[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100593542":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":31,"locations":37,"responsibleParty":738,"collaborators":30,"id":740,"slug":741,"hasResults":742,"nctId":743,"briefTitle":744,"officialTitle":745,"acronym":746,"eligibilityCriteria":747,"healthyVolunteers":742,"sex":748,"minAge":749,"maxAge":30,"enrollmentInfo":750,"targetDuration":30,"studyType":753,"phases":754,"briefSummary":756,"conditions":757,"keywords":759,"overallStatus":79,"whyStopped":30,"lastUpdateSubmitDate":764,"lastUpdatePostDateStruct":765,"startDateStruct":768,"completionDateStruct":770,"leadSponsor":772,"locationsCount":773},{"fullName":5,"class":6},"AstraZeneca","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Baxdrostat","EXPERIMENTAL","Baxdrostat administered orally, once daily (QD).",[13],"Drug: Baxdrostat",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo","PLACEBO_COMPARATOR","Matching placebo administered orally, once daily (QD).",[19],"Drug: Placebo",[21,27],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Baxdrostat tablet administered orally, once daily (QD).",[9],[26],"CIN-107",{"type":22,"name":15,"description":28,"armGroupLabels":29,"otherNames":30},"Placebo tablet matching baxdrostat, administered orally, once daily (QD).",[15],null,[32],{"name":33,"role":34,"phone":35,"phoneExt":30,"email":36},"AstraZeneca Clinical Study Information Center","CONTACT","1-877-240-9479","information.center@astrazeneca.com",[38,52,60,69,78,87,96,105,110,119,128,137,147,155,164,172,181,190,198,207,216,224,234,242,250,261,270,278,287,297,302,307,315,323,328,336,344,352,360,368,373,381,391,399,407,415,423,431,436,446,454,462,470,478,486,496,504,512,520,528,533,543,551,559,567,572,580,585,588,596,604,607,615,618,628,636,641,646,654,664,672,680,688,691,699,709,717,725,733],{"facility":39,"status":40,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":30},"Research Site","NOT_YET_RECRUITING","Los Angeles","California","90048","United States","US",{"type":47,"coordinates":48},"Point",[49,50],-118.24368,34.05223,{"lat":50,"lon":49},{"facility":39,"status":40,"city":53,"state":42,"zip":54,"country":44,"countryCode":45,"cosmosGeoPoint":55,"geoPoint":59,"contacts":30},"San Francisco","94110",{"type":47,"coordinates":56},[57,58],-122.41942,37.77493,{"lat":58,"lon":57},{"facility":39,"status":40,"city":61,"state":62,"zip":63,"country":44,"countryCode":45,"cosmosGeoPoint":64,"geoPoint":68,"contacts":30},"Farmington","Connecticut","06030",{"type":47,"coordinates":65},[66,67],-72.83204,41.71982,{"lat":67,"lon":66},{"facility":39,"status":40,"city":70,"state":71,"zip":72,"country":44,"countryCode":45,"cosmosGeoPoint":73,"geoPoint":77,"contacts":30},"Chicago","Illinois","60611",{"type":47,"coordinates":74},[75,76],-87.65005,41.85003,{"lat":76,"lon":75},{"facility":39,"status":79,"city":80,"state":71,"zip":81,"country":44,"countryCode":45,"cosmosGeoPoint":82,"geoPoint":86,"contacts":30},"RECRUITING","Springfield","62702",{"type":47,"coordinates":83},[84,85],-89.64371,39.80172,{"lat":85,"lon":84},{"facility":39,"status":40,"city":88,"state":89,"zip":90,"country":44,"countryCode":45,"cosmosGeoPoint":91,"geoPoint":95,"contacts":30},"Baltimore","Maryland","21287",{"type":47,"coordinates":92},[93,94],-76.61219,39.29038,{"lat