[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100593732":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":33,"centralContacts":34,"locations":40,"responsibleParty":733,"collaborators":33,"id":735,"slug":736,"hasResults":737,"nctId":738,"briefTitle":739,"officialTitle":740,"acronym":741,"eligibilityCriteria":742,"healthyVolunteers":737,"sex":743,"minAge":744,"maxAge":33,"enrollmentInfo":745,"targetDuration":33,"studyType":748,"phases":749,"briefSummary":751,"conditions":752,"keywords":754,"overallStatus":43,"whyStopped":33,"lastUpdateSubmitDate":755,"lastUpdatePostDateStruct":756,"startDateStruct":759,"completionDateStruct":761,"leadSponsor":763,"locationsCount":764},{"fullName":5,"class":6},"Akeso","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Ak112 arm","EXPERIMENTAL","AK112 intravenous \\[IV\\]),every 3 weeks",[13],"Drug: AK112",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo arm","PLACEBO_COMPARATOR","Placebo intravenous \\[IV\\]),every 3 weeks",[19],"Other: Placebo",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","AK112","AK112 20mg\u002Fkg, intravenous \\[IV\\]),Q3W",[9],[27],"Ivonescimab",{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"OTHER","Placebo","Placebo, intravenous \\[IV\\]),Q3W",[15],null,[35],{"name":36,"role":37,"phone":38,"phoneExt":33,"email":39},"Zhifang Yao, M.D.","CONTACT","+86-0760-89873999","clinicaltrials@akesobio.com",[41,60,70,80,89,102,116,130,140,153,166,180,194,208,221,230,243,257,270,284,299,313,323,337,350,363,377,391,405,415,428,442,452,465,479,492,506,520,534,548,558,571,583,599,612,626,640,650,664,677,691,705,719],{"facility":42,"status":43,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Beijing Cancer Hospital","RECRUITING","Beijing","Beijing Municipality","100142","China","CN",{"type":50,"coordinates":51},"Point",[52,53],116.39723,39.9075,{"lat":53,"lon":52},[56,58],{"name":57,"role":37,"phone":33,"phoneExt":33,"email":33},"Rong Yu, M.D.",{"name":57,"role":59,"phone":33,"phoneExt":33,"email":33},"PRINCIPAL_INVESTIGATOR",{"facility":61,"status":43,"city":44,"state":45,"zip":62,"country":47,"countryCode":48,"cosmosGeoPoint":63,"geoPoint":65,"contacts":66},"The First Medical Center of Chinese PLA General Hospital","100853",{"type":50,"coordinates":64},[52,53],{"lat":53,"lon":52},[67,69],{"name":68,"role":37,"phone":33,"phoneExt":33,"email":33},"Yi Hu, M.D.",{"name":68,"role":59,"phone":33,"phoneExt":33,"email":33},{"facility":71,"status":43,"city":44,"state":45,"zip":72,"country":47,"countryCode":48,"cosmosGeoPoint":73,"geoPoint":75,"contacts":76},"Beijing Chest Hospital","101149",{"type":50,"coordinates":74},[52,53],{"lat":53,"lon":52},[77,79],{"name":78,"role":37,"phone":33,"phoneExt":33,"email":33},"Gen Lin, M.D.",{"name":78,"role":59,"phone":33,"phoneExt":33,"email":33},{"facility":81,"status":43,"city":44,"state":45,"zip":72,"country":47,"countryCode":48,"cosmosGeoPoint":82,"geoPoint":84,"contacts":85},"Beijing Luhe Hospital, Capital Medical University",{"type":50,"coordinates":83},[52,53],{"lat":53,"lon":52},[86,88],{"name":87,"role":37,"phone":33,"phoneExt":33,"email":33},"Dong Yan, M.D.",{"name":87,"role":59,"phone":33,"phoneExt":33,"email":33},{"facility":90,"status":43,"city":91,"state":91,"zip":92,"country":47,"countryCode":48,"cosmosGeoPoint":93,"geoPoint":97,"contacts":98},"Cancer Hospital, Chinese Academy of Medical Sciences","Beijin","100021",{"type":50,"coordinates":94},[95,96],111.40836,35.93305,{"lat":96,"lon":95},[99,101],{"name":100,"role":37,"phone":33,"phoneExt":33,"email":33},"Zhijie Wang, M.D.",{"name":100,"role":59,"phone":33,"phoneExt":33,"email":33},{"facility":103,"status":43,"city":104,"state":105,"zip":106,"country":47,"countryCode":48,"cosmosGeoPoint":107,"geoPoint":111,"contacts":112},"The First Affiliated Hospital of Chongqing