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Dargart",{"facility":1324,"status":258,"city":1325,"state":1326,"zip":1327,"country":248,"countryCode":249,"cosmosGeoPoint":1328,"geoPoint":1332,"contacts":1333},"University of Oklahoma Health Sciences Center","Oklahoma City","Oklahoma","73104",{"type":251,"coordinates":1329},[1330,1331],-97.51643,35.46756,{"lat":1331,"lon":1330},[1334,1337],{"name":268,"role":269,"phone":1335,"phoneExt":228,"email":1336},"405-271-8777","ou-clinical-trials@ouhsc.edu",{"name":1338,"role":240,"phone":228,"phoneExt":228,"email":228},"Rene Y. McNall-Knapp",{"facility":1340,"status":258,"city":1341,"state":1342,"zip":1343,"country":248,"countryCode":249,"cosmosGeoPoint":1344,"geoPoint":1348,"contacts":1349},"Legacy Emanuel Children's Hospital","Portland","Oregon","97227",{"type":251,"coordinates":1345},[1346,1347],-122.67621,45.52345,{"lat":1347,"lon":1346},[1350,1352],{"name":268,"role":269,"phone":1351,"phoneExt":228,"email":228},"503-413-2560",{"name":1353,"role":240,"phone":228,"phoneExt":228,"email":228},"Jason M. Glover",{"facility":1355,"status":258,"city":1341,"state":1342,"zip":1356,"country":248,"countryCode":249,"cosmosGeoPoint":1357,"geoPoint":1359,"contacts":1360},"Oregon Health and Science University","97239",{"type":251,"coordinates":1358},[1346,1347],{"lat":1347,"lon":1346},[1361,1364],{"name":268,"role":269,"phone":1362,"phoneExt":228,"email":1363},"503-494-1080","trials@ohsu.edu",{"name":1365,"role":240,"phone":228,"phoneExt":228,"email":228},"Linda C. Stork",{"facility":1367,"status":258,"city":1368,"state":1369,"zip":1370,"country":248,"countryCode":249,"cosmosGeoPoint":1371,"geoPoint":1375,"contacts":1376},"Geisinger Medical Center","Danville","Pennsylvania","17822",{"type":251,"coordinates":1372},[1373,1374],-76.61273,40.96342,{"lat":1374,"lon":1373},[1377,1380],{"name":268,"role":269,"phone":1378,"phoneExt":228,"email":1379},"570-271-5251","HemonCCTrials@geisinger.edu",{"name":1381,"role":240,"phone":228,"phoneExt":228,"email":228},"Jagadeesh Ramdas",{"facility":1383,"status":258,"city":1384,"state":1369,"zip":1385,"country":248,"countryCode":249,"cosmosGeoPoint":1386,"geoPoint":1390,"contacts":1391},"Children's Hospital of Philadelphia","Philadelphia","19104",{"type":251,"coordinates":1387},[1388,1389],-75.16362,39.95238,{"lat":1389,"lon":1388},[1392,1395],{"name":268,"role":269,"phone":1393,"phoneExt":228,"email":1394},"267-425-5544","CancerTrials@email.chop.edu",{"name":1396,"role":240,"phone":228,"phoneExt":228,"email":228},"Jane E. Minturn",{"facility":1398,"status":258,"city":1399,"state":1369,"zip":1400,"country":248,"countryCode":249,"cosmosGeoPoint":1401,"geoPoint":1405,"contacts":1406},"Children's Hospital of Pittsburgh of UPMC","Pittsburgh","15224",{"type":251,"coordinates":1402},[1403,1404],-79.99589,40.44062,{"lat":1404,"lon":1403},[1407,1410],{"name":268,"role":269,"phone":1408,"phoneExt":228,"email":1409},"412-692-8570","jean.tersak@chp.edu",{"name":1411,"role":240,"phone":228,"phoneExt":228,"email":228},"James T. 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Belyea",{"facility":1597,"status":258,"city":1598,"state":1583,"zip":1599,"country":248,"countryCode":249,"cosmosGeoPoint":1600,"geoPoint":1604,"contacts":1605},"VCU Massey Comprehensive Cancer Center","Richmond","23298",{"type":251,"coordinates":1601},[1602,1603],-77.46026,37.55376,{"lat":1603,"lon":1602},[1606,1609],{"name":268,"role":269,"phone":1607,"phoneExt":228,"email":1608},"804-628-6430","CTOclinops@vcu.edu",{"name":1610,"role":240,"phone":228,"phoneExt":228,"email":228},"Christopher Park",{"facility":1612,"status":258,"city":1613,"state":1614,"zip":1615,"country":248,"countryCode":249,"cosmosGeoPoint":1616,"geoPoint":1620,"contacts":1621},"Seattle Children's