":94,"lon":93},{"facility":39,"status":79,"city":97,"state":98,"zip":99,"country":44,"countryCode":45,"cosmosGeoPoint":100,"geoPoint":104,"contacts":30},"Boston","Massachusetts","02111",{"type":47,"coordinates":101},[102,103],-71.05977,42.35843,{"lat":103,"lon":102},{"facility":39,"status":79,"city":97,"state":98,"zip":106,"country":44,"countryCode":45,"cosmosGeoPoint":107,"geoPoint":109,"contacts":30},"02115",{"type":47,"coordinates":108},[102,103],{"lat":103,"lon":102},{"facility":39,"status":79,"city":111,"state":112,"zip":113,"country":44,"countryCode":45,"cosmosGeoPoint":114,"geoPoint":118,"contacts":30},"Ann Arbor","Michigan","48109",{"type":47,"coordinates":115},[116,117],-83.74088,42.27756,{"lat":117,"lon":116},{"facility":39,"status":79,"city":120,"state":121,"zip":122,"country":44,"countryCode":45,"cosmosGeoPoint":123,"geoPoint":127,"contacts":30},"Rochester","Minnesota","55902",{"type":47,"coordinates":124},[125,126],-92.4699,44.02163,{"lat":126,"lon":125},{"facility":39,"status":79,"city":129,"state":130,"zip":131,"country":44,"countryCode":45,"cosmosGeoPoint":132,"geoPoint":136,"contacts":30},"Olive Branch","Mississippi","38654",{"type":47,"coordinates":133},[134,135],-89.82953,34.96176,{"lat":135,"lon":134},{"facility":39,"status":138,"city":139,"state":140,"zip":141,"country":44,"countryCode":45,"cosmosGeoPoint":142,"geoPoint":146,"contacts":30},"WITHDRAWN","Kansas City","Missouri","64151",{"type":47,"coordinates":143},[144,145],-94.57857,39.09973,{"lat":145,"lon":144},{"facility":39,"status":40,"city":148,"state":148,"zip":149,"country":44,"countryCode":45,"cosmosGeoPoint":150,"geoPoint":154,"contacts":30},"New York","10065",{"type":47,"coordinates":151},[152,153],-74.00597,40.71427,{"lat":153,"lon":152},{"facility":39,"status":40,"city":156,"state":157,"zip":158,"country":44,"countryCode":45,"cosmosGeoPoint":159,"geoPoint":163,"contacts":30},"Cleveland","Ohio","44195",{"type":47,"coordinates":160},[161,162],-81.69541,41.4995,{"lat":162,"lon":161},{"facility":39,"status":79,"city":165,"state":157,"zip":166,"country":44,"countryCode":45,"cosmosGeoPoint":167,"geoPoint":171,"contacts":30},"Columbus","43210",{"type":47,"coordinates":168},[169,170],-82.99879,39.96118,{"lat":170,"lon":169},{"facility":39,"status":138,"city":173,"state":174,"zip":175,"country":44,"countryCode":45,"cosmosGeoPoint":176,"geoPoint":180,"contacts":30},"Portland","Oregon","97239",{"type":47,"coordinates":177},[178,179],-122.67621,45.52345,{"lat":179,"lon":178},{"facility":39,"status":79,"city":182,"state":183,"zip":184,"country":44,"countryCode":45,"cosmosGeoPoint":185,"geoPoint":189,"contacts":30},"Bethlehem","Pennsylvania","18017",{"type":47,"coordinates":186},[187,188],-75.37046,40.62593,{"lat":188,"lon":187},{"facility":39,"status":40,"city":191,"state":183,"zip":192,"country":44,"countryCode":45,"cosmosGeoPoint":193,"geoPoint":197,"contacts":30},"Philadelphia","19104",{"type":47,"coordinates":194},[195,196],-75.16362,39.95238,{"lat":196,"lon":195},{"facility":39,"status":79,"city":199,"state":200,"zip":201,"country":44,"countryCode":45,"cosmosGeoPoint":202,"geoPoint":206,"contacts":30},"Columbia","South