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Jana Pawla II Spsk Nr 6 Sum W Katowicach","Katowice","Silesian Voivodeship","40-752",{"type":72,"coordinates":1173},[1174,1175],19.02173,50.2597,{"lat":1175,"lon":1174},[1178,1181],{"name":79,"role":59,"phone":1179,"phoneExt":55,"email":1180},"+48322071700","urszulachlebowczyk@wp.pl",{"name":1182,"role":84,"phone":55,"phoneExt":55,"email":55},"Urszula Grzybowska-Chlebowczyk",{"facility":1184,"status":133,"city":1185,"state":1186,"zip":1187,"country":1078,"countryCode":1079,"cosmosGeoPoint":1188,"geoPoint":1192,"contacts":1193},"Twoja Przychodnia SCM","Szczecin","West Pomeranian Voivodeship","71-434",{"type":72,"coordinates":1189},[1190,1191],14.55302,53.42894,{"lat":1191,"lon":1190},[1194,1197],{"name":79,"role":59,"phone":1195,"phoneExt":55,"email":1196},"+48914332919","gawdis@twojaprzychodnia.com",{"name":1198,"role":84,"phone":55,"phoneExt":55,"email":55},"Beata Gawdis-Wojnarska",{"facility":1200,"status":65,"city":1201,"state":55,"zip":1202,"country":1078,"countryCode":1079,"cosmosGeoPoint":1203,"geoPoint":1207,"contacts":1208},"SPZOZ Centralny Szpital Kliniczny UM w Lodzi","Lodz","91-738",{"type":72,"coordinates":1204},[1205,1206],19.47395,51.77058,{"lat":1206,"lon":1205},[1209,1212],{"name":79,"role":59,"phone":1210,"phoneExt":55,"email":1211},"+48426177792","ewa.toporowska-kowalska@umed.lodz.pl",{"name":1213,"role":84,"phone":55,"phoneExt":55,"email":55},"Ewa Toporowska-Kowalska",{"facility":1215,"status":65,"city":1201,"state":1216,"zip":1217,"country":1078,"countryCode":1079,"cosmosGeoPoint":1218,"geoPoint":1220,"contacts":1221},"Instytut Centrum Zdrowia Matki Polki","Łódź Voivodeship","93-338",{"type":72,"coordinates":1219},[1205,1206],{"lat":1206,"lon":1205},[1222,1225],{"name":79,"role":59,"phone":1223,"phoneExt":55,"email":1224},"+48422711341","elcia@friend.pl",{"name":1226,"role":84,"phone":55,"phoneExt":55,"email":55},"Elzbieta Czkwianianc",{"facility":1228,"status":1229,"city":1230,"state":55,"zip":1231,"country":1232,"countryCode":1233,"cosmosGeoPoint":1234,"geoPoint":1238,"contacts":55},"Detska fakultna nemocnica s poliklinikou Banska Bystrica","TERMINATED","Banská Bystrica","974 09","Slovakia","SK",{"type":72,"coordinates":1235},[1236,1237],19.14932,48.73947,{"lat":1237,"lon":1236},{"facility":1240,"status":1229,"city":1241,"state":55,"zip":1242,"country":1232,"countryCode":1233,"cosmosGeoPoint":1243,"geoPoint":1247,"contacts":55},"Narodny ustav detskych chorob","Bratislava","833 40",{"type":72,"coordinates":1244},[1245,1246],17.10674,48.14816,{"lat":1246,"lon":1245},{"facility":1249,"status":133,"city":1250,"state":1251,"zip":1252,"country":1253,"countryCode":55,"cosmosGeoPoint":1254,"geoPoint":1258,"contacts":1259},"Kyungpook National University Chilgok hospital","Daegu","Daegu Gwang'yeogsi","41404","South Korea",{"type":72,"coordinates":1255},[1256,1257],128.59111,35.87028,{"lat":1257,"lon":1256},[1260,1263],{"name":79,"role":59,"phone":1261,"phoneExt":55,"email":1262},"+82532003780","benkang@knu.ac.kr",{"name":1264,"role":84,"phone":55,"phoneExt":55,"email":55},"Ben Kang",{"facility":1266,"status":133,"city":1267,"state":1268,"zip":1269,"country":1253,"countryCode":55,"cosmosGeoPoint":1270,"geoPoint":1274,"contacts":1275},"Gachon University Gil Medical Center","Incheon","Incheon Gwang'yeogsi","21565",{"type":72,"coordinates":1271},[1272,1273],126.70515,37.45646,{"lat":1273,"lon":1272},[1276,1279],{"name":79,"role":59,"phone":1277,"phoneExt":55,"email":1278},"+82324603213","ryoo518@gilhospital.com",{"name":1280,"role":84,"phone":55,"phoneExt":55,"email":55},"Eell Ryoo",{"facility":1282,"status":133,"city":1283,"state":55,"zip":1284,"country":1253,"countryCode":55,"cosmosGeoPoint":1285,"geoPoint":1289,"contacts":1290},"Seoul National University