Hospital","Seattle","Washington","98105",{"type":251,"coordinates":1617},[1618,1619],-122.33207,47.60621,{"lat":1619,"lon":1618},[1622,1624],{"name":268,"role":269,"phone":1623,"phoneExt":228,"email":228},"866-987-2000",{"name":1625,"role":240,"phone":228,"phoneExt":228,"email":228},"Sarah E. Leary",{"facility":1627,"status":258,"city":1628,"state":1614,"zip":1629,"country":248,"countryCode":249,"cosmosGeoPoint":1630,"geoPoint":1634,"contacts":1635},"Providence Sacred Heart Medical Center and Children's Hospital","Spokane","99204",{"type":251,"coordinates":1631},[1632,1633],-117.42908,47.65966,{"lat":1633,"lon":1632},[1636,1639],{"name":268,"role":269,"phone":1637,"phoneExt":228,"email":1638},"800-228-6618","HopeBeginsHere@providence.org",{"name":1640,"role":240,"phone":228,"phoneExt":228,"email":228},"Judy L. Felgenhauer",{"facility":1642,"status":258,"city":1643,"state":1614,"zip":1644,"country":248,"countryCode":249,"cosmosGeoPoint":1645,"geoPoint":1649,"contacts":1650},"Mary Bridge Children's Hospital and Health Center","Tacoma","98405",{"type":251,"coordinates":1646},[1647,1648],-122.44429,47.25288,{"lat":1648,"lon":1647},[1651,1654],{"name":268,"role":269,"phone":1652,"phoneExt":228,"email":1653},"253-403-1461","research@multicare.org",{"name":1655,"role":240,"phone":228,"phoneExt":228,"email":228},"Robert G. Irwin",{"facility":1657,"status":258,"city":1658,"state":1659,"zip":1660,"country":248,"countryCode":249,"cosmosGeoPoint":1661,"geoPoint":1665,"contacts":1666},"University of Wisconsin Carbone Cancer Center - University Hospital","Madison","Wisconsin","53792",{"type":251,"coordinates":1662},[1663,1664],-89.40123,43.07305,{"lat":1664,"lon":1663},[1667,1670],{"name":268,"role":269,"phone":1668,"phoneExt":228,"email":1669},"800-622-8922","clinicaltrials@cancer.wisc.edu",{"name":1671,"role":240,"phone":228,"phoneExt":228,"email":228},"Nicholas J. Pytel",{"facility":1673,"status":258,"city":1674,"state":1659,"zip":1675,"country":248,"countryCode":249,"cosmosGeoPoint":1676,"geoPoint":1680,"contacts":1681},"Marshfield Medical Center-Marshfield","Marshfield","54449",{"type":251,"coordinates":1677},[1678,1679],-90.1718,44.66885,{"lat":1679,"lon":1678},[1682,1685],{"name":268,"role":269,"phone":1683,"phoneExt":228,"email":1684},"800-782-8581","oncology.clinical.trials@marshfieldresearch.org",{"name":1686,"role":240,"phone":228,"phoneExt":228,"email":228},"Michelle A. Manalang",{"facility":1688,"status":258,"city":1689,"state":1659,"zip":1690,"country":248,"countryCode":249,"cosmosGeoPoint":1691,"geoPoint":1695,"contacts":1696},"Children's Hospital of Wisconsin","Milwaukee","53226",{"type":251,"coordinates":1692},[1693,1694],-87.90647,43.0389,{"lat":1694,"lon":1693},[1697,1700],{"name":268,"role":269,"phone":1698,"phoneExt":228,"email":1699},"414-955-4727","MACCCTO@mcw.edu",{"name":1701,"role":240,"phone":228,"phoneExt":228,"email":228},"Sarah Rumler",{"facility":1703,"status":258,"city":1704,"state":1705,"zip":1706,"country":1707,"countryCode":1708,"cosmosGeoPoint":1709,"geoPoint":1713,"contacts":1714},"IWK Health Centre","Halifax","Nova Scotia","B3K 6R8","Canada","CA",{"type":251,"coordinates":1710},[1711,1712],-63.57688,44.64269,{"lat":1712,"lon":1711},[1715,1718],{"name":268,"role":269,"phone":1716,"phoneExt":228,"email":1717},"902-470-8520","Research@iwk.nshealth.ca",{"name":1719,"role":240,"phone":228,"phoneExt":228,"email":228},"Craig Erker",{"facility":1721,"status":258,"city":1722,"state":1723,"zip":1724,"country":1707,"countryCode":1708,"cosmosGeoPoint":1725,"geoPoint":1729,"contacts":1730},"Centre Hospitalier Universitaire Sainte-Justine","Montreal","Quebec","H3T 1C5",{"type":251,"coordinates":1726},[1727,1728],-73.58781,45.50884,{"lat":1728,"lon":1727},[1731,1734],{"name":268,"role":269,"phone":1732,"phoneExt":228,"email":1733},"514-345-4931","yvan.samson@umontreal.ca",{"name":1735,"role":240,"phone":228,"phoneExt":228,"email":228},"Monia Marzouki",{"facility":1737,"status":258,"city":1738,"state":1723,"zip":1739,"country":1707,"countryCode":1708,"cosmosGeoPoint":1740,"geoPoint":1744,"contacts":1745},"Centre