Carolina","29203",{"type":47,"coordinates":203},[204,205],-81.03481,34.00071,{"lat":205,"lon":204},{"facility":39,"status":138,"city":208,"state":209,"zip":210,"country":44,"countryCode":45,"cosmosGeoPoint":211,"geoPoint":215,"contacts":30},"Brownsville","Texas","78526",{"type":47,"coordinates":212},[213,214],-97.49748,25.90175,{"lat":214,"lon":213},{"facility":39,"status":79,"city":217,"state":209,"zip":218,"country":44,"countryCode":45,"cosmosGeoPoint":219,"geoPoint":223,"contacts":30},"Dallas","75390",{"type":47,"coordinates":220},[221,222],-96.80667,32.78306,{"lat":222,"lon":221},{"facility":39,"status":79,"city":225,"state":30,"zip":226,"country":227,"countryCode":228,"cosmosGeoPoint":229,"geoPoint":233,"contacts":30},"Brisbane","4102","Australia","AU",{"type":47,"coordinates":230},[231,232],153.02809,-27.46794,{"lat":232,"lon":231},{"facility":39,"status":79,"city":235,"state":30,"zip":236,"country":227,"countryCode":228,"cosmosGeoPoint":237,"geoPoint":241,"contacts":30},"Clayton","3168",{"type":47,"coordinates":238},[239,240],145.11667,-37.91667,{"lat":240,"lon":239},{"facility":39,"status":79,"city":243,"state":30,"zip":244,"country":227,"countryCode":228,"cosmosGeoPoint":245,"geoPoint":249,"contacts":30},"Perth","6000",{"type":47,"coordinates":246},[247,248],115.8614,-31.95224,{"lat":248,"lon":247},{"facility":39,"status":79,"city":251,"state":252,"zip":253,"country":254,"countryCode":255,"cosmosGeoPoint":256,"geoPoint":260,"contacts":30},"Calgary","Alberta","T2T 5C7","Canada","CA",{"type":47,"coordinates":257},[258,259],-114.08529,51.05011,{"lat":259,"lon":258},{"facility":39,"status":79,"city":262,"state":263,"zip":264,"country":254,"countryCode":255,"cosmosGeoPoint":265,"geoPoint":269,"contacts":30},"Ottawa","Ontario","K1H 7W9",{"type":47,"coordinates":266},[267,268],-75.69812,45.41117,{"lat":268,"lon":267},{"facility":39,"status":79,"city":271,"state":263,"zip":272,"country":254,"countryCode":255,"cosmosGeoPoint":273,"geoPoint":277,"contacts":30},"Toronto","M4G 3E8",{"type":47,"coordinates":274},[275,276],-79.39864,43.70643,{"lat":276,"lon":275},{"facility":39,"status":79,"city":279,"state":280,"zip":281,"country":254,"countryCode":255,"cosmosGeoPoint":282,"geoPoint":286,"contacts":30},"Montreal","Quebec","H4J 1C5",{"type":47,"coordinates":283},[284,285],-73.58781,45.50884,{"lat":285,"lon":284},{"facility":39,"status":79,"city":288,"state":30,"zip":289,"country":290,"countryCode":291,"cosmosGeoPoint":292,"geoPoint":296,"contacts":30},"Beijing","100034","China","CN",{"type":47,"coordinates":293},[294,295],116.39723,39.9075,{"lat":295,"lon":294},{"facility":39,"status":79,"city":288,"state":30,"zip":298,"country":290,"countryCode":291,"cosmosGeoPoint":299,"geoPoint":301,"contacts":30},"100044",{"type":47,"coordinates":300},[294,295],{"lat":295,"lon":294},{"facility":39,"status":79,"city":288,"state":30,"zip":303,"country":290,"countryCode":291,"cosmosGeoPoint":304,"geoPoint":306,"contacts":30},"100191",{"type":47,"coordinates":305},[294,295],{"lat":295,"lon":294},{"facility":39,"status":79,"city":308,"state":30,"zip":309,"country":290,"countryCode":291,"cosmosGeoPoint":310,"geoPoint":314,"contacts":30},"Changsha","430033",{"type":47,"coordinates":311},[312,313],112.97087,28.19874,{"lat":313,"lon":312},{"facility":39,"status":79,"city":316,"state":30,"zip":317,"country":290,"countryCode":291,"cosmosGeoPoint":318,"geoPoint":322,"contacts":30},"Chengdu","610041",{"type":47,"coordinates":319