[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100622705":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":31,"centralContacts":30,"locations":36,"responsibleParty":54,"collaborators":30,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":30,"eligibilityCriteria":62,"healthyVolunteers":58,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":30,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":76,"overallStatus":38,"whyStopped":30,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Hangzhou Sciwind Biosciences Co., Ltd.","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"XW003 Injection","EXPERIMENTAL","once weekly",[13],"Drug: XW003 injection",{"label":15,"type":16,"description":11,"interventionNames":17},"Placebo","PLACEBO_COMPARATOR",[18],"Drug: placebo with matching volume",[20,27],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","XW003 injection","subcutaneous injection",[9],[26],"Ecnoglutide injection",{"type":21,"name":28,"description":23,"armGroupLabels":29,"otherNames":30},"placebo with matching volume",[15],null,[32],{"name":33,"affiliation":34,"role":35},"Linong Ji, Dr","Peking University People's Hospital","PRINCIPAL_INVESTIGATOR",[37],{"facility":34,"status":38,"city":39,"state":40,"zip":30,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"RECRUITING","Beijing","Beijing Municipality","China","CN",{"type":44,"coordinates":45},"Point",[46,47],116.39723,39.9075,{"lat":47,"lon":46},[50],{"name":33,"role":51,"phone":52,"phoneExt":30,"email":53},"CONTACT","(86)010-88324516","jiln@bjmu.edu.cn",{"type":55,"investigatorFullName":30,"investigatorTitle":30,"investigatorAffiliation":30,"oldNameTitle":30,"oldOrganization":30},"SPONSOR","100622705","phase-3-a-study-of-xw003-in-obese-participants-with-obstructive-sleep-apnea-but-not-receive-positive-airway-pressure-therapy-100622705",false,"NCT07387094","A Study of XW003 in Obese Participants With Obstructive Sleep Apnea But Not Receive Positive Airway Pressure Therapy","A Multi-center, Randomized, Double-blind, Placebo-controlled Phase III Study to Assess the Efficacy and Safety of XW003 Injections in Obese Participants With Obstructive Sleep Apnea But Not Receive Positive Airway Pressure Therapy","Inclusion Criteria:\n\n1. Body mass index (BMI) ≥ 28.0 kg\u002Fm2;\n2. The results of PSG meet the diagnosis criteria of OSA and with an AHI ≥15 at screening;\n3. Participants must not have used PAP for at least 4 weeks prior to screening and not use PAP during the study;\n4. Have a history of at least 1 self-reported unsuccessful dietary effort to lose body weight.\n\nExclusion Criteria:\n\n1. History of endocrine disorders which have significant impact on body weight;\n2. Diagnosis of diabetes (except gestational diabetes), ketoacidosis or hypertonic state\u002Fcoma;\n3. HbA1c ≥6.5% at screening;\n4. Fasting blood glucose ≥7.0 mmol\u002FL or 2-hour blood glucose ≥11.1 mmol\u002FL after oral glucose tolerance test (OGTT) at screening; participants with FBG ≥6.1 mmol\u002FL but \\\u003C7.0 mmol\u002FL require OGTT;\n5. Have diagnosis of Cheyne Stokes Respiration, or diagnosis of Central or Mixed Sleep Apnea with % of mixed or central apneas\u002Fhypopneas ≥50%;\n6. Respiratory and neuromuscular diseases that could interfere with the results of the trial;\n7. Diagnosis of Obesity Hypoventilation Syndrome or daytime hypercapnia;\n8. Change of body weight \\>5% within 3 months prior to screening (self-reported);\n9. Have a prior or planned surgical treatment for obesity (except liposuction or abdominoplasty if performed more than 1 year prior to screening);\n10. Have received any medication for body weight loss and blood glucose lowering or medication that could lead to significant body weight increase, within 3 months prior to screening.","ALL","18 Years","75 Years",{"count":67,"type":68},140,"ESTIMATED","INTERVENTIONAL",[71],"PHASE3","The aim of the study is to assess the efficacy and safety of XW003 injections in obese participants with OSA but not receiving PAP",[74,75],"OSA - Obstructive Sleep Apnea","Obesity",[77,78,75,79,80],"XW003","Ecnoglutide","OSA","GLP-1","2026-04-09",{"date":83,"type":84},"2026-04-14","ACTUAL",{"date":86,"type":84},"2026-02-09",{"date":88,"type":68},"2027-12-16",{"name":5,"class":6},1]