[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100610633":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":36,"centralContacts":41,"locations":47,"responsibleParty":342,"collaborators":35,"id":344,"slug":345,"hasResults":346,"nctId":347,"briefTitle":348,"officialTitle":349,"acronym":35,"eligibilityCriteria":350,"healthyVolunteers":346,"sex":351,"minAge":352,"maxAge":353,"enrollmentInfo":354,"targetDuration":35,"studyType":357,"phases":358,"briefSummary":360,"conditions":361,"keywords":35,"overallStatus":363,"whyStopped":35,"lastUpdateSubmitDate":364,"lastUpdatePostDateStruct":365,"startDateStruct":368,"completionDateStruct":370,"leadSponsor":372,"locationsCount":373},{"fullName":5,"class":6},"Beijing QL Biopharmaceutical Co.,Ltd","INDUSTRY",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Zovaglutide dose 1","EXPERIMENTAL","administered subcutaneously (SC), Q4W",[13],"Drug: Zovaglutide dose 1",{"label":15,"type":10,"description":11,"interventionNames":16},"Zovaglutide dose 2",[17],"Drug: Zovaglutide dose 2",{"label":19,"type":20,"description":21,"interventionNames":22},"Placebo","PLACEBO_COMPARATOR","Administered subcutaneously (SC), Q4W",[23],"Drug: Placebo",[25,30,33],{"type":26,"name":9,"description":11,"armGroupLabels":27,"otherNames":28},"DRUG",[9],[29],"ZT002 Injection",{"type":26,"name":15,"description":11,"armGroupLabels":31,"otherNames":32},[15],[29],{"type":26,"name":19,"description":11,"armGroupLabels":34,"otherNames":35},[19],null,[37],{"name":38,"affiliation":39,"role":40},"Linong Ji, MD","Peking University People's Hospital","PRINCIPAL_INVESTIGATOR",[42],{"name":43,"role":44,"phone":45,"phoneExt":35,"email":46},"yuanyuan Zhang, PhD","CONTACT","13581521105","yuanyuan@qlbiopharm.com",[48,66,79,94,108,123,133,142,151,165,175,185,191,200,211,226,241,253,268,277,288,302,312,321,331],{"facility":49,"status":35,"city":50,"state":51,"zip":52,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"Xuancheng People's Hospital","Xuancheng","Anhui","242099","China","CN",{"type":56,"coordinates":57},"Point",[58,59],118.75528,30.9525,{"lat":59,"lon":58},[62],{"name":63,"role":44,"phone":64,"phoneExt":35,"email":65},"Chongbing Huang, Master","86-563-3033406","2658836019@qq.com",{"facility":67,"status":35,"city":68,"state":69,"zip":70,"country":53,"countryCode":54,"cosmosGeoPoint":71,"geoPoint":75,"contacts":76},"Gansu Provincial Hospital","Lanzhou","Gansu","730099",{"type":56,"coordinates":72},[73,74],103.83987,36.05701,{"lat":74,"lon":73},[77],{"name":78,"role":44,"phone":35,"phoneExt":35,"email":35},"Jinyang Wang, Doctor",{"facility":80,"status":35,"city":81,"state":82,"zip":83,"country":53,"countryCode":54,"cosmosGeoPoint":84,"geoPoint":88,"contacts":89},"Guangzhou Red Cross Hospital","Guangzhou","Guangdong","510235",{"type":56,"coordinates":85},[86,87],113.25,23.11667,{"lat":87,"lon":86},[90],{"name":91,"role":44,"phone":92,"phoneExt":35,"email":93},"Jianmin Ran, Doctor","86-20-61883706","ranjm@163.com",{"facility":95,"status":35,"city":96,"state":82,"zip":97,"country":53,"countryCode":54,"cosmosGeoPoint":98,"geoPoint":102,"contacts":103},"Huizhou Central People's Hospital","Huizhou","516008",{"type":56,"coordinates":99},[100,101],114.41523,23.11147,{"lat":101,"lon":100},[104],{"name":105,"role":44,"phone":106,"phoneExt":35,"email":107},"Shu