},[320,321],104.06667,30.66667,{"lat":321,"lon":320},{"facility":39,"status":138,"city":316,"state":30,"zip":324,"country":290,"countryCode":291,"cosmosGeoPoint":325,"geoPoint":327,"contacts":30},"610500",{"type":47,"coordinates":326},[320,321],{"lat":321,"lon":320},{"facility":39,"status":79,"city":329,"state":30,"zip":330,"country":290,"countryCode":291,"cosmosGeoPoint":331,"geoPoint":335,"contacts":30},"Chongqing","400042",{"type":47,"coordinates":332},[333,334],106.55771,29.56026,{"lat":334,"lon":333},{"facility":39,"status":79,"city":337,"state":30,"zip":338,"country":290,"countryCode":291,"cosmosGeoPoint":339,"geoPoint":343,"contacts":30},"Nanjing","2100008",{"type":47,"coordinates":340},[341,342],118.77778,32.06167,{"lat":342,"lon":341},{"facility":39,"status":79,"city":345,"state":30,"zip":346,"country":290,"countryCode":291,"cosmosGeoPoint":347,"geoPoint":351,"contacts":30},"Shanghai","200025",{"type":47,"coordinates":348},[349,350],121.45806,31.22222,{"lat":350,"lon":349},{"facility":39,"status":79,"city":353,"state":30,"zip":354,"country":290,"countryCode":291,"cosmosGeoPoint":355,"geoPoint":359,"contacts":30},"Tianjin","300050",{"type":47,"coordinates":356},[357,358],117.17667,39.14222,{"lat":358,"lon":357},{"facility":39,"status":79,"city":361,"state":30,"zip":362,"country":290,"countryCode":291,"cosmosGeoPoint":363,"geoPoint":367,"contacts":30},"Wuhan","430030",{"type":47,"coordinates":364},[365,366],114.26667,30.58333,{"lat":366,"lon":365},{"facility":39,"status":79,"city":361,"state":30,"zip":369,"country":290,"countryCode":291,"cosmosGeoPoint":370,"geoPoint":372,"contacts":30},"430060",{"type":47,"coordinates":371},[365,366],{"lat":366,"lon":365},{"facility":39,"status":79,"city":374,"state":30,"zip":375,"country":290,"countryCode":291,"cosmosGeoPoint":376,"geoPoint":380,"contacts":30},"Xianyang","750004",{"type":47,"coordinates":377},[378,379],108.70261,34.33778,{"lat":379,"lon":378},{"facility":39,"status":79,"city":382,"state":30,"zip":383,"country":384,"countryCode":385,"cosmosGeoPoint":386,"geoPoint":390,"contacts":30},"Amiens","80054","France","FR",{"type":47,"coordinates":387},[388,389],2.3,49.9,{"lat":389,"lon":388},{"facility":39,"status":79,"city":392,"state":30,"zip":393,"country":384,"countryCode":385,"cosmosGeoPoint":394,"geoPoint":398,"contacts":30},"Bois-Guillaume","76230",{"type":47,"coordinates":395},[396,397],1.12219,49.4602,{"lat":397,"lon":396},{"facility":39,"status":79,"city":400,"state":30,"zip":401,"country":384,"countryCode":385,"cosmosGeoPoint":402,"geoPoint":406,"contacts":30},"Bordeaux","33076",{"type":47,"coordinates":403},[404,405],-0.58046,44.84124,{"lat":405,"lon":404},{"facility":39,"status":79,"city":408,"state":30,"zip":409,"country":384,"countryCode":385,"cosmosGeoPoint":410,"geoPoint":414,"contacts":30},"Lille","59037",{"type":47,"coordinates":411},[412,413],3.05512,50.63391,{"lat":413,"lon":412},{"facility":39,"status":79,"city":416,"state":30,"zip":417,"country":384,"countryCode":385,"cosmosGeoPoint":418,"geoPoint":422,"contacts":30},"Marseille","13005",{"type":47,"coordinates":419},[420,421],5.38107,43.29695,{"lat":421,"lon":420},{"facility":39,"status":79,"city":424,"state":30,"zip":425,"country":384,"countryCode":385,"cosmosGeoPoint":426,"geoPoint":430,"contacts":30},"Paris","75018",{"type