Medical University","Chongqing","Chongqing Municipality","400016",{"type":50,"coordinates":108},[109,110],106.55771,29.56026,{"lat":110,"lon":109},[113,115],{"name":114,"role":37,"phone":33,"phoneExt":33,"email":33},"Ge Luo, M.D.",{"name":114,"role":59,"phone":33,"phoneExt":33,"email":33},{"facility":117,"status":43,"city":118,"state":119,"zip":120,"country":47,"countryCode":48,"cosmosGeoPoint":121,"geoPoint":125,"contacts":126},"Fujian Cancer Hospital","Fuzhou","Fujian","350014",{"type":50,"coordinates":122},[123,124],119.30611,26.06139,{"lat":124,"lon":123},[127,129],{"name":128,"role":37,"phone":33,"phoneExt":33,"email":33},"Haipeng Xu, M.D.",{"name":128,"role":59,"phone":33,"phoneExt":33,"email":33},{"facility":131,"status":43,"city":118,"state":119,"zip":132,"country":47,"countryCode":48,"cosmosGeoPoint":133,"geoPoint":135,"contacts":136},"PLA No. 900 Hospital of the Joint Support Force","350025",{"type":50,"coordinates":134},[123,124],{"lat":124,"lon":123},[137,139],{"name":138,"role":37,"phone":33,"phoneExt":33,"email":33},"Zongyang Yu, M.D.",{"name":138,"role":59,"phone":33,"phoneExt":33,"email":33},{"facility":141,"status":43,"city":142,"state":119,"zip":143,"country":47,"countryCode":48,"cosmosGeoPoint":144,"geoPoint":148,"contacts":149},"Longyan First Hospital","Longyan","364000",{"type":50,"coordinates":145},[146,147],117.01775,25.07485,{"lat":147,"lon":146},[150,152],{"name":151,"role":37,"phone":33,"phoneExt":33,"email":33},"Chunyue Wang, M.D.",{"name":151,"role":59,"phone":33,"phoneExt":33,"email":33},{"facility":154,"status":43,"city":155,"state":119,"zip":156,"country":47,"countryCode":48,"cosmosGeoPoint":157,"geoPoint":161,"contacts":162},"Zhangzhou Municipal Hospital of Fujian Province","Zhangzhou","363000",{"type":50,"coordinates":158},[159,160],117.65556,24.51333,{"lat":160,"lon":159},[163,165],{"name":164,"role":37,"phone":33,"phoneExt":33,"email":33},"Li Lin, M.D.",{"name":164,"role":59,"phone":33,"phoneExt":33,"email":33},{"facility":167,"status":43,"city":168,"state":169,"zip":170,"country":47,"countryCode":48,"cosmosGeoPoint":171,"geoPoint":175,"contacts":176},"Gansu Provincial Cancer Hospital","Lanzhou","Gansu","730050",{"type":50,"coordinates":172},[173,174],103.83987,36.05701,{"lat":174,"lon":173},[177,179],{"name":178,"role":37,"phone":33,"phoneExt":33,"email":33},"Shihong Wei, M.D.",{"name":178,"role":59,"phone":33,"phoneExt":33,"email":33},{"facility":181,"status":43,"city":182,"state":183,"zip":184,"country":47,"countryCode":48,"cosmosGeoPoint":185,"geoPoint":189,"contacts":190},"Jiangmen Central Hospital","Jiangmen","Guangdong","529030",{"type":50,"coordinates":186},[187,188],113.08333,22.58333,{"lat":188,"lon":187},[191,193],{"name":192,"role":37,"phone":33,"phoneExt":33,"email":33},"Gengsheng Yu, M.D.",{"name":192,"role":59,"phone":33,"phoneExt":33,"email":33},{"facility":195,"status":43,"city":196,"state":197,"zip":198,"country":47,"countryCode":48,"cosmosGeoPoint":199,"geoPoint":203,"contacts":204},"Liuzhou People's Hospital","Liuzhou","Guangxi","545006",{"type":50,"coordinates":200},[201,202],109.40698,24.32405,{"lat":202,"lon":201},[205,207],{"name":206,"role":37,"phone":33,"phoneExt":33,"email":33},"Leili Wang, M.D.",{"name":206,"role":59,"phone":33,"phoneExt":33,"email":33},{"facility":209,"status":43,"city":210,"state":197,"zip":211,"country":47,"countryCode":48,"cosmosGeoPoint":212,"geoPoint":216,"contacts":217},"Affiliated Cancer Hospital of Guangxi Medical University","Nanning","530021",{"type":50,"coordinates":213},[214,215],108.31667,22.81667,{"lat":215,"lon":214},[218,220],{"name":219,"role":37,"phone":33,"phoneExt":33,"email":33},"Jiangqiong Huang, M.D.",{"name":219,"role":59,"phone":33,"phoneExt":33,"email":33},{"facility":222,"status":43,"city":210,"state":197,"zip":211,"country":47,"countryCode":48,"cosmosGeoPoint":223,"geoPoint":225,"contacts":226},"The