Hospital","Seongnam","Seoul",{"type":72,"coordinates":1286},[1287,1288],127.7548,36.4052,{"lat":1288,"lon":1287},[1291,1293],{"name":79,"role":59,"phone":55,"phoneExt":55,"email":1292},"mjschj@snu.ac.kr",{"name":1294,"role":84,"phone":55,"phoneExt":55,"email":55},"Jin Soo Moon",{"facility":1296,"status":133,"city":1284,"state":55,"zip":1297,"country":1253,"countryCode":55,"cosmosGeoPoint":1298,"geoPoint":1302,"contacts":1303},"Samsung Medical Center - PPDS","6351",{"type":72,"coordinates":1299},[1300,1301],126.9784,37.566,{"lat":1301,"lon":1300},[1304,1307],{"name":79,"role":59,"phone":1305,"phoneExt":55,"email":1306},"+82234103901","smc_yhc@naver.com",{"name":1308,"role":84,"phone":55,"phoneExt":55,"email":55},"Yon-Ho Choe",{"facility":1310,"status":87,"city":1311,"state":1312,"zip":1313,"country":1314,"countryCode":1315,"cosmosGeoPoint":1316,"geoPoint":1320,"contacts":55},"Hospital Sant Joan de Deu - PIN","Esplugues de Llobregat","Barcelona","8950","Spain","ES",{"type":72,"coordinates":1317},[1318,1319],2.08809,41.37732,{"lat":1319,"lon":1318},{"facility":1322,"status":87,"city":1323,"state":1324,"zip":1325,"country":1314,"countryCode":1315,"cosmosGeoPoint":1326,"geoPoint":1330,"contacts":55},"Hospital de Sagunto","Sagunto","Valencia","46520",{"type":72,"coordinates":1327},[1328,1329],-0.26667,39.68333,{"lat":1329,"lon":1328},{"facility":1332,"status":87,"city":1333,"state":55,"zip":1334,"country":1314,"countryCode":1315,"cosmosGeoPoint":1335,"geoPoint":1339,"contacts":55},"Hospital Infantil Universitario Nino Jesus - PIN","Madrid","28009",{"type":72,"coordinates":1336},[1337,1338],-3.70256,40.4165,{"lat":1338,"lon":1337},{"facility":1341,"status":87,"city":1342,"state":55,"zip":1343,"country":1314,"countryCode":1315,"cosmosGeoPoint":1344,"geoPoint":1348,"contacts":55},"Hospital Regional Universitario de Malaga - Hospital Materno Infantil","Málaga","29011",{"type":72,"coordinates":1345},[1346,1347],-4.42034,36.72016,{"lat":1347,"lon":1346},{"facility":1350,"status":87,"city":1351,"state":55,"zip":1352,"country":1314,"countryCode":1315,"cosmosGeoPoint":1353,"geoPoint":1357,"contacts":55},"Hospital Universitario Virgen del Rocio - PPDS","Seville","41013",{"type":72,"coordinates":1354},[1355,1356],-5.97317,37.38283,{"lat":1356,"lon":1355},{"facility":1359,"status":65,"city":527,"state":1360,"zip":1361,"country":1362,"countryCode":1363,"cosmosGeoPoint":1364,"geoPoint":1368,"contacts":1369},"Kings College Hospital","London, City of","SE5 9RS","United Kingdom","UK",{"type":72,"coordinates":1365},[1366,1367],-0.12574,51.50853,{"lat":1367,"lon":1366},[1370,1373],{"name":79,"role":59,"phone":1371,"phoneExt":55,"email":1372},"+442032991674","babu.vadamalayan@nhs.net",{"name":1374,"role":84,"phone":55,"phoneExt":55,"email":55},"Babu Vadamalayan",{"facility":1376,"status":65,"city":527,"state":1360,"zip":1377,"country":1362,"countryCode":1363,"cosmosGeoPoint":1378,"geoPoint":1380,"contacts":1381},"Great Ormond Street Hospital (GOSH)","WC1N 3AJ",{"type":72,"coordinates":1379},[1366,1367],{"lat":1367,"lon":1366},[1382,1385],{"name":79,"role":59,"phone":1383,"phoneExt":55,"email":1384},"+447779142231","kelsey.jones@gosh.nhs.uk",{"name":1386,"role":84,"phone":55,"phoneExt":55,"email":55},"Kelsey Jones",{"facility":1388,"status":65,"city":1389,"state":1390,"zip":1391,"country":1362,"countryCode":1363,"cosmosGeoPoint":1392,"geoPoint":1396,"contacts":1397},"Noahs Ark Childrens Hospital for Wales - PPDS - PIN","Cardiff","South Glamorgan","CF14 4XW",{"type":72,"coordinates":1393},[1394,1395],-3.18,51.48,{"lat":1395,"lon":1394},[1398,1401],{"name":79,"role":59,"phone":1399,"phoneExt":55,"email":1400},"+448888888888","amar.wahid@wales.nhs.uk",{"name":1402,"role":84,"phone":55,"phoneExt":55,"email":55},"Amar Wahid",{"facility":1404,"status":65,"city":1405,"state":1406,"zip":1407,"country":1362,"countryCode":1363,"cosmosGeoPoint":1408,"geoPoint":1412,"contacts":1413},"Birmingham Children's Hospital NHS Foundation