":47,"coordinates":427},[428,429],2.3488,48.85341,{"lat":429,"lon":428},{"facility":39,"status":79,"city":424,"state":30,"zip":432,"country":384,"countryCode":385,"cosmosGeoPoint":433,"geoPoint":435,"contacts":30},"75908",{"type":47,"coordinates":434},[428,429],{"lat":429,"lon":428},{"facility":39,"status":79,"city":437,"state":30,"zip":438,"country":439,"countryCode":440,"cosmosGeoPoint":441,"geoPoint":445,"contacts":30},"Berlin","12203","Germany","DE",{"type":47,"coordinates":442},[443,444],13.41053,52.52437,{"lat":444,"lon":443},{"facility":39,"status":79,"city":447,"state":30,"zip":448,"country":439,"countryCode":440,"cosmosGeoPoint":449,"geoPoint":453,"contacts":30},"Düsseldorf","40225",{"type":47,"coordinates":450},[451,452],6.77927,51.22319,{"lat":452,"lon":451},{"facility":39,"status":79,"city":455,"state":30,"zip":456,"country":439,"countryCode":440,"cosmosGeoPoint":457,"geoPoint":461,"contacts":30},"Kaiserslautern","67655",{"type":47,"coordinates":458},[459,460],7.77161,49.443,{"lat":460,"lon":459},{"facility":39,"status":79,"city":463,"state":30,"zip":464,"country":439,"countryCode":440,"cosmosGeoPoint":465,"geoPoint":469,"contacts":30},"München","80336",{"type":47,"coordinates":466},[467,468],13.31243,51.60698,{"lat":468,"lon":467},{"facility":39,"status":79,"city":471,"state":30,"zip":472,"country":439,"countryCode":440,"cosmosGeoPoint":473,"geoPoint":477,"contacts":30},"Reinfeld (Holstein)","23858",{"type":47,"coordinates":474},[475,476],10.49227,53.8311,{"lat":476,"lon":475},{"facility":39,"status":79,"city":479,"state":30,"zip":480,"country":439,"countryCode":440,"cosmosGeoPoint":481,"geoPoint":485,"contacts":30},"Würzburg","97080",{"type":47,"coordinates":482},[483,484],9.95121,49.79391,{"lat":484,"lon":483},{"facility":39,"status":79,"city":487,"state":30,"zip":488,"country":489,"countryCode":490,"cosmosGeoPoint":491,"geoPoint":495,"contacts":30},"Belagavi","590010","India","IN",{"type":47,"coordinates":492},[493,494],74.50447,15.85212,{"lat":494,"lon":493},{"facility":39,"status":79,"city":497,"state":30,"zip":498,"country":489,"countryCode":490,"cosmosGeoPoint":499,"geoPoint":503,"contacts":30},"Delhi","110029",{"type":47,"coordinates":500},[501,502],77.23149,28.65195,{"lat":502,"lon":501},{"facility":39,"status":79,"city":505,"state":30,"zip":506,"country":489,"countryCode":490,"cosmosGeoPoint":507,"geoPoint":511,"contacts":30},"Hyderabad","500012",{"type":47,"coordinates":508},[509,510],78.45636,17.38405,{"lat":510,"lon":509},{"facility":39,"status":79,"city":513,"state":30,"zip":514,"country":489,"countryCode":490,"cosmosGeoPoint":515,"geoPoint":519,"contacts":30},"Kolkata","700020",{"type":47,"coordinates":516},[517,518],88.36304,22.56263,{"lat":518,"lon":517},{"facility":39,"status":40,"city":521,"state":30,"zip":522,"country":489,"countryCode":490,"cosmosGeoPoint":523,"geoPoint":527,"contacts":30},"Mumbai","400008",{"type":47,"coordinates":524},[525,526],72.88261,19.07283,{"lat":526,"lon":525},{"facility":39,"status":79,"city":521,"state":30,"zip":529,"country":489,"countryCode":490,"cosmosGeoPoint":530,"geoPoint":532,"contacts":30},"400012",{"type":47,"coordinates":531},[525,526],{"lat":526,"lon":525},{"facility":39,"status":79,"city":534,"state":30,"zip":535,"country":536,"countryCode":537,"cosmosGeoPoint":538,"geoPoint