First Affiliated Hospital of Guangxi Medical University",{"type":50,"coordinates":224},[214,215],{"lat":215,"lon":214},[227,229],{"name":228,"role":37,"phone":33,"phoneExt":33,"email":33},"Qing Bu, M.D.",{"name":228,"role":59,"phone":33,"phoneExt":33,"email":33},{"facility":231,"status":43,"city":232,"state":232,"zip":233,"country":47,"countryCode":48,"cosmosGeoPoint":234,"geoPoint":238,"contacts":239},"Guangdong Provincial People's Hospital","Guangzhou","510080",{"type":50,"coordinates":235},[236,237],113.25,23.11667,{"lat":237,"lon":236},[240,242],{"name":241,"role":37,"phone":33,"phoneExt":33,"email":33},"Jing Li, M.D.",{"name":241,"role":59,"phone":33,"phoneExt":33,"email":33},{"facility":244,"status":43,"city":245,"state":246,"zip":247,"country":47,"countryCode":48,"cosmosGeoPoint":248,"geoPoint":252,"contacts":253},"Guizhou Provincial People's Hospital","Guiyang","Guizhou","400042",{"type":50,"coordinates":249},[250,251],106.71667,26.58333,{"lat":251,"lon":250},[254,256],{"name":255,"role":37,"phone":33,"phoneExt":33,"email":33},"Yu Zhang, M.D.",{"name":255,"role":59,"phone":33,"phoneExt":33,"email":33},{"facility":258,"status":43,"city":259,"state":246,"zip":260,"country":47,"countryCode":48,"cosmosGeoPoint":261,"geoPoint":265,"contacts":266},"The Second Affiliated Hospital of Zunyi Medical University","Zunyi","563000",{"type":50,"coordinates":262},[263,264],106.90722,27.68667,{"lat":264,"lon":263},[267,269],{"name":268,"role":37,"phone":33,"phoneExt":33,"email":33},"Shiyun Xing, M.D.",{"name":268,"role":59,"phone":33,"phoneExt":33,"email":33},{"facility":271,"status":43,"city":272,"state":273,"zip":274,"country":47,"countryCode":48,"cosmosGeoPoint":275,"geoPoint":279,"contacts":280},"The Fourth Hospital of Hebei Medical University","Shijiazhuang","Hebei","050011",{"type":50,"coordinates":276},[277,278],114.47861,38.04139,{"lat":278,"lon":277},[281,283],{"name":282,"role":37,"phone":33,"phoneExt":33,"email":33},"Jun Wang, M.D.",{"name":282,"role":59,"phone":33,"phoneExt":33,"email":33},{"facility":285,"status":43,"city":286,"state":273,"zip":287,"country":47,"countryCode":48,"cosmosGeoPoint":288,"geoPoint":292,"contacts":293},"Tangshan People's Hospital","Tangshan","063001",{"type":50,"coordinates":289},[290,291],118.18319,39.64381,{"lat":291,"lon":290},[294,296,297],{"name":295,"role":37,"phone":33,"phoneExt":33,"email":33},"Zhiwu Wang, M.D.",{"name":295,"role":59,"phone":33,"phoneExt":33,"email":33},{"name":298,"role":59,"phone":33,"phoneExt":33,"email":33},"Guilan Dong, M.D.",{"facility":300,"status":43,"city":301,"state":302,"zip":303,"country":47,"countryCode":48,"cosmosGeoPoint":304,"geoPoint":308,"contacts":309},"Harbin Medical University Cancer Hospital","Harbin","Heilongjiang","150081",{"type":50,"coordinates":305},[306,307],126.65,45.75,{"lat":307,"lon":306},[310,312],{"name":311,"role":37,"phone":33,"phoneExt":33,"email":33},"Yan Yu, M.D.",{"name":311,"role":59,"phone":33,"phoneExt":33,"email":33},{"facility":314,"status":43,"city":301,"state":302,"zip":315,"country":47,"countryCode":48,"cosmosGeoPoint":316,"geoPoint":318,"contacts":319},"The Second Affiliated Hospital of Harbin Medical University","150086",{"type":50,"coordinates":317},[306,307],{"lat":307,"lon":306},[320,322],{"name":321,"role":37,"phone":33,"phoneExt":33,"email":33},"Yu Yang, M.D.",{"name":321,"role":59,"phone":33,"phoneExt":33,"email":33},{"facility":324,"status":43,"city":325,"state":326,"zip":327,"country":47,"countryCode":48,"cosmosGeoPoint":328,"geoPoint":332,"contacts":333},"Anyang Cancer Hospital","Anyang","Henan","455000",{"type":50,"coordinates":329},[330,331],114.38278,36.096,{"lat":331,"lon":330},[334,336],{"name":335,"role":37,"phone":33,"phoneExt":33,"email":33},"Anping