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Subject must have had adequate trials of at least 2 ASMs, which were given (and tolerated) at adequate therapeutic doses, without achieving sustained seizure freedom.\n* Treatment with a stable dose of 1 to 3 allowable current ASMs for at least one month prior to screening, during baseline, and throughout the duration of the DBP\n* Able to keep accurate seizure diaries\n\nExclusion Criteria:\n\n* Previously documented electroencephalogram which shows any pattern not consistent with focal etiology of seizures.\n* History of focal aware non-motor seizures only, non-epileptic psychogenic seizure, primary generalized seizure, developmental and epileptic encephalopathy, including Lennox-Gastaut syndrome.\n* Seizures secondary to drug or alcohol use, ongoing infection, neoplasia, demyelinating disease, degenerative neurological disease, metabolic illness, progressive structural lesion, encephalopathy, or progressive central nervous system (CNS) disease.\n* History of status epilepticus or repetitive seizures within the 12-month period preceding Visit 1 where the individual seizures cannot be counted.\n* History of neurosurgery for seizures \\\u003C1 year prior to Visit 1, or radiosurgery \\\u003C2 years prior to enrollment.\n* Any medical condition or personal circumstance that, in the opinion of the investigator, exposes the subject to unacceptable risk by participating in the study or prevents adherence to the protocol.","ALL","18 Years",{"count":890,"type":891},360,"ESTIMATED","INTERVENTIONAL",[894],"PHASE3","The X-TOLE3 Phase 3 clinical trial is a randomized, double-blind, placebo-controlled study that will evaluate the clinical efficacy, safety and tolerability of XEN1101 administered as adjunctive therapy in focal-onset seizures.",[897],"Focal Onset Seizures",[899],"Epilepsy","2026-05-12",{"date":902,"type":903},"2026-05-14","ACTUAL",{"date":905,"type":903},"2023-05-09",{"date":907,"type":891},"2026-12",{"name":5,"class":6},95]