":542,"contacts":30},"Bologna","40138","Italy","IT",{"type":47,"coordinates":539},[540,541],11.33875,44.49381,{"lat":541,"lon":540},{"facility":39,"status":79,"city":544,"state":30,"zip":545,"country":536,"countryCode":537,"cosmosGeoPoint":546,"geoPoint":550,"contacts":30},"Brescia","25123",{"type":47,"coordinates":547},[548,549],10.21472,45.53558,{"lat":549,"lon":548},{"facility":39,"status":79,"city":552,"state":30,"zip":553,"country":536,"countryCode":537,"cosmosGeoPoint":554,"geoPoint":558,"contacts":30},"Florence","50134",{"type":47,"coordinates":555},[556,557],11.24626,43.77925,{"lat":557,"lon":556},{"facility":39,"status":79,"city":560,"state":30,"zip":561,"country":536,"countryCode":537,"cosmosGeoPoint":562,"geoPoint":566,"contacts":30},"Milan","20149",{"type":47,"coordinates":563},[564,565],12.59836,42.78235,{"lat":565,"lon":564},{"facility":39,"status":79,"city":560,"state":30,"zip":568,"country":536,"countryCode":537,"cosmosGeoPoint":569,"geoPoint":571,"contacts":30},"20162",{"type":47,"coordinates":570},[564,565],{"lat":565,"lon":564},{"facility":39,"status":79,"city":573,"state":30,"zip":574,"country":536,"countryCode":537,"cosmosGeoPoint":575,"geoPoint":579,"contacts":30},"Torino","10126",{"type":47,"coordinates":576},[577,578],11.99138,44.88856,{"lat":578,"lon":577},{"facility":39,"status":79,"city":581,"state":30,"zip":582,"country":583,"countryCode":584,"cosmosGeoPoint":30,"geoPoint":30,"contacts":30},"Kawasaki-shi","216-8511","Japan","JP",{"facility":39,"status":79,"city":586,"state":30,"zip":587,"country":583,"countryCode":584,"cosmosGeoPoint":30,"geoPoint":30,"contacts":30},"Kodaira-shi","187-8510",{"facility":39,"status":79,"city":589,"state":30,"zip":590,"country":583,"countryCode":584,"cosmosGeoPoint":591,"geoPoint":595,"contacts":30},"Minatoku","108-8329",{"type":47,"coordinates":592},[593,594],130.59341,32.57237,{"lat":594,"lon":593},{"facility":39,"status":79,"city":597,"state":30,"zip":598,"country":583,"countryCode":584,"cosmosGeoPoint":599,"geoPoint":603,"contacts":30},"Ōta-ku","143-8541",{"type":47,"coordinates":600},[601,602],139.71605,35.56126,{"lat":602,"lon":601},{"facility":39,"status":79,"city":605,"state":30,"zip":606,"country":583,"countryCode":584,"cosmosGeoPoint":30,"geoPoint":30,"contacts":30},"Shinjuku-ku","162-8666",{"facility":39,"status":79,"city":608,"state":30,"zip":609,"country":583,"countryCode":584,"cosmosGeoPoint":610,"geoPoint":614,"contacts":30},"Yokohama","230-8765",{"type":47,"coordinates":611},[612,613],139.65,35.43333,{"lat":613,"lon":612},{"facility":39,"status":79,"city":616,"state":30,"zip":617,"country":583,"countryCode":584,"cosmosGeoPoint":30,"geoPoint":30,"contacts":30},"Yufu-shi","879-5593",{"facility":39,"status":79,"city":619,"state":30,"zip":620,"country":621,"countryCode":622,"cosmosGeoPoint":623,"geoPoint":627,"contacts":30},"Barcelona","08036","Spain","ES",{"type":47,"coordinates":624},[625,626],2.15899,41.38879,{"lat":626,"lon":625},{"facility":39,"status":79,"city":629,"state":30,"zip":630,"country":621,"countryCode":622,"cosmosGeoPoint":631,"geoPoint":635,"contacts":30},"Madrid","28034",{"type":47,"coordinates":632},[633,634],-3.70256,40.4165,{"lat":634,"lon":633},{"facility":39,"status":79,"city":629,"state":30,"zip":637,"country":621,"countryCode":622,"cosmosGeoPoint":638