Zheng, M.D.",{"name":335,"role":59,"phone":33,"phoneExt":33,"email":33},{"facility":338,"status":43,"city":339,"state":326,"zip":340,"country":47,"countryCode":48,"cosmosGeoPoint":341,"geoPoint":345,"contacts":346},"The First Affiliated Hospital of Xinxiang Medical University","Xinxiang","453100",{"type":50,"coordinates":342},[343,344],113.80151,35.19033,{"lat":344,"lon":343},[347,349],{"name":348,"role":37,"phone":33,"phoneExt":33,"email":33},"Qingqin Zhang, M.D.",{"name":348,"role":59,"phone":33,"phoneExt":33,"email":33},{"facility":351,"status":43,"city":352,"state":326,"zip":353,"country":47,"countryCode":48,"cosmosGeoPoint":354,"geoPoint":358,"contacts":359},"Henan Cancer Hospital","Zhengzhou","450008",{"type":50,"coordinates":355},[356,357],113.64861,34.75778,{"lat":357,"lon":356},[360,362],{"name":361,"role":37,"phone":33,"phoneExt":33,"email":33},"Yanqiu Zhao, M.D.",{"name":361,"role":59,"phone":33,"phoneExt":33,"email":33},{"facility":364,"status":43,"city":365,"state":366,"zip":367,"country":47,"countryCode":48,"cosmosGeoPoint":368,"geoPoint":372,"contacts":373},"Jingzhou First People's Hospital","Jingzhou","Hubei","434000",{"type":50,"coordinates":369},[370,371],112.19028,30.35028,{"lat":371,"lon":370},[374,376],{"name":375,"role":37,"phone":33,"phoneExt":33,"email":33},"Yonghua Yang, M.D.",{"name":375,"role":59,"phone":33,"phoneExt":33,"email":33},{"facility":378,"status":379,"city":380,"state":366,"zip":381,"country":47,"countryCode":48,"cosmosGeoPoint":382,"geoPoint":386,"contacts":387},"Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","NOT_YET_RECRUITING","Wuhan","430022",{"type":50,"coordinates":383},[384,385],114.26667,30.58333,{"lat":385,"lon":384},[388,390],{"name":389,"role":37,"phone":33,"phoneExt":33,"email":33},"Xiaorong Dong, M.D.",{"name":389,"role":59,"phone":33,"phoneExt":33,"email":33},{"facility":392,"status":43,"city":393,"state":394,"zip":395,"country":47,"countryCode":48,"cosmosGeoPoint":396,"geoPoint":400,"contacts":401},"Hunan Cancer Hospital","Changsha","Hunan","410013",{"type":50,"coordinates":397},[398,399],112.97087,28.19874,{"lat":399,"lon":398},[402,404],{"name":403,"role":37,"phone":33,"phoneExt":33,"email":33},"Yongzhong Luo, M.D.",{"name":403,"role":59,"phone":33,"phoneExt":33,"email":33},{"facility":392,"status":43,"city":393,"state":394,"zip":395,"country":47,"countryCode":48,"cosmosGeoPoint":406,"geoPoint":408,"contacts":409},{"type":50,"coordinates":407},[398,399],{"lat":399,"lon":398},[410,412,413],{"name":411,"role":37,"phone":33,"phoneExt":33,"email":33},"Lin Wu, M.D.",{"name":411,"role":59,"phone":33,"phoneExt":33,"email":33},{"name":414,"role":59,"phone":33,"phoneExt":33,"email":33},"Huai Liu, M.D.",{"facility":416,"status":43,"city":417,"state":394,"zip":418,"country":47,"countryCode":48,"cosmosGeoPoint":419,"geoPoint":423,"contacts":424},"The First Affiliated Hospital of South China University","Hengyang","421001",{"type":50,"coordinates":420},[421,422],112.61888,26.88946,{"lat":422,"lon":421},[425,427],{"name":426,"role":37,"phone":33,"phoneExt":33,"email":33},"Yuehua Li, M.D.",{"name":426,"role":59,"phone":33,"phoneExt":33,"email":33},{"facility":429,"status":43,"city":430,"state":431,"zip":432,"country":47,"countryCode":48,"cosmosGeoPoint":433,"geoPoint":437,"contacts":438},"General Hospital of the PLA Eastern Theater Command","Nanjing","Jiangsu","210002",{"type":50,"coordinates":434},[435,436],118.77778,32.06167,{"lat":436,"lon":435},[439,441],{"name":440,"role":37,"phone":33,"phoneExt":33,"email":33},"Xiangfeng Lv, M.D.",{"name":440,"role":59,"phone":33,"phoneExt":33,"email":33},{"facility":443,"status":43,"city":430,"state":431,"zip":444,"country":47,"countryCode":48,"cosmosGeoPoint":445,"geoPoint":447,"contacts":448},"Jiangsu Cancer