Hospitalier Universitaire de Sherbrooke-Fleurimont","Sherbrooke","J1H 5N4",{"type":251,"coordinates":1741},[1742,1743],-71.89908,45.40008,{"lat":1743,"lon":1742},[1746,1749],{"name":268,"role":269,"phone":1747,"phoneExt":228,"email":1748},"819-820-6480","crcinformation.chus@ssss.gouv.qc.ca",{"name":1750,"role":240,"phone":228,"phoneExt":228,"email":228},"Josee Brossard",{"facility":1752,"status":258,"city":1753,"state":228,"zip":1754,"country":1707,"countryCode":1708,"cosmosGeoPoint":1755,"geoPoint":1759,"contacts":1760},"CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL)","Québec","G1V 4G2",{"type":251,"coordinates":1756},[1757,1758],-71.21454,46.81228,{"lat":1758,"lon":1757},[1761,1764],{"name":268,"role":269,"phone":1762,"phoneExt":228,"email":1763},"418-525-4444","rechclinique@crchudequebec.ulaval.ca",{"name":1765,"role":240,"phone":228,"phoneExt":228,"email":228},"Bruno Michon",{"type":1767,"investigatorFullName":228,"investigatorTitle":228,"investigatorAffiliation":228,"oldNameTitle":228,"oldOrganization":228},"SPONSOR",[1769],{"name":1770,"class":1771},"National Cancer Institute (NCI)","NIH","100468634","phase-3-a-study-of-treatment-for-medulloblastoma-using-sodium-thiosulfate-to-reduce-hearing-loss-100468634",false,"NCT05382338","A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss","A Phase 3 Study of Sodium Thiosulfate for Reduction of Cisplatin-Induced Ototoxicity in Children With Average-Risk Medulloblastoma and Reduced Therapy in Children With Medulloblastoma With Low-Risk Features","Inclusion Criteria:\n\n* PRE-ENROLLMENT: Patients must be ≥ 4 years and ≤ 21 years of age at the time of enrollment\n* PRE-ENROLLMENT: Patient is suspected to have newly-diagnosed medulloblastoma by institutional diagnosis\n\n  * Please note: Patients with a pending result of CSF cytology tests are eligible for NCI-2014-02057 (APEC14B1-Central Nervous System \\[CNS\\]) and CNS\u002FMedulloblastoma Pre Enrollment Eligibility Screening\n* PRE-ENROLLMENT: The patient and\u002For their parents or legal guardians must have signed informed consent for APEC14B1 Part A - Eligibility Screening and consent for the Molecular Characterization Initiative (MCI)\n* PRE-ENROLLMENT: The required specimens are projected to be submitted under APEC14B1-CNS as soon as possible, preferably within 5 days of definitive surgery\n* PRE-ENROLLMENT: All patients must have rapid central pathology review under APEC14B1-CNS prior to study enrollment on ACNS2031 step 1 in order to avoid discordant diagnoses and to verify diagnosis criterion for treatment on ACNS2031.\n\n  * Note: Patients with a pending result of CSF cytology tests are eligible for the rapid central pathology screening review. Confirmation of CSF negativity is needed for enrollment on the ACNS2031 protocol\n* PRE-ENROLLMENT: All patients must have rapid central molecular screening review under APEC14B1-CNS prior to study enrollment on ACNS2031 step 1, in order to avoid discordant diagnoses and to verify diagnosis criterion for treatment on ACNS2031\n* PRE-ENROLLMENT: All patients who have histopathology confirmed must have rapid central imaging screening review under APEC14B1 prior to study enrollment on ACNS2031 step 1\n\n  * Note: Patients must not have metastatic disease on cranial or spinal MRI. Patients with \\> 1.5 cm\\^2 residual tumor after initial surgical resection may undergo a second surgical resection prior to subsequent therapy to render them eligible for this study. The day of the second resection to remove residual tumor will be regarded as the day of definitive surgery (Day 0) and must be within a month (31 days) of the initial resection\n* PRE-ENROLLMENT: All patients who have histopathology confirmed must have rapid central audiology review under APEC14B1-CNS prior to study enrollment on ACNS2031 step 