Li Li, Doctor","86-752-2288848","150656301@qq.com",{"facility":109,"status":35,"city":110,"state":111,"zip":112,"country":53,"countryCode":54,"cosmosGeoPoint":113,"geoPoint":117,"contacts":118},"The Second Affiliated Hospotal of Guangxi Medical University","Nanning","Guangxi","530006",{"type":56,"coordinates":114},[115,116],108.31667,22.81667,{"lat":116,"lon":115},[119],{"name":120,"role":44,"phone":121,"phoneExt":35,"email":122},"Yuzhen Liang, Doctor","86-771-3517665676","Liangyuzhen26@163.com",{"facility":124,"status":35,"city":125,"state":126,"zip":127,"country":53,"countryCode":54,"cosmosGeoPoint":128,"geoPoint":132,"contacts":35},"Handan First Hospital","Handan","Hebei","056002",{"type":56,"coordinates":129},[130,131],114.48764,36.60999,{"lat":131,"lon":130},{"facility":134,"status":35,"city":135,"state":126,"zip":136,"country":53,"countryCode":54,"cosmosGeoPoint":137,"geoPoint":141,"contacts":35},"Hebei Petro China Cental Hospital","Langfang","065000",{"type":56,"coordinates":138},[139,140],116.71471,39.52079,{"lat":140,"lon":139},{"facility":143,"status":35,"city":144,"state":126,"zip":145,"country":53,"countryCode":54,"cosmosGeoPoint":146,"geoPoint":150,"contacts":35},"First Hospital of Qinhuangdao","Qinhuangdao","066000",{"type":56,"coordinates":147},[148,149],119.58936,39.94104,{"lat":149,"lon":148},{"facility":152,"status":35,"city":153,"state":126,"zip":154,"country":53,"countryCode":54,"cosmosGeoPoint":155,"geoPoint":159,"contacts":160},"The Second Hospital of Hebei Medical University","Shijiangzhuang","050005",{"type":56,"coordinates":156},[157,158],118.28833,39.40013,{"lat":158,"lon":157},[161],{"name":162,"role":44,"phone":163,"phoneExt":35,"email":164},"Lihun Zhang, Master","86-311-66002778","zhanglihui10510@163.com",{"facility":166,"status":35,"city":167,"state":168,"zip":169,"country":53,"countryCode":54,"cosmosGeoPoint":170,"geoPoint":174,"contacts":35},"The Fourth Affiliated Hospital Harbin Medical University","Harbin","Heilongjiang","150001",{"type":56,"coordinates":171},[172,173],126.65,45.75,{"lat":173,"lon":172},{"facility":176,"status":35,"city":177,"state":178,"zip":179,"country":53,"countryCode":54,"cosmosGeoPoint":180,"geoPoint":184,"contacts":35},"The First Affiliated Hospital of Henan University of Science & Technology","Luoyang","Henan","471000",{"type":56,"coordinates":181},[182,183],112.43684,34.67345,{"lat":183,"lon":182},{"facility":186,"status":35,"city":177,"state":178,"zip":187,"country":53,"countryCode":54,"cosmosGeoPoint":188,"geoPoint":190,"contacts":35},"Luoyang Third People's Hospital","471002",{"type":56,"coordinates":189},[182,183],{"lat":183,"lon":182},{"facility":192,"status":35,"city":193,"state":178,"zip":194,"country":53,"countryCode":54,"cosmosGeoPoint":195,"geoPoint":199,"contacts":35},"The First Affiliated of Nanyang Medical College","Nanyang","473000",{"type":56,"coordinates":196},[197,198],112.54659,33.00524,{"lat":198,"lon":197},{"facility":201,"status":35,"city":193,"state":178,"zip":202,"country":53,"countryCode":54,"cosmosGeoPoint":203,"geoPoint":205,"contacts":206},"Nanyang Second People's Hospital","473009",{"type":56,"coordinates":204},[197,198],{"lat":198,"lon":197},[207],{"name":208,"role":44,"phone":209,"phoneExt":35,"email":210},"Junjie