Trust","Birmingham","West Midlands","B4 6NH",{"type":72,"coordinates":1409},[1410,1411],-1.89983,52.48142,{"lat":1411,"lon":1410},[1414,1417],{"name":79,"role":59,"phone":1415,"phoneExt":55,"email":1416},"+4401213338705","rafeeq.muhammed@nhs.net",{"name":1418,"role":84,"phone":55,"phoneExt":55,"email":55},"Rafeeq Muhammed",{"facility":1420,"status":65,"city":527,"state":55,"zip":1421,"country":1362,"countryCode":1363,"cosmosGeoPoint":1422,"geoPoint":1424,"contacts":1425},"Barts Health NHS Trust","E1 1BB",{"type":72,"coordinates":1423},[1366,1367],{"lat":1367,"lon":1366},[1426,1428],{"name":79,"role":59,"phone":1399,"phoneExt":55,"email":1427},"marco.gasparetto@nhs.net",{"name":1429,"role":84,"phone":55,"phoneExt":55,"email":55},"Marco Gasparetto",{"facility":1431,"status":65,"city":1432,"state":55,"zip":1433,"country":1362,"countryCode":1363,"cosmosGeoPoint":1434,"geoPoint":1438,"contacts":1439},"Royal Manchester Children's Hospital - PPDS","Manchester","M27 4HA",{"type":72,"coordinates":1435},[1436,1437],-2.23743,53.48095,{"lat":1437,"lon":1436},[1440,1443],{"name":79,"role":59,"phone":1441,"phoneExt":55,"email":1442},"+441617012371","andrew.fagbemi@mft.nhs.uk",{"name":1444,"role":84,"phone":55,"phoneExt":55,"email":55},"Andrew (Sunday) Fagbemi",{"type":1446,"investigatorFullName":55,"investigatorTitle":55,"investigatorAffiliation":55,"oldNameTitle":55,"oldOrganization":55},"SPONSOR","100422322","phase-3-a-study-of-vedolizumab-in-children-and-teenagers-with-moderate-to-severe-crohns-disease-cd-100422322",false,"NCT04779320","A Study of Vedolizumab in Children and Teenagers With Moderate to Severe Crohn's Disease (CD)","A Randomized, Double-Blind, Phase 3 Study to Evaluate the Efficacy and Safety of Vedolizumab Intravenous as Maintenance Therapy in Pediatric Subjects With Moderately to Severely Active Crohn's Disease Who Achieved Clinical Response Following Open-Label Vedolizumab Intravenous Therapy","Main Inclusion Criteria:\n\n1. The participants has moderately to severely active CD, unresponsive or intolerant to their current standard of care (SOC).\n2. The participants weigh ≥10 kg at the time of screening and enrollment into the study.\n3. Participants with Crohn's disease (CD) diagnosed at least 1 month before screening. Participants with moderately to severely active CD defined by a Pediatric Crohn's Disease Activity Index (PCDAI) \\>30 and an simple endoscopic score for Crohn's Disease (SES-CD) \\>6 (or an SES-CD ≥4 if disease is confined to terminal ileum) at screening endoscopy.\n4. Participants who have failed, lost response to, or been intolerant to treatment with at least 1 of the following agents: corticosteroids, immunomodulators (eg, azathioprine (AZA), 6-mercaptopurine (6-MP), methotrexate \\[MTX\\]), and\u002For tumor necrosis factor (TNF)-α antagonist therapy (eg, infliximab, adalimumab). This includes participants who are dependent on corticosteroids or exclusive or partial enteral nutrition to control symptoms and who are experiencing worsening of disease in the moderate-to-severe range when attempting to wean off corticosteroids or discontinue exclusive enteral nutrition.\n5. Participants with extensive colitis or pancolitis of \\>8 years' duration or left-sided colitis of \\>12 years' duration must have documented evidence of a negative surveillance colonoscopy within 12 months before screening.\n6. Participants with vaccinations that are up-to-date based on the countrywide accepted schedule of childhood vaccines.\n\nMain Exclusion Criteria:\n\n1. Participants who have received either (1) an investigational biologic (other than those listed in Exclusion Criterion #1) within 60 days or 5 half-lives before screening (whichever is longer); or (2) an approved biologic or biosimilar agent within 2 weeks before the first dose of study drug or at any time during the screening period.