1\n* Patients must be \\>= 4 years and =\\\u003C 21 years of age at the time of enrollment\n* Patients must be newly diagnosed and have eligibility confirmed by rapid central pathology and molecular screening reviews performed on APEC14B1 and via the Molecular Characterization Initiative\n* Average-risk cohort\n\n  * Clinico-pathologic criteria:\n\n    * M0 disease\n    * No diffuse anaplastic histology AND\n  * Molecular criteria:\n\n    * SHH, p53wt, GLI2 normal, MYCN normal, no chromosome 14q loss\n    * Group 3, MYC normal, no isochromosome 17q\n    * Group 4, no chromosome 11 loss\n* Low-risk features cohort\n\n  * Clinico-pathologic criteria:\n\n    * M0 disease\n    * No diffuse anaplastic histology AND\n  * Molecular criteria:\n\n    * Group 4, chromosome 11 loss\n* Patients must have negative lumbar CSF cytology\n\n  * Note: CSF cytology for staging should be performed no sooner than 14 days post operatively to avoid false positive CSF. Ideally, CSF should be obtained between day 14 and day 21 to allow for final staging status before enrollment onto the study. Patients with positive CSF cytology obtained 0 to 14 days after surgery should have cytology repeated to determine eligibility and final CSF status. Patients with negative CSF cytology from lumbar puncture obtained 0 to 14 days after surgery do not need cytology repeated. Patients with negative CSF cytology from lumbar puncture obtained prior to surgery do not need cytology repeated post-operatively\n* Patients must have eligibility confirmed by Rapid Central Imaging Review performed on APEC14B1. Patients must have =\\\u003C 1.5 cm\\^2 cross-sectional area of residual tumor. Whole brain MRI with and without gadolinium and spine MRI with gadolinium must be performed\n* Patients must weigh \\> 10 kg\n* Patients must be enrolled, and protocol therapy must be projected to begin, no later than 31 days after definitive diagnostic surgery (day 0)\n* Peripheral absolute neutrophil count (ANC) \\>= 1000\u002FuL (within 7 days prior to enrollment)\n* Platelet count \\>= 100,000\u002FuL (transfusion independent) (within 7 days prior to enrollment)\n* Hemoglobin \\>= 8.0 g\u002FdL (may receive red blood cell count \\[RBC\\] transfusions) (within 7 days prior to enrollment)\n* A serum creatinine (within 7 days prior to enrollment) based on age\u002Fsex as follows:\n\n  * 4 to \\\u003C 6 years (age); 0.8 mg\u002FdL (male) 0.8 mg\u002FdL (female)\n  * 6 to \\\u003C 10 years (age); 1 mg\u002FdL (male) 1 mg\u002FdL (female)\n  * 10 to \\\u003C 13 years (age); 1.2 mg\u002FdL (male) 1.2 mg\u002FdL (female)\n  * 13 to \\\u003C 16 years (age); 1.5 mg\u002FdL (male) 1.4 mg\u002FdL (female)\n  * \\>= 16 years (age); 1.7 mg\u002FdL (male) 1.4 mg\u002FdL (female) OR a 24 hour urine Creatinine clearance \\>= 70 mL\u002Fmin\u002F1.73 m\\^2 (within 7 days prior to enrollment) OR a glomerular filtration rate (GFR) \\>= 70 mL\u002Fmin\u002F1.73 m\\^2 (within 7 days prior to enrollment). GFR must be performed using direct measurement with a nuclear blood sampling method OR direct small molecule clearance method (iothalamate or other molecule per institutional standard)\n  * Note: Estimated GFR (eGFR) from serum creatinine, cystatin C or other estimates are not acceptable for determining eligibility\n* Total bilirubin =\\\u003C 1.5 x upper limit of normal (ULN) for age (within 7 days prior to enrollment)\n* Serum glutamic pyruvic transaminase (SGPT) (alanine aminotransferase \\[ALT\\]) =\\\u003C 135 U\u002FL (within 7 days prior to enrollment)\n\n  * Note: For the purpose of this study, the ULN for SGPT (ALT) has been set to the value of 45 U\u002FL\n* Central nervous system function defined as:\n\n  * Patients with seizure disorder may be enrolled if on anticonvulsants and well controlled\n  * Patients must not be in status epilepticus, a coma or assisted ventilation at the time of study