Hospital","210009",{"type":50,"coordinates":446},[435,436],{"lat":436,"lon":435},[449,451],{"name":450,"role":37,"phone":33,"phoneExt":33,"email":33},"Lin Shi, M.D.",{"name":450,"role":59,"phone":33,"phoneExt":33,"email":33},{"facility":453,"status":43,"city":454,"state":431,"zip":455,"country":47,"countryCode":48,"cosmosGeoPoint":456,"geoPoint":460,"contacts":461},"Xuzhou Municipal Hospital","Xuzhou","221002",{"type":50,"coordinates":457},[458,459],117.28386,34.20442,{"lat":459,"lon":458},[462,464],{"name":463,"role":37,"phone":33,"phoneExt":33,"email":33},"Haitao Yin, M.D.",{"name":463,"role":59,"phone":33,"phoneExt":33,"email":33},{"facility":466,"status":43,"city":467,"state":468,"zip":469,"country":47,"countryCode":48,"cosmosGeoPoint":470,"geoPoint":474,"contacts":475},"The First Affiliated Hospital of Gannan Medical University","Gannan","Jiangxi","341000",{"type":50,"coordinates":471},[472,473],114.99776,26.78132,{"lat":473,"lon":472},[476,478],{"name":477,"role":37,"phone":33,"phoneExt":33,"email":33},"Jie Li, M.D.",{"name":477,"role":59,"phone":33,"phoneExt":33,"email":33},{"facility":480,"status":43,"city":481,"state":468,"zip":482,"country":47,"countryCode":48,"cosmosGeoPoint":483,"geoPoint":487,"contacts":488},"The First Affiliated Hospital of Nanchang University","Nanchang","330006",{"type":50,"coordinates":484},[485,486],115.85306,28.68396,{"lat":486,"lon":485},[489,491],{"name":490,"role":37,"phone":33,"phoneExt":33,"email":33},"Longhua Sun, M.D.",{"name":490,"role":59,"phone":33,"phoneExt":33,"email":33},{"facility":493,"status":43,"city":494,"state":495,"zip":496,"country":47,"countryCode":48,"cosmosGeoPoint":497,"geoPoint":501,"contacts":502},"Jilin Cancer Hospital","Changchun","Jilin","130000",{"type":50,"coordinates":498},[499,500],125.32278,43.88,{"lat":500,"lon":499},[503,505],{"name":504,"role":37,"phone":33,"phoneExt":33,"email":33},"Haifeng Liu, M.D.",{"name":504,"role":59,"phone":33,"phoneExt":33,"email":33},{"facility":507,"status":43,"city":508,"state":509,"zip":510,"country":47,"countryCode":48,"cosmosGeoPoint":511,"geoPoint":515,"contacts":516},"The First Hospital of China Medical University","Shenyang","Liaoning","110001",{"type":50,"coordinates":512},[513,514],123.43278,41.79222,{"lat":514,"lon":513},[517,519],{"name":518,"role":37,"phone":33,"phoneExt":33,"email":33},"Bo Jin, M.D.",{"name":518,"role":59,"phone":33,"phoneExt":33,"email":33},{"facility":521,"status":43,"city":522,"state":523,"zip":524,"country":47,"countryCode":48,"cosmosGeoPoint":525,"geoPoint":529,"contacts":530},"Ningxia Medical University General Hospital","Yinchuan","Ningxia","750004",{"type":50,"coordinates":526},[527,528],106.27306,38.46806,{"lat":528,"lon":527},[531,533],{"name":532,"role":37,"phone":33,"phoneExt":33,"email":33},"Yanyang Wang, M.D.",{"name":532,"role":59,"phone":33,"phoneExt":33,"email":33},{"facility":535,"status":43,"city":536,"state":537,"zip":538,"country":47,"countryCode":48,"cosmosGeoPoint":539,"geoPoint":543,"contacts":544},"Shandong Provincial Hospital","Jinan","Shandong","250021",{"type":50,"coordinates":540},[541,542],116.99722,36.66833,{"lat":542,"lon":541},[545,547],{"name":546,"role":37,"phone":33,"phoneExt":33,"email":33},"Zhe Yang, M.D.",{"name":546,"role":59,"phone":33,"phoneExt":33,"email":33},{"facility":549,"status":43,"city":536,"state":537,"zip":550,"country":47,"countryCode":48,"cosmosGeoPoint":551,"geoPoint":553,"contacts":554},"Shandong Cancer Hospital","250117",{"type":50,"coordinates":552},[541,542],{"lat":542,"lon":541},[555,557],{"name":556,"role":37,"phone":33,"phoneExt":33,"email":33},"Hui Zhu, M.D.",{"name":556,"role":59,"phone":33,"phoneExt":33,"email":33},{"facility":559,"status":43,"city":560,"state":537,"zip":561,"country":47,"countryCode":48,"cosmosGeoPoint":562,"geoPoint":566,"contacts":567},"Linyi Cancer