,"geoPoint":640,"contacts":30},"28040",{"type":47,"coordinates":639},[633,634],{"lat":634,"lon":633},{"facility":39,"status":79,"city":629,"state":30,"zip":642,"country":621,"countryCode":622,"cosmosGeoPoint":643,"geoPoint":645,"contacts":30},"28046",{"type":47,"coordinates":644},[633,634],{"lat":634,"lon":633},{"facility":39,"status":79,"city":647,"state":30,"zip":648,"country":621,"countryCode":622,"cosmosGeoPoint":649,"geoPoint":653,"contacts":30},"Seville","41013",{"type":47,"coordinates":650},[651,652],-5.97317,37.38283,{"lat":652,"lon":651},{"facility":39,"status":79,"city":655,"state":30,"zip":656,"country":657,"countryCode":658,"cosmosGeoPoint":659,"geoPoint":663,"contacts":30},"Kaohsiung City","80756","Taiwan","TW",{"type":47,"coordinates":660},[661,662],120.31333,22.61626,{"lat":662,"lon":661},{"facility":39,"status":79,"city":665,"state":30,"zip":666,"country":657,"countryCode":658,"cosmosGeoPoint":667,"geoPoint":671,"contacts":30},"Taichung","40705",{"type":47,"coordinates":668},[669,670],120.6839,24.1469,{"lat":670,"lon":669},{"facility":39,"status":79,"city":673,"state":30,"zip":674,"country":657,"countryCode":658,"cosmosGeoPoint":675,"geoPoint":679,"contacts":30},"Taipei","10002",{"type":47,"coordinates":676},[677,678],121.52639,25.05306,{"lat":678,"lon":677},{"facility":39,"status":79,"city":681,"state":30,"zip":682,"country":657,"countryCode":658,"cosmosGeoPoint":683,"geoPoint":687,"contacts":30},"Taoyuan","333",{"type":47,"coordinates":684},[685,686],121.29696,24.99368,{"lat":686,"lon":685},{"facility":39,"status":79,"city":689,"state":30,"zip":690,"country":657,"countryCode":658,"cosmosGeoPoint":30,"geoPoint":30,"contacts":30},"Yunlin","640",{"facility":39,"status":79,"city":692,"state":30,"zip":693,"country":657,"countryCode":658,"cosmosGeoPoint":694,"geoPoint":698,"contacts":30},"Zhubei","302",{"type":47,"coordinates":695},[696,697],121.00778,24.83833,{"lat":697,"lon":696},{"facility":39,"status":79,"city":700,"state":30,"zip":701,"country":702,"countryCode":703,"cosmosGeoPoint":704,"geoPoint":708,"contacts":30},"Cambridge","CB2 0QQ","United Kingdom","UK",{"type":47,"coordinates":705},[706,707],0.11667,52.2,{"lat":707,"lon":706},{"facility":39,"status":79,"city":710,"state":30,"zip":711,"country":702,"countryCode":703,"cosmosGeoPoint":712,"geoPoint":716,"contacts":30},"Cardiff","CF14 4XW",{"type":47,"coordinates":713},[714,715],-3.18,51.48,{"lat":715,"lon":714},{"facility":39,"status":79,"city":718,"state":30,"zip":719,"country":702,"countryCode":703,"cosmosGeoPoint":720,"geoPoint":724,"contacts":30},"Dundee","DD1 9SY",{"type":47,"coordinates":721},[722,723],-2.97489,56.46913,{"lat":723,"lon":722},{"facility":39,"status":79,"city":726,"state":30,"zip":727,"country":702,"countryCode":703,"cosmosGeoPoint":728,"geoPoint":732,"contacts":30},"London","EC1A 7BE",{"type":47,"coordinates":729},[730,731],-0.12574,51.50853,{"lat":731,"lon":730},{"facility":39,"status":79,"city":726,"state":30,"zip":734,"country":702,"countryCode":703,"cosmosGeoPoint":735,"geoPoint":737,"contacts":30},"SE1 9RT",{"type":47,"coordinates":736},[730,731],{"lat":731,"lon":730},{"type":739,"investigatorFullName":30,"investigatorTitle":30,"investigatorAffiliation":30,"oldNameTitle":30,"oldOrganization":30},"SPONSOR","100593542","phase-3-a-study-to-assess-efficacy-and-safety-of-baxdrostat-in-participants-with-primary-aldosteronism-100593542",false,"NCT07007793","A