enrollment\n* Auditory function defined as:\n\n  * Patients must have normal hearing (defined as International Society of Pediatric Oncology \\[SIOP\\] grade 0) in at least one ear confirmed by rapid central audiology review performed on APEC14B1 prior to enrollment\n* All patients and\u002For their parents or legal guardians must sign a written informed consent\n* All institutional, Food and Drug Administration (FDA), and National Cancer Institute (NCI) requirements for human studies must be met\n\nExclusion Criteria:\n\n* Patients with metastatic disease by either MRI evaluation or lumbar CSF cytology are not eligible. Patients who are unable to undergo a lumbar puncture for assessment of CSF cytology are ineligible\n* Patients must not have received any prior radiation therapy or chemotherapy (tumor-directed therapy) other than surgical intervention and\u002For corticosteroids\n* Patients must not have any known hypersensitivity to STS, sulfates\u002Fsulfites, or other thiol agents (e.g., amifostine, n-acetylcysteine, MESNA, and captopril)\n* Pregnancy and Breastfeeding:\n\n  * Female patients who are pregnant since fetal toxicities and teratogenic effects have been noted for several of the study drugs. A pregnancy test is required for female patients of childbearing potential\n  * Lactating females who plan to breastfeed their infants\n  * Sexually active patients of reproductive potential who have not agreed to use an effective contraceptive method for the duration of their study participation","ALL","4 Years","21 Years",{"count":1783,"type":1784},225,"ESTIMATED","INTERVENTIONAL",[1787],"PHASE3","This phase III trial tests two hypotheses in patients with low-risk and average-risk medulloblastoma. Medulloblastoma is a type of cancer that occurs in the back of the brain. The term, risk, refers to the chance of the cancer coming back after treatment. Subjects with low-risk medulloblastoma typically have a lower chance of the cancer coming back than subjects with average-risk medulloblastoma. Although treatment for newly diagnosed average-risk and low-risk medulloblastoma is generally effective at treating the cancer, there are still concerns about the side effects of such treatment. Side effects or unintended health conditions that arise due to treatment include learning difficulties, hearing loss or other issues in performing daily activities. Standard therapy for newly diagnosed average-risk or low-risk medulloblastoma includes surgery, radiation therapy, and chemotherapy (including cisplatin). Cisplatin may cause hearing loss as a side effect. In the average-risk medulloblastoma patients, this trial tests whether the addition of sodium thiosulfate (STS) to standard of care chemotherapy and radiation therapy reduces hearing loss. Previous studies with STS have shown that it may help reduce or prevent hearing loss caused by cisplatin. In the low-risk medulloblastoma patients, the study tests whether a less intense therapy (reduced radiation) can provide the same benefits as the more intense therapy. The less intense therapy may cause fewer side effects. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Cisplatin is in a class of medications known as platinum-containing compounds. It works by killing, stopping or slowing the growth of cancer cells. The overall goals of this study are to see if giving STS along with standard treatment (radiation therapy and chemotherapy) will reduce hearing loss in medulloblastoma patients and to compare the overall outcome of patients with medulloblastoma treated with STS to patients treated without STS on a previous study in order to make sure that survival and recurrence of tumor is not worsened.",[1790],"Childhood Medulloblastoma","2026-05-01",{"date":1793,"type":1794},"2026-05-05","ACTUAL",{"date":1796,"type":1794},"2023-02-20",{"date":1798,"type":1784},"2029-12-31",{"name":5,"class":6},105]