Shang, Master","86-377-63023388","Junjieshang163@163.com",{"facility":212,"status":35,"city":213,"state":214,"zip":215,"country":53,"countryCode":54,"cosmosGeoPoint":216,"geoPoint":220,"contacts":221},"Yichang Central People's Hospital","Yichang","Hubei","443003",{"type":56,"coordinates":217},[218,219],111.28472,30.71444,{"lat":219,"lon":218},[222],{"name":223,"role":44,"phone":224,"phoneExt":35,"email":225},"Chaoyang Zeng, Doctor","86-717-6487063","Zengzhaoyang68@163.com",{"facility":227,"status":35,"city":228,"state":229,"zip":230,"country":53,"countryCode":54,"cosmosGeoPoint":231,"geoPoint":235,"contacts":236},"Yueyang People's Hospital","Yueyang","Hunan","414022",{"type":56,"coordinates":232},[233,234],113.09481,29.37455,{"lat":234,"lon":233},[237],{"name":238,"role":44,"phone":239,"phoneExt":35,"email":240},"Dijun Zhou, Doctor","86-730-8725393","z121300@126.com",{"facility":242,"status":35,"city":243,"state":229,"zip":244,"country":53,"countryCode":54,"cosmosGeoPoint":245,"geoPoint":249,"contacts":250},"Zhuzhou Central Hospital","Zhuzhou","412007",{"type":56,"coordinates":246},[247,248],113.15,27.83333,{"lat":248,"lon":247},[251],{"name":252,"role":44,"phone":35,"phoneExt":35,"email":35},"Lihua Zhou, Doctor",{"facility":254,"status":35,"city":255,"state":256,"zip":257,"country":53,"countryCode":54,"cosmosGeoPoint":258,"geoPoint":262,"contacts":263},"The Second People's Hospital of Lianyungang","Lianyungang","Jiangsu","222002",{"type":56,"coordinates":259},[260,261],119.21556,34.59845,{"lat":261,"lon":260},[264],{"name":265,"role":44,"phone":266,"phoneExt":35,"email":267},"Haixia Wen, Doctor","86-518-85775897","wenhaixialyg@163.com",{"facility":269,"status":35,"city":270,"state":256,"zip":271,"country":53,"countryCode":54,"cosmosGeoPoint":272,"geoPoint":276,"contacts":35},"Nanjing Jiangning Hospital","Nanjing","210000",{"type":56,"coordinates":273},[274,275],118.77778,32.06167,{"lat":275,"lon":274},{"facility":278,"status":35,"city":270,"state":256,"zip":279,"country":53,"countryCode":54,"cosmosGeoPoint":280,"geoPoint":282,"contacts":283},"The Second Affiliated Hospital of Nanjing Medical University","210011",{"type":56,"coordinates":281},[274,275],{"lat":275,"lon":274},[284],{"name":285,"role":44,"phone":286,"phoneExt":35,"email":287},"Yibing Lu, Doctor","86-25-58509670","luyibing2004@126.com",{"facility":289,"status":35,"city":290,"state":256,"zip":291,"country":53,"countryCode":54,"cosmosGeoPoint":292,"geoPoint":296,"contacts":297},"The Affiliated Hospital of Xuzhou Medical University","Xuzhou","221006",{"type":56,"coordinates":293},[294,295],117.28386,34.20442,{"lat":295,"lon":294},[298],{"name":299,"role":44,"phone":300,"phoneExt":35,"email":301},"Hongwei Ling, Doctor","86-516-85806507","Ling_hongwei@126.com",{"facility":303,"status":35,"city":304,"state":305,"zip":306,"country":53,"countryCode":54,"cosmosGeoPoint":307,"geoPoint":311,"contacts":35},"Central Hospital Affiliated to Shandong First Medical University","Jinan","Shandong","250000",{"type":56,"coordinates":308},[309,310],116.99722,36.66833,{"lat":310,"lon":309},{"facility":313,"status":35,"city":314,"state":305,"zip":315,"country":53,"countryCode":54,"cosmosGeoPoint":316,"geoPoint":320,"contacts":35},"Zibo