Hospital","Linyi","276000",{"type":50,"coordinates":563},[564,565],118.34278,35.06306,{"lat":565,"lon":564},[568,570],{"name":569,"role":37,"phone":33,"phoneExt":33,"email":33},"Jianhua Shi, M.D.",{"name":569,"role":59,"phone":33,"phoneExt":33,"email":33},{"facility":572,"status":43,"city":560,"state":537,"zip":561,"country":47,"countryCode":48,"cosmosGeoPoint":573,"geoPoint":575,"contacts":576},"Linyi People's Hospital",{"type":50,"coordinates":574},[564,565],{"lat":565,"lon":564},[577,579,582],{"name":578,"role":37,"phone":33,"phoneExt":33,"email":33},"Zhongmin Zhang, M.D.",{"name":580,"role":581,"phone":33,"phoneExt":33,"email":33},"Xueliang Xu, M.D.","SUB_INVESTIGATOR",{"name":578,"role":59,"phone":33,"phoneExt":33,"email":33},{"facility":584,"status":43,"city":585,"state":537,"zip":586,"country":47,"countryCode":48,"cosmosGeoPoint":587,"geoPoint":591,"contacts":592},"Qingdao Central Hospital of Health and Rehabilitation Sciences University","Qingdao","266000",{"type":50,"coordinates":588},[589,590],120.38042,36.06488,{"lat":590,"lon":589},[593,595,597,598],{"name":594,"role":37,"phone":33,"phoneExt":33,"email":33},"Zhen Zhang, M.D.",{"name":596,"role":37,"phone":33,"phoneExt":33,"email":33},"Xiaotao Zhang, M.D.",{"name":594,"role":59,"phone":33,"phoneExt":33,"email":33},{"name":596,"role":59,"phone":33,"phoneExt":33,"email":33},{"facility":600,"status":43,"city":601,"state":537,"zip":602,"country":47,"countryCode":48,"cosmosGeoPoint":603,"geoPoint":607,"contacts":608},"Zaozhuang Municipal Hospital","Zaozhuang","277100",{"type":50,"coordinates":604},[605,606],117.55417,34.86472,{"lat":606,"lon":605},[609,611],{"name":610,"role":37,"phone":33,"phoneExt":33,"email":33},"Shifeng Kan, M.D.",{"name":610,"role":59,"phone":33,"phoneExt":33,"email":33},{"facility":613,"status":43,"city":614,"state":615,"zip":616,"country":47,"countryCode":48,"cosmosGeoPoint":617,"geoPoint":621,"contacts":622},"Weifang No.2 People's Hospital","Weifang","Shangdong","261041",{"type":50,"coordinates":618},[619,620],119.10194,36.71,{"lat":620,"lon":619},[623,625],{"name":624,"role":37,"phone":33,"phoneExt":33,"email":33},"Kunning Yang, M.D.",{"name":624,"role":59,"phone":33,"phoneExt":33,"email":33},{"facility":627,"status":43,"city":628,"state":629,"zip":630,"country":47,"countryCode":48,"cosmosGeoPoint":631,"geoPoint":635,"contacts":636},"Fudan University Shanghai Cancer Center","Shanghai","Shanghai Municipality","200032",{"type":50,"coordinates":632},[633,634],121.45806,31.22222,{"lat":634,"lon":633},[637,639],{"name":638,"role":37,"phone":33,"phoneExt":33,"email":33},"Zhengfei Zhu, M.D.",{"name":638,"role":59,"phone":33,"phoneExt":33,"email":33},{"facility":641,"status":43,"city":628,"state":629,"zip":642,"country":47,"countryCode":48,"cosmosGeoPoint":643,"geoPoint":645,"contacts":646},"Shanghai Pulmonary Hospital","200433",{"type":50,"coordinates":644},[633,634],{"lat":634,"lon":633},[647,649],{"name":648,"role":37,"phone":33,"phoneExt":33,"email":33},"Fengying Wu, M.D.",{"name":648,"role":59,"phone":33,"phoneExt":33,"email":33},{"facility":651,"status":43,"city":652,"state":653,"zip":654,"country":47,"countryCode":48,"cosmosGeoPoint":655,"geoPoint":659,"contacts":660},"Shanxi Cancer Hospital","Taiyuan","Shanxi","300013",{"type":50,"coordinates":656},[657,658],112.56028,37.86944,{"lat":658,"lon":657},[661,663],{"name":662,"role":37,"phone":33,"phoneExt":33,"email":33},"Hongwei Li, M.D.",{"name":662,"role":59,"phone":33,"phoneExt":33,"email":33},{"facility":665,"status":43,"city":666,"state":653,"zip":667,"country":47,"countryCode":48,"cosmosGeoPoint":668,"geoPoint":672,"contacts":673},"Tangdu Hospital, The Fourth Military Medical University","Xi’an","710038",{"type":50,"coordinates":669},[670,671],113.52486,35.99785,{"lat":671,"lon":670},[674,676],{"name":675,"role":37,"phone":33,"phoneExt":33,"email":33},"Xiaolong