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IMED Hospital","Burjassot","Valencia","46100",{"type":61,"coordinates":1826},[1827,1828],-0.41327,39.50984,{"lat":1828,"lon":1827},{"facility":1831,"status":54,"city":1804,"state":40,"zip":1832,"country":1794,"countryCode":1795,"cosmosGeoPoint":1833,"geoPoint":1837,"contacts":40},"Centro de Oftalmologia Barraquer","08021",{"type":61,"coordinates":1834},[1835,1836],2.15899,41.38879,{"lat":1836,"lon":1835},{"facility":1839,"status":54,"city":1804,"state":40,"zip":1840,"country":1794,"countryCode":1795,"cosmosGeoPoint":1841,"geoPoint":1843,"contacts":40},"Instituto de Microcirugia Ocular","08035",{"type":61,"coordinates":1842},[1835,1836],{"lat":1836,"lon":1835},{"facility":1845,"status":54,"city":1804,"state":40,"zip":1846,"country":1794,"countryCode":1795,"cosmosGeoPoint":1847,"geoPoint":1849,"contacts":40},"Institut Catala De Retina S.L.","8022",{"type":61,"coordinates":1848},[1835,1836],{"lat":1836,"lon":1835},{"facility":1851,"status":54,"city":1852,"state":40,"zip":1853,"country":1794,"countryCode":1795,"cosmosGeoPoint":1854,"geoPoint":1858,"contacts":40},"Hospital Universitario Virgen Macarena","Seville","41009",{"type":61,"coordinates":1855},[1856,1857],-5.97317,37.38283,{"lat":1857,"lon":1856},{"facility":1860,"status":54,"city":1823,"state":40,"zip":1861,"country":1794,"countryCode":1795,"cosmosGeoPoint":1862,"geoPoint":1866,"contacts":40},"Fundacion Aiken De La Comunitat Valenciana","46004",{"type":61,"coordinates":1863},[1864,1865],-0.37966,39.47391,{"lat":1865,"lon":1864},{"facility":1868,"status":54,"city":1869,"state":40,"zip":1870,"country":1794,"countryCode":1795,"cosmosGeoPoint":1871,"geoPoint":1875,"contacts":40},"Hospital Clinico Universitario Lozano Blesa. IIS Aragon","Zaragoza","50009",{"type":61,"coordinates":1872},[1873,1874],-0.87734,41.65606,{"lat":1874,"lon":1873},{"facility":1877,"status":54,"city":1869,"state":40,"zip":1870,"country":1794,"countryCode":1795,"cosmosGeoPoint":1878,"geoPoint":1880,"contacts":40},"Miguel Servet University Hospital",{"type":61,"coordinates":1879},[1873,1874],{"lat":1874,"lon":1873},{"facility":1882,"status":54,"city":825,"state":1883,"zip":1884,"country":1885,"countryCode":1886,"cosmosGeoPoint":1887,"geoPoint":1891,"contacts":40},"Liverpool University Hospitals NHS Foundation Trust-Royal Liverpool University Hospital, St Paul's Eye Unit-Ophthalmology","Merseyside","L7 8XP","United Kingdom","UK",{"type":61,"coordinates":1888},[1889,1890],-2.97794,53.41058,{"lat":1890,"lon":1889},{"facility":1893,"status":54,"city":1894,"state":1895,"zip":1896,"country":1885,"countryCode":1886,"cosmosGeoPoint":1897,"geoPoint":1901,"contacts":40},"York and Scarborough Teaching Hospitals NHS Foundation Trust","York","North Yorkshire","YP31 8HE",{"type":61,"coordinates":1898},[1899,1900],-1.08271,53.95763,{"lat":1900,"lon":1899},{"facility":1903,"status":54,"city":1303,"state":40,"zip":1904,"country":1885,"countryCode":1886,"cosmosGeoPoint":1905,"geoPoint":1909,"contacts":40},"University Hospitals Bristol NHS Foundation Trust","BS1 2LX",{"type":61,"coordinates":1906},[1907,1908],-2.59665,51.45523,{"lat":1908,"lon":1907},{"facility":1911,"status":54,"city":1912,"state":40,"zip":1913,"country":1885,"countryCode":1886,"cosmosGeoPoint":1914,"geoPoint":1918,"contacts":40},"Moorfields Eye Hospital NHS Foundation Trust, Moorfields Eye Hospital","London","EC1V 2PD",{"type":61,"coordinates":1915},[1916,1917],-0.12574,51.50853,{"lat":1917,"lon":1916},{"facility":1920,"status":54,"city":1912,"state":40,"zip":1921,"country":1885,"countryCode":1886,"cosmosGeoPoint":1922,"geoPoint":1924,"contacts":40},"Imperial College Healthcare NHS Trust","NW1 5QH",{"type":61,"coordinates":1923},[1916,1917],{"lat":1917,"lon":1916},{"facility":1926,"status":54,"city":1927,"state":40,"zip":1928,"country":1885,"countryCode":1886,"cosmosGeoPoint":1929,"geoPoint":1933,"contacts":40},"The Newcastle Upon Tyne Hospitals NHS Foundation Trust","Newcastle upon Tyne","NE1 4LP",{"type":61,"coordinates":1930},[1931,1932],-1.61396,54.97328,{"lat":1932,"lon":1931},{"type":1935,"investigatorFullName":40,"investigatorTitle":40,"investigatorAffiliation":40,"oldNameTitle":40,"oldOrganization":40},"SPONSOR","100557714","phase-3-a-study-investigating-subcutaneously-administered-pozelimab-in-combination-with-cemdisiran-or-cemdisiran-alone-in-adult-participants-with-geographic-atrophy-100557714",false,"NCT06541704","A Study Investigating Subcutaneously Administered Pozelimab in Combination With Cemdisiran or Cemdisiran Alone in Adult Participants With Geographic Atrophy","A