Municipal Hospital","Zibo","255400",{"type":56,"coordinates":317},[318,319],118.06333,36.79056,{"lat":319,"lon":318},{"facility":322,"status":35,"city":323,"state":324,"zip":325,"country":53,"countryCode":54,"cosmosGeoPoint":326,"geoPoint":330,"contacts":35},"Xi'an Daxing Hospital","Xi’an","Shanxi","710000",{"type":56,"coordinates":327},[328,329],113.52486,35.99785,{"lat":329,"lon":328},{"facility":39,"status":35,"city":332,"state":35,"zip":35,"country":53,"countryCode":54,"cosmosGeoPoint":333,"geoPoint":337,"contacts":338},"Beijing",{"type":56,"coordinates":334},[335,336],116.39723,39.9075,{"lat":336,"lon":335},[339],{"name":38,"role":44,"phone":340,"phoneExt":35,"email":341},"86 10-88324973","jiln@bjmu.edu.cn",{"type":343,"investigatorFullName":35,"investigatorTitle":35,"investigatorAffiliation":35,"oldNameTitle":35,"oldOrganization":35},"SPONSOR","100610633","phase-3-a-study-of-zovaglutide-in-subjects-with-overweight-or-obesity-horizon-1-100610633",false,"NCT07230119","A Study of Zovaglutide in Subjects With Overweight or Obesity (HORIZON-1)","A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Phase 3 Study to Evaluate the Efficacy and Safety of Zovaglutide in Adults With Overweight or Obesity.","Inclusion Criteria:\n\n* 1\\. Male or female subjects aged≥18years and≤75 years at the time of signing the ICF.\n* 2.At screening and prior to randomization, BMI must meet one of the following criteria:\n\n  1. BMI≥28kg\u002Fm²regardless of comorbidities；\n  2. BM≤24 kg\u002Fm² and\\\u003C28 kg\u002Fm², with at least one of the following comorbidities: prediabetes, hypertension, dyslipidemia, fatty liver disease, obstructive sleep apnea syndrome due to overweight, or weight-bearing joint pain.\n* 3.Weight change due to diet and exercise alone within 3 months prior to screening and randomization did not exceed 5%.\n\nExclusion Criteria:\n\n* 1.Previously diagnosed obesity caused by monogenic mutations, other diseases, or medications.\n* 2.Previous diagnosis of diabetes; or HbA1c ≥ 6.5% or fasting blood glucose ≥ 7.0 mmol\u002FL at screening.\n* 3.Used of medicines or treatments that affect weight within 3 months prior to screening.\n* 4.History of acute or chronic pancreatitis, or pancreatic injury.\n* 5.History of medullary thyroid carcinoma (MTC) or type 2 multiple endocrine neoplasia (MEN2) in personal or family history.\n* 6.History of depression\u002Fanxiety disorder, or prior diagnosis of moderate-to-severe anxiety\u002Fdepressive state, or history of severe psychiatric disorders;\n* 7\\. PHQ-9 scale score is ≥ 15 at screening;\n* 8\\. Screening C-SSRS questionnaire suicide ideation response of \"Category 4 or 5,\" or any \"yes\" response to suicidal behavior questions.","ALL","18 Years","75 Years",{"count":355,"type":356},744,"ESTIMATED","INTERVENTIONAL",[359],"PHASE3","This study will evaluate the percentage change in body weight from baseline and proportion of subjects achieving ≥ 5% weight loss from baseline after 52 weeks of treatment with Zovaglutide in subjects with overweight\u002Fobesity.",[362],"Overweight , Obesity","NOT_YET_RECRUITING","2025-12-17",{"date":366,"type":367},"2025-12-23","ACTUAL",{"date":369,"type":356},"2026-03-08",{"date":371,"type":356},"2027-06-26",{"name":5,"class":6},25]