Yan, M.D.",{"name":675,"role":59,"phone":33,"phoneExt":33,"email":33},{"facility":678,"status":43,"city":679,"state":680,"zip":681,"country":47,"countryCode":48,"cosmosGeoPoint":682,"geoPoint":686,"contacts":687},"Mianyang Central Hospital","Mianyang","Sichuan","621000",{"type":50,"coordinates":683},[684,685],104.68168,31.46784,{"lat":685,"lon":684},[688,690],{"name":689,"role":37,"phone":33,"phoneExt":33,"email":33},"Xiaobo Du, M.D.",{"name":689,"role":59,"phone":33,"phoneExt":33,"email":33},{"facility":692,"status":43,"city":693,"state":694,"zip":695,"country":47,"countryCode":48,"cosmosGeoPoint":696,"geoPoint":700,"contacts":701},"Tianjin Cancer Hospital","Tianjin","Tianjin Municipality","300060",{"type":50,"coordinates":697},[698,699],117.17667,39.14222,{"lat":699,"lon":698},[702,704],{"name":703,"role":37,"phone":33,"phoneExt":33,"email":33},"Dingzhi Huang, M.D.",{"name":703,"role":59,"phone":33,"phoneExt":33,"email":33},{"facility":706,"status":43,"city":707,"state":708,"zip":709,"country":47,"countryCode":48,"cosmosGeoPoint":710,"geoPoint":714,"contacts":715},"The First Affiliated Hospital of Xi'an Jiaotong University","Shaxi","Xi'an","710061",{"type":50,"coordinates":711},[712,713],106.503,28.2158,{"lat":713,"lon":712},[716,718],{"name":717,"role":37,"phone":33,"phoneExt":33,"email":33},"Yu Yao, M.D.",{"name":717,"role":59,"phone":33,"phoneExt":33,"email":33},{"facility":720,"status":43,"city":721,"state":722,"zip":723,"country":47,"countryCode":48,"cosmosGeoPoint":724,"geoPoint":728,"contacts":729},"The First Affiliated Hospital of Wenzhou Medical University","Wenzhou","Zhejiang","325000",{"type":50,"coordinates":725},[726,727],120.66682,27.99942,{"lat":727,"lon":726},[730,732],{"name":731,"role":37,"phone":33,"phoneExt":33,"email":33},"Yuping Li, M.D.",{"name":731,"role":59,"phone":33,"phoneExt":33,"email":33},{"type":734,"investigatorFullName":33,"investigatorTitle":33,"investigatorAffiliation":33,"oldNameTitle":33,"oldOrganization":33},"SPONSOR","100593732","phase-3-a-study-of-ak112-as-consolidation-treatment-for-patients-with-limited-stage-small-cell-lung-cancer-who-have-not-progressed-following-concurrent-chemoradiation-therapy-100593732",false,"NCT07010263","A Study of AK112 as Consolidation Treatment for Patients With Limited Stage Small-cell Lung Cancer Who Have Not Progressed Following Concurrent Chemoradiation Therapy","A Multicenter, Randomized, Double-blind, Phase III Clinical Study of Comparing the Efficacy and Safety of AK112 (PD-1\u002FVEGF Bispecific Antibody) Versus Placebo as Consolidation Treatment for Patients With Limited Stage Small-Cell Lung Cancer Who Have Not Progressed Following Concurrent Chemoradiation Therapy","AK112-311","Inclusion Criteria:\n\nInclusion Criteria:\n\n1. The subjects voluntarily participated in the study with full informed consent and signed written informed consent form.\n2. Aged ≥18 years on day fo signing the informed consent.\n3. Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.\n4. Life expectancy ≥ 3 months\n5. Histologically or cytologically confirmed small cell lung cancer.\n6. Documented limited-stage SCLC (Stage I-III SCLC \\[T any, N any, M0\\] according to the American Joint Committee on Cancer Staging Manual \\[AJCC Cancer Staging Manual, 8th Edition\\] or the Veterans Administration Lung Study Group (VALG) stage.\n7. Have Received concurrent chemoradiotherapy regimen as defined in protocol and have not progressed following concurrent chemoradiotherapy.\n8. Adequate organ function.\n9. Women of childbearing potential must have a negative serum pregnancy test within 7 days prior to the first dose and agree to take effective contraception measures during the study drug administration and within 120 days after the last dose.