03-31",{"name":5,"class":6},1]