\n2. Participants with active cerebral\u002Fmeningeal disease, signs\u002Fsymptoms or history of progressive multifocal leukoencephalopathy (PML) or any other major neurological disorders including stroke, multiple sclerosis, brain tumor or neurodegenerative disease.\n3. The participants had a clinically significant infection (eg, pneumonia, pyelonephritis, coronavirus disease 2019 \\[COVID-19\\]) within 30 days prior to first dose of study drug.\n4. The participants has received any live vaccinations within 30 days prior to first dose.\n5. Participants who currently require surgical intervention or are anticipated to require surgical intervention for CD during this study.\n6. Participants who have had subtotal or total colectomy or have a jejunostomy, ileostomy, colostomy, ileo-anal pouch, known fixed stenosis of the intestine, short bowel syndrome, or \\>3 small intestine resections.\n7. Participants with a current diagnosis of indeterminate colitis.\n8. Participants with clinical features suggesting monogenic very early-onset inflammatory bowel disease.\n9. Active or latent tuberculosis (TB), as evidenced by a diagnostic TB test performed within 30 days of screening or during the screening Period that is positive, defined as:\n\n   * Positive QuantiFERON test or 2 successive indeterminate QuantiFERON tests, OR\n   * A TB skin test reaction ≥5 mm.\n10. Participants with evidence of positive hepatitis B surface antigen (HBsAg) or hepatitis B core antibody (HBcAb). Hepatitis B virus (HBV) immune participants(i.e., hepatitis B surface antigen \\[HBsAg\\]-negative and hepatitis B antibody-positive) may, however, be included.\n\n    Note: If a participant tests negative for HBsAg, but positive for HBcAb, the participant would be considered eligible if the absence of HBV DNA is confirmed by HBV DNA polymerase chain reaction reflex testing performed in the central laboratory.\n11. Participants with chronic hepatitis C virus (HCV) (ie, positive HCV antibody \\[HCVAb\\] and HCV RNA).\n\n    Note: Participants who are HCVAb-positive without evidence of HCV RNA may be considered eligible (spontaneous viral clearance or previously treated and cured \\[defined as no evidence of HCV RNA at least 12 weeks before baseline\\]).\n12. The participants has any identified congenital or acquired immunodeficiency (eg, common variable immunodeficiency, human immunodeficiency virus \\[HIV\\] infection, organ transplantation).\n13. The participant has evidence of dysplasia or history of malignancy other than a successfully treated non-metastatic cutaneous squamous cell or basal cell carcinoma or localized carcinoma in situ of the cervix.\n14. Participants with positive stool studies for ova and\u002For parasites or stool culture at screening visit.\n15. Participants with positive Clostridioides difficile (C difficile) stool test at screening visit.\n\nOther inclusion\u002Fexclusion criteria may apply.","ALL","2 Years","17 Years",{"count":1458,"type":1459},120,"ESTIMATED","INTERVENTIONAL",[1462],"PHASE3","Vedolizumab is a medicine that helps to reduce inflammation and pain in the digestive system. In this study, children and teenagers with moderate to severe Crohn's disease will be treated with vedolizumab.\n\nThe main aim of the study is to check if participants achieve remission after treatment with the vedolizumab. Remission means symptoms improve or disappear and an endoscopy shows no signs of inflammation.\n\nParticipants will receive 3 infusions of vedolizumab over 6 weeks. Then, those who have a clinical response will receive either a high dose or low dose of vedolizumab once every 8 weeks. They will receive the same dose every time.",[1465],"Crohn's Disease (CD)",[1467],"Drug Therapy","2026-04-30",{"date":1470,"type":1471},"2026-05-05","ACTUAL",{"date":1473,"type":1471},"2022-02-10",{"date":1475,"type":1459},"2027-09-13",{"name":5,"class":6},96]