Study to Assess Efficacy and Safety of Baxdrostat in Participants With Primary Aldosteronism","A Randomised, Double-Blind, Placebo-Controlled, Parallel-Group Study to Assess the Efficacy and Safety of Baxdrostat in Adult Participants With Primary Aldosteronism","BaxPA","Inclusion Criteria:\n\n* Male or female participants must be ≥ 18 years of age\n* Participants with a documented diagnosis of PA that fulfils the criteria defined in the 2016 or 2025 Endocrine Society Guidelines.\n* Participants willing and able to cease dosing of MRA or potassium sparing diuretics per study requirement for participants taking an MRA or potassium sparing diuretic at Screening.\n* eGFR ≥ 45 mL\u002Fmin\u002F1.73m2 at Screening\n* Serum potassium level ≥ 3.0 and \\\u003C 5.0 mmol\u002FL at Screening determined as per the central laboratory.\n* Have a stable regimen of antihypertensive medications for at least 4 weeks prior to randomisation\n* Mean seated SBP on AOBPM of ≥ 135 mmHg and ≤ 170 mmHg and mean DBP of\n\n  ≤ 105 mmHg.\n* Serum potassium (local lab) \\> 3.0 mmol\u002FL at randomization.\n\nExclusion Criteria:\n\n\\- If not taking an MRA or potassium sparing diuretic at Screening: Mean seated SBP \\> 170 mmHg or mean seated DBP \\>105 mmHg (on AOBPM).\n\nIf taking an MRA or potassium sparing diuretic at Screening: Mean seated SBP \\> 160 mmHg or mean seated DBP ≥ 100 mmHg.\n\n* Previous surgical intervention for an adrenal adenoma or have a planned adrenalectomy, renal nerve denervation, or adrenal ablative procedure during the course of the study.\n* Has the following known secondary causes of HTN: renal artery stenosis, uncontrolled or untreated hyperthyroidism, uncontrolled or untreated hypothyroidism, pheochromocytoma, Cushing's syndrome, aortic coarctation.\n* Serum sodium level \\\u003C 135 mmol\u002FL at Screening, determined as per central laboratory.\n* New York Heart Association functional HF class IV at Screening.\n* Persistent atrial fibrillation.\n* Treatment with any MRA or potassium-sparing diuretic within 2 weeks prior to Randomisation.","ALL","18 Years",{"count":751,"type":752},250,"ESTIMATED","INTERVENTIONAL",[755],"PHASE3","This is a Phase III, multicentre, randomised, double-blind, placebo-controlled, parallel-group study to evaluate the safety, tolerability, and efficacy of baxdrostat versus placebo, on the reduction of Seated Blood Pressure (SBP) and achieving normalization of the Renin Angiotensin Aldosterone System (RAAS) in approximately 180 participants ≥ 18 years of age with Primary Aldosteronism (PA), with or without prior treatment with Mineralocorticoid Receptor Antagonists (MRAs) or potassium-sparing diuretics.\n\nBaxdrostat (or placebo) will be administered once daily, up-titrated after 2 weeks based on clinical response and tolerability.\n\nThe study is planned to be conducted globally in approximately 90 study centres and 12 countries.",[758],"Primary Hyperaldosteronism",[760,761,762,9,26,763],"Primary hyperaldosteronism","Primary aldosteronism","PA","Aldosterone","2026-04-17",{"date":766,"type":767},"2026-04-20","ACTUAL",{"date":769,"type":767},"2025-08-07",{"date":771,"type":752},"2028-02-18",{"name":5,"class":6},89]