\n\nExclusion Criteria:\n\n1. Histologically or cytological confirmed the presence of mixed small cell lung cancer or non-small cell lung cancer components.\n2. Toxicities from previous anti-tumor treatments have not resolved to grade 0 or 1 based on the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE v5.0), or to the levels specified in inclusion\u002Fexclusion criteria, except for alopecia.\n3. Symptoms or signs of primary disease deterioration that the investigator judges clinically unacceptable, such as cachexia.\n4. Presence of pleural effusion, pericardial effusion, or ascites, which was clinically symptomatic or requiring frequent drainage.\n5. History of active malignant tumors within the previous 5 years.\n6. Received major surgery within 28 days prior to the first dose of study drug, or expected to undergo major surgery during the study period within 28 days after the first dose of study drug.\n7. Uncontrolled comorbidities, including but not limited to decompensated cirrhosis, nephrotic syndrome, uncontrolled metabolic disorders, severe active peptic ulcer disease or gastritis, and other related diseases..\n8. Have serious neurological or mental illnesses, including dementia and epileptic seizures.\n9. Pregnant or lactating women.\n10. Have cardiovascular or cerebrovascular diseases or risk factors.\n11. Prior treatments with systemic non-specific immunomodulatory therapy (such as interleukin, interferon, thymosin, etc.) within 2 weeks before the first administration of the study drugs. Prior treatment with Chinese herbal medicine or traditional Chinese patent medicines with anti-tumor indications within 1 weeks before the first administration of the study drugs.\n12. Prior treatments targeting immune mechanisms, including, but not limited to, immune checkpoint inhibitors, immune checkpoint agonists, immune cell therapy.\n13. Prior treatments with anti-angiogenic therapy.\n14. Subjects requiring systemic treatment with corticosteroids (\\>10mg\u002Fday prednisone or equivalent dose) or other immunosuppressive drugs within 14 days prior to the first dose of study drug.\n15. Known history of severe hypersensitivity reactions to other monoclonal antibodies or with a known history of allergy or hypersensitivity reactions to any of study drugs or their components.\n16. Active autoimmune diseases that require systemic treatment within 2 years prior to the study, or autoimmune diseases that the investigator judges to be potentially recurrent or require planned treatment.\n17. Known interstitial lung disease or non infectious pneumonia, which currently has symptoms or requires systemic corticosteroid treatment in the past,or investigator juges may affect the toxicity assessment or management related to the study treatment.\n18. Known severe infection within 4 weeks prior to the first dose of study drug. Known active tuberculosis. Known active syphilis infection. Known history of immunodeficiency or positive HIV test results.\n19. .Known history of allogeneic organ transplantation and allogeneic hematopoietic stem cell transplantation.\n20. Active hepatitis B or active hepatitis C.\n21. Received a live vaccine within 30 days prior to the first dose of study drug, or planning to receive a live vaccine during the study period.","ALL","18 Years",{"count":746,"type":747},560,"ESTIMATED","INTERVENTIONAL",[750],"PHASE3","This is a randomized, double-blind, phase III clinical study to compare the efficacy and safety of AK112 to placebo as consolidation treatment for patients with limited stage small cell lung cancer who have not progressed following concurrent chemoradiation therapy.",[753],"Small Cell Lung Cancer",[23,27],"2026-03-04",{"date":757,"type":758},"2026-03-05","ACTUAL",{"date":760,"type":758},"2025-06-13",{"date":762,"type":747},"2029-07-31",{"name":5,"class":6},53]