Multicenter, Randomized, Double-Masked, Placebo-Controlled Phase 3 Study of the Efficacy, Safety, and Tolerability of Subcutaneously Administered Pozelimab in Combination With Cemdisiran or Cemdisiran Alone in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration","SIENNA","Key Inclusion Criteria:\n\n1. Study eye with diagnosis of GA of the macula secondary to AMD as described in the protocol\n2. Total GA area in the study eye measuring between ≥2.5 mm\\^2 and ≤17.5 mm\\^2 as described in the protocol\n3. BCVA of 55 letters or better using ETDRS charts (20\u002F80 Snellen equivalent) in the study eye as described in the protocol\n4. Sufficiently clear ocular media, adequate pupillary dilation and fixation to permit quality fundus imaging in the study eye as described in the protocol\n5. Willing and able to comply with clinic visits and study-related procedures, including completion of the full series of meningococcal vaccinations and pneumococcal vaccination required per protocol\n\nKey Exclusion Criteria:\n\n1. GA in either eye due to causes other than AMD, such as Stargardt disease, cone rod dystrophy or toxic maculopathies like hydroxychloroquine maculopathy\n2. History or current evidence of Macular Neovascularization (MNV) and\u002For exudation or Peripapillary Choroidal Neovascularization (PPCNV) in either eye as described in the protocol\n3. Prior or current Intravitreal (IVT) treatment of any kind for any indication in study eye or fellow eye, except approved or investigational IVT complement inhibitor therapy or anti-VEGF therapy, as long as last dose was ≥6 months prior to randomization\n4. Prior intraocular surgery except cataract extraction or minimally invasive glaucoma surgery in study eye as long as date of these procedures was ≥3 months prior to randomization\n5. Comorbid progressive ocular condition (eg, diabetic retinopathy, macular edema, uncontrolled glaucoma, full thickness macular hole) in study eye that could affect central vision and confound study\n6. Any ophthalmologic condition that reduces the clarity of the media and that, in the opinion of the investigator interferes with ophthalmologic examination of the study eye (e.g., advanced cataract or corneal abnormalities) as described in the protocol\n\n   Systemic Exclusion criteria\n7. History or current use of systemic complement inhibitor therapy within 6 months prior to randomization as described in the protocol\n8. History of solid organ or bone marrow transplantation\n9. Use of chronic (\\>14 days) systemic corticosteroids (oral or parenteral, ≥20 mg oral prednisone or equivalent) within the previous 30 days prior to the first screening visit as described in the protocol\n10. Current or prior use of systemic immunosuppressive therapy other than corticosteroids within 12 months prior to randomization or the likelihood of treatment with any such agent during the study inclusive of the screening period as described in the protocol\n11. Not meeting meningococcal or pneumococcal vaccination requirements as described in the protocol\n12. Carrier of Neisseria meningitidis based on culture collected during screening\n13. Has a hemoglobin A1C ≥ 8.0% during screening as described in the protocol\n\nNOTE: Other protocol-defined Inclusion\u002F Exclusion Criteria apply","ALL","50 Years","85 Years",{"count":1948,"type":1949},975,"ESTIMATED","INTERVENTIONAL",[1952],"PHASE3","This study is researching experimental (study) drugs called pozelimab and cemdisiran. The study is focused on participants who have Geographic Atrophy (GA) caused by Age-related Macular Degeneration (AMD). Geographic atrophy is a medical term that refers to later-stage cases of AMD which is an eye condition affecting central vision (what one sees straight ahead).\n\nThe purpose of this study is to evaluate the progression rate of Geographic Atrophy in eyes of patients treated with cemdisiran alone or in combination with pozelimab compared to those treated with placebo.\n\nThe study is looking at several other research questions, including:\n\n* What side effects may happen from taking the study drug(s)\n* How much study drug(s) are in the blood at different times\n* Whether the body makes antibodies against the study drug(s) (which could make the study drug(s) less effective or could lead to side effects)",[1955,1956],"Age-related Macular Degeneration (AMD)","Geographic Atrophy (GA)",[1958],"GA secondary to AMD","2026-06-16",{"date":1961,"type":1962},"2026-06-17","ACTUAL",{"date":1964,"type":1962},"2024-10-30",{"date":1966,"type